Details for gene: AKR1B1


This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]


Symbol
AKR1B1
Name
aldo-keto reductase family 1 member B
Entrez ID
231
Ensembl ID
ENSG00000085662    (more details)
KEGG ID
hsa:231    (more details)
OMIM ID
103880
Uniprot ID
P15121  
GO ID
hsa:231    (more details)
Chromosome
7
Strand
-1
Start
134442356
End
134459284
miRNA Interactions
hsa-miR-29a-3p (RPM: 1246.9046) / hsa-miR-124-3p (RPM: 4110.4386) / hsa-miR-34a-5p (RPM: 81.3502) / hsa-miR-147a (RPM: 0.0014) / hsa-miR-374a-5p (RPM: 52.6724) / hsa-miR-138-5p (RPM: 67.2828) / hsa-miR-129-2-3p (RPM: 79.8688) / hsa-miR-128-3p (RPM: 329.321) / hsa-miR-1226-3p (RPM: 2.778) / hsa-miR-342-5p (RPM: 28.1628) / hsa-miR-191-5p (RPM: 12993.8088) /
Involved Diseases
cataract /
Involved Pathways
Metabolic pathways / Glycerolipid metabolism / Pentose and glucuronate interconversions / Fructose and mannose metabolism / Galactose metabolism / Folate biosynthesis / Metabolism / Metabolism of lipids / Metabolism of steroids / Metabolism of steroid hormones / Pregnenolone biosynthesis / Fructose metabolism / Fructose biosynthesis / Metabolism of carbohydrates /
Sequence
GGAAAGAATCCGCTGCCACTAGGACCAGGCGGAAGAAGCATCCCCGCCGACCCTTGGGGAAGGCCGCCGCGGCACCCCCAGCGCAACCAATCAGAAGGCTCCTTCGCGCAGCGGCGCGCCAACCGCAGGCGCCCTTTCTGCCGACCTCACGGGCTATTTAAAGGTACGCGCCGCGGCCAAGGCCGCACCGTACTGGGCGGGGGTCTGGGGAGCGCAGCAGCCATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACCTGGAAGGTAGGTGCTCGTGGGGGCGCGGGCCCGGGGCTCGCCTCACACTCTCCGCGCGGCCTGTATTGGCGAGGGACCCCGAGTGACCCTGAGCAGCTCGCCCCGCGGACGCCCGGCGTGCTGGGAGCCACGCGCGGGCTTGCAGGGTCCCCAGCGGGCTGGGGTCGGCCTTGCAGAGACCGGGGGCCTTGGCTCCCCGGGTTGGCCCTGGGCGTCAGGGCAGCATCCTGCGAGTGGGGTTTGGGAGCAGCTCACGGGAGCCCCCGCCCTACCGCGGGCAACCCTTGATGGGCGGCCCACCAGTCCGCATTTTGGGTCCTAGCGGGCGCCCCAAGCGGCACAACGCGAGAGGGAGGCGGGGAAAGTGGGCTTCACAGACCGGTGGACCTCGGGCGCAGACAGGGACGTGGAGCCGTCGGCAAGGTGTGGGAGCGCAGACCCAGCCTCCTTTCCCTCGAGGCACCTGTAGCCCGGTTGCCTCACTTGTAAATAGTTGGTCTCAATCGTTTCGATTCTTGCCCTCCCTGAGGAATAAGCATCTCAAGCCGGTAGAGGGCAGAGAATTAGGTGGCGCGAGTTTGCCCGGACCCAGCTGTTAACAAGGCGCAGTGCGGAGCTCCTCGGCCAGGCGCCGCCTCGGGGTGCCCTGGGTCTGGAACTCGGGAGAAAAATCTGGGCACCCCGTAGCTAGTTGATAATTCAGGAGGCGCCAAGGTTAGCATTTTCCCTGTAAAACCTCAACACCACACAGCGTCCCCGAGAAGTGCCTAGCCGGATGAGAATGACAATAGGACATGAAACATCATAGGATATGAAAAATGATAATATGATATGAAAAACCAAAAATAATAGCCTGAGCCTGATTATCTGAAAATTGAGCAACAAAGGTGGTGGTATGGGAGCTGAGGCAAAACCTAGAATTTTTAACCTTCTAAGTATTGCATATTATATTCCACAGCCATAACCTGGGTTTCTCAGTTTCTGTTTTTGTTGTTTGCTTGTTTGTTTGTGACAGGGTCTCGTTGCCCAAGCTGGGGTGCAGTGGCACAATCATGGTTCATTGCAGCCTGGAACTCCTGGGCTCAAGTGATCCTCCTGCCTCAGCACTGCGGGTAGCTGGGACTACAGGCGCTCACCACCACACCTGGCTAATCTTTTTTCTTCCCCGCAGAGACAGTCTCCGCTTGTTGCTTAGGGTGATCTCCAATTCCTGGGCTCAAAGCGCTCCTCCCACCTCGCCTCCCAAAGCTACAGGTGTGAACCATCTGGCAGGCCCACGTCCCAGGTTTTTCTCTTAAAATTTGAATATGGGCCTGGGCGTTGGATATTTACACACAGACAAGGGAAGAAAACAACAGAAAGAACTGAGTGAACTGTGAGATGTTTGAAATAGGACAGAAGAGTTTACATGTACCCTAAAACCTGCTGTTGAAAATTAGTAAATATAAGGTAAGAAAAAGGTCATTTGCATCAGGGAGAGTGTTTCTTGGCCAGAATGATCAGGGTACGTGATTTGTTTCCTCCAAAAACTCCAGTGGTGTCTCTAAGGTTGTAATTGAATTACAACCATGACACCAAGCTAATTTCCATCTGTTGCATGTTATGCTCTTGGAATGGATGCAGAAGGATGCTTTCTTGGCAATAGCAAATACTTTCTAAGCATGATGCAACGCACAGATATATACATGTAACTGGAATAAAAATTACTTAACAGTACTTAACCTATGTAGGCTGCATTTCAATATTTTTTTCTATTCCATTTTTCCAAAAATTATTGTCATACCTCCAGAAGCTAGTTTTGTGACCCATCATTTGAAAATCACTACTCTAGGGTAAATAAGGAGTAAAAGTTTATTTTTTTTTTTTTGAGACAGGGGCTCAGTGTCACCCAGGCTGGAGTGCAGTGGCATGATCATGATTCACTGTAGCCTTAACCTCTTGGGCTCAAGTGGTCCTCATACCTCAGCCTCCCAAGTAGCTGGGACCACAGGTGTGTGCCACCACACTCGGGTAGTTTGTTTTTAATTTTTTGTAGAGACAGGTTTCCCTATGTTGTCCAGGCTGAGGAGTAAAAGTTTATGAAAGAGGGTTTCAGATTATTCACTTGAGCACTCAATGCCCCAAAAAGCTATGTATTTGTTTAAGATAACATCACATCATAACATCTGTACATTTAGGTTATGCATTCCAGTAGACAGAGTTCATTGAGAAATTGGATAATGTCTGCTTCATTCATTACTATTTCTAGCACTTCTCACAGTGCCTGGCAAATATAGGAGTAGGTATCCAAAAGTTATGTGTTGAATTCATATGAAGAAGTAAAACGACTTTAGAGATAGCTGTATGGTGAAAACGCCCACTTGTATTCCTGTGGATGAGGAGATCAGGTTGGTGTAGAATTGTACGGTGGGGGCAGCGGGGAATGGTGGGTCAAAGTAATGGTATAAGGATGGACTTGGAATCAACTTCCTTTTTTTTTTTAATGACTTAAAACCTTTCCCTGGGGCCGGGCGCGGTGGCTCACACCTGTAACCCCAGCACTTTGGGAGGCAGAGGCGGGCAGATCATGAGGTCAGAAGATAGAGACCGTCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCCGGCATCGTGGCACGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAAAATCGCTTGAACCCCAGATGTGGAGGTTGCAGTGAGCCGAGGTCCCGCCACTGCACTCCAGCCTGGGCGATGGAGCAAGACTCCATCTAAAAAAACAACCAAACAAAAAAACCTTTCCCTTGTATGTGTGTATGTATTCTTTCACAGATGCTCGACAGAAGATGTGATCCTTTGCCTGTCTTTGTGACAGCTGGAGGAGGCCCTGCAGGCAGGTGCAGTTCCTTATTCTCCTGGGTCTTCCCATGCCGTAGCGGCTGTGTTGTACCTTTCAGACCCTCAGCAGGGCTCTGGTAGTCTCTACTCTTGAAGGTCCTCAAACTCCATTCTCTTCTCAGGTGAGGGTTTCAGGCAGATGGGGAGACCATCTCTGCCCCAGACCCATGTGGCTTGGACAGGGTTTCTTTCTGGCAGTCTTGCCTTCTACATTGGATAGTAAACAATTACACCTGTAATCCCAGCACTTTGGAAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCTGGCCAACATGGTGAAACCCCCTCTCTACTAAAAATACAAAAATTAGCCCGGCATGGTGGTGGGTGCCTGTAATCCCAGCTGCTTGGGAGGCTGAGGCAGGAGAATCACTTGAATCCAGAAGGTAGAGGTTGCCATGATCTGAGATTGTGCCACTGCACTCCAGCCTAGGCGACAAGAGCAAAAAAAAACTCGGTCTCAGAAACAACAACAACAACAAAAACCCATCACAGCATTGTAAAGCCAGGAAGCTTTTAAAACAGAGATGATGTCTGGTGCCCACCAGTGTCTTGTTACTGATAGTGTTTTTAATCTAGTTGAAAAATTGTTGGAGGTAAAAGTCATTGTAAGTCTCCTATGTATGCTCACAGAATACTCCTAGGGCTGAAGGTACAACTATGTTTCTCCATCTTTTGCCATGATCACTACCTCCCTCCCACCTAGGAGCCTTGTGAGACTTTTTTTTCCCCTAATTTGCCCCAAAATAAAATTGTAATATCAGAGATAATATTGTACTTCTGCTTATGGCCAGTAGCCTTCTAGAGGGTCACAAGCTGTTCTATAAGCTGAGGGGGGTTTTTTTGCCCCAGAGAACTAATTTTTGTCTCTTTGGGGACAATAGCACCCACTTTAAGAATGCATGAGGTAAAAGAAAATGTGCCAGGAAAGACTTGCTCCACCTTCCCCAAGTGGGGTAAGCTTGTGATGGCCCAAGATCCTTGGATGGGGTGAGGGTTGAGGCGCTGTGGGCATGGAGGTAACACAGGAGCCAGATTTACTGTTCACTTCCCTGGTGTCTCTAAAGCCCCCATCTCTTCCTCTTCAAGACCAAAGACATTTAAATAAGCCCTGCCCCTACAGGGTCAGTCCTGGTCCATGCACATCTCAACTAGTTGGAAACAGCAGTGTCTTAGAATTTGGGACAAATTGATTAAAACAGAACAGGAGGAAGTTAATTTCTGCTGCCAAACCTGATTCTGAGTGATCGTTTCCTGTTCCTTGCTCCAGGATTATCAGCACAGCATTCTCATGCTTCCTACTCAGGACCGTTTCTTTACCCAAAGTGAAGTTTCCTTTGCCCCCTCCCCTTATCCTTTGATTTCAGTAGTAACACCTGCTAACTAGAGAACATTTCAAAAATGAAGAGTTCCCTGTTCCCAGAGATCCCCGTGGTTAATATTGCAAAATATCCAATCTCTGAGATACTTTGGTTTTACCATAAACACTGTCCTGTGACCGTCTTCCTGTTTAGCACTGTGGCTTGCTTTTTGACTTGCAGAGGGAAGAGAGGGAGGGGTATCTTGAAGTAACTAGCAAGACCTGTAAGCAAAAGGGAAGAAGACTAGGTTTTAAAAGGAGTGTTGTATCTGTGTAGGAGGGAGACACTGATTTTAGTTATCAGTGTCTCAGAGTTGGTATTAGCCAGCCGGTGTTATCAAAGGAGGAACTAGGACCGCTGTCTTGAAGGAGGTGGTGGAGGACTCAAGGGCAGAGGCTTCTCACTGCCATCACTTGGTGCCATCAGCCCAGAGCATTTCAAGTCACTGCCCAACGTAGAGCTTTGCAGAGCCAGAAGTTCTGGGAGGAATGGGCATGCATGGTTTTGCCCATCAAGGGCACACAGATTAGTGGCAGGATCGGGTTAGAAACATGTAGGATTTGTATGATTGAGCTGTAATTGGAGTGTTTCATATACTGCATTTCTACAGCTCTCATCAGTAATGGCTGTGCCTGGATGCCACCCAGCATGTTTTCATAGTTTACCTTCTTTTTAGAAGTCAATCTGGACCCCTCCTTCTGTTTGCATTTTCTCTTTGTTGACATGGAATGGGGAGATGTTGTCATCCTGTGTTGGCATTCCCAAGTTTAGTGAATGGTTTCTCACCATAGCTTAAGTTGGCTGCTTCATTTTTCATAAGGCAAATTAGTTTCTCTCAGGGAAGGGCTGTACATTGAGATCATTAACATAGAATGTGGTTGTGGATCCTCGTACATTTTCATTGCAGAGGTGACTTTTTCCCTCCAGCACCTTTGATCAGCCTCCCAGCACACATGTCTCCAGCGAATGGCACATATCCAAGGAATGATCAGCAGCTTCTTCGTGACCTCTTGCAGTCATTGCTGTCTTTTACTTTTCTAGAAAAACCTCTCACAACTTTTTTTTCATGTCGTGCCAACGCAAGCTTGATTATCCTAGTCTGTGCTCTTTTGGTTCCAAAGAACTGAAAAACCACTTTAATCTTAAGCAGGAAAAAAAAAAGTGTGTTTGGGGTGGGGATTGATTGACTTCCCCAAACAACAGCCGCTGACATTAGGTGTTTGAGATTCAGGGTTGTAAATGTTGTCACCAGGATTTGGCCTCCCTCCACTTTCCTGCAGCAGCTCCAGGCTGACATTCTCCCAGCTCAGTGACCCCAGCAGAACCGGGGCTGGACTCAGGGGTTCCAATTCAAGTGCAAAGATTGAGTCTTATGGCCTGGATTGAGTCATGTTCCTGTCCCCGCACCAGTTGCATGGCAGGCAGTGCGTGGCTAGGCTGAGCCTGCGGAGTGTGCCCTCAGCAGCTCCTCAGAGAAAAATCAATCAAGGCGCCATCAAGCCTGGAGAAAGTTCAGTGTGTCCTGGGCAGTTTCCTGCCTGGGCCCCAGTTGTTCTTTCTGGGGTAGGGATGTCCTCTGCTCTCCCTGCTGTCATCAGTGGTGGTTGTGCCCGGACACCACTCAGGGCCTGTGGTAAGGCATTCTTTCTGGAAATTGAGATTCTCTGTTCCTTCAACCGTGCAGAGTGGGGAAGGCTGCAAGAGCAGCTTCTGAGGTCCTCCAGTCAAATAAGAGGTCGCCAGGTCCTCTGAGGGTCGTCCCCTCTTAACCCACACCTTCGATGAGCATCCCCACCCTGCCTCGCTGCTCCCTCTGAGGTGGAGAGTGAGCTCCATGCTAACAGGCTCTGGTAACGGGCTTGTTCAACTGGGCCCCTTTCTTCCCCAAAGCCTGTTGAAAATAGCTGATGTCAAAACACAGATGTCTGCAGCTGCTATGGCCCTGGGGGGTTTTTCTTTTCATTTGTTTCTACCCCAGCTCTCCAAAGGAATGTGCTCTGTTCATTCAACAGCCCGCTGCACATGTTTATTGCTCAGCTCTGTGATCATAGCAGGATAGTGAAAGTTGGGGGATACGTGTCCATGCAGCCTACCTGGGTGCCAGTGAAGCGCGATGCCATGTAGGCACTTCCTCCTCCTCTTCAGTAGCCAGGCTCCCCACAGCTGTTCTGGTTACTCAGATGGTCAGGTGGCTTGGCCATGGACACCCATTCAGTCATTTTGCCAGGTCAGCCACTAACCATTTGGTGATCTTCCATGATCCACATTCCCCCTCGTTTCCCTTTAACTTATTTCTCTCTGCTGATACCTCTGAGGGGCCATCTCCCGTGTCTCCACCCCTTGAAGCAGATCCTCATACAGTGAGAATTGACACATGGGCCTTTGAATAAACATCAGTGATGTGCTTAACTTCATGATAATCTCCCAGAACCGCTTGAAAACAAGCGACTGCCGGTATCAGAAGCCATGCATGAAAAGAGAGCGTAAGGGGCAGGCATTCACTGGCTGAACTGGGGAGCCACATGGGAATTGGGGTCCATAGGACATCTATTTTTGAAATATTTTGAGATATTTGAAGGAAATGGTTTCCCTTACTATCTCAGCATTCAGAGTGTGGGGAAATGTTTTTAATACAGTGGTTTGCAAATCAGTGGATGTGAAGAAGCAAGAAAATGAGATGGCTTCAGCATATCTTTTAAAAGTGATCTCACCTACACTTAAGTGGCTGTCAGATTCTCCTACAGGGCAATGCTGTGTGGCCTTTCACTTCCATCCCCCGCGTCTGAGGCTGATAGTCCAGAATGCTGCTGAGGAAGTGCACGTGGTCTGTCTTTGCTGAACAAAGTGGCAGGCTGGTCAGCAGGTATCGGTGGCTGCCACTGCCCCTCCTCCTTGCTGTGCAGACTCTGCATTCTGCGGGGCTCACGTTCTTTCTCCTTTCAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTACCGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAGGAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGGTATCGTTCCGCGGTGGGGCTGGAAGGGGCTCTCGGTCCCATCATCTGTTGGTGCATCAGCCCAAAGCCAAGTCCACACTCAATACAGCTACACTTTTCACTGATGGGCGATTCTTCCCGGGGAAACGTATCACCCACGGCCATACAGGGCTCCAGAGCTCGCCCATCCTTGGCTCTCTGTTGAATGGTCATTCCATCTGGGCCCATTGCTTAGAGTCCCGTGCTGATGAGGCTGAGGTTGTGGATTGGCCCTCCCTTTCCAGGGAGTCGCTTTCAAGGATGGAACTTGGTTCCCATCTGCAAACTGAATCTCCAGTGCTAGCCACTGTCTTTGACCTGAGATACTGATGCACAAAGGACATGAGGCAGGAGGATGGGGCTGGCTCCACAAACACCAGCCCGGGGGGAAAGTTTCGAGAGTTCTTGCTTAGGCCTAGGGCAGGCTAGCCAATCTGTCCATTCCATTTTGTGTCCTCTGGTCCTTGTAAGAGGTCTCTGTGACCTGGTCATCCTGCCTGCCTTTGGAAAGTTAGGATCCAGTACGCAGTGGAAATGCCCTCACAACCATTCACAGCATCATGGTAAAGCAAATGGGTTTTGGGGAGAGGAGACTGCTCTGTCTTTCCAGCCAGGAAGCTGCCTTGTGGCTGGCAATGATGACATGTGCCCTCTCGCTGGCTTAGCTGTGGTGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTGAAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGGTATGGGATGCCTGGTGCAGACCAGGTCCCTTGGGGCTCAGGTGCAACCTGTGGTGTGTTTTGAGCTCCCTTAGCAGATTACGTGTGGGTGACTTTCTGTTCTTGCTGCTCAAGGTATAGCCAGTGGACCATCAGCACTGGCATCACCTGGGAGCGTCTTAGAAATCACAGTCTCGGGCCCCACGCAGGCCATTTGAATCCGCACCAGCAGTGACTCATACGCACACTTCTTCAAAGTTTGAGGAGCACTGCTCTTTGCCAGTTGGTAGATGTGCAATTTAAAACTGTCAGCAAACACAGCTGCTGTCTGTAGTGCACACAGCCATGAGGCACGGTCAGCCCTGGCCCTCCCCTCCAGGCACGTGCACACACCAACCCCCATACACATGAGTCCCTACCCACGTTCTACATGCATACCCTGTCCTGTGGAGGCCCGGTAACTATTTGCAGTCTAGTTGTTGGCACAAGAAGAACTTGAGAGTTACTTTGTCTTTTGCCTTTTTTCTAGCCACTGCCTCAGTTTTCTGCTGTGAGCCAGGTTCAAAGTGTGGGTTTAGCTTTATCCCGTAGCCCTGTTTTATTGCACCACAGCATATCAGGGCTGAAGGGACTTGACTTTTATCTTTTGATTTTAGGGGTAAGCTGGGGAGGCTGGGCCAGGTGGTAGTTTTATAGGCCAGTGACCCGCCAGGCCTTGGGCCCTGTGAGTCCTGGTCTTGAGTCCTTCCTGTATCCACACATTGCAGTCAGTGGCGGGGCTAGTCTCTGTGACCAAGTAGTGTCCATGTCTCCGTCTGACAGTCTCAGCTCCAGCCCGTTTGATAAAGAAGTGTTGGCTATCTGCCTATTTCCTTTTCATAGTGGCACACAGATTATCCCTAGCCAGCTGTGGTGGTTTAGAATTGTTTTAGATGCCAGCTTCCCCCAGCAGGTCTGTGAAGGACTATTACTGATTGTTTTGTTTGTTTGTTTTTTATTGTAATGACAGCCTGGGAAGGAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGACACGTGGGCGGTAAGACAGCCCCTGGTTGGACCTTGTTTTCGTGACTGGTTCCCTCTTCTTCTTAGAAGCAATCTGCCTGCCATTTCTCACATTGCATTTTGTTATTCTGTCCCTGTTGTTTGCTCTCTCTTTTTTTTTTTTTGAGTTGGGGTCTCCCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCACCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTGTTTGCTCTTCTTATCTCATTAAAGCCAGCCTGGCTTTCGTCTCACTGTCTCTTAGCTTCTGAAAGGTCTAATTCACTGGCACTGAAGAGTGAGGGCAGGACCCGTTAAACTGGTGCAAACGACACTTCTGATCCTGTCCTTTCTGGGTTCGTTTCTGCACCACACAGACACTTTTCTCTGTAGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCCAACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCTGCAGTTAACCAGGTAAACATCCCCCAACGACACTGGCATTGCAACGTTGCTGTTTTACTGTCTGATGCTGGTAGGGATTTCTCGTCCACCTCACCCAGCAAGTGGCCAGGAGGCAGCTCCTGGGTGTTGGCAGAGTCCTGAGTTATGATTCAGCATGACACAGCACATCTGGGAGAGGAAACTTACAGGAAAGAAAGAGTTTGAGCCTGGCTTGTGACGATTTGGGGTCTGACAAAGAGGCAGCCATGAGATCCTCAGAACTGTGATAGTTGATAAGTGGCTAAAGCCAAGAAAAGCCTCTAGGGCCCATGAGAACATCTATAATAAGATAATAATAACACCAAGGATACTACCTGGGAACTGTAGGAAGTTACAGCTTATCTGGGAAATAGGGTGTTTGTTATACATAGTTTTCTGTATGGGGTAGGGAGGGACTTTAGCATAGGAAGCTTCATCTGTGTCCCATCAGCGTGTAGCCACAGTGCTCCCATCAGCTCTTGTTTTTGCATTTGCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGCCAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGGTGAGCTTCCCACAGGCTCATGCTCCTGTGTCACTTGGTGAAGATTAGAAAAGACTAAAAAGAACAATTCAGCCTCAAGGAAGATGTTTCTGGGGGTGATCTGCAAAACTTCCCCTGAGCCTCTTGCTGGTTTTCCTGGAAGGGTTGGAGTTTCTAGTAGCAAGACACCTACTCTTTTTCCAAAGGGTTGGGGGTTCTTAACCCAGCTCTGAGGAGGAGACTGGTGGCTGCCCTCTGAGGTCGATGGGAGGATTAGGGTTGGGGTTTCTGGCTGCTGTGAGTGGTGGCCATGATGGTGTGACCTGGACTGTCTTTCTATCCTCAGGGCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAGCACAATAAAACTACAGCCCAGGTACAGCCACTTCAGGTGTTGCTGACCGTCCACAACTGCCTGCATTCCTGACAGTCCTGTTAGCCAAGAGGAGGAAGTGACTGAGCCTGTTACACCCTCACAGGAAGTATGGTTAGGGGTCCTCAAGTACAGAGTGGAAAGGGCACAGATCGGGGTTTTAGAAGACTCTGGCATGGGCTCTTAGATTAATAGTGCCTGCCCCCACTACTGCAAGGGTGACTGCCACGAGGGCCAGCGCTTGTTCATTCATGTGGAACCTCATCTGTACAAATGTAAGAGCTCTTAGCCGTGCAGGGAATGTTCTTTCTCCTGAGTGGTAGTGTGCATTTCTAGCCAGTGGAGGGCCTCATGTGGTCTCATGATATGCCTGAGACACTGAAGCGTGTGGCACAGTGGCTAGCGCAGGACTCTGGAGTCAGATCTGGACCTGAATGCGTCGCCTACCTGTTGCTAGCTGTGACCTGACATCTTGGAGCCCCTCTCTGATCACCTGTGGAGTTCTAGCACGTCCTTCTGCAGGTTGTGTGTGTGAGAGACTGAGATGATGGGTGCGAGTGCCTGGCATGTATACACACTCACTGTCTCCTTGGGCTCACAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTGATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTAAGATCTTGGCTGGTCAGGCCTGGCCCTCCTCCATGGAGTGGGGGATGGGGGAGGCCTCTCATCCTGTCTCTGGAGTGTCATCTGTGGGATCACCACCATCCTCTCTTCTGAGGCCAGGGAGCTGTGGCGAGCAAGCCAAGACTGAGACTGACACCTCACCAGTGGAGCCGTGTGCAGGGGCAGGCCTTGGGCCTCCAGGGCCCCGTGCTGTGCACGCATACACCTACACCTTTGCTCAGGCCCTTCAGCCACACCGAGAGGTTACCCGGGGAGAATCTCGCTCTTGAGCTTCACTGCCTGGACCTGCCCTGCACTGGAGCTCTGTCAGCTACCAGCTGCATAACCCTGGGCAAGTCGCTTAACTGCTCGATGCCTCAGCTTCCCTATCTATAAAATAATATCCATTTTGAGGGTTGTTACGAAGATTAAGTGATGCATCAGAGCACTTCACATGGTGCTTAATACCTTAGTAAGTGATCGAGAAATGTTGCTGTGCTGATAAGTCCAGGGACTGCAAAGGACCCTCTGGGCCATTTAGTCCATTCACCAGCTCTGCAAGGAGTTCGTGTGATGATGGGCAGAGCCTAGACCTGTGTCAGGACTCTGGCGAAGCGCTCAGTGTGGCAGCTGGAGCAGCTCAGGCTACTTGGCGCCACCTCCCTCCCTGCCTGCCCTTGCAGCATTGGTGGCGGGGGTGTGGGGGAGGGGGGGGGCACGCCCAAAGGAGAGCAGCTCAGGGGAGTCCTGATGGCCCAAGAGCCTCTGTTCTCACTGAGCAAAGTGGCTCTGCCAGGGATGCTCTGTCTTTATCCAAGATCTGTGCCGAGCGCAGCACAGCCATGGGCCTGGGGCTCTTGGGCAGGCCCCAGCTTAGGTGAGCAGCTGATTTTGCCCAATTCCACTGCCCAAAGACTGTGGCCATAGTGCCTGCCACCTGTCACATATGAGACAGGGATGAGAGTGATCCCTGAAGAGGGAAGTGGAGCTCATTGTTTAGGAGAGGAGACGTTTTTCTTCTTACGTGCAGGTAGATGTTCTAAGTACACAAGATAAAATGGCAAAACAGTGGCCACTGAGGGAAAGGCATATCCCACCAGAGATGCATCGTTTGTTTCGTATTTCATTTTTTAAGGAATTAGGAAAGAAAAAATAAATGACTAATCTCAAAATGCTAACCTAATTATTTTATTTTTGCATCTTACTGTATAGCTTTTGCACATTTTTCTGTGATCATAACCACAGAGCCTGTAGCAGACTCTCTTTCTGCACATTCTGTGATCATCTGAAGCTAAGAGCCCTTCGGCTCTGGGAGTGTGTGTCAGCCTCTTGTGGGTCTCACCCAGTGGTGCCTGCCTGCCTCCCTCCCTCCCAGCCTCCATGCCAGCTGAGTTCTGTACCGTCTGCTGCCTTCATGCAGGTGGTTCTCTTCTCCCAGTATACCTTTCTTGCCCTCTCTGTCAAAATCTTATACTTCTTAGGCCATGTCAAATACCATCTCCTCTTCGGCTGTGGTTGTTCAGTTTCCCGGCTGGAATCCCTTTGGAATACCTCTGCCCTTCCTGTGCTGTTGAGTGTCTTATACAGTGTGTGATTAGTTATTTGTATTACAGTTGTAGAAATACCTCTGCCCTTTGTTTGCTTCATAAAATAGAGGCAAAGACACATCTTACCCATAATTATATTCCTCACTGCAACTTATCACAATAGAAGTGCTCAGTAGTGTTTTTTGAAATGAAATAAAATGTATCATTTCCCTGGGAGGTTCTGGAAAGGAAGGACTGTTTCCATCGTTCCATATATTATCTAGCCCAACATGCACATTTCCTGAATACTAATATATCAGCTTTTCCTAAGTTCAGTTTATCTTATCGCTCCTCTCTGCTCAAAGCCATGGAAGACATCTGGGTCCTGCACAGTATTTTGTCTTTTATTTTTATTTGCAGAGCTTACTGGATTTTTTTGTTTGTTTTTTAGGTCTTTGACTTTGAACTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCCTTGTTGAGGTGAGTGAGCCCCAGTGTGAGGAGCAGTTCCCAGGAGATATTCAGATGCTGCACAGCAAGAGAGTGATCCCTGCAGGCCTCAGCGCCAATGTGCTCTCGTCACAGCTGTTCTTGCTTTGCACATTACCTTGCTTTCTCAGCCACGTGACTTGCATCAGCTGAACTGCATGGAGCCAAGATGCCAAGAGATCCGCTCTTGATATCTTCTTCCAGCCCTGGGGCATTGTTGGCCTGGCCTGAAGTAACTACATATTTTGGCTTTCCATTCAATTTTTAAATCCTAGCAGTTCATCTGAAACTAGGTGATCCCAGGTGACCCTGGATCAAACTCTGGAAGAATTTGCCTGTGACTTTTTGTCTTAATGACCCTAATGAAAGGGGTTTGGTCGGGAGCCCCTGGGGCTGAGGTTTGAGACAGTCCCGGCTCTGACCTGGTAAGCCACATGGCTCCAAAACAGGCCCTCCCTCTGAGCAGCAGGCACCTCAGTTCCTCCAGCCACACATCCTCTGGTTCTGTTTCCTCTGCATGGTAGTTTGGAAGGAGCTGCCTAGGAAGGTTTTCTGTGGGGTTTTCTCTTTTCCTACCATTACAATAACTAGGTGACGCATGTAACTCACTTTCTGCTTTCAAGAAGGAACTTCTCATTTTGCAGTGGAGACTGAGACTCTGTTTCTCTCTCACTACCCTTATTCTTGTCTGAGCTCTGTGTTTCCACACTCTCTCCTTTAGTACTTCCTCTTCTAAGCAAAATGTGAACATTCCCTAAGATGGGGTGGGCTACCAGCTTTCCCTTTCCAGCGTCTGTCCCATCTCCCTCCCCGGAGTTTGCACTGCTGGTGGCTTCAGCCACCGCCCCAGGCAGATGTTTGCCCAGTCTGCGTCCTGGACAATAACTCTGGCCCTGCTTCAGGCATATGCGTGCCTGGCAAGCCTGCTGCTGCCACACTGTGGCCTCACACTCAAAATAGGCCGCAAACAGAGCATGTCACAGGCAGCCCCAGGCCAGTGCCCTTTCAGACATCTCTGTTAATGCTACTTAGCCCTAGACATTAAAATCATTTTTGGATCTAGTGGACAAGGAGGAGAGGAGTGAATCAGTCACCAAGCTACATTCGTTCTCCTTTCAGAATCTCTCCCATTCATCCGTCTTCCTTTTCCCCTCCCACTTGAGACAGAGTGGATTGAAGCTTTCAGGGCTGAGGAAACACAGTGGTTTTCTCATTGCTCCCTTTACAGTTAGGCTCCTCTGCCCTCCAGTATTGTGCTAGAAACTTCTGTTCGATTATCCTGTTGCGTGGCGGTGAGTGGGAGGAAGAGGCTAGCCCTGACATGCTCAGGTCTCCTAGGGAGTTTTCGCTAACTACACACACACCACCCCTCTGGCAGATAATGCTTTACTGAGCCTGACCTGCTGATGTCAGTGTCACTGTGGGTATACAAAAAAGGCAGACCATGGAGAACTTTTGAATAAGAGTTACAGACTGTAAGCACCCAGCTCAGATTACATAACTCTGGCCTTGCGTGAGCTGCCCAGCTATCTGTCCAGTGTTCCTGCCTTTATGTTCCTAGCACAGCCATTGGCCCTACTAGATGGACAGTGAGTGAGCCTTGACAAACACGTCTGCACCTGTGCTCCCTGCCATGTGCTCCCTGCCCTGTGCTCCCTGCCCTGTTTCCAATATAAAATCGCCGACCGTTGATTGGGCTCACTTCAGCCCCCACTGATACAAGGAGGCTCCCTCTGTCCTCAGAGCACTTGCCGTTGCTTCTCTTATCCTTTGAGATTCAGTCACATACAGACTTTTAACATCCCTTTTTTTTTTTGAAATGGGCTCCTACTCTGTCACCCAGGCTGGAATGTAATGGCATGATCACAGCTCACTGCAGCCTTGACCTCCTGGGCTCAAATGATCCTCCCACCTCAGCCTCCCAAGTAGCTGGGGCCATGGGCATGCACCACCATGCCTGGTTAATTTAAAAAGTTTTTTTATTAAGATGGAAATCTTGCTATGTTGCCCAGGCTAGTCGCAAACCCCTAGCCTCAAGTGATCCTCTCGCTTCAGCCTGGGATTACAGGCGTGAGCCACTGTGTCTGGCCTGCCTTCTCATATTATTACACAAGATGTTTAAGACCACAAAATACTGTCTGGTCCTGCCAGCTAGACTGAGTTACTGGAAGGCAGAAATCGTGTTGCCGTCCTGCACGGCCCAGGCACAGTGCTGGGCACATGGGGAGGGTGGTGTCCCTCACACATGTGCTGCTTGATGACAGTAGTGGTAGAGGGGTCTGGAGGGTGAGTTGCTTCCCCCAGCTGCAGAACCATCATCTGCACACTCAGAACTAGCTTGTTGCCTCTGAGGTTCTATTTTATTTCTTCAGTGAGACACATCATTTCTCTGTTGGGAGTTGGGTATAGTCAAAATCACCTCTTCAAAAAGCAACTGTTTTCTCCTTTCTCCTGACAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGAAGCTGTGGTTGCCTGCTCGTCCCCAAGTGACCTATACCTGTGTTTCTTGCCTCATTTTTTTCCTTGCAAATGTAGTATGGCCTGTGTCACTCAGCAGTGGGACAGCAACCTGTAGAGTGGCCAGCGAGGGCGTGTCTAGCTTGATGTTGGATCTCAAGAGCCCTGTCAGTAGAGTAGAAGTCTCTTCCAGTTTGCTTTGCCCTTCTTTCTACCCTGCTGGGGAAAGTACAACCTGAATACCCTTTTCTGACCAAAGAGAAGCAAAATCTACCAGGTCAAAATAGTGCCACTAACGGTTGAGTTTTGACTGCTTGGAACTGGAATCCTTTCAGCAAGACTTCTCTTTGCCTCAAATAAAAAGTGCTTTTGTGA

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