Details for gene: CASP3


The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]


Symbol
CASP3
Name
caspase 3
Entrez ID
836
Ensembl ID
ENSG00000164305    (more details)
KEGG ID
hsa:836    (more details)
OMIM ID
600636
Uniprot ID
P42574  
GO ID
hsa:836    (more details)
Chromosome
4
Strand
-1
Start
184627696
End
184649509
miRNA Interactions
hsa-miR-30c-5p (RPM: 3890.0396) / hsa-miR-29c-3p (RPM: 661.3514) / hsa-miR-30d-5p (RPM: 9562.1366) / hsa-miR-30a-5p (RPM: 15590.711) / hsa-miR-30e-5p (RPM: 2305.0396) / hsa-miR-124-3p (RPM: 4110.4386) / hsa-miR-26a-5p (RPM: 45169.4864) / hsa-miR-34a-5p (RPM: 81.3502) / hsa-miR-182-5p (RPM: 77446.6216) / hsa-miR-101-3p (RPM: 3335.0564) / hsa-miR-26b-5p (RPM: 2999.0356) / hsa-miR-30b-5p (RPM: 1466.5144) / hsa-miR-335-3p (RPM: 837.9252) / hsa-miR-19b-3p (RPM: 197.0578) / hsa-miR-19a-3p (RPM: 25.4064) / hsa-miR-3680-3p (RPM: 0.0112) / hsa-miR-374a-5p (RPM: 52.6724) / hsa-miR-138-5p (RPM: 67.2828) / hsa-miR-144-3p (RPM: 6.9904) / hsa-miR-590-3p (RPM: 4.5954) / hsa-miR-129-5p (RPM: 135.1492) / hsa-miR-3662 (RPM: 0.0344) / hsa-miR-582-5p (RPM: 8.1398) / hsa-let-7b-5p (RPM: 3396.2052) / hsa-let-7f-5p (RPM: 17066.6836) / hsa-miR-129-2-3p (RPM: 79.8688) / hsa-let-7c-5p (RPM: 4028.6728) / hsa-miR-1301-3p (RPM: 47.2112) / hsa-miR-32-3p (RPM: 2.4438) / hsa-miR-452-5p (RPM: 23.696) / hsa-let-7i-5p (RPM: 2025.2084) / hsa-miR-186-5p (RPM: 1645.2832) / hsa-miR-5010-3p (RPM: 1.8422) / hsa-miR-98-5p (RPM: 1660.0964) / hsa-let-7e-5p (RPM: 3790.2074) / hsa-miR-153-3p (RPM: 53.4548) / hsa-miR-429 (RPM: 100.5032) / hsa-let-7g-5p (RPM: 3559.4376) / hsa-miR-221-3p (RPM: 758.7978) / hsa-miR-128-3p (RPM: 329.321) / hsa-miR-30e-3p (RPM: 538.304) / hsa-miR-30a-3p (RPM: 889.1386) / hsa-let-7a-5p (RPM: 32160.4734) / hsa-miR-30d-3p (RPM: 57.136) / hsa-let-7b-3p (RPM: 92.0818) / hsa-miR-7-5p (RPM: 19.3682) / hsa-miR-577 (RPM: 1.8138) / hsa-miR-1276 (RPM: 0.9142) / hsa-miR-548n (RPM: 0.0924) / hsa-miR-29b-1-5p (RPM: 1.1774) / hsa-let-7d-5p (RPM: 1078.3154) / hsa-miR-181d-5p (RPM: 168.2728) / hsa-miR-181b-5p (RPM: 3069.8278) / hsa-miR-888-5p (RPM: 0.8278) / hsa-miR-3174 (RPM: 0.2344) / hsa-miR-21-3p (RPM: 238.3548) / hsa-miR-1-3p (RPM: 26.3428) / hsa-miR-302a-5p (RPM: 0.1518) / hsa-miR-197-3p (RPM: 347.3274) / hsa-miR-26a-1-3p (RPM: 1.711) / hsa-miR-200b-5p (RPM: 9.0166) / hsa-miR-1229-3p (RPM: 1.3764) / hsa-let-7f-2-3p (RPM: 13.1322) / hsa-miR-33a-5p (RPM: 5.9422) / hsa-miR-23b-3p (RPM: 2125.0486) / hsa-miR-23a-3p (RPM: 613.2568) / hsa-miR-1260a (RPM: 220.2948) / hsa-miR-23c (RPM: 1.4294) / hsa-miR-22-5p (RPM: 21.6092) / hsa-miR-708-3p (RPM: 46.9334) / hsa-miR-5682 (RPM: 0.013) / hsa-miR-421 (RPM: 76.7678) / hsa-miR-224-5p (RPM: 33.3102) / hsa-miR-885-5p (RPM: 171.0098) / hsa-miR-222-3p (RPM: 1699.0194) / hsa-miR-629-3p (RPM: 0.715) / hsa-miR-200a-5p (RPM: 14.0094) / hsa-miR-382-5p (RPM: 9.8234) / hsa-miR-744-3p (RPM: 3.4814) / hsa-miR-379-5p (RPM: 13.6026) / hsa-miR-17-3p (RPM: 13.6088) / hsa-miR-20a-3p (RPM: 0.8156) / hsa-miR-196a-5p (RPM: 0.311) / hsa-miR-155-5p (RPM: 106.9134) / hsa-miR-425-5p (RPM: 187.631) / hsa-miR-628-3p (RPM: 10.2162) / hsa-miR-629-5p (RPM: 7.1172) / hsa-miR-33b-5p (RPM: 5.2366) / hsa-miR-193b-5p (RPM: 3.2336) / hsa-miR-29a-5p (RPM: 3.125) / hsa-miR-363-3p (RPM: 298.497) / hsa-miR-562 (RPM: 0.002) / hsa-miR-501-5p (RPM: 3.2752) / hsa-miR-140-5p (RPM: 21.3322) / hsa-miR-5011-3p (RPM: 0.0008) / hsa-miR-3200-3p (RPM: 32.0156) / hsa-miR-1275 (RPM: 5.7258) / hsa-miR-24-2-5p (RPM: 18.574) / hsa-miR-24-1-5p (RPM: 3.1364) / hsa-miR-126-3p (RPM: 494.5936) / hsa-miR-1260b (RPM: 243.165) / hsa-miR-100-5p (RPM: 3365.0918) / hsa-miR-522-5p (RPM: 0.0018) / hsa-miR-99a-5p (RPM: 1181.6944) / hsa-miR-6797-3p (RPM: 0.1958) /
