Details for gene: CPSF1


Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]


Symbol
CPSF1
Name
cleavage and polyadenylation specific factor 1
Entrez ID
29894
Ensembl ID
ENSG00000285049    (more details)
KEGG ID
hsa:29894    (more details)
OMIM ID
618827
Uniprot ID
Q10570  
GO ID
hsa:29894    (more details)
Chromosome
8
Strand
-1
Start
144393229
End
144409335
miRNA Interactions
hsa-miR-30a-5p (RPM: 15590.711) / hsa-miR-27a-3p (RPM: 980.3062) / hsa-miR-103a-2-5p (RPM: 0.387) / hsa-let-7b-5p (RPM: 3396.2052) / hsa-miR-199b-5p (RPM: 234.7942) / hsa-let-7a-5p (RPM: 32160.4734) / hsa-miR-199a-5p (RPM: 174.3046) / hsa-let-7d-5p (RPM: 1078.3154) / hsa-miR-22-3p (RPM: 26348.475) / hsa-miR-1-3p (RPM: 26.3428) / hsa-miR-197-3p (RPM: 347.3274) / hsa-miR-22-5p (RPM: 21.6092) / hsa-miR-221-5p (RPM: 32.1456) / hsa-miR-885-3p (RPM: 18.2314) / hsa-miR-146a-5p (RPM: 774.8698) / hsa-miR-17-5p (RPM: 83.6404) / hsa-miR-504-5p (RPM: 27.4444) / hsa-miR-1307-3p (RPM: 130.8454) / hsa-miR-218-5p (RPM: 36.775) /
Involved Diseases
myopia /
Involved Pathways
mRNA surveillance pathway / RNA Polymerase II Transcription / Gene expression (Transcription) / Transport of Mature mRNA Derived from an Intronless Transcript / Transport of Mature mRNAs Derived from Intronless Transcripts / tRNA processing in the nucleus / mRNA Splicing - Major Pathway / mRNA Splicing / mRNA 3'-end processing / Transport of Mature Transcript to Cytoplasm / Processing of Capped Intron-Containing Pre-mRNA / tRNA processing / RNA Polymerase II Transcription Termination / Processing of Capped Intronless Pre-mRNA / Processing of Intronless Pre-mRNAs / Metabolism of RNA /
Sequence
GAGTTCGCTGCTGTCCCGGTTCCTCTCGAGTCGGCTCCAACTGCCAGGTGGGCGGCCGGGCGGGCGGCCGAGGCGGCAGCGCGAGGCCGGGGAGGGGCGCGGTGCGGGGCCGGGCTCCTGCGTGGGCGACCCCGCTCACCCTTCCTCTCCCGGCCTTGCGCAGCCCGGGTTGGCGCCATGTACGCCGTGTACAAACAGGCGCATCCGCCCACCGGTCTGGAGTTCTCCATGTACTGCAACTTCTTCAACAACAGCGAGCGCAACCTGGTAGTGGCCGGGACCTCGCAGCTCTACGTGTACCGCCTCAACCGCGACGCCGAGGTAGGTCGGGCCCTGGGAGCCCTCCCGGCTGTCCGCGACGTGGGTGCTCTCACCGCCCCCGGTTGCAGATGGAAGAGCCAAGCCCCAGACAAGTTGAGTGATTTGCTTAACGTTCCTCAGCCTGAGGAGCCAGGACATGACCCTGAATCTCTTGTGCTCAGATCCTTTCTCACAGCTGCTACCCTGTTCTGCCTCCCTTCCTACCCCACCGGGAAGGGCGCGCTGCCCTAGCCGTCTTGTTTGCTCTTCCGTTTTTTCAGCAAGTTGTTCGGAAGGAGCGAACGCCCACTGTGCGCTGGGTAGCAGAGATACCATGTGAACCACACCTGCAGACACTTGGGGAAGGGGAACATCTAAATAAACACACCTGCCCCTGCAGCAAGTGCTGCTGCGGGAATAAAGGAGTGAAGGAAGGAGACTGTGTATTTCCAGTCGCATGATCAGAAGAGCCTGTCTGAGGCAGAGCGGGAGTTTGTCGGGGGAAGGACATTGGTAGCACAAGGAACAAGGCCAGGTCTAGGATGGGGACAGACTGTTGACAGGAGTCTTGGTACAGTGGGGCACACGCCTCAAGGGTTTGGGAAATACAGTGGTGTTTTGGTTGCCGGAGGGTTGAAAGCTGGTCCAGGAAAGCAACTTGCAAGAGGCAGTTTCTCCATTGCTCTTGAAGGGAGGAGTACCTCTTACCCAGGCCCAGGGATGGTGAGAGGAGGGTGTTCCAGGCAGAAGAAACAGCCTGTGCACAGGCCCAAAGCAGTTGAGGGTGGAGAGACATGCACAGTGTGGCCGTGGTATAGACTGGATGTGGTGGTGGGGATGGAGGGAGGTAGGCCGTGGTCAGGACTATTCTCCACAAAGCAGGGAGGAGCCACAAGAGGGTTGTGAATAGGGGCTGACCCAGCAGGCAGATGGGTCAGAAGCTCAGGCCAAAGGAGGCCAACCCTCCTGGGCACCTACCCCGGCATACATATGTATTTGCTGGCCAGGGCTCCTGTCCTCTGAAGGCTTGACGAGGGCTGGAGTTTCTGCTCCTAACACACTATTGGCAGGAGGCCGCAGTTCCTCACCACATGGGCCCCTCCCTGGGGCAGCTCACAACATGGCAGCCTCCCTCACAATGAGACACCCACCAAGACTGAAGCCACGGCGAGTCCTGTAACCGAATCTCAGGCTGGGTGCACTGGCTCACACCTATAGTCCCACACTTTGGGAGGCTGAAGTGGGATGACTGCTTGAGGCCAGGAGTTCAGGACTGGCCTGAGCAACATAGCAAGACCCCATCTCTACAAATAATTTTTTTTTTTGTTTTTCCTGGTGAGACGGAGTCTTGCTGTGTCACTCAGGCTGGAATGAAGTGGTGTGATCTCAGCTAACTTTAACCTCCGCCTCGTGGGTTCAGGCAATTCTTGTGCCTCAGCTCCCTAAACCCTCCACCAAGTAGCTGGGATTACAGGTGTGTGACACCACGCCCGGCTAATTTTTTTTTTGTATTTTTAATAGAGACAGGGTTTCGCCACATTGGCCAGGCTGGTCTCAAACTCCTGAGCTCAGGCAGTCCACTCACCTTGGCCTTCCAAAGTGCTGGGATTACAGGAGTGCACCACTGTGCTTGGCCCAAATATAAAATATAAAAGTTAGCTGGGCATAGTGGCCTGTGTGTAGTCCTAGCTACATGGGAGGCCAGGGTGGGAGGATCGCTCAAGCCCAGGAGGTCAAGGCTGCAGTGAGCTATAATTGCACCATTACACTCCAGCCTGGACAACAGAGTGAGACCCTATCTCAAAAAAAAAAAAAAAAGGCCAGGCACGTTGGCTCACACCTATCATCTTAGCGCTTTGGGAGGCCGAGGCAGGTAGTAGATCACCTGAGGTCATGGGTTCGAGACCAGTCTGGCCAACGTGGCAAAACCCTGTGTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCAGGCATCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGTAGGCGGAGGTTGCAGTGAGCCGAGATTGCACTCCACTCCAGCCTGGGTGACAGAGCAAAACTCCATCTAAAAAAAAAAAGTAGTAGTAATACACTGTTAACCTTCTGTCATATTCTGCTGGTCATATCTACCAACCCTGGTGGGGGTTGCGGAGGGTGCAACACCTCCCAGCATTCACTGCAGAGGACATTGTGCTGCCTTGGATGCTGGCCACCGTAGATTGGCTGAGGTGCTCATTCCACATCAGGTAGCAGTGCAGAGCAGGAAGCGTTGTGCTGCCTTGGACGCTGGCCACCGTAGGTTGGCCGAGGTGCTCATTCCACATCAGGCAGCAGTGCAGAGCAGGAGGGTGTGTGCAAGAGTCTAGAATTGAGGATTGAGGTCTGGTATGGAGGTCAAGTCAGAGTCTTCAGCCTGGGGTTGGTGTCTGCCCTTGGAAACTGGTTGAGATCACCCAGAATATAGACAAAGACAGGGTCTTGGGGCACCCCAACATTGAGAGATTGGGGAGATGAGAGGCCATGAAAGAGCTGGAGGTGGCATGGCCTGGAAGGCAGGGGGAAAGCTGGACAGGGCCCTGGAGGCCCAGGGAAGGCAGCTGGGAGGGACTCGACACTGGGTCCCACGCTGTTGAGCCTCAGGTGATGCCTGGTGACTGACAGGGCAGTCTGGTGGGCACGAGGGGTTGTGGTCTGAATGGAGCAGGGGTAAGAGCCCAGCAGGGGAGGAGAGTCAGTAACAGTGAACACAGACAACTCTGGAGGAGATGTGCGTAAACTGAAGCAAGAAATGGAGCCATAAATAGCAGGAAAAGAGGTTTTCTTCTTCTGTTTTGTTTTTTGTTTTTAAGAAACGGGGTCTTGCTATGTTGTCCAGGCTGGCCTCGAACTCCTGTGCTCAAGCCATCCTCCTGGGGTCAGTCTAGTCGTGGCTCTGTAACTAACTGCCCTGGAATATGCAAACGAGGTCTTTTATCATAATCGCAGACCTGGAAGCCAGGTTTTCAGGGATTCATCAGAGTGTGGGGAGCCCTTGGCTCTCCTCCACCAGGGCAAGCCTTGACAGGGATGACTTGAAGAGCTGGGGACAGGCTAGATGTGTCTTCCCCTACCCCCACACCGTCCCTCCACTCTCCCCTGTCCCCAGCATGGCTAGCTTGGTTTTCCTGGCAGCATGGTGGTGTTGGTGTAGTTGAGCTTCTTGCAGGAACTCAGAGCCCTAGGAGGCTAAGGCAGAAGCTGCCAGTCACTTTAAGGGCTAGACCAGGAGGGCACCGTCCCTGCCACCACAGTCTGCCCTAAAGGCAGCCTCCAGCCCAGATTCACCTGGAGAGGGAGGGAGACAGCCACCTTTCATACAGCTGTCTTTTTTTTTTCTTTTTTGAGAGAGAGTCTCCCTCTGTCACCCAGGATAGAGTGCAACAGTGCGATCTCAGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAGTTCTCCTGCCTCAACCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTTGTATTTTTGGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTTCCAAAGTGCTGGGATTACAGGTGTGAGCCACGGAGCCCGGCCAAGACATTCCCAGGTGTTTAGATGAGACATTTGTATTTTTGACAGGAACACCACAGAAGAGGCAAACAGCAGCCCCATCAGCTTTCAGGAGGCGGCGGAGGCCTTTGCCTCATGACTGGATGCTGATGCTTTGATGCTTGGTTGGGTAGTGTTGGCCTGGATTCCCCCACTGTAAGGTTATTTCTTCCTTTTGTAACTAAAAGTATCTTGTAGGGACTTATTTTGAAACCCTGTAAACGTCCTCTTATTCAGATTTTCAAGGTTTTTTTTTCTTTCTTTCTTTCTCTTTTTTTTTTTAGACGGAGTCTCGCTCTATCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCACCTCCTGGGTTCAAGCGATTCCCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGACTAATGTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCGCCTGACCCCGTGATCCGCTTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAGCCTTTGGTCGCTATTTCTTTAGCTATTGATTCTGTCCCCTTTCCCCCAACATGCCAGTTAGACCATTTGACTATGTACACATTTTTCTTAAAATCCTTCTGAGTGGTGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGCAGGCCGAGGTGGGTGGATTGCCTGAGCTCAGGAGTTCAAGACCAGCCTGTCCAAGATGGTGAAACCCCGAGTCTACTAAAATACAAAAAAAAAAAAAATTAGGCGTGGTGGTGGGCGCTTGTAGTCCCAGCTACTCGGTAAGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGCTTGCAGTAAGCCAAGATTGTGCCACTGCACTCTAGCCTGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAATTCTTCTGAGTGGTTACCCCTGTTTCTTGCATGTACACAGAAGTGCAGTTGATCTCTGTATATTGACCTTATACTTGGCAGAGTGGATCAGGCGTCCTTGGCTGGTCCTGACCAAGAGGGAAAACTTCTTTTTTTGTTTGTTTTTTTGAGACCAAGTCTCTCTCTTGTCCCCCAGGCTGGAGTGCAATGGCATGATCTTGGCTCACTGCAACCTCCGCCTCCCGGATTCAAGCGATTCTCCTGCCTTAGCCTCCTGAGTAGCTGGGACTACAGGCACCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGATTTCACTATGTCACCATGTTGGCTAGACTGGTCTCGAACTCCTTACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTCAAAAGGGAAAACTTGTAATGTTTCACTCCCAGCACCACATTGCTGTAGACTTTTTGTAGATACCCTTTATTTGATTAAGGAAGTTGGGCGCGGTGGCTCATGTCTATAATCCTTGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGGGTTCGAGACCATCCTGGCCAACATGGCAAAACCCTATCTATTAAAAATACAAAAATAGCCGGGCATGGTAGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGGGAGCTGAGATCACACTACTGCCCTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAATTTAAAAAAATAAATAAATTAGTCAGGTGTGGTGACTCACATGTGGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGGATCACCTAAGCCCAGGAGGTCGAGGCTGCAGTGAAACATGATTGCTCCTCTGCACTCCAACCTGGGAGACAGTGAGGCCCTATGTCAAAAAACAAAGGCCTGGCGTGGTGGCTCATGCCTGTAATCCCAGCGCTTTGAGAGGCCGAGGTGAGTGTATCGCTTGAGGTCAGGGGTTGAAGACCAGCCTGGCCATGGCAAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGGACGTGGTGGTGGGCGCCTATAATCCCAGCTACTGAGGAGGCTGAGACAGGAGAATCGCTTGAACCTGGAAGGCAGAGGTTGCAGTGAGCCAAAATCACACCATTGCACTCCAGCCTGGGCAACAAAGTGAGACTCCATCTCAAAAAAAAAAAAAAAATTTTCCTCCTATTTTTGCTTTACTAGGAGTTTTTATCACGAATGCCTTTATCAGATGCTTTTTTTGTATCCACTAAAATGACATGATTTTTCTCCTTAATTTTGACAGCATGGTAAGTTTAGCGATGGCTGTTCTTGCGGAAATCTAGTTTTGCGTTCCTGGAATAACTCAACCCAGTTGTGTTACAATACCCCTGCTTGTCACTGGGCTCATCTGCAGGCGTTTTGAGGAGGTTGGTGTCACTTCCTGTCCCACCTGTCTGTGGGCTGTTGGGGTGGCCTGAGCCACCTGCGGTGCCGTCAGCCCCACATGAGTGGGTGTGTGTTTTTTTTTTAAGTGTGTCATTACTTCTGAAACCTTTGGTAGAATTTGCGGGTGAAGCCCTGGAGTTGCCCTTGTCGCTGTGAGATGGGTATTGGTTTGTGGATGCTTCTTCTGTATCTCTTAACCAGCTTCCAAGATGCCCTCCCCATAGCACAAGTCCATCGTGAAAAATGACCTTGAGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTAAGGTGGGCGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGACATGGTGGCACGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTTCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAACAAAAAACAAAAAACAAAAAAAAACAAAACAAAAACCACTTTTCCCTTGCCTTGAGGCAATGGCATATAAATCTGCTAGCTAGTTAAACTAGCTACCTAGTAGCAAAGAACACACAGCCTCTTATCATTCTGGGAGGGCAGTGAAAAGGGAGGAGATAGAGAGGCAGCCTGGGGGAGCCCGAGGCGTCAGGATAGCGCAGGGCTTCCTCTTCTCTAACAGGCACGCAGATCAGTAGCTACAGATACCCCTTGGCTCTGGCTTCCTGCCCTGTGACATTTGGACCCAGGGGCCGGGGCTGGGCTGCTGTAGGTGTGCAACCAGGCAGGTTTGGGGGTGTGCAGACACAGAGTGCACTCTAACCCTGAGTGCTTGCCGCACAGGGCCTGGCTGCTAGGGAGCCGTGAGGTAGGGGCTTCCTGGGGAGGGGCCTGTGCCAGGGCTGGGCCGTGGGCATGAGAGCGTGAATGGGGGTCGCTGTGGGGGGCTGTGCACAGCTGTCTCCAGAAGCCCTTCTCCCTGCTGCAGAGAGGGTTTGGGCAGAGCTCCCAGGAGGCAGGGGCCAGGCTTGGTGGTCTTTTCTCGTTCCCCGGATGAGGTGAGCTGCCAGATGTGGCCCCTCACTGCCCTGTCTTTCTCTCCCCTCCAGGCTCTGACCAAGAATGACAGGAGCACAGGTGAGTGTGGTGGGGCGGCCTGGGGCTGTGCGGGTGCCAGGCATGGCTGGGCCCTGACCCTGAGCCCTGGTGTCTCCCCTAGAGGGGAAGGCCCACCGGGAGAAGCTCGAGCTTGCTGCCTCCTTCTCCTTCTTTGGCAACGTCATGTCCATGGCCAGCGTGCAGCTGGCAGGAGCCAAGCGGGATGCCCTGCTCCTAAGCTTCAAGGATGCCAAGGTGAGTGGTAGGCTTGGTGGGGTAGGCCTGGCCAAGGCGTGGGAGTGGGTGCCAGGGCCTGGGTACAGCCGTTGGTTGCCGGGGGCGACACTGTCAGGACCGGCAGTCGGCAGCCACGGCTGTGCCCTCTGACCGCAGCTGTCTGTGGTGGAGTACGACCCGGGCACCCATGACCTGAAGACCCTGTCACTGCACTACTTTGAGGAGCCTGAGCTTCGGGTAGGGCCGCGCTCCCGCCCCCGCCCAGGCCCCGCCCAGCCACCCTCCCTCCCCCTGCAGCTGGGTTCTGTGGCCCCAAGTGTTTCCCTCGGGGTCTCCTATGCTGGGCCTGGCTGATGCCCCCTCTGCCCCCAGGACGGGTTTGTGCAGAATGTACACACGCCGCGAGTGCGGGTGGACCCCGACGGGCGCTGTGCAGCCATGCTTGTCTACGGCACGCGGCTGGTGGTCCTGCCCTTCCGCAGGGAGAGCCTGGCTGAGGAGCACGAGGGGCTCGTGGGTGAGGGGTGAGTGCCAGCTGAGGCAGGCTGTGGTGCTGGGGTGGGAGGCGCCAGAGCCCGAGCTCCCCTCCCCGCCTCCCCTCCTCTCCTGCTGAAGCCCCTGGCCCCCCAGGCAGAGGTCCAGCTTCCTGCCCAGCTACATCATCGACGTGCGGGCCCTAGACGAGAAGCTGCTCAACATCATCGACCTGCAGTTCCTGCATGGCTACTACGAGCCTACCCTCCTCATCCTGTTTGAGCCCAACCAGACCTGGCCTGGGTGAGCCCCCTAAGGAGGCCCCTCTGCACTGTGGGCCCCCTAGCTGCCTCTGCCTGGGGTGGGGCCCATGGGGTTTAGGGCGGGGCCTATGGGGTGTGGTGGGGCTTGCTCGGGAGGAGCTGGGCCTGGGTCTCTGCGGGGAGGCAAGGCCCTTGGCTGACCCACTGGCGTCCCCAGGCGCGTGGCCGTGCGGCAGGACACGTGCTCCATTGTGGCCATCTCACTGAACATCACGCAGAAGGTGCACCCCGTCATCTGGTCCCTCACCAGCCTGCCCTTTGACTGCACCCAGGCTCTGGCTGTGCCCAAGCCCATAGGTGTGTGTCCTGGGAGTGGATAGGGGAGTGTGTGGAGAGAGCACTGAGCCTGCCCACCAGCCTGTGTCCACCTCCAGGTGGGGTGGTGGTGTTTGCCGTCAACTCGCTGTTGTACCTGAACCAGAGCGTCCCCCCGTATGGCGTGGCTCTCAACAGCCTCACCACAGGAACCACGGCTTTCCCGCTTCGTGAGTGTGGGGTGGCTGGGGCGGGGGGGGCCCGGGGACGGCTTGGGCCTGCCTAGTCGGCCTGACCACCCACCCCACAGGCACCCAGGAGGGTGTGCGGATCACCCTGGACTGCGCCCAGGCCACCTTCATCTCCTACGACAAGATGGTCATCTCCCTCAAGGGCGGCGAGATGTGAGCCCCTCCCCCGCCCATGAACTCTGCCCACACCGCCCCCCACAAGTCCTGTAGGGTCCCCTGGCCCCCTTCACTCCCCCAGGGTCCCCATCCCCGACTCAGAATTCTCCCTGCCCCCAGCTACGTGCTGACCCTCATCACCGACGGCATGCGCAGTGTCCGAGCGTTCCACTTTGACAAGGCGGCCGCCAGCGTCCTCACCACCAGCGTGAGTTGGGACTAGGGGTTGGGTCTGGGTCCAGACCCGGCCCAGCCATCACACACCTGCCCTCCCTCAGATGGTCACCATGGAGCCCGGGTACCTGTTCCTGGGTTCTCGCCTGGGCAATTCCCTCCTCCTCAAGTACACGGAGAAGCTGCAGGAGCCCCCGGCCAGTGCTGTCCGTGAGGCTGCCGACAAGGTGGGTTTCCTGGGCCCATTGGGCCACCACCCTTCATGTGGGCACTGCTGTGGCATGCCACTCAGTGCCCCTCCTGCCTCACAGGAAGAGCCTCCCTCAAAGAAGAAGCGAGTGGATGCGACGGCCGGCTGGTCAGGTGAGGGCCGGTCCAGGGCTGGTCAGGAGCGGGGCCAGGTGACCCAGGGCTGCGCTCAAGTGGGCTCTCTGTGTGCAGCTGCGGGTAAGTCGGTGCCGCAGGATGAGGTGGACGAGATTGAAGTGTACGGCAGCGAGGCCCAGTCGGGAACACAGCTGGCCACCTACTCCTTTGAGGTGAGATTGAGGCAGCAGGGCCCCCGTCCCAGCCAGCGCCCCCAGCGGGCCCCTGACTCTTGCTGTGCCGCAGGTGTGTGACAGCATCCTGAACATTGGACCCTGTGCCAATGCCGCCGTGGGCGAGCCTGCCTTCCTCTCTGAAGAGGTGCCCAGGGTTGGGGTCGGGGCTGGGGGCAGGGGCTGGAGTGTGAGGGGGGGTGGGGGGCATAGTCCTCACCCCCGAGTCCTGTGCAGTTTCAGAACAGCCCCGAGCCGGACCTGGAGATTGTGGTTTGCTCCGGCCACGGGAAGAACGGGGCTTTGTCGGTGCTGCAGGTGTGTGGGCAGGTAGGGGGCGGGCGCCTCCTGGTGGGACCTGGGTGGGCTCACACCCCCATCACACCCCCACCCCATCATCATTCTAGAAGAGCATCCGGCCCCAGGTGGTGACAACCTTTGAGCTTCCCGGCTGCTATGACATGTGGACAGTCATCGCCCCGGTGCGTAAGGAGGAGGTAGGTGCGAGCCTGCTGCAGGGAGGCCCTGGGATGGGACCGGCGCTGCCTTCTCATAGGCCGGGGGTGCCCAGGTCGCACCTGCGTGCCTGCCTTCACTGGACTGTGGCTTCCAGCCTGCCCCCCTTTGGCCCTGACAGGAGGACAATCCCAAGGGGGAGGGCACAGAGCAGGAACCCAGCACCACCCCTGAAGCAGACGACGACGGCCGCAGACACGGATTCCTGATTCTGAGCCGGGAAGACTCCACCATGGTGAGGGGCAGGGCCTGGGACCTGGGACCTGGGGCTGGGGTCCCCTGCGGGGGGCGCCTCCCTCACAGCTGTCGCCCGCAGATCCTGCAGACGGGGCAGGAGATCATGGAGCTGGACACCAGTGGCTTCGCCACTCAGGGCCCCACGGTCTTTGCTGGGAACATCGGGGACAACCGCTACATTGTCCAAGTGTCACCACTGGGCATCCGCCTGCTGGAAGGAGGTAGGTGGGGGGGGTGGTTGGGCCCTGGGCATCTGCCTGCTGGAAGGAGGTAGGTGGGTGGGGACGGTGGGGGGGAGGTGGTTGGGCCCTGGGCATCCGCCTGCTGGAAGGAGGTAGGTGGGTGGGGACGGTGGTGGGGAGGCGCATGCTGACTGCCCCATGCCTACAGTGAATCAGCTGCACTTCATCCCCGTGGACCTGGGCGCCCCCATCGTGCAGTGCGCCGTGGCCGACCCCTATGTGGTCATCATGAGