Details for gene: VEGFA


This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. [provided by RefSeq, Jun 2020]


Symbol
VEGFA
Name
vascular endothelial growth factor A
Entrez ID
7422
Ensembl ID
ENSG00000112715    (more details)
KEGG ID
hsa:7422    (more details)
OMIM ID
603933
Uniprot ID
P15692  
GO ID
hsa:7422    (more details)
Chromosome
6
Strand
1
Start
43770184
End
43786487
miRNA Interactions
hsa-miR-30c-5p (RPM: 3890.0396) / hsa-miR-15a-5p (RPM: 139.425) / hsa-miR-1277-5p (RPM: 3.0234) / hsa-miR-29b-3p (RPM: 118.8178) / hsa-miR-20a-5p (RPM: 55.9816) / hsa-miR-141-3p (RPM: 2843.5066) / hsa-miR-195-5p (RPM: 125.6474) / hsa-miR-29c-3p (RPM: 661.3514) / hsa-miR-133a-3p (RPM: 411.6588) / hsa-miR-30d-5p (RPM: 9562.1366) / hsa-miR-30a-5p (RPM: 15590.711) / hsa-miR-4524a-5p (RPM: 0.0932) / hsa-miR-15b-5p (RPM: 133.5752) / hsa-miR-29a-3p (RPM: 1246.9046) / hsa-miR-30e-5p (RPM: 2305.0396) / hsa-miR-124-3p (RPM: 4110.4386) / hsa-miR-34a-5p (RPM: 81.3502) / hsa-miR-16-5p (RPM: 2473.4704) / hsa-miR-106b-5p (RPM: 35.4204) / hsa-miR-126-5p (RPM: 3089.0568) / hsa-miR-200a-3p (RPM: 157.5826) / hsa-miR-424-5p (RPM: 9.04) / hsa-miR-27b-3p (RPM: 22876.2392) / hsa-miR-101-3p (RPM: 3335.0564) / hsa-miR-205-5p (RPM: 5027.3352) / hsa-miR-3163 (RPM: 0.012) / hsa-miR-147a (RPM: 0.0014) / hsa-miR-106a-5p (RPM: 7.9736) / hsa-miR-338-3p (RPM: 158.4942) / hsa-miR-19b-3p (RPM: 197.0578) / hsa-miR-497-5p (RPM: 49.4968) / hsa-miR-125b-5p (RPM: 10044.3546) / hsa-miR-3941 (RPM: 0.0008) / hsa-miR-374a-5p (RPM: 52.6724) / hsa-miR-339-5p (RPM: 44.716) / hsa-miR-107 (RPM: 234.4574) / hsa-miR-138-5p (RPM: 67.2828) / hsa-miR-590-3p (RPM: 4.5954) / hsa-miR-223-3p (RPM: 14.321) / hsa-miR-3662 (RPM: 0.0344) / hsa-miR-503-5p (RPM: 0.0972) / hsa-miR-205-3p (RPM: 1.669) / hsa-miR-495-3p (RPM: 8.062) / hsa-miR-5688 (RPM: 0.6258) / hsa-miR-148a-3p (RPM: 10339.6222) / hsa-miR-3127-3p (RPM: 0.1826) / hsa-miR-603 (RPM: 0.0052) / hsa-miR-125a-5p (RPM: 11539.4616) / hsa-miR-200c-3p (RPM: 348.3196) / hsa-miR-152-3p (RPM: 242.0024) / hsa-miR-612 (RPM: 0.0216) / hsa-miR-369-3p (RPM: 7.3414) / hsa-miR-378a-5p (RPM: 22.027) / hsa-miR-361-5p (RPM: 182.4758) / hsa-miR-200b-3p (RPM: 566.8348) / hsa-miR-206 (RPM: 4.6758) / hsa-miR-766-5p (RPM: 0.1124) / hsa-miR-9-5p (RPM: 3525.806) / hsa-miR-186-5p (RPM: 1645.2832) / hsa-miR-150-5p (RPM: 64.1654) / hsa-miR-5193 (RPM: 0.0094) / hsa-miR-429 (RPM: 100.5032) / hsa-miR-128-3p (RPM: 329.321) / hsa-miR-7-1-3p (RPM: 13.9534) / hsa-miR-372-3p (RPM: 0.0034) / hsa-miR-7-2-3p (RPM: 0.451) / hsa-miR-7-5p (RPM: 19.3682) / hsa-miR-1293 (RPM: 0.4392) / hsa-miR-373-3p (RPM: 0.0958) / hsa-miR-190a-5p (RPM: 14.2908) / hsa-miR-876-3p (RPM: 0.2528) / hsa-miR-19b-1-5p (RPM: 0.1482) / hsa-miR-374b-5p (RPM: 72.7188) / hsa-miR-410-3p (RPM: 194.4724) / hsa-miR-10a-3p (RPM: 0.0878) / hsa-miR-214-3p (RPM: 21.2784) / hsa-miR-520a-3p (RPM: 0.0858) / hsa-miR-3126-5p (RPM: 0.6218) / hsa-miR-302d-3p (RPM: 0.0012) / hsa-miR-576-5p (RPM: 10.7352) / hsa-miR-199a-5p (RPM: 174.3046) / hsa-miR-101-5p (RPM: 15.2398) / hsa-miR-21-5p (RPM: 5494.851) / hsa-miR-203a-3p (RPM: 1346.5646) / hsa-miR-326 (RPM: 10.9272) / hsa-miR-145-5p (RPM: 548.8656) / hsa-miR-181c-5p (RPM: 1285.07) / hsa-miR-362-3p (RPM: 1.4456) / hsa-miR-181a-5p (RPM: 52364.6344) / hsa-miR-329-3p (RPM: 4.2748) / hsa-miR-185-5p (RPM: 29.191) / hsa-miR-33a-3p (RPM: 1.692) / hsa-miR-21-3p (RPM: 238.3548) / hsa-miR-1-3p (RPM: 26.3428) / hsa-miR-873-5p (RPM: 18.2502) / hsa-miR-24-3p (RPM: 581.6226) / hsa-miR-511-5p (RPM: 1.3606) / hsa-miR-378a-3p (RPM: 1540.7796) / hsa-miR-23b-3p (RPM: 2125.0486) / hsa-miR-199a-3p (RPM: 731.3038) / hsa-miR-670-5p (RPM: 0.0038) / hsa-miR-141-5p (RPM: 20.664) / hsa-miR-4735-5p (RPM: 0.022) / hsa-miR-19a-5p (RPM: 0.3142) / hsa-miR-185-3p (RPM: 4.0636) / hsa-miR-3924 (RPM: 0.0066) / hsa-miR-4719 (RPM: 0.006) / hsa-miR-660-3p (RPM: 0.609) / hsa-miR-708-3p (RPM: 46.9334) / hsa-miR-5682 (RPM: 0.013) / hsa-miR-526b-5p (RPM: 0.2456) / hsa-miR-665 (RPM: 0.445) / hsa-miR-374a-3p (RPM: 56.346) / hsa-miR-1292-5p (RPM: 0.815) / hsa-miR-299-3p (RPM: 3.441) / hsa-miR-146a-5p (RPM: 774.8698) / hsa-miR-330-3p (RPM: 21.3424) / hsa-miR-874-3p (RPM: 170.3494) / hsa-miR-155-5p (RPM: 106.9134) / hsa-miR-532-5p (RPM: 129.2058) / hsa-miR-34b-5p (RPM: 1.8778) / hsa-miR-34b-3p (RPM: 5.6562) / hsa-miR-93-5p (RPM: 357.1536) / hsa-miR-629-5p (RPM: 7.1172) / hsa-miR-17-5p (RPM: 83.6404) / hsa-miR-20b-5p (RPM: 24.4036) / hsa-miR-16-1-3p (RPM: 0.0972) / hsa-miR-504-5p (RPM: 27.4444) / hsa-miR-297 (RPM: 0.0048) / hsa-miR-335-5p (RPM: 265.7294) / hsa-miR-134-5p (RPM: 29.8712) / hsa-miR-140-5p (RPM: 21.3322) / hsa-miR-125a-3p (RPM: 24.5112) / hsa-miR-363-5p (RPM: 0.4074) / hsa-miR-642b-5p (RPM: 0.1552) / hsa-miR-409-5p (RPM: 6.6458) / hsa-miR-194-3p (RPM: 0.633) / hsa-miR-520g-3p (RPM: 0.0022) / hsa-miR-520h (RPM: 0.0012) / hsa-miR-374b-3p (RPM: 5.4276) / hsa-miR-296-5p (RPM: 12.5874) / hsa-miR-126-3p (RPM: 494.5936) / hsa-miR-340-3p (RPM: 15.2654) / hsa-miR-522-5p (RPM: 0.0018) / hsa-miR-218-5p (RPM: 36.775) / hsa-miR-191-5p (RPM: 12993.8088) / hsa-miR-99b-5p (RPM: 14318.7458) / hsa-miR-423-3p (RPM: 1928.5158) / hsa-miR-383-5p (RPM: 1.9172) / hsa-miR-6748-5p (RPM: 0.0138) / hsa-miR-6759-5p (RPM: 0.0204) / hsa-miR-6793-5p (RPM: 0.0736) / hsa-miR-8485 (RPM: 0.0894) / hsa-miR-6838-5p (RPM: 0.079) / hsa-miR-95-5p (RPM: 0.9772) / hsa-miR-6871-3p (RPM: 0.027) / hsa-miR-1252-3p (RPM: 0.0174) / hsa-miR-942-3p (RPM: 0.031) / hsa-miR-6766-5p (RPM: 0.0116) / hsa-miR-6745 (RPM: 0.0012) / hsa-miR-6769b-5p (RPM: 0.003) / hsa-miR-1-5p (RPM: 0.0594) / hsa-miR-6873-5p (RPM: 0.0094) / hsa-miR-6769a-5p (RPM: 0.0464) / hsa-miR-523-3p (RPM: 0.0016) / hsa-miR-6870-3p (RPM: 0.0056) / hsa-miR-598-5p (RPM: 0.1746) / hsa-miR-6875-5p (RPM: 0.643) /
Involved Diseases
diabetic retinopathy / corneal neovascularization / Age-related macular degeneration (AMD) /
Involved Pathways