Involved Diseases
diabetic retinopathy /
Involved Pathways
MAPK signaling pathway / Salmonella infection / Epstein-Barr virus infection / MicroRNAs in cancer / p53 signaling pathway / Apoptosis / Pathogenic Escherichia coli infection / Pathways in cancer / Proteoglycans in cancer / Natural killer cell mediated cytotoxicity / TNF signaling pathway / Serotonergic synapse / Non-alcoholic fatty liver disease (NAFLD) / Alzheimer's disease / Parkinson's disease / Amyotrophic lateral sclerosis (ALS) / Huntington's disease / Prion diseases / Epithelial cell signaling in Helicobacter pylori infection / Pertussis / Legionellosis / Toxoplasmosis / Amoebiasis / Tuberculosis / Hepatitis C / Hepatitis B / Measles / Influenza A / Herpes simplex infection / Viral carcinogenesis / Colorectal cancer / Small cell lung cancer / Viral myocarditis / Apoptosis / Apoptotic cleavage of cellular proteins / Cytokine Signaling in Immune system / Immune System / Caspase-mediated cleavage of cytoskeletal proteins / Signaling by Interleukins / Programmed Cell Death / Apoptotic execution phase / Degradation of the extracellular matrix / Extracellular matrix organization / Signal Transduction / Intrinsic Pathway for Apoptosis / Activation of caspases through apoptosome-mediated cleavage / Cytochrome c-mediated apoptotic response / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / SMAC, XIAP-regulated apoptotic response / Apoptotic factor-mediated response / Apoptosis induced DNA fragmentation / p75 NTR receptor-mediated signalling / Signaling by Hippo / Cell death signalling via NRAGE, NRIF and NADE / NADE modulates death signalling / Stimulation of the cell death response by PAK-2p34 / Apoptotic cleavage of cell adhesion proteins / Caspase activation via Dependence Receptors in the absence of ligand / Other interleukin signaling / Caspase activation via extrinsic apoptotic signalling pathway / Death Receptor Signalling /
Sequence
AGGGGCGGGCGGGAGGCGGGGCTGGCGCTGGAGCACATCTCCCGGCGGCGGGCCGCGGAAGCAGTGCAGACGCGGCTCCTAGCGGATGGGTGCTATTGTGAGGCGGTTGTAGAAGGTATGAGGAGGCTGTGCGGTGACTGCCGCCCTCGCTCCGGGCCGTCAGCCCTGCCCCCGCTCCCTGCGTTCTCCCAGGCCCTGCGCCCGCCCGGGTACCTGCCCGGTCTGGAAGGCGGAGTGTTTGTTTTGCCACCTCGCCCGGGCGGGGGCGAGCAGTGAAGCCCGCGGAGCGAGAGACTTGGCCCGGAGGCGGGAGCCTGGGCCGGGGCCGGGGAAGCCAGGCAGCGGGTTAAGGCTTTTGATTTAGGGAGAGGGACCTGGGGGTAACCTAAGGAAAGGCCTCAGGTCATCGGAGGGGAGACCTGGCCCGGGGGCGGGAGGCTGGGCTGGGACCGGGGAGGCCGGGCAGCGCGAGGCCGGGCCGGGGAGGCCAGGCAGCGGGAGGCCTGGCCAGGGGAACCGAGCCCGGGGCCGGGAGGTCGGGCACGGGGCACCGAGCTCCGAGGGCGGGAGACCTGGCGGCCGGCCGAGTGCCGGAAGGCCGGGTCAGGCGGCGGAAGGCAGCGGCAAGCTGGGAAACGGACGGCGCTACCGCCGGCGGAGGAGTGGCCCCGGGAAGCGGTGCTGCGAGGGCTGGGGCGGCCGGGTGCTGACTGTGAGATACTCGCCCTGGGGGCTGATCCTTCCAATTTTGGACGAGGCTTCCGTCTCTGCTGCCTTCCATGCCTGGGGCCTGGATTATCCCGGGTTGACAATGTGGTTTAGCTCTTCCAGAGAGATAGTTGCAGGGTTTAAACTCCAATTCCTTTTCGGCCCTGCAGAGTTTCGTGAGTGCTCGCAGCTCATACCTGTGGCTGTGTATCCGTGGCCACAGCTGGTTGGCGTCGCCTTGAAATCCCAGGCCGTGAGGAGTTAGCGAGCCCTGCTCACACTCGGCGCTCTGGTTTTCGGTGGGTGTGCCCTGCACCTGCCTCTTCCCCCATTCTCAGTAAGTGGCACCCAAGCAGGAAACCGGAAAACATCGTTCGCAGCCCCCTCTCGCCCACCCACTTCTTTTCCTGCTTAGTCGCCAAGCCTTGTCGACCTTGTAAATGTCTGCCAGATCTGTCCGCGTCTCTCTATCTCTGATTTCAGCCGTCTGACCACAGCAGCCTCTTCCCTGGTCTCTCCACTTCCAGACCCGCCTGCTCCTTTGCAGTCCACTTTTTACAGCACAGGCAGAGGGATCTTTATGAAATGAAAGTCTAGAAAGCTCGTCCTTTGCCCTTAGGTTAAACCCAGCACTTAATATGGCTAACAAACCCCTGCGTGTGTTGGGTCCTGAGTGCCCCCACCCCTCCTTATCTTTAGCACCGGTTCGATTTCTGCACGGCAATGCTGACCTTCATACCTAGTGTCTGCCTGCAACACCTCTGCACTCCCTTTCTCCCGCCATCACATTTGATTAGAAGAGCTGCTACTTAAATTTCTGTTTTCATTAAACAGTTTAAGGTTAAATCTTCCTATGCTGTGTTCTTTCTGCAGCCAGCATTCCCTAAGAGAGATGTGTCATATCCTTTGCAGTTGCTTGTTTACTATCTTCCCTGCTAGATTTGCAAGCAAACTCCAGGAGGGACGGACTTGGTTTATCTTGGTATCCTTAGTGTCTTGCCCCAAATGCGGGGCCTGGCATAACACAGTGAATGCCCATCCATTGTATTTTTACTTTTATGCCCTATCTAGAAAAAGTAGACCTGGTTTAGGATTATTCAGCAAATAATAATTAGAAAAGAAATGGTAGAGGTGACATACGGAGTCACTGAAACGATGTAAACCTGCAAGATAGCTGAAAGAGGGCCAGGCAAGGTGGTTAGACCAGACTGTATCAAAATGGGCTCAGCCACTGTGAATGTGCGTGCTGTGGTTACATAATCTCTAAAAATGAAATATAAAGCTTAAATCATCTCTATCACAGCCCGATGCTTGGACTTTGGTTTTGCTTTGCCTTTTTGCAAAAGAAGGTTTTTGAAAGTGAAAATTATTTTAGTGAATGGATGAACAGTTTATTGGAGTATGGCAATAAAACCTGTTCAAAGTAAGAGACATTAGACATTGTACCTAGTTAAATCAGATTTGCTTTTGCTATCCTGAATAAAGGCCTTGCCTCTTGCCATTTGAAGAGACTGGCATCTGATATAGGCAATTATAATGCTTCTTTACTGTTTTGTTTTCAAACCTCGTTTAACACAATCTCCTACTGCTTCATCCCCCTACAAAGCAGTCTTTATTTTGATGAATGATATATTACATTGCTTCTGGTGCCTACTATTAGATCTTTAAGCTCTGCCCCAAAGATAAGAAGCACTGGTGTTTGGGCCTAAACAAAGATGGGAGAATTCTTAGATTTATATAATATTCTTTCTCTGCATGTTTTGTTCTTACCTTCACATGTTGCCTGTAGAGCTTCTTTGCATTACAATAATGAAATCAAGCTACCTGATATGTATTGGACACGGTCTGGCATCTGCCTTGTTGAGCCACTTTTGAATACCAGTGAGCATCGGTATAAGCCCTGAATAGAGATAGGGTTTGTCTCTTCCACTGCTTGATACACTCAGGGTCTAGTATAGTACTCTGCACACAGTTGGTGTTCAGTAAATTGTTATGGTGCAAATATCAAATGAATAAATGCTACTGAATCTGAGTTTTGGCAGTTTCAGTCTTCCTGACAGCAGGATTTCTTCAAGCGGTTTTAAACTTGAATCTGATTCTGCAAAGTAGTCATCCTTGGTGGGAGTGCTGAGGCTTTAAAGTCATCTGTAATTTTTATAAAAAGGCATCCGAGATCCTCCATTTTACACTTATATCATACAAATCATTTAGATCTGTGAAGGCTTTCCCATTTTCTCCTTTTGTCCTTCCAAAAACACCATCTTAGGACTTCACCTGGCACAGGGAAGACAGATCGTTTGCACATACTAAGTGCCCTTCTTTCTAACTTGTGTCATAAACTCAGAGGCTTTGAATAGTGGAGAGTGCTCTGTACTGTCTTCCTGGTCACGTGGCCCTTGCCAGAGGAAAGGAAAGGATGGTTTGTTTGTATAGTACAATGGAACTTATTTCAATGTATTCTGTATTTGATTTTACATTCCTGTTCTCATATTTTTACCTTAATTACATAACAAATATTAAAAGATTGACTTCACCAGGCCCAGTTACAATCGCCAGTTTGATAATTCTTATACGTACTCAAATGAATTCAGAGACCAGATGGGAAAAGATTTTGATAAAACCTCTGGTACATCACAACTGAAGTCTTTTCTTGTCCAAACTATTGTGAAACAGATGTTCTTTCTGTTTCATTTGCTAAATCTGGAAACGTGACTGCTTTTGAGACTTTGTCCTCTCTGACAGGTAATAAATATAATCCTGATATTTTTCAAGTTGTTTGACAGAAGTGTAATCTCCCCAGAAGTCCTGCTGGACAGGCTTCACTTTTCCTTTGGAGGAACACAGAGATACAGGGAATATGTTTTAATGACATATACCTAACGCTGAACATGAAACCAGTTATTTTACTTTTATTATTATTATTTTTAGAAACAGCCTTGCTGTGTCACCCAAGCTCAAGTGCAGTGGTGCGATCATAGCTCACTGCAGCCTCCAATTCCTATGCTCAAGTAATCCTCTTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGTGTGCCACCATGCCAGGCTACTTGTTTTTACTTTGTTATAGAGATGGGGTCTCTCTGTGTTGCCCAGACTGGTCTTGAACACATGATCTCAACCATTCCTCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGCGAGCCACTGTGTCTGGCCTATTTCACTTTAGAAGTAAATTGAATGCCACATGCGAAGTTTGTTAAATTTTTTTAAAAAAGGAAAGAAAACACAAAAGTAAACTACCTAGTCGCATCAGAAATGCCATAGTCATTTTTGCCATTTTTTCATTCATTAGAATTCAGTGCATTATGTTATTTTGTTATCTCTGCAGTAACTTTCTATCATGTTATTTATTTTCTTTGTCTTATTTAAAGCTTCTGAGATTATGGATTTTTGTTTCCTTCCCTGAAGTTAAGTGTTATCATTCCTATATAGTACTAAGCTGTCTACAGAATAGTGGGAGTCTGCCCTCTTGAGTTGGGAAGATCCTAGTTTGAATCTTGGCTGTGCGACTTTAAAGTTCATTAACTTCTCTTAGCCTCAGTCACCTGAACTCTGCAGTGGGGATCCTTATGCCTCAGAGTGTCATTGGGAGGACTCACGAAAATACGCTTGTACTTTGAGTTCAGTACCTAGCCTGTATGAGCCAGCATTAAGAGGGACAGTCATCACGCAGCGCTTTGCACACAGCTCTCACGCCACATCCTTTGGCTACTGTTTTGGTAAATCTTTACTAGTAAATGTTTCTTAAAAGCATTTACATTCATGGACATGATTCAGAAACTAACAGTTGTTTTTTAGGTCTCACTTTGAGATTTAAAAACCCTTAGGGCAGAGACCAGATTTTATTTCTTACCTCAGAGTTTCCCTGTAGGACAGGAACCAGCAACAGCCTAATGAGCTGATTAAGAATTTTAGAGATTTAAAATTTAAATTAGGATTGCCAGTTTTAGAGACTGGCACATAAATGTTTTCATTTAAGGCAGTGACTGTTTCCTTTAGGATATGATTTTTTATCTTTCTAAGATGAGATCACCATCCTCAGAATAATTTGTACCCCGCTGGGCACTAGCTAATGGAGGTGATGTCATGCTAAGCAGCACTTCAGTGAGTTTTGCGGGAACCAAAGCTCTGCTCCCAGGAGTGTGGATTTGGTGCTTTCATGTGGAAAAAGCGGATGATGACAAGTAGAGAGCAAATGTGCGCATGTCTGATGCTGTAAGGATTTCCTTTACCATCATATAAATTTTTAAAGTATATCAAAATAAACTGATAACTGAGAAAATATATGTTGTTCAGATACTAATAATGAAGTTAATGAAGTCCACTATAGTATTTGTCCCTGAGAAATCTTTATCAAATATTTTAAATCCTATTGTAAAATAATGTATTTTTTCTTTCAGTTTTAGAGACTGGCAATCCTAATTTAACATCTCCTTTTGAATTCCCCACCACAGGCACACTTTCACACATTCACTCTTTAATAACAGGTTGTTTCAAATTGTTAATACTTTATAGCTTAATATAGAAATTTCACTTTAGAAATTAATTTTTATTTCTCTGCCTTAATGCTATAGATGTTGTAGTCTGCTTTACTTCAGTATTGTAATGAGTAGTTGGCTAACCACCATGTAAATAGGGAGAACATTCTAGTTTTTTACTTGTGTAGGAAAACACAGCTTGAAATGTCTAAGTATCTATTTTAGAGTGAAGTAAATTTATACTGACAATATTTTTTTGTGTTTGAAGACCTGACTGTTACAGCGTTGGTGGCAAGTGTTAAGGGATCCAGGAACTAGACAAGTGATTCTGAGACCTGAGTTCCAGGTTTCTAAGTAATATCAGTTGGTCTACTGAGAACTTTGCCATAAACATATGTGTTCAGAAATTTCCTTTCTTAGCAGCAGCATCCTGAATTGAACAGAATTACACACACATCAGCCCAGTAAGAAACAATTCATGTTAAGTCCATTGCTATGCCAGGATAAATCTTTTAAATCACAATTATTTTTCCTATTTATATTTTGTCAAATAAGAATGTTCTAAAAACCAAAATTTCTGTTTTCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACGGCAAGCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCCGAACTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCAAAATTTCTGTTTTCATTTAAGGCAGTGACTATTTCCCTTAGGATGTGATTTTTTTATCCTTCTAAGATGAGATCACCATCCTCAGAATAATTTGTACCCTGCTGGGCACTAGCTAATGGAGGTGATGTCATGCTAAGCAGCACTTCAGTGAGTTTTGCGGGAACCAAAGCTCTGCTCCCAGGAGTGTGGATTTGGTGCTTTCATGTGGAAAAAGCGGATGATGACAAGTAGAGAGCAAATGTGCGCATGTCTGATGCTGTAAGGATTTCATCTACCATCATATAAATTTTTAGAAGTATATCAAAATAAACTGATAACTGAGGCAATGTATGTTGTTCAGATACTAATAATGAAGTTAATGAAGTCCACTATAGTATTTGTATAGTATTTGTATATTACAGTACTCTGAAAAGCTGGTCACTATTTAAAGTTTCCATTACCAGTCACAAGGAGAGAATAATTTTATCCCACAATTTTATTGCTGGCAAAAGACACAAGTTTATTAAAAGTCAGTATTTCAGTGTAAGAGTTACTAGACTGTTTGCAGAAGTGTTCAAAAGAGATCTTTAGGTCCTTGGTTGTCTGTGGAAGCTGATCAGCATTTAGGGGTTCCTGAGCACAGACTGTGAACCCTGCATTTGGCACATGCATTCAGAGAGCCAATTTGAGGCAGACTGGGGGCTAGAAAGGATACTGCCAGGAGCTCCAGGTTCAGCTTCCGAAGTTATTAAGTCTTATTTCCCAGTTTTTAAATTAGACTTCATTTTTTAGAGCAGTTTTAGGTTCAAACCAAAATTGAGAAGAACGTACAGAGACATCCTGTATCCCACCTGCCCCCCAACACGTGCGTAGTCTCCCCCATTATCAACATCCTGCACCAGAGTAGTACATTCTTACAAAGGAACCTACACTGACACGTCATCATCACCCAAACGCCATCGTTCACAATCAAGTTCACTCTTGGTGCTGTTTATCCTATGGTTTTGGACAAATTTACAAGGACTTGTATCCACCATTATATTGTCACACTGAGTAGTTTCACTGCCTTAAAAAGTCTCCGTGCGGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGATCACGAGGTTAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCTGGCATGGTGGCATGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAAACCTAAAGGCGGAGGTTGCAGTGAGCCGAGACCACGCCACTGCACTCCAGCCTGAGCAAGGAGCGAAATTCCATCTCAAAACAAAAAAAAAAAAAAAAAAAAATTCTCTGTGCTGTCTCCCTCCCTCCTAGCCACTGGCAACCACTGATCTTTTTACTGTCTCCATAGTTTTGCCTTTTCCAGATTGTCAGATAGTTGGAATCATGCGGTATATATGGCCTTTTCAAACTGGCTTCTTTCACTTAGTAATAATGCATTTAAAGTGTTCATGGCTTGCTAGCTCATTTCTTTTTAGTGCTCAGTAATATTCTGTTCTCTGGATATACCACGGTTTATTTATTCATTCACCGACTGAAGGACATCTTAGTTGCTTCTAGTTTTGACAGTTATGAATAAAACTGCTATAAACATCTGTGTGCAGGCTTTTGTGTGAACATAAGTTTTCAACTCCTTTGGGTAAATACCAAAGAGTGCGTATTTACCATATGGCTGGATCATATGGTAAGAGTATGTTTAGTTTTGTAGGAAACTGCCAAACTGTCTTTCGAGTTGGCTGTACCATTTTGCATTTCCACGAGCAGTGATTGAGAATCCCTGTTGCTCCACATCCTCACCAGCATTTGGTGTTGATGGTGTTCTGGTTTTGGCCATTCTGCTAGGTATGTAATGATACCTCATTGTTGCTTTAATTAGCATTTCCCATTATTTGCAGTCTGTGTATCTTTGATGAGGCCCACTGGATTTTCACTTTAGATTTTCTATAGATTGGCCATAAAGTCTTGAAACAAAGATATTTTCTCATGGATTATAATGCAATATCAGTAAACTATTATGTGTTCACCTACGTTTCCAGACTTGTTAGCTACCCTGTACTGTTCTCTCAGTTAATCAAGTTAACCACAATTTGTTTCTCAACCACAGGTGGCTAATGATTTTGTATGTGGTCTGTCCGCTTTGAATTGATGTGCATGGGGCAAGTTGGTCTCTATGATATTCATGGTTCAAGGAAGTTCGAGATTTCCTGGTACCTAATACATGTTTATTGTACATATGAAAGAAAAAAGGGCAGATAGAGGGGAACATGGTACTGAGCATGATAGAGGCAAGGAAGGGTGGCTACTTTGATAGGAGAATACCCCTATTTTTGTCACTCTTGAAACAGGGCCAAGAGTTGAAATTGGCTAGAACAATCCTGACCTTTGTTGATATTATTTTATAGAATAATATTTGTTACTGTTTTCTCACTTTTAAAAAATGCAGATGTTATAGAAAAATTAGAAGATATAGAGGAATGTTAAGGAGTAAATAAGGTGTCAGTAATGCCATCACCCAGACAGCCACTGTTAATAAATATGTTAATATGTGAAGACATACTAATATGTAATATGTACTGAGTGACTAATGGCAGGTCACTTAGTAGCTGTCTCGATTATCAGATCAACTGTCATGGTATGGCAGTGTTTATGTTCAGGTACCCGTATTAGTTATTGTTGTTAATCCCTTTCTGCGCCCAAGTTATAAACTAAACTTTTTCATAGGTATGTACGTATAGGAAAAAATATGCTGCATATAGGCTCAGTACTGTATTTGGTTTCAAGCATCTACTGGGGGACTTGGGAGGTACCCCCTGCCCCTGCCCCACAGGTATACTACTGTATAATTATTCTTCTATCTAAAGTAAGATCTAATGGAAGATAGGAACTTTGTCTTGTCTTCCACTCTGTCCTATTTCCCAGGATGATACCTGGCACAAAGTATTTGTTTACTGACAAACTAAAAGATGATTTATCCCAATTATACTCACATCTTCCCTTGATTTTCCAGAAAGCCTACAGGAAGTAAGATGGTAGAAAAGCAAAGTCTTCGTAGAAATGCAGAGCATAGACTGGCTCTTGGAGAAGGTCAAACATCACCCTCTCCTGTGGTTAAATTGAGATGGTGGCACTGGCTGTCTTCTATATTATTGCTGCACCTTTCCTCACCAGGGGTGCACACAAAACTGGGAGAGAGGGGAGGAAGGAGCTTAGCTTTGTCTTAATAGAAGGGAAGAAATGATGTTTTCCAAGAGACCTTGAAATTGGGGACCTTGGTAAAGGTTTCAGTTTGGGAAGATAAAAAAGTCCTGGGATGGATTCCAACAGTGTAACTGTACTCAATGCCACTGAGCTGTACGCTTAAGAGTGGTAAATTTTATGTCTATTTCACCACAGTTTTAAAGATTAAAATTTTTAAAAGTGGGGGAAGTTACCTAGGACTTTCTAGAAGGACTTTTGAGGGTGAGCAAGTTCTGTTATAGGCTTGTGTATTATTTTGGTATTTCTGATTTTATCATAGGAGTGAGGTTAAAGTTGTATTTTGACTGGAATTTTTGACATTGTCAGGGTTTCTAGAGTGTGGAGAAGGTCACTCAGTATTTTTTGTTTTTGTTTTTTGTTTTGCCTTTGTTCTTGTTTTCCTCTATTTAGGGAGGTGGATTGCCATGGGAAGTACCTTTGCTTCGAAAAGCCAGAAAATGCCTGGTAGAACTCCAGAAAAGTAGTAAGGAGCTGGCTTCTTCAGAGGCAGCATAGCAGAGTGGGAAGAGGGCCCTGTCACTTAGATTGTGACTGTCGACAAAGTCACTTAACCACCAGAAGTTGGGTTTTCTGACGTTTAGAATTTTGAAAAGATTAAAACTGAGTGCCTTGCAAAGTACCTGGTATATATTAAGTGCTCAATAAGTGATAGTTGCTTTGATTCTAAGAACTGGTTCACCTTGTGAGATATAATTGTGTAATGGAAGAATGAAAGCAGAAACTTTAGTTTCTACTTTTACATTTCCTGGGCCATTTTACTACCCTAAATGAGAAGCTGGGCTTCCAAAACCCACTTTAAAAGTAAAGACTAGGCCGGGTGCGGTGGCTCTTGCCTGTAATCCCAGCACTTTAGGAGGCCTAGGTGGGCAGATCACTTGAACTCAGGAGTTTGAGACCAGCCTGGGCAATACAGCGAGACCGTATGTCTACAAAAAATACAAAAATTAGCCAGACATGGTGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATTTGAGTCCAGGAGATCGAAGCTGCAGTGAGCCGTGATTGCGCCGCTGCCCTCCAGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAGAAAAAAAAAAAAAGAATAAAGATTAATGGAGATTTGGAACATCTTGATACTGTATCTTGGGAATCTAAGCATTGTAGAATTGTGTTATGTGAGTTATACCATTGTGGTGGGAAGTTTTTGATTTTTGTTTTAACTGTGTTGAGTTGCAGTTCTTAGAAATGACCCGAGGTGTTGTCTTACAAAAGAAATAAACTGTAATCTGTATCTTGATCTGATGAGGGTATGTAAATATAAAAAATCGAGCTGTATACTTTCTATATGCTTTATGTAGTTCACTATATATAATTCATAGCTCAATTAAAAAGAGAGAGAGAGGCTAAATTGTATGTACCATTGCAAAGAAATCATTATCCCCAGAACTGACTCACATACACCTTTAACAGTAGAGGGAGAACTGAGGTATTAATTTGGAAAAATAATCACTGGGATAATTAATATAATGCAGTGGTTTTATGACTGATTTTTTATTAACTTCTATTTTCTTTGTATTCTAGTTAATAAAGGTATCCATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCGTGAGTATTTAAATTGAATTCTTTATAATCAGAGAAAGATGGGGATGTGTAATAAGCAAACCTCGAGCAGTGGGGCAAGAGGAAAGAGAGTGGTCTCTCTCTCAGGCCAGAGAGACCAAGTGACTTCCTACCTCAGACAGCTGTGTGGCTTTGCATAAACTGACTTTTCTTCTCTGAACCTCGTCTTTAACATGGGGCTAAAACTTTCACAGAACTGAAGGGAAGATGAAAGGAAAGGCCTAGTAGGGTGTGTGACCCATAGTTGGAAACCTAGTCCTGGAACCAAAAGGACACCACAGGAGAGGCAGGACTCCCAAGCGCCGGTGCTTTCTACCCTCCCGAATCGCTCTATAGGATTAGAGGGTTTAGGTTTGGGAGGAGTTTCTTGACCTCTTGTTTATGAGTTTTTACGACTAAAATGCAATGCCAGTTTTCAGTCCGGGGACAAACTGCCTAGTTATGGATGAATTTTACCCTTTTTTTCCCCGTGTCTTTTTGGAATATTCTGCTTATTAATGCTTCCAATAACTAGCAGATGGAAAAAGGAAAAAGATAAAACTCAAATTCACTTTTTAATTCTTGTCTGTTATTATTTATTTGGGATCTCTCGTAATACTTTAAATTCTGAAAGTTTATTTCTGAAACCCAGTATTGTTATTCTCGGCTGCCCTGAATATTACAAACTAATTTTATTACTAAACAATATGATTACAGAAATACTATTAACAAGTTACCACTAAAGATTTCACAATTTTGTTTAGCAAAGGGATTTTTCTAGAAAGTAAACTTTTAAAATGCAGTCCCATTTTAGAGAGTTGTTGCTGTCATTTAAATCATTTTAGCCAGTGCAGTGGCTTGCTCCTGTAATCCCAGCTACGTGGGAGCTGTGGCAGGAGGATCACTTGAGGTGGAGAGTTTGAAACCAGCCTGGGCAACATAACGAGACCCTGTCTCTACAAAAAAACAAAAAACAATTAGTCCACCATAGTGTGTGTGCTTGTAGTCAGTCCTAGCTACACGCCAGAGGTTACAGTGAAGTAAGACCCCATCTCTTCAAAAAAATCCTTTGAAAGTGATTTACACATTTTCCTACTATTTTTTTTTTCTTTCTTTTTTGAGACAGGCTGGAGTGCAGTGATCTGATTATGGCTCACTGCACTCCTGGGCTCCAGTAATCCTCCTGAGTAGCTAGGACTACAGACATGTGCCACCATGCCTGGTTATTTTTGTTTTTTATTTTTGTAGAGATGGGGGTCTTGCTGTGTTGCCCAGGCTGGTCTCCAATGCCTGGCCTCAAGGGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGAGTACAGGTGTGAACCACCCTGCCTGGCCCTACCTTTTCATGTCATGCAGAACACCACTTCAATAACAAGTTGCACGGAAGCCCCAGACAGGTTTAGGGTTGTTTCGATCCTTTGGTAAGTTGCCCTCACAGTCCCGGCTTTCACAGCCTCTGCCTTTTATTAGGAGTATCCCCTCGTGGACTAGCTATCATATGCTTGTAAAGTACCTACCTCCTTAGGAGGCACCCAGAGCACGTGGGGAAGGGGTGTCGGGAGCTGGGAGTCATAAGTCCCATGATCCATCATCTGTAGGACTCAAAGGTCAAGTCACGCTTTCAGGATTTAACTTCAGTCTGTAAATGTGAGGCTGTTCACCTCTGGTTAAAAATCATAACTGTTTTCTCACGTTGACTCCTTTAATTTACTACATTTAATCTTTTTCCAACAGTATTTTTGGAATTGTGTATAATGTGAGATGCTCTTAAGGTTAAGTGCATGAGTATATGGACTGTAGGTGTTAGTGTTTGGTAGTTCCTAGACCTGTTTTTGCCTGACTCTTGGTCTAGATCAGGGATCAAGCTTAAGGCCTGTTTTTATCAACTTTCGTTGGAATATAGGCACATCCATTCGCTTACATATTGTCCTAAGCCCGTTTCACCAGTATAATTGAGCAGCTATGGCTGGGCACAGTGGCTCACAACTGTAATCCCAGCACTTTTGGAGGCCAAGGCAGGAGGATCACTTGAGGCCAGGAGTTCAAGACTAGCCTGGGCAACATAGCGAGATCCTGTCTCTAAAAAAGAAAATACAGAAATTAGCTGGGCATGGTGGGGCATGCCTGTCTGTAGTCCTAGCTACTCAGAAGGCTGAGGAAGGAGTATCACTGGAGCCCAAGAGTTCAAAGTTGCAGTGAGCTATGATGGCACCACTGCACTCCAGCTTGGGTGACAGAGCCAGACCATGTCTCAAAAAAAAAAAAAAAAGAATAGAATTGAGTAGCTGTAACAGAAACCAGATGGCCCACAAGCCTAAAACACTTAATATTTAGCCCATTAAAAAAAAAGTTTACTGACCCCAATCTAGATAGCAGAGGTTTTTTTAGATAAGTGACTTCCAGACAGATATTTTCAATTATTTACAATAATGCTTTTATATATTAATAAATTACTAATTTGTTTAGCTCATGGGGTTTAAGGAATAATTTATGAATTGTGATAAATATTGTGCTTTGAGTTATATTTGCATTTTGTTGATTTCCCATCATTTCAGGGTAATTTTTAAGATTTTTACTCTTACCTCAAAGGATAAAATATTTCACAAAGTTAATAAGTAATTTTTAAATTATAAAGGTATTTGATGAAATTTTGAAGAATTTAGAGGAAAATGTAAAACATGGAAGTTAAAAGCCTGAACTCTGAAGTCCAACAGATGCTTTCCTTCCTTCTTGGCTGTGACACAATATTTGCATAACCTTTAGCACATTACTTAGCCTCACGTCAGGTCATTTTCTCATCTGTATAACTGTTGATGTGAAATTGAAATGAAGACAGCCTGGTTTATAACATTCAACAAGTGTTAACTGTTACTGTGAGTTATAAAAATTGCACTAATATAAACAGAAGGCGTGGTCATTTCTACCTTTGTAAAGCTATTATTTGATTTCTAAACAGAAAGATCATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGATTATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGTATGTGTCTTACATAATTTTTAATCCTTTTCAAATGTTTGTGCCATTTACATTTGATATAATATTAAAAGCAGTATTATTGAGGTATTAGACAGTAAACCGTGACACAGACTAGCTGTGAAGTAGAGATTGGGCAGGACCTACAGGTCCTCTGATACACTGTGAACGCGTCACTCTTCTGCCCAACTTCATAGCCTCCTCTTGCTGGCCTCCTATCTGTATGCTTGGTTGCCTCTGCCCTGACTTCTCTGTAGCCCTTGCTTCTTTTTCTTCTTTCTGCTTCCTCTTTGATCCCAATGGAAGGTTCTCAAAAAAACAGTTAAGTGGTAGTATTTATTTTTTCCCCAGAAACTGCAAGAGATATCACAAGCATTGCCTTATTTAATTTATGACAACCTGGAAAGTAACGATGAGATTCTGAAAGGTTAAAGACCTCGCGCAGTCACACAGTATGGCGGCAGAGCTAGGTCTGTGTGGCTCCAAAGCCCAAGCTCTGAATCCATCTTCTGTTCTGCTTCACTTCCTTGTATCCTCATGTGCTCTGTTGCCTGTCTTCCCTTACCCTACGAAGCTCCCCATCTTAGAGAGACCTTTCTTTTACTCTGTTCCTTTTGATTCCTTTGATATTTTGTCTCCTTCCCTTCTTCCTTAAATTTTGAATACATGTAGTTTAAGCTTGTACTCTTCATTTGTTTCCATTCCTTCTTGAGTCTTTTTCCATTTTCTGTCTCTACTACTAAAACTGCTTGCTTTAAATTTACCATGGCCTTGCCACCAGATCCCCCTCTCGATTTCTGTACTATGTACAACTTGAATGTAGTACTACATTTGAGAATGTTTTTTTAGAAATATAGATAATAAAATCCTTCACAGTGCCAAAAAAGCTAATTAATATTTGGTGTATTGTTATTTTTTCTTGGCAGTTCTTTTTAAAGCTTGATTTTATTCATAACGTATAAGCAATGTTGTCTTCTGCTTGTTTCACTTAAAGGAATAGCATTTTTCATATTGCTGCATAATTTTCATATCTGTTATAATGATTATATAATACTGCATCCCCAAAACTACCATTCACTTAATTTGAATAATTTACTGTATGAATGAACATTATGGCTGTTTCCCTTTTAAATTGATGCTATGATAATTCTTTGAATTGGCCTATTAATCATATTAGAGTTAATTTTTAATTAGAGAAGCTGTAGTAGATCTAAGGTGGGCCAGTACCTATCAGAGTGGTGGTGGAAATGGAAGGAAGCCAGATTACACTGGGAAGATAGCAGGGTTTGTGTCAGATTAATTATAAGGAGTGAGAAGAGAATAGTTGAAAATGGAGCTCTAAATGGCATCAGTTTTATTGCTTTTGGCTATAAGTTGAGATGCCACCTTCAACCATTAACTTAAAAACACAACACCTTGTTTACTTTTGCTTTACGCATATTTGAAAATTTACTTCTAGATATTCTGCCTCACATTTCTAGTTAGGATACCTCCTTCCTATAGAATTTTGCACTGTTGGCTCTATTGTTTCAAAAACCAAAAACAAGCATATTATTCCACTACCACCAGCACCTCCCCCCACATATTTAGACCAGCAGTCTGGGTTTTGCCCAGTGAGCTCCTTTCCTACTTTGCAATGTAAAGGTCAGGTTCTCATGAGATCTCTGGCAGGCTGGTGTTGGGCCAGGCGCCATGGCTCACACATGTAATCCCAACACTTTGGGAGGCCAAGGCAGGAGGATCCTTGAGCACCAAAGTTCAAGATCAGTCTGGGCAACACAGGGAAATCCCATCTCTACAAAACAGAAAAAAGGTAGCAGGGTGTGGTGGTGCGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGTGGGAAGATAGCTTGAATCTGGGAGGTTGAGGCTGCAGTGAGCTGTGGTTGCTGTACTCTAGCCTGGGCCACAGAGCAAGATCCTGTCTAAAAAATAAAAATAAATAAAAATTAAAAGGCAGCCAACACATCAGCACCAGAAGCCAGTGACCTTGTCACACAGCTGAGATAATCAACAACATTTTGGAGATACATGTAGACTTTCTGTATTTAATCTTCATACCCATCAAATTTACTCAATTCTGAGGGATGTTTCCCACCAAGATTTAGCATTTTGAAATCTGAGTGCATCATGCAGTCAATCTGTACGTTAATGTGGAAGGTTCTCTAAAGGAGTGGTAGAAAGCCCAGGAGCCCTGGATACAGGCCCAGCATAGCTTTGTCACTTTGGACTGGTTTGTTAACTCTGCTACATGTCCCACATCTGCACAAGTGAAACTAGTAATAATATGACTCTCATGGTGATTGGAAGGATTAGAGATTAGCCATAGCAGAATACCTGATGAACAGTAATAATGTTTGGGGGTTTTCCTTGAAGGCACTATAAATGTTGTAATGCTATCTTAAAATTGTTGGGAAGTTAGAGTCAGAGAAACGCATTTCCTCTGAGTGTGACAGATGTGTGTATGTATTATAGGATCGTATTGTTTTCTAGTCTTATTTTTTTAAACTGATGATTTTCCCATGGCAACATTTTATCTGTGAAAATGACAACATAGTATATCCCATTATATAAGTTAGTATAGCTTGTCTAACCAAACCCTTATTGTTAGACATTTGTGTTTTTCACTACCTAAACCGCTGTGAAAGACATCATTTTGGCTATAACACTGATGAGCTTATATTATGAAGTATCTTATAAGCTACAAAATTGAAGAAATTTTGTTCACCATGTTCAAAATAGTTAGAATTCTCTTACCATTTAAAAGGAAGAATTTATTGTGGACTTCTGAATTGCTGAGTAGTTAATTTCATTTCAAAGTAGTTATTCTTTGTTTTCCATACAATTAAAAGTAATTCTTTCTGTTCCAAGGAATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAACTTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATGCGTGATGGTAAGAAGAAACAATTAGAATGAACTTCATTGTACAATTAATTTTATACTATGGTCTAGCAATAATTATATGTATAATAAAATATGAGAATTGTGGAATTATACTGTACATAACCCTAATCTTACATACTTTAGTAAGAAGTTTAAAAAAAGTTATTTATGCCAACTTCCTAAAATGGTTTGAGATGTGTTGCCGTGCCCCAGGTTAGGTTAAGATGACCTCTTAGTTTTAGTCTCAGTTTCTTCATCATGTTCCCATACAGTATATCTGAAGTTGTTGAATAAAGTCATGGATTTTTTTTCCTTTTATTTGCAAATGTCTTTACAGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGCCATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACAAACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATTCAGGTAATGTCTAACTGAGTGATTTGGTTATTGACGATTAAGCAGGGGTTACTATTCTCAACTGTAAATTATCCAAAGGATAATTTTTTTCCTGAAGCTAATGAACTATTGTTACTTTTCATTTATTTACCACTTAAAAGATATAGAGTAAATTTTAATTTTATACTTATATCAAAAAGACTCAGCATAATTAACATCCTTTTTTTTTTTTTTTTTTTTTTTTTTAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAGTGGCGCGATCTCCGCTCACTGCAAGCTCTGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCTGCCACCAGGCCCAGCTAATTTTTAAATTTTTTTTTAATAGAGACAGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCAAGTCATCCGCCCGCCTTGGCCTCCCAAATTGCTGGGATTAAAGGCGTGAGCCACCGCGCCCGGCCAATTAACATCCATTTTTACATAGCATTTCAATTTTTTAGAACTAAGTTATGTGTTCACACACAAATTTTTATAAATAAATATTTATTTTCTAACACCCAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGATGACATGGCGTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCACCTGGTGAGAACGTTACACATAATGAATGTTACATGTGGATTTTAAATGAATTAACTGTGACTGATCATAGAATTATACAATGAAAAGTGTGTTTCAGAGACTGTCAAGATTTTGATATCCCTAAAGATATCAAAACTTGTCTATATTTTAGGGAACCTTCATCAAAGAGAAGTCTCAAAAAGTTGTCTTTAGCCAAAAGTTTGGCTAGAAAATATGCATATATAGCCAGGCACAGTGACTCACGCCTGTAATCCTAGCGCTTTGGGAGGCCGAGGCAGGTGGATCACTTGAGGTCAGGAGTTCAAAACCAGCCTGGCCAACCTCATCTCTACTAAAAATACAGAAAAATTAGCTGGGCATGGTGGCACACGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAAGCAAAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTTCAGCCTGGGCGACAGAGTGAGACTCCGTCTCAAAGGAAAAAAAGAAAAGAAAATATGCATATGTAGAGTAGACTAGCACGATGTCATTCATTGGACTTTATCAGGTAGATCTCCGCTACTAATATCAGGTAGAATATTACGTGGCAACAGAGGCCAAGTCAGAGCTTCCCCTGCATCTTAGAGAAGAAGAGAGGTACGTTTCTCAGGAGTTATTTGAAAGGTAGTAAATAAAAAAGATAAACATGACTAGTATACAAGAGGATAGATGTGGAGTGGGAGAAAAGAAGGTAAAAAACGATACATGAATGTGCCGTTAACCTCCACGTTTTTACTGTTCTGCTGCACACGTCATCATCTAAATAAACATTTGTGGATTATACCACCATTTACTCACACAGCTAAGGGTGTCGGAGAGTTTGGAAACTTTAGGTAAATGTATTCTTAAGCAGTGTTGCATTTTAAAATATGCTCAATATGGTTTATCTTATCCTCTAGGCATCTTTCCAAGCAAAGTACCTCTAAGTTAAAAGCAATGGGTCTAATAGTTAACCTAGAAAAAAAAGTATGATAAATATACTATTTTCCCTTTTTGGACCAATACTTGGTAGTGTGTTTATTATACTTTATTCAGATGCTCTGTAGACAAGTAGGACACTCAAAGCAATTTGTTTCTTGGCTAAGTCAGTATTAAAATAAGGTGAAATCTGATTGGAACACTGTGCTACTTACAATGATCCTTTTTATACATCTTTACTTTTGCATCTTACCTTCTGCGTGTTTGCTCTTCTTGCCTATTGAAAGGGGAGTCCAGAAAGTAAAACTTTCAATAATTCAGTGTTCGTGAAGCTGGTCCCCGGCCAGCTTTGCTGAAAGCAGGGGGTGTACGCATAGCACACATTCGTCCTTCAGCATCATTTCTTCTGAAACCAAAGGTGTCTTTTTTTTTTTATTTGTATGACTAATAAGACTTATGTAAGTTTATGCTTATTTTTGCCTTTATGACTACATAATAATTTATAGAATCAACTAAAATCAGCTATCCATGGTATTTTGCTTGTATTTTGCCTTTTAGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGTGCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAACCGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAACAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAAAGAAATGGTTGGTTGGTGGTTTTTTTTAGTTTGTATGCCAAGTGAGAAGATGGTATATTTGGTACTGTATTTCCCTCTCATTTTGACCTACTCTCATGCTGCAGAGGGTACTTTAAGACATACTCCTTCCATCAAATAGAACCACTATGAAGCTACCTCAAACTTCCAGTCAGGTAGTTGCAATTGAATTAAATTAGGAATAAATAAAAATGGATACTGGTGCAGTCATTATGAGAGGCAATGATTGTTAATTTACAGCTTTCATGATTAGCAAGTTACAGTGATGCTGTGCTATGAATTTTCAAGTAATTGTGAAAAAGTTAAACATTGAAGTAATGAATTTTTATGATATTCCCCCCACTTAAGACTGTGTATTCTAGTTTTGTCAAACTGTAGAAATGATGATGTGGAAGAACTTAGGCATCTGTGGGCATGGTCAAAGGCTCAAACCTTTATTTTAGAATTGATATACACGGATGACTTAACTGCATTTTTAGACCATTTATCTGGGATTATGGTTTTGTGATGTTTGTCCTGAACACTTTTGTTGTAAAAAAATAATAATAATGTTTAATATTGAGAAAGAAACTAATATTTTATGTGAGAGAAAGTGTGAGCAAACTAACTTGACTTTTAAGGCTAAAACTTAACATTCATAGAGGGGTGGAGTTTTAACTGTAAGGTGCTACAATGCCCCTGGATCTACCAGCATAAATATCTTCTGATTTGTCCCTATGCATATCAGTTGAGCTTCATATACCAGCAATATATCTGAAGAGCTATTATATAAAAACCCCAAACTGTTGATTATTAGCCAGGTAATGTGAATAAATTCTATAGGAACATATGAAAATACAACTTAAATAATAAACAGTGGAATATAAGGAAAGCAATAAATGAATGGGCTGAGCTGCCTGTAACTTGAGAGTAGATGGTTTGAGCCTGAGCAGAGACATGACTCAGCCTGTTCCATGAAGGCAGAGCCATGGACCACGCAGGAAGGGCCTACAGCCCATTTCTCCATACGCACTGGTATGTGTGGATGATGCTGCCAGGGCGCCATCGCCAAGTAAGAAAGTGAAGCAAATCAGAAACTTGTGAAGTGGAAATGTTCTAAAGGTGGTGAGGCAATAAAAATCATAGTACTCTTTGTAGCAAAATTCTTAAGTATGTTATTTTCTGTTGAAGTTTACAATCAAAGGAAAATAGTAATGTTTTATACTGTTTACTGAAAGAAAAAGACCTATGAGCACATAGGACTCTAGACGGCATCCAGCCGGAGGCCAGAGCTGAGCCCTCAGCCCGGGAGGCAGGCTCCAGGCCTCAGCAGGTGCGGAGCCGTCACTGCACCAAGTCTCACTGGCTGTCAGTATGACATTTCACGGGAGATTTCTTGTTGCTCAAAAAATGAGCTCGCATTTGTCAATGACAGTTTCTTTTTTCTTACTAGACCTGTAACTTTTGTAAATACACATAGCATGTAATGGTATCTTAAAGTGTGTTTCTATGTGACAATTTTGTACAAATTTGTTATTTTCCATTTTTATTTCAAAATATACATTCAAACTTAAAATTA

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