Details for gene: SOD1


The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020]


Symbol
SOD1
Name
superoxide dismutase 1
Entrez ID
6647
Ensembl ID
ENSG00000142168    (more details)
KEGG ID
hsa:6647    (more details)
OMIM ID
618598
Uniprot ID
P00441  
GO ID
hsa:6647    (more details)
Chromosome
21
Strand
1
Start
31659666
End
31668931
miRNA Interactions
hsa-miR-34a-5p (RPM: 81.3502) / hsa-miR-16-5p (RPM: 2473.4704) / hsa-miR-101-3p (RPM: 3335.0564) / hsa-miR-27a-3p (RPM: 980.3062) / hsa-miR-377-3p (RPM: 4.0398) / hsa-miR-582-5p (RPM: 8.1398) / hsa-miR-579-3p (RPM: 0.0084) / hsa-miR-125b-2-3p (RPM: 492.7724) / hsa-miR-361-5p (RPM: 182.4758) / hsa-miR-206 (RPM: 4.6758) / hsa-miR-664a-3p (RPM: 65.4214) / hsa-miR-143-3p (RPM: 93089.5152) / hsa-miR-21-5p (RPM: 5494.851) / hsa-miR-33a-3p (RPM: 1.692) / hsa-miR-139-5p (RPM: 36.887) / hsa-miR-197-3p (RPM: 347.3274) / hsa-miR-1299 (RPM: 7.6252) / hsa-miR-378a-3p (RPM: 1540.7796) / hsa-miR-23b-3p (RPM: 2125.0486) / hsa-miR-224-5p (RPM: 33.3102) / hsa-miR-140-3p (RPM: 779.3088) / hsa-miR-651-5p (RPM: 2.417) / hsa-miR-874-3p (RPM: 170.3494) / hsa-miR-155-5p (RPM: 106.9134) / hsa-miR-218-5p (RPM: 36.775) /
Involved Diseases
diabetic retinopathy /
Involved Pathways
Parkinson's disease / Amyotrophic lateral sclerosis (ALS) / Huntington's disease / Prion diseases / Peroxisome / Cellular responses to stress / Cellular responses to external stimuli / Cytokine Signaling in Immune system / Immune System / Signaling by Interleukins / Hemostasis / Platelet degranulation / Platelet activation, signaling and aggregation / Response to elevated platelet cytosolic Ca2+ / Detoxification of Reactive Oxygen Species / Interleukin-12 family signaling / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / Interleukin-12 signaling /
Sequence
GTAGTCGCGGAGACGGGGTGCTGGTTTGCGTCGTAGTCTCCTGCAGCGTCTGGGGTTTCCGTTGCAGTCCTCGGAACCAGGACCTCGGCGTGGCCTAGCGAGTTATGGCGACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCAGTGCAGGGCATCATCAATTTCGAGCAGAAGGCAAGGGCTGGGACGGAGGCTTGTTTGCGAGGCCGCTCCCACCCGCTCGTCCCCCCGCGCACCTTTGCTAGGAGCGGGTCGCCCGCCAGGCCTCGGGGCCGCCCTGGTCCAGCGCCCGGTCCCGGCCCGTGCCGCCCGGTCGGTGCCTTCGCCCCCAGCGGTGCGGTGCCCAAGTGCTGAGTCACCGGGCGGGCCCGGGCGCGGGGCGTGGGACCGAGGCCGCCGCGGGGCTGGGCCTGCGCGTGGCGGGAGCGCGGGGAGGGATTGCCGCGGGCCGGGGAGGGGCGGGGGCGGGCGTGCTGCCCTCTGTGGTCCTTGGGCCGCCGCCGCGGGTCTGTCGTGGTGCCTGGAGCGGCTGTGCTCGTCCCTTGCTTGGCCGTGTTCTCGTTCCTGAGGGTCCCGCGGACACCGAGTGGCGCAGTGCCAGGCCCAGCCCGGGGATGGCGACTGCGCCTGGGCCCGCCTGGTGTCTTCGCATCCCTCTCCGCTTTCCGGCTTCAGCGCTCTAGGTCAGGGAGTCTTCGCTTTTGTACAGCTCTAAGGCTAGGAATGGTTTTTATATTTTTAAAAGGCTTTGGAAAACAAAAATACGCAACAGAGACCGTTTGTGTGACACTTTGCAGGGAAGTTTGCTGGCCTCTGTTCTAGGTCATGATTGGGCTGCAAGGGCAGAGAAGGTAGCCTTGAACAGAGGTCCTTTTCCTCCTCCTAAGCTCCGGGAGCCAGAGGTTTAACTGACCCTTTTGGGGATTTTTGAGGGCAGTGATCTTAACTTTGGGTGCACAGTTAGCTTATTTGAAGATCTTACTAAAAATACACCAGAGCCCAACCTCCGACCAATTACATCAAAACCTGTCCTAGTGCAGGGTGAGTATTGCTGTTTTTTGAAAGTTTCCAAAAGTGATTTTGATGTGCACCTACGATTGAGAACTGTCGTTTGAGGACAGTGGGTGGAGTTTCGTATTTGGAAATTAGAAGACCTGGAGTTTCCATTACACCGAATTGGCACTTAATAACTGTTGTCGGAGCATTTCTTAAGCCACATTTTCGTAAAGTGGCTTTAAAATTGCTCTGCCAGTAGGCAGGTTGCTAAGATGGTCAGAGACAAACTTCTGAACGACTCTTGTAAAATATACAGAAATATTTTCAGAACTTTTATCAGTAAAATTACAAAACGTGTTGCAAGGAAGGTGCTTGTGATAACACTGTCCCCAGAACCTTAGTGAAGTTACCAACTGGTGGAAAATTTTCTCTTGCACTCGGCTTAAAAATCATGAGGGAATATTTACTATACGAATGAGATTCAGTCTTTAAAGGGGTTTACAGAAACGTGAGAGGACAGGAACAGTTAGTCTGTGTAAATGTCTGAAATATATGTGAGGGAGATAATGAGTTTAGCCTTTTTCTTTAATAGGTCTCCAGATTTTCTGGAAAAGGTTCTTTGGCATTTGACTCCATTTTGCTGTTTCATTTGTCAGACTTCTTTTTGTCCCTCTTTACTTCTCCCCACATAATTCACCAGTACTAGTGTTTTGTTTTTCAGACCAAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGGGTAGCTGGGACTACAGGCGCGCGCCGCCACGCCTGGCTAATTTTTTATATTTTAGTAGAGACGGCGTTTCACCATGTTGGCCAGGATGGTCTCGATCTGTTGACGTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCCCGCCCGGCCACCAGTGCTATTCTTAAGACGCCTCTGAGGAATCCCTTCTCCCTGGCCATTGAGAATCCATGCATGAACCCAGGTTTTCCACCTTCCCTGAGCAGCTTGCATAGTTCCTTCTTTTAAGCGCCTGACTTCGTTTTGTTTGGTGCCCGTTGTACCTGAGAATGAGCCTTGGATAGTGGAGCATTCCAGCTTTCCAGATATGCAGAGATAATACATTGGCTATCAGCTACTTGGCTTGGCCTATTCCGTGTTTAAAATCTTGGACTCTTTGCTAGTTTTTACAGATCAGAATTTTTCACGTATTAATCCAGTTTTCCTAGCTTCTCTTGAAGAATTTTTGGAGATCTCTTCATACTGAGCCTTCATTAGCCCAGGACAGTACTGCTGTAGCAGTTCATATATTTTTTCGCTTCCCAGGCCTGTGTTATTCACTTAAGTTCATAGCCTGGTCCCTGCAGGGTTGTACCCGAGCACAGCTACTTAGATGTCCTGAATGTATTACCGGTTAAATGGAGGTTTCAAAGAACCTGCTGTTTTTGGCCCTGTGCTCTTGATAACAGAGTGTTTGAGGGACAACTTTCACATTTGAGTTTTTCCAAAATTAAAGGTTGTAGAAGAGTCACAGTATCTATTGTCAAAAAGAAAAGAATTTAAAAAGGCAGCAATTGCCAGGATACTTCATTTGAGCAATGATATTTTCCAGTGGAAAGTCACATCTTAAGGGTTAATGCCCCTTAACTGTTGGCCGTATTTGAAAACAAACCAAGCTAAAAACAAGAGACACTGACATGTTGTATGACGGTGTGGTGTGGATGTTGTGTTTATTTTAGTCCTGAGATCTAGTTGTAACTTCCTTGATTTCTGTATGTAGCCACGGAGCACCATTACCTGTCACCATTACCTGAATGGCTATACTGCTTGCTTTCATTTTGGTAGAGTGGAAAGGTTACCTAGGTTTCAGTGCTTGAAAAGATTTCAGAAAGCAGTAGTACGTCTGGTTAGACTAGAATCAGTCCTCTCCTGGGGGCAGTGGAATATAATATTTTCTGACTGCTAATTAAAAATACCTGTGATAGCCGGGCGTGGTGGCTTACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGTGGATCACGAGGTCAGCAGATGGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATGCAAAAAAATTAGCCGGGTGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCATGAACCTGGGAGGCGGAGCTTGCAGTGAGCCGAGATCATGTCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCGTCTCAAAAAAAAAAAGAAAAAAACTTATGATGGACACTTAAAAACACTCACTGAGTGGGGAGTGGAGAGCAGGGGTCCCAGGGTAGCCTGTTGGACATTTCCAGGGCGACTTTTTCTTTTTTTTTTTTTAAAGTCAAGTGAGTATGCCATATGGAAAAGGGTGTGCGTGGAGAAAAAGCAAGGGGCTCCAGAGTGTAGGATGAGACATACACCTTTTGGGTTAAAAAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTTGTCTCAAAATAAAAAACGTTTACATGTACATGTATATTCAACATGTACAAATATAACCTATTCAAAAGTATTTACTACATAAATAGGTACTTACATTACCTATTTACTGTAATAGTCAAAGCCTATGAAGTATCTAACACTGATGTGTAGGTACTCACTTTGCTTGCCACTCTATTAGGTGCTTTTTATGTTATTTAATCATGAAGCCTGGCCACAGGGTGCTTGTGCATTGAGTGTGGGAACAAGATTACCATCTCCCTTTTGAGGACACAGGCCTAGAGCAGTTAAGCAGCTTGCTGGAGGTTCACTGGCTAGAAAGTGGTCAGCCTGGGATTTGGACACAGATTTTTCCACTCCCAAGTCTGGCTGCTTTTTACTTCACTGTGAGGGGTAAAGGTAAATCAGCTGTTTTCTTTGTTCAGAAACTCTCTCCAACTTTGCACTTTTCTTAAAGGAAAGTAATGGACCAGTGAAGGTGTGGGGAAGCATTAAAGGACTGACTGAAGGCCTGCATGGATTCCATGTTCATGAGTTTGGAGATAATACAGCAGGTGGGTGTTGTGCTGTGCTGGTGACCCATACTTGTTCACCCTAGTTAGATAAACAGTAGAGTAGCCCCTAAACGTTAAAACCCCTCAACTTGTTTTTGTTTTTGAGAAAGGGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGCTGTGCGATCATGGCTGACCTTAGCCTTGACCTCCCAGGCTCCATTGATCCTCATGCCTTGGCCCGTAGCTGGGACTACAGGTACACACCACCACGCCTGGCTAATTTTTGTATTTTTTTCTAGAGGTGGGGTTTCATCATGTTGCCCAGGCTGGTCTTGAACTGCTGGGCTCAAGTGGTCTATCCTCCTCGACCTCCCAAAGTGCTGGGATTACATGTGTGAGCCACTGTGCCTGGGAAAACCCTCAACTTTTCTTTTAAAAAAGAGGTCAACTTTATTGTATATAAGCACTGTGCTAAAATTGCAGGAACTGGGACCATATCCTGATTTTTGTAATAATGCCAGCAGAGTACACACAAGAAAAGTAACTGCACTAGATTGTGAAGACTGGGGTGGACCTGCTTCTGAAGGTCCAGTGCCCTTTGTCTTAAGATTTGGTGTAGTGTGTCTTTAGAAACCAAAAAAAGAGAAGAAGATCAACCTTAAGATTAGCCACAAAACTGGGCTTTGATACCTAGGTGTGGAAAAGAAAGGGAAAGAGTTGATGTTTTGTCTTACAGCATCATTGTAGAAGAGGGTGTTTTTTTGTTTGTTTGTTTTTTGAGACGGAGTCTTACTCTGTGGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGCCCCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCCCGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAAGATGGTCTCTCTCCTGACCTCGTGATCCGCCTGTCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCACCCAGCCAGAAGAGGGTGTTTTTTAAAGAAGGCAAATAGGAAATAAAAACTTGGGCTCTTAACTTTTGTAATGATCCCAGGTGTTTGAGCTGGGGGTTGAGGGTGGGTGCCTCGAGCAAAGGGGCTGCATTTATTTGCATAATGCCATGTAAGAGTAGCTCTACACCCCAAACACAGGCTTCTTAGTGGGACCAAAGTATGATACAAACTGAAGATGGAATGCAGAGGATTATTGGTACTTTGGAATATGCTTAAAAAAAATTTTTTTAAAGTATTTTTAAAAAATCAGGCAACCCCTGAACCAGAGTAGGTTCAGAGAAACTGCCAAATTTTATTTTCTTAATTTGGGATTGGAAGCAAGTTAACAGAAGTTTATGAGTTAAGTTGCATTTAGTGATCTTTTGCCATATTTGAGTAATAATCTGATTTTTTTGTTTATAGATTTCTTCTTAAATTAACTTTATTCATCTTGCTAATTTAGTTTCAAATAGTGATTTGTAATGATCAGATTTGATCCATTTCTGTAATTGCTGAAATTCCCCCGAGTTGCTTTTTGGCTTTACCGCCTCTGGTCTGGGAGGTGATTGCTCTGCTGCTTCCTGTAACTTGCCTGCCTTTCTCCCTGTGTGGGACTCCTGCGGGTGAGAGCGTGGCTGAAGACAGCCGTGTTATGAAAGGGCCTCCTGTGCTGTCGAGGTTGTGCTCTGTGAATGTCATCCCCTGGTGCACAGCAGCACCTTCTACACAGGATACAGTTGGAATGCCGCCCCCTCGAGTTGTGTAAGGCAGCAGCCTTGGCCCTTGCACATAAGATGCTGTTGAATATTCTGCCTGCACCAAGTAAAGGGCACAGATAGAACTGCTTGGCATATGTTGCTGGGGAGATGAGTTTTTTGTAAAGTATACTACGTTCTTAAGAATTTGGATCATAACCATGGGATTTTAATAATAGAAAAACTGTTGAAGATCAGTCTGGTCCCTTATTTTTACAGTGAAGAAGCCAAAGCCCAGAGAAGGGTGTTAACTTTACAAGTGTCAGACAGTAGTTAGAACTTGGTGGGGTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTACTAAGTAGCTGGGACTATAGGTGCGCACCACCACGCCTAGCTAATTTTTGTATTTTTTCAGTAGAGACAGGGTTTTGCTATGCTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATCCAGCCACCTCAGCTTCCCAAAGTGCTGGGGTTCCAGGTGTTAGCCACCATGCCTGGCCATAGACTTGTTTCTGTTCCCTTCTCACTGTGGCTGTACCAAGGTGTTGCTTATCCCAGAAGTCGTGATGCAGGTCAGCACTTTCTCCATGGGAAGTTTTAGCAGTGTTTCTTTTTAGAATGTATTTGGGAACTTTAATTCATAATTTAGCTTTTTTTTCTTCTTCTTATAAATAGGCTGTACCAGTGCAGGTCCTCACTTTAATCCTCTATCCAGAAAACACGGTGGGCCAAAGGATGAAGAGAGGTAACAAGATGCTTAACTCTTGTAATAATGGCGATAGCTTTCTGGAGTTCATATGGTATACTACTTGTAAATATGTGCTAAGATAATTCCGTGTTTCCCCCACCTTTGCTTTTGAACTTGCTGACTCATCTAAACCCCTGCTCCCAAATGCTGGAATGCTTTTACTTCCTGGGCTTAAAGGAATTGACAAATGGGGACACTTAAAACGATTTGGTTTTGTAGCATTTATTGAATATAGAACTAATACAAGTGCCAAAGGGGAACTAATACAGGAAATGTCATGAACAGTACTGTCAACCACTAGCAAAATCAATCATCATTGTGAAACATAGGAAGCTTCTGTAGATAAAAAAAAAAATTGATACTGAAAACTAGTCGAGACTCCATTTATATGTGTATGTTTTCTGAAAGCCTTTCAGAAAAATATTAAATTTAAGGACAAGATTTTTATATCAGAGGCCTTGGGACATAGCTTTGTTAGCTATGCCAGTAATTAACAGGCATAACTCAGTAACTGAGAGTTTACCCTTTGGTACTTCTGAAATCAGGTGCAGCCCCATCTTTCTTCCCAGAGCATTAGTGTGTAGACGTGAAGCCTTGTTTGAAGAGCTGTATTTAGAATGCCTAGCTACTTGTTTGCAAATTTGTGTCTACTCAGTCAAGTTTTAATTTAGCTCATGAACTACCTTGATGTTTAGTGGCATCAGCCCTAATCCATCTGATGCTTTTTCATTATTAGGCATGTTGGAGACTTGGGCAATGTGACTGCTGACAAAGATGGTGTGGCCGATGTGTCTATTGAAGATTCTGTGATCTCACTCTCAGGAGACCATTGCATCATTGGCCGCACACTGGTGGTAAGTTTTCATAAAAGGATATGCATAAAACTTCTTCTAACATACAGTCATGTATCTTTTCACTTTGATTGTTAGTCGCGGTTTCTAAAGATCCAGATAAACTGTACTTGCAGTTCAAATTAGGAAAAGCAATTTTATTGGACAATTACGGTGAAAATGAATTATTTTATCTAGGTCAGTTAAGAACACTGTTCTGCTAAGATGCAGTAAAAAGCAGGTTACATTTGACCATATTAGATCTGAGTTTGGAAAACAGAAGTAGTCTTTAGTTTTAAAATGGCCAGATTTTCTTGCCAGGATTGGGTTTCTCACTTGTTAAACAGAACATTTTGTTAAGTTTAAAACCTGGGATGGACTTAAGTATTCATGTTCATTCATGTTCATTCAGGACTGCAGGTTATCATGACTTGTTTAACTTGTGGGAAGCTGTTGTCCCAAGTTATCCTGGGGAACTGCATCTGGTTCTTGCAAAACACCAAGTAGACAGGCTCTCTTTTACCTCCCCTTGAGGGCATTAACATTCAGTAGTCACTTCCATTCAGTTAACCCTTTATTTTTATGGTTTTTCTTGAGCCATAGTTGTAAAGCAGAAAAATCATTTATAAAGGTTTGTTGAACAAAATTCAAAATACTGTTGCTTAAAGTATTAAGATTTTTTAGGATTATACCTTACTTATAGGCCCGTCATTCATTTGGCATGAAATTTTGAGTTTTATTCACTTTCACTTTCCTTTTTTTCCAAAGCAATTAAAAAAACTGCCAAAGTAAGAGTGACTGCGGAACTAAGGTTACTGTAACTTACCATGGAGGATTAAGGGTAGCGTGTGGTGGTCTACAACATAGTTATTTGGGTTTTAGTATTTCATTTAGACAGCAACACTTACCTAATGTTTAAAGGTAATGTCTTTGCAACACCAAGAAAAAGCTTTGAGTAGTAGTTTCTACTTTTAAACTACTAAATATTAGTATATCTCTCTACTAGGATTAATGTTATTTTTCTAATATTATGAGGTTCTTAAACATCTTTTGGGTATTGTTGGGAGGAGGTAGTGATTACTTGACAGCCCAAAGTTATCTTCTTAAAATTTTTTACAGGTCCATGAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAAAGTACAAAGACAGGAAACGCTGGAAGTCGTTTGGCTTGTGGTGTAATTGGGATCGCCCAATAAACATTCCCTTGGATGTAGTCTGAGGCCCCTTAACTCATCTGTTATCCTGCTAGCTGTAGAAATGTATCCTGATAAACATTAAACACTGTAATCTTAAAAGTGTAATTGTGTGACTTTTTCAGAGTTGCTTTAAAGTACCTGTAGTGAGAAACTGATTTATGATCACTTGGAAGATTTGTATAGTTTTATAAAACTCAGTTAAAATGTCTGTTTCAATGACCTGTATTTTGCCAGACTTAAATCACAGATGGGTATTAAACTTGTCAGAATTTCTTTGTCATTCAAGCCTGTGAATAAAAACCCTGTATGGCACTTATTATGAGGCTATTAAAAGAATCCAAATTCAAACTAAA

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