MAPK signaling pathway / Ras signaling pathway / Rap1 signaling pathway / PI3K-Akt signaling pathway / MicroRNAs in cancer / Calcium signaling pathway / Focal adhesion / HIF-1 signaling pathway / Pathways in cancer / Renal cell carcinoma / VEGF signaling pathway / Proteoglycans in cancer / Pancreatic cancer / Bladder cancer / Rheumatoid arthritis / Cellular responses to stress / Cellular responses to external stimuli / Generic Transcription Pathway / RNA Polymerase II Transcription / Gene expression (Transcription) / Cytokine Signaling in Immune system / Immune System / Signaling by Interleukins / Interleukin-4 and Interleukin-13 signaling / Disease / Infectious disease / SARS-CoV Infections / Hemostasis / Signal Transduction / Signaling by Receptor Tyrosine Kinases / Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors / Platelet degranulation / Regulation of gene expression by Hypoxia-inducible Factor / Cellular response to hypoxia / Signaling by VEGF / VEGF ligand-receptor interactions / VEGF binds to VEGFR leading to receptor dimerization / VEGFA-VEGFR2 Pathway / VEGFR2 mediated cell proliferation / Platelet activation, signaling and aggregation / Response to elevated platelet cytosolic Ca2+ / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / Potential therapeutics for SARS /
Sequence
AAAAGTCGGCTGGTAGCGGGGAGGATCGCGGAGGCTTGGGGCAGCCGGGTAGCTCGGAGGTCGTGGCGCTGGGGGCTAGCACCAGCGCTCTGTCGGGAGGCGCAGCGGTTAGGTGGACCGGTCAGCGGACTCACCGGCCAGGGCGCTCGGTGCTGGAATTTGATATTCATTGATCCGGGTTTTATCCCTCTTCTTTTTTCTTAAACATTTTTTTTTAAAACTGTATTGTTTCTCGTTTTAATTTATTTTTGCTTGCCATTCCCCACTTGAATCGGGCCGACGGCTTGGGGAGATTGCTCTACTTCCCCAAATCACTGTGGATTTTGGAAACCAGCAGAAAGAGGAAAGAGGTAGCAAGAGCTCCAGAGAGAAGTCGAGGAAGAGAGAGACGGGGTCAGAGAGAGCGCGCGGGCGTGCGAGCAGCGAAAGCGACAGGGGCAAAGTGAGTGACCTGCTTTTGGGGGTGACCGCCGGAGCGCGGCGTGAGCCCTCCCCCTTGGGATCCCGCAGCTGACCAGTCGCGCTGACGGACAGACAGACAGACACCGCCCCCAGCCCCAGCTACCACCTCCTCCCCGGCCGGCGGCGGACAGTGGACGCGGCGGCGAGCCGCGGGCAGGGGCCGGAGCCCGCGCCCGGAGGCGGGGTGGAGGGGGTCGGGGCTCGCGGCGTCGCACTGAAACTTTTCGTCCAACTTCTGGGCTGTTCTCGCTTCGGAGGAGCCGTGGTCCGCGCGGGGGAAGCCGAGCCGAGCGGAGCCGCGAGAAGTGCTAGCTCGGGCCGGGAGGAGCCGCAGCCGGAGGAGGGGGAGGAGGAAGAAGAGAAGGAAGAGGAGAGGGGGCCGCAGTGGCGACTCGGCGCTCGGAAGCCGGGCTCATGGACGGGTGAGGCGGCGGTGTGCGCAGACAGTGCTCCAGCCGCGCGCGCTCCCCAGGCCCTGGCCCGGGCCTCGGGCCGGGGAGGAAGAGTAGCTCGCCGAGGCGCCGAGGAGAGCGGGCCGCCCCACAGCCCGAGCCGGAGAGGGAGCGCGAGCCGCGCCGGCCCCGGTCGGGCCTCCGAAACCATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTTGCCTTGCTGCTCTACCTCCACCATGCCAAGGTAAGCGGTCGTGCCCTGCTGGCGCCGCGGGCCGCTGCGAGCGCCTCTCCCGGCTGGGGACGTGCGTGCGAGCGCGCGCGTGGGGGCTCCGTGCCCCACGCGGGTCCATGGGCACCAGGCGTGCGGCGTCCCCCTCTGTCGTCTTAGGTGCAGGGGGAGGGGGCGCGCGCGCTAGGTGGGAGGGTACCCGGAGAGAGGCTCACCGCCCACGCGGGCCCTGCCCACCCACCGGAGTCACCGCACGTACGATCTGGGCCGACCAGCCGAGGGCGGGAGCCGGAGGAGGAGGCCGAGGGGGCTGGGCTTGCGTTGCCGCTGCCGGCTGAAGTTTGCTCCCGGCCGCTGGTCCCGGACGAACTGGAAGTCTGAGCAGCGGGGGCGGGAGCCAGAGACCAGTGGGCAGGGGGTGCTCGGACCTTGGACCGCGGGAGGGCAGAGAGCGTGGAGGGGGCAGGGCGCAGGAGGGAGAGGGGGCTTGCTGTCACTGCCACTCGGTCTCTTCAGCCCTCGCCGCGAGTTTGGGAAAAGTTTTGGGGTGGATTGCTGCGGGGACCCCCCCTCCCTGCTGGGCCACCTGCGCCGCGCCAACCCCGCCCGTCCCCGCTCGCGTCCCGCTCGGTGCCCGCCCTCCCCCGCCCGGCCGGGTGCGCGCGGCGCGGAGCCGATTACATCAGCCCGGGCCTGGCCGGCCGCGTGTTCCCGGAGCCTCGGCTGCCCGAATGGGGAGCCCAGAGTGGCGAGCGGCACCCCTCCCCCCGCCAGCCCTCCGCGGGAAGGTGACCTCTCGAGGTAGCCCCAGCCCGGGGATCCAGAGAACCATCCCTACCCCTTCCTACTGTCTCCAGACCCTACCTCTGCCCAGTGCTAGGAGGAATTTCCTGACGCCCCTTCTCTTCACCCATTTCCTTTTTAGCCTGGAGAGAAGCCCCTGTCACCCCGCTTATTTTCATTTCTCTCTGCGGAGAAGATCCATCTAACCCCTTTCTGGCCCCAGAGTCCAGGGAAAGGATGATCACTGTCAGAAGTCGTGGCGCGGGAGCCCACTGGGCGCTTTGTCACATTCCACCGAAAGTCCCGACTTGGTGACAGTGTGCTTCCCTTCCCTCGCCAACAGTTCCGAGTGAGCTGTGCTTTAGCTCTCGTGGGGGTGGGTCAAGGGAGGATTTGAAGAGTCATTGCCCCACTTTACCCTTTTGGAGAAATGGCTTGAAATTTGCTGTGACACGGGCAGCATGGGAATAGTCCTTCCTGAACCCTGGAAAGGAGCTCCTGCCAGCCTTGCACACACTTTGTCCTGGTGAAAGGCAGCCCTGGAGCAGGTGTTTTTTTGGAACTCCAAACCTGCCCACCCAACTTGCTTCTGAAAGGGACTCTAAAGGGTCCCTTTCCGCTCCTCTCTGACGCCTTCCCTCAGCCAGAATTCCCTTGGAGAGGAGGCAAGAGGAAAGCCATGGACAGGGGTCGCTGCTAACACCGCAAGTTCCTCAGACCCTGGCACAAAGGCCTTGGCTACAGGCCTCCAAGTAGGGAGGAGGGGGAGGAGTGGCTGCCTGGCCACAGTGTGACCTTCAGAGGCCCCCAGAGAAGGACACCTGGCCCCTGCCTGCCTAGAACCGCCCCTCCTGTGCTCCCTGGCCTTGGAAGGGGTATGAAATTTCCGTCCCCTTTCCTCCTTGGGGCCCAGGAGGAGTGGAGGGTCCCGGGAGAATATTGTCAGGGGGAAGGCAGGGGGTGTCATGGGAATGGGTGAGGGGGCTGAGGTGCAGAATCCAGGGGGTCCCTGCAGGAGCCGCAGTGGTAAGCTGTCCAGCTGGAAGCCTGGTAACTGTTGTTTTCTCTTGAGAGGGGCTTCCTGTGACCTTGGCTGTCTCTGGGAGCAGGGCTGGGGTACCTGAGTGGGGTGCATTTGGGGTGTGTGGGAAGGAGAGGGAAAGAAAGATGGACAGTGGGACTCTCCCCTAGCAGGGTCTGGTGTTCCGTAGGCTAGAGTGCCCCTCTGCTCTGCGAGTGCTGGGCGGGAGGGGAGTTGGTGAGAGCTGGAGACCCCCAGGAAGGGCTGGCAGAAGCCTTTCCTTTTGGGTGCTGTCAGGTCCGCATGTCTTGGCGTGTTGACCTTCACAGCTTCTGGCGAGGGGAGGAATGATCTGATGCGGGTGGGGAGGGTTAGAGGAGGCCTCAGGCCTAAGGTGGTGCAGGGGGCCCCCTAGGGGCTGGGCAGTGCCAAGGCATAAAAGCCTTCCCTGGTCCCTGGTGGCATTTGAAGGTGCCCAGGTGAGAGGGGCTTGGCACCTCCTCACCCTGGGAGGGAGAAGAAACCAGGGAACAGGTAGGAGTGGGAGACAGGTGAGGCTTTGGAAATCTATTGAGGCTCTGGAGAGATTTGTGTAGAGAGGAAAATGTGGTTCTCCCCCAGGGTCTCCTCCTGGGTTTTTACCCTCTAAGCAACCTGTGGGCATGCTGGGTTATTCCTAAGGACTAGAAGAGCTTGGATGGGGGAGGGTGGTTGGTGCCCTTCGGTCCTCGGCACCCCCCTCCGTCTCCAACACCAGCTCACCCTGGTATTTGTCATGTCAGCAGGAGAAGGTCACCATGTTGTTTTTCTCGCCCCTAGTCCTTCCTTCCTGCCCCAGTCCAAATTTGTCCTCCTATTTGACCTTAATACTTACCATGGCTTTGGACCAGGGAACTAGGGGGATAGTGAGAGCAGGGAGAGGGAAGTGTGGGGAAGGTACAGGGGACCTCGACAGTGAAGCATTCTGGGGTTTTCCTCCTGCATTTCGAGCTCCCCAGCCCCCAACATCTGGTTAGTCTTTAACTTCCTCGGGTTCATAACCATAGCAGTCCAGGAGTGGTGGGCATATTCTGTGCCCGTGGGGACCCCCGGTTGTGTCCTGTTCGACTCAGAAGACTTGGAGAAGCCAGAGGCTGTTGGTGGGAGGGAAGTGAGGAGGGAGGAGGGGCTGGGTGGCTGGGCCTGTGCACCCCAGCCCCTGCCCATGCCCATGCCTTGCTCTCTTTCTGTCCTCAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGGTGAGTCCCCCTGGCTGTTGGATGGGGTTCCCTGTCCTCTCAGGGGATGGGTGGATGGCCTAATTCCTTTTTCTTCAGAACTGTGGGGAGGAAGGGGAAGGGGCACAGGAATATAAGGATCAAGAAAGAAAGAGCTGGGCACCACGAGGTTCACCCTCAGTTTCGTGAGGACTCTCCGCTGTTCAGGTCTCTGCTAGAAGTAGGACTTGTTGCCTTTTTCTTCTGCTCTTTCCAGTAAAATTTTATTTGGAGAAGGAGTCGTGCGCACAGAGCAGGAAGACAGTGTTCAGGGATCCTAGGTGTTGGGGGAAGTGTCCCTTGTTTCCCCTAGCTCCCAGGGGAGAGTGGACATTTAGTGTCATTTCCTATATAGACATGTCCCATTTGTGGGAACTGTGACCCTTCCTGTGTGAGCTGGAGGCACAGAGGGCTCAGCCTAATGGGATCTCTCCTCCCTTCCCTGGTTTGCATTCCTTTGGGGGTGGAGAAAACCCCATTTGACTATGTTCGGGTGCTGTGAACTTCCCTCCCAGGCCAGCAGAGGGCTGGCTGTAGCTCCCAGGCGCCCCGCCCCCCTGCCCAACCCCGAGTCCGCCTGCCTTTTGTTCCGTTGTGGTTTGGATCCTCCCATTTCTCTGGGGACACCCTGGCTCTCCCCACCACTGACTGTGGCCTGTGCTCTCCACCTCTGGGGAGGGAAGGCCCTGGGGTCTTCCTTCCCGCGAGTTTCCCTGACCTAAATCTGGCGTGGCTGGGTAGTGGCCAGCAGTGGTGATGCCCAGCCTGTTCTGCCTCCTCCTTCCCCACCCCAGGAGCCCTTTCCTTGGCCTAGGACCTGGCTTCTCAGCCACTGACCGGCCCCCTGCTTCCAGTGCGCCACTTACCCCTTCCAGCTTCCCAGTGGTCTCTGGTCTGGGAGAGGCAGGACAAAGGTCTTTGTTTGCTGGAGAAAAGGTTGTCTGCGATAAATAAGGAAAACCACGAAAGCCTGGTTGTTGGAGTGTACGTGTGTGCTCCCCCAGGCAGTGGAGGCCAGCCCTCCTTGGAGGGGCGGCTGCCTGATGAAGGATGCGGGTGAGGTTCCCCGCCTCCACCTCCCATGGGACTTGGGGATTCATTCCAAGGGGAAGCTTTTTGGGGGAATTCCTACCCCAGGTCTTTTTACCCTCAGTTACCAACCCCTTGCCCAGGCCAGACCTTCCTGCTATCCCCTCCTGGGCCACAAGCCTGGCCCTCCTCTGTCCCAATTGTGATGAAGGGGCAGTTCAAAACTTCTTGATTAGTCATCTTCTCCCCTATCGACTTGGCTTTAAAAAATGACCTTTTCAGACTTCTAGTCTCGTTCACTCTTTTTGATGATGCTTTGCCGTAACCCTTCGTGGGTAGAGAAGGATTCTGTGCCCATTGGTGGTCTGGATAAAAGAAATAGAGACCTCACAGGAAGCAGTGGACTGGCCTGTTTCCCCACTGTTCTTTCTGTTTTCACACCTGTGGCCTTCTCCCCACCTTCTTCCCAATCAACCTATTGTGTACATAGCCCCCCTCATTGTCCTTTATTCTTCTGGAAAGCAGACCTTGGAGGGAGGAGTGAGGGGGAGGCTCAGCTGTGGTCTCTGGGGGGTGGGGGTTGGGAGCTGGGGTGGAAGTCCACGAAGCATACACTTAAGATGCTTTGGTGAAGTTCTAAACTTCATATTACCCAGGCTGAAAAAAGAGCACTTGTTCCTAGGGCTGGAAATGGAAGCCAAAACACCACCTTTTTCAGCCTGTTTCAGCATCTTTAGAGATCAGCCCAACCCACTTACACAGTTGAGCAGAGTTGGAGGCCTAGAGAGGGGAGGGACTGGCCCAAGGTCATACCAACTCATGGCCAGAGCCTGGGCCTCCTCACTGGCCAGGTGTTATTTCTTCCCTCTGGGTAGGGAACCTATTTCAGGGACAGGATTGCTATGTGGTAGTGGTGGTGGGGTGCGATAGGCGTGGCAGGCTGGGCCACAATTTGGAGTAGTCATGCCAGAGTCCTGCATTTATTTATTCTCAAGGGCCCCGCCTCTGTGGCCCAGAATTACCCCTTCATGCTCCAGTGCACCCCAGGCTTCGTGGCCAGCCTGGGAAACTGTCTCTACCCTGGTCTCCCTTCAGATCAGCTTCTAGAAATGTTTCGTGGCTACAGTGGCAGCACTGTTTTTTCCATGATGCAAGCAGTTTGCCCTCTTGGGCGGGGTTATCAGTGGCTGGCAGGGCTGGCACAGCGTGTCCGCCCACTGCCACCTGTGGGTTCCAGGAGGGCCCAGCCCCTGTGCTGATGCCCACCACCTTCTCAGCTCATGTCTGGGGAAGAGGACTGGCAGGGGGAAAGGTGCCTCCTCCTGAAAGGTGCCTCCTCTGTTTTTGCCTAATATAGGCTTGGGAACACTTTGATGTCAGCTAATTCTGACTCCTTTACTTACTAGCTGTGCGGCCTTGGGGCAACTTACTTAGCCTCTTTGAGCCTCCTGTTCCCCATCTGTAAAATGGAATCTCAATAGTGTCTAATAGTACCATGTGGAGAAACTTGTGTGAAATGATAGCTGTGGACTACTGTACACAGTACTCAGGATGTAGTAAGTGCTCAATAAACAGCTGTTGGTATGGTTGACGTTATGGTAGTGGTTGTGGGGAGGACGTAGGAAACTGGAGACTAGCTTGGCAAAGCTGGCTCTTCCTCCTTTTAGGGAAAGCTTAGAGCATCCCCATGGGGTATACCCATACTCAGACTGTCCTCTGGCATCGAGGTTGGCCCAGGATTCAGTTCAGCTGTCACAGTGAGGTGGCGGGATCAGATGTGGCAGGCCATGTCCCTTGGAACTTGAGTACATCGTGTGATCTCTGGAATGAAAACAGGCCTTCACCAGTGTTGATGGTGGAAAGCTTAGGGAAGTGCTTCAAACACAGTAGGAGGGACTTACGTTAGATTTTGGAAGGACTTGCCTGATTCGGAAGCTCCAAAGAGTGGCATTACAGAGCTGGGTGGAGAGAGGGGCTAGCCATCTTTTGTGTCGCCCACCGGGCTCATGTGTCATCGCCTCTCATGCAGTGGTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGACATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTGATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCCAACATCACCATGCAGGTGGGCATCTTTGGGAAGTGGGGCAAGGGGGGGATAGGGAGGGGGGTAACACTTTGGGAACAGGTGGTCCCAGGTCGTTTCCTGGCTAGATTTGCCTTGTCTGGCTCCTGCCCCTGAGTTGCACAGGGGAGGTATGGTGGGGTCTTGCCTTCTGTGGAGAAGATGCTTCATTCCCAGCCCAGGTTCCCAGCAAGCCCCAACCATCTCCTTCTCCCTGATGGTTGCCCATGGGCTCAGGAGGGGACAGATGGATGCCTGTGTCAGGAGCCCCTCTCTCCCTCTCTTGGAGAGAGTCCTGAGTGCCCCCCCTTCTTGGGGGCTTTGTTTGGGAAGCTGGATGAGCCTGGTCCATGGAGAGTTTAAAAAGTCTTTTGGTGTTACCTGGTAATGGGGCACATCTCAGCCCAGATAGGGTGGGAGGGAGCTGTGAAACACAGGGAGGGGGTTGCTTTCGGGTATCTACTAGGAGTCAGGGTGAAGCCTAGAGAGGATGAAAGAAGGGGAGGGGATGGGGAGTGGTAAGAACCTAGGATTTGAATTCCCAGCCTGGCCAACCCTTGCAGCCATGTCTTGGCCTCAAGTGGAACAAGGGCTCCTTGAGGCCAGCAGGGTTGGGGGAGTTGGGGTGGGCCTGAGCCTCTTTCCTGCTAGAGCTCTTGGTCCTCCCTGCCTCCACCACCCATCCCTGCTCTGCAGAACCCCTGGGTGCTGAGTGGCAGGAGCCCCAGGGTTGTCCCATCTGGGTATGGCTGGCTGGGTCACTAACCTCTGTGATCTGCTTCCTTCCTTTCCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATGAGCTTCCTACAGCACAACAAATGTGAATGCAGGTGAGGATGTAGTCACGGATTCATTATCAGCAAGTGGCTGCAGGGTGCCTGATCTGTGCCAGGGTTAAGCATGCTGTACTTTTTGGCCCCCGTCCAGCTTCCCGCTATGTGACCTTTGGCATTTTACTTCAATGTGCCTCAGTTTCTACATCTGTAAAATGGGCACAATAGTAGTATACTTCATAGCATTGTTATAATGATTAAACAAGTTATATATGAAAAGATTAAAACAGTGTTGCTCCATAATAAATGCTGTTTTTACTGTGATTATTATTGTTGTTATCCCTATCATTATCATCACCATCTTAACCCTTCCCTGTTTTGCTCTTTTCTCTCTCCCTACCCATTGCAGACCAAAGAAAGATAGAGCAAGACAAGAAAAGTAAGTGGCCCTGACTTTAGCACTTCTCCCTCTCCATGGCCGGTTGTCTTGGTTTGGGGCTCTTGGCTACCTCTGTTGGGGGCTCCCATAGCCTCCCTGGGTCAGGGACTTGGTCTTGTGGGGGACTTGTGGTGGCAGCAACAATGGGATGGAGCCAACTCCAGGATGATGGCTCTAGGGCTAGTGAGAAAACATAGCCAGGAGCCTGGCACTTCCTTTGGAAGGGACAATGCCTTCTGGGTCTCCAGATCATTCCTGACCAGGACTTGCTGTTTCGGTGTGTCAGGGGGCACTGTGGACACTGGCTCACTGGCTTGCTCTAGGACACCCACAGTGGGGAGAGGGAGTGGGTGGCAGAGAGGCCAGCTTTTGTGTGTCAGAGGAAATGGCCTCTTTTGGTGGCTGCTGTGACGGTGCAGTTGGATGCGAGGCCGGCTGGAGGGTGGTTTCTCAGTGCATGCCCTCCTGTAGGCGGCAGGCGGCAGACACACAGCCCTCTTGGCCAGGGAGAAAAAGTTGAATGTTGGTCATTTTCAGAGGCTTGTGAGTGCTCCGTGTTAAGGGGCAGGTAGGATGGGGTGGGGGACAAGGTCTGGCGGCAGTAACCCTTCAAGACAGGGTGGGCGGCTGGCATCAGCAAGAGCTTGCAGGGAAAGAGAGACTGAGAGAGAGCACCTGTGCCCTGCCCTTTCCCCCACACCATCTTGTCTGCCTCCAGTGCTGTGCGGACATTGAAGCCCCCACCAGGCCTCAACCCCTTGCCTCTTCCCTCAGCTCCCAGCTTCCAGAGCGAGGGGATGCGGAAACCTTCCTTCCACCCTTTGGTGCTTTCTCCTAAGGGGGACAGACTTGCCCTCTCTGGTCCCTTCTCCCCCTCCTTTCTTCCCTGTGACAGACATCCTGAGGTGTGTTCTCTTGGGCTTGGCAGGCATGGAGAGCTCTGGTTCTCTTGAAGGGGACAGGCTACAGCCTGCCCCCCTTCCTGTTTCCCCAAATGACTGCTCTGCCATGGGGAGAGTAGGGGGCTCGCCTGGGCTCGGAAGAGTGTCTGGTGAGATGGTGTAGCAGGCTTTGACAGGCTGGGGAGAGAACTCCCTGCCAAGTACCGCCCAAGCCTCTCCTCCCCAGACCTCCTTAACTCCCACCCCATCCTGCTGCCTGCCCAGGGCTCCAGGACACCCAGCCCTGCCTCCCAGTCCAGGTCGTGCTGAGCAGGCTGGTGTTGCTCTTGGTTCCGTGCCAGCTCCCAAGGTAGCCGCTTCCCCCACACCGGGATTCCCAGAGGTTCTGTCGCAGTTGCAAATGAAGGCACAAGGCCTGATACACAGCCCTCCCTCCCACTCCTGCTCCCCATCCAGGCAGGTCTCTGACCTTCTCCCCAAAGTCTGGCCTACCTTTTATCACCCCCGGACCTTCAGGGTCAGACTTGGACAGGGCTGCTGGGCAAAGAGCCTTCCCTCAGGCTTTGCCCCCTGCCGGGGACTGGGAGCCACTGTGAGTGTGGAGACCTTTGGGTCCTGTGCCCTCCACCCAGTCTCGGCTTCCCACCAAAGCCTTGTCAGGGGCTGGGTTTGCCATCCCATGGTGGGCAGCGTGAGGAGAAGAAAGAGCCATCGAGTGCTTGCTGCCCAGACACGCCTGTGTGCGCCCGCGCATGCCTCCCCAGAGACCACCTGCCTCCTGACACTTCCTCCGGGAAGCGGCCCTGTGTGGCTTTGCTTTGGTCGTTCCCCCATCCCTGCCCACCTTACCACTTCTTTTACTCCCCCCACCGCCCCCGCTCTCTCTCTGTCTCTGTTTTTTTATTTTCCAGAAAATCAGTTCGAGGAAAGGGAAAGGGGCAAAAACGAAAGCGCAAGAAATCCCGGTATAAGTCCTGGAGCGTGTACGTTGGTGCCCGCTGCTGTCTAATGCCCTGGAGCCTCCCTGGCCCCCAGTACAACCTCCGCCTGCCATTCCCTGTAACCCTGCCTCCCTCCCCTGGTCCTTCCCTGGCTCTCATCCTCCTGGCCCGTGTCTCTCTCTCACTCTCTCACTCCACTAATTGGCACCAACGGGTAGATTTGGTGGTGGCATTGCTGGTCCAGGGTTGGGGTGAATGGGGGTGCCGACTTGGCCTGGAGGATTAAGGGAGGGGACCCTGGCTTGGCTGGGCACCGATTTTCTCTCACCCACTGGGCACTGGTGGCGGGCCCATGTTGGCACAGGTGCCTGCTCACCCAACTGGTTTCCATTGCTCTAGGCTTCTGCACTCGTCTGGAAGCTGAGGGTGGTGGGGAGGGCAGACATGGCCCAAGAAGGGCTGTGAATGACTGGAGGCAGCTTGCTGAATGACTCCTTGGCTGAAGGAGGAGCTTGGGTGGGATCAGACACCATGTGGCGGCCTCCCTTCATCTGGTGGAAGTGCCCTGGCTCCTCACGGAGGTGGGGCCTCTGGAGGGGAGCCCCCTATTCCGGCCCAACCCATGGCACCCACAGAGGCCTCCTTGCAGGGCAGCCTCTTCCTCTGGGTCGGAGGCTGTGGTGGGCCCTGCCCTGGGCCCTCTGGCCACCAGCGGCCTGGCCTGGGGACACCGCCTCCGGGCTTAGCCTCCCATCACACCCTACTTTAGCCCACCTTGGTGGAAGGGCCTGGACATGAGCCTTGCACGGGGAGAAGGTGGCCCCTGATTGCCATCCCCAGCAGGTGAAGAGTCAAGGCGTGCTCCGATGGGGGCAACAGCAGTTGGGTCCCTGTGGCCTGAGACTCACCCTTGTCTCCCAGAGACACAGCATTGCCCCTTATGGCAGCCTCTCCCTGCACTCTCTGCCCGTCTGTGCCCGCCTCTTCCTGCGGCAGGTGTCCTAGCCAGTGCTGCCTCTTTCCGCCGCTCTCTCTGTCTTTTGCTGTAGCGCTCGGATCCTTCCAGGGCCTGGGGGCTGACCGGCTGGGTGGGGGTGCAGCTGCGGACATGTTAGGGGGTGTTGCATGGTGATTTTTTTTCTCTCTCTCTGCTGATGCTCTAGCTTAGATGTCTTTCCTTTTGCCTTTTTGCAGTCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACGTGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTAAACGAACGTACTTGCAGGTTGGTTCCCAGAGGGCAAGCAAGTCAGAGAGGGGCATCACACAGAGATGGGGAGAGAGAGAGAGAAAGAGAGTGAGCGAGCGAGCGAGCGGGAGAGCGCCTGAGAGGGGCCAGCTGCTTGCTCAGTTTCTAGCTGCCTGCCTGGTGACTGCTGCCTTCTCTGCTTTTAAGGCCCCTGTGGTGGGCTGCAGGCACTGGTCCAGCCTGGCGGGGCCTGTTCCGAGGTTGCCCTGGTTGCCTGAGTGGTAGGCTGGTGTGGCTTAGTGTAGTGGTGTGGACGCAAGCTGTGTGTTGTGTCCTGTGGTCCTTCTGCTCATAGTGGCTGTTGGTCCTGATGTTATTACTACCTCTGGTAGTAATGCTGAGAAGCTGAAAGCCGATTCCAGGTGTGGACAATGTCAACAAAGCACAGATGCTCTCGCTGGGGCCTTGCCTCGGCCCTTTGAAGTCTGCATGGCTGGGCTTCTCACTCACTCAGTGTTTCTTGCTGGGGGAAGGAATTGAGTCTCCCACTTCAGACTGGGCCTCCCTGAGGAAAGGGTTGTGTCTCCCCACTCAGACTGAGGTTCCCTGAGGGTAGGGCTGTGTCTCTCCCCTCCGACCTGGGCTCCCTGATAGGGCTGTCTCCCCGCTCAGACTGAGGCTCCCTCAGGCCAGGGCTATGTCTCCCTCCTCAGACTGGGGCTCTGAGGGCAAGGGGTCTGGCTGTTCGTTTAGGATGGGGCACTTTTGCCTACACACTGAAGGAGCTGTAGCATCCAAGAATACTAGATACCTTTAATCCTCCACCAGTCATGGTGACAACCCCAAGCAGCCCACACATTTTCAAGTGCCCCCAGGATGCGTGGAGGGAGGGGTCTGTGCCCATTCTCCTGACATTAGCCTGTGAGCTCCGTAAGCCCGGGCCTCGTTTACGTACCTTTGTGAGCCCCGGGCATCTGTACCTCTTTCCTTTGCCCATACTGGGGACCAAGGAAGTGTCAAGTGCATGAGTGAATGTGTGACTCAGTTCAGAGGGTGAGGTCAGGAGCACAGGGTCGGGACAGGTGGCTGGCATCTTTTAATGCCTTAGCTTATGTTCTTTATACCAACTTGGCCTGTGCTCAGAGTGAGGGAGGCCCTGGGGGTCAGGGTAAGCGTCAGTCAGGGAGGCAAGACTTTGTGGGGATTTCCTAGACAGGGCCAAGGCACCCCCAGCTCACCCCGAGGCTGTGTTAGGGAAGTCCTTGGAGTGTCTCCCCTCCCCCAGCAATGTTCTTGTGGCTTGTGTGTGCTCAGGGGATGCTGGGAACCAGGCCTGGGTAGTTGGTGTGGGGTGCTGTCTGTCTTGGCCCTATGTGAAACCAAGAGGGCGTATATTAGTGCTGGGGTGGGGGCTCTGCCTAACTTCAGGGCTGGATGAGGGGAGTCTCAGTTCCCCAGGGGTCCTTGGGAAAGATAAGGGACTTGACATTTTAGGGTTTTTAGGTGATTATTCTGCTGATGGGGGTTTGTGTGAAGTGACCTGGGAGCTAACTGAAGTTACTCTAACCTCCCAATACCTTTACCCAACCCCCAAGCTGGCTGTATCTGGGAATATCAGTTTCCAAAATTGGAGGCTTAGGACTCCGTTTCGGGGCTCCCCAGAAGGGTAGGGCCTGTTCTGCCTCCTTCTCACAATCACCCAGGGGCAGGGGCATGCTGAGAAAGTTCTTGGAGGCCCCCTTTGCTTCAGCTGGAGTAGTGAAGCCGCCGAATTGTCTCTCCCCATCCTAAGTGAAGCAGCATATTTGAAAGGAAAGACAACCTGTTACCTGGGCCTGCAACCTCCAGGCAGCTCAAGAGAGATGAGGCCTACAGCCACAGTGGGAGGGGACATGGGGAATGGAGATGGTCCCTCACCTTCCTGGGGCCTCCTGCTCTACGCTACCCCCTCGGGAGCCTCCTGTCCCCAGGGCAGGCCCTTGCCATTGTTGGTCACCCGGCCAAGCCTCTCTGCCTCAGGCGTTCTCCCAGAAGATCTGCCCACTCTCTTCCCCACACCAGCCCCTAGAGACTGAACTGAAAACCCTCCTCAGCAGGGAGCCTCTTCTGATTAACTTCATCCAGCTCTGGTCACCCATCAGCTCTTAAAATGTCAAGTGGGGACTGTTCTTTGGTATCCGTTCATTTGTTGCTTTGTAAAGTGTTCCCATGTCCTTGTCTTGTCTCAAGTAGATTGCAAGCTCAGGAGGGTAGACTGGGAGCCCCTGAGTGGAGCTGCTGCTCAGGCCGGGGCTCCCTGAGGGCAGGGCTGGGGCTGTTCTCATACTGGGGCTTTCTGCCCCAGGACCACACCTTCCTGTCCTCTCTGCTCTTATGGTGCCGGAGGCTGCAGTGACCCAGGGGCCCCCAGGAATGGGGAGGCCGCCTGCCTCATCGCCAGGCCTCCTCACTTGGCCCTAACCCCAGCCTTTGTTTTCCATTTCCCTCAGATGTGACAAGCCGAGGCGGTGAGCCGGGCAGGAGGAAGGAGCCTCCCTCAGGGTTTCGGGAACCAGATCTCTCACCAGGAAAGACTGATACAGAACGATCGATACAGAAACCACGCTGCCGCCACCACACCATCACCATCGACAGAACAGTCCTTAATCCAGAAACCTGAAATGAAGGAAGAGGAGACTCTGCGCAGAGCACTTTGGGTCCGGAGGGCGAGACTCCGGCGGAAGCATTCCCGGGCGGGTGACCCAGCACGGTCCCTCTTGGAATTGGATTCGCCATTTTATTTTTCTTGCTGCTAAATCACCGAGCCCGGAAGATTAGAGAGTTTTATTTCTGGGATTCCTGTAGACACACCCACCCACATACATACATTTATATATATATATATTATATATATATAAAAATAAATATCTCTATTTTATATATATAAAATATATATATTCTTTTTTTAAATTAACAGTGCTAATGTTATTGGTGTCTTCACTGGATGTATTTGACTGCTGTGGACTTGAGTTGGGAGGGGAATGTTCCCACTCAGATCCTGACAGGGAAGAGGAGGAGATGAGAGACTCTGGCATGATCTTTTTTTTGTCCCACTTGGTGGGGCCAGGGTCCTCTCCCCTGCCCAGGAATGTGCAAGGCCAGGGCATGGGGGCAAATATGACCCAGTTTTGGGAACACCGACAAACCCAGCCCTGGCGCTGAGCCTCTCTACCCCAGGTCAGACGGACAGAAAGACAGATCACAGGTACAGGGATGAGGACACCGGCTCTGACCAGGAGTTTGGGGAGCTTCAGGACATTGCTGTGCTTTGGGGATTCCCTCCACATGCTGCACGCGCATCTCGCCCCCAGGGGCACTGCCTGGAAGATTCAGGAGCCTGGGCGGCCTTCGCTTACTCTCACCTGCTTCTGAGTTGCCCAGGAGACCACTGGCAGATGTCCCGGCGAAGAGAAGAGACACATTGTTGGAAGAAGCAGCCCATGACAGCTCCCCTTCCTGGGACTCGCCCTCATCCTCTTCCTGCTCCCCTTCCTGGGGTGCAGCCTAAAAGGACCTATGTCCTCACACCATTGAAACCACTAGTTCTGTCCCCCCAGGAGACCTGGTTGTGTGTGTGTGAGTGGTTGACCTTCCTCCATCCCCTGGTCCTTCCCTTCCCTTCCCGAGGCACAGAGAGACAGGGCAGGATCCACGTGCCCATTGTGGAGGCAGAGAAAAGAGAAAGTGTTTTATATACGGTACTTATTTAATATCCCTTTTTAATTAGAAATTAAAACAGTTAATTTAATTAAAGAGTAGGGTTTTTTTTCAGTATTCTTGGTTAATATTTAATTTCAACTATTTATGAGATGTATCTTTTGCTCTCTCTTGCTCTCTTATTTGTACCGGTTTTTGTATATAAAATTCATGTTTCCAATCTCTCTCTCCCTGATCGGTGACAGTCACTAGCTTATCTTGAACAGATATTTAATTTTGCTAACACTCAGCTCTGCCCTCCCCGATCCCCTGGCTCCCCAGCACACATTCCTTTGAAATAAGGTTTCAATATACATCTACATACTATATATATATTTGGCAACTTGTATTTGTGTGTATATATATATATATATGTTTATGTATATATGTGATTCTGATAAAATAGACATTGCTATTCTGTTTTTTATATGTAAAAACAAAACAAGAAAAAATAGAGAATTCTACATACTAAATCTCTCTCCTTTTTTAATTTTAATATTTGTTATCATTTATTTATTGGTGCTACTGTTTATCCGTAATAATTGTGGGGAAAAGATATTAACATCACGTCTTTGTCTCTAGTGCAGTTTTTCGAGATATTCCGTAGTACATATTTATTTTTAAACAACGACAAAGAAATACAGATATATCTTAAAAAAAAAAAAGCATTTTGTATTAAAGAATTTAATTCTGATCTCAAA

Back to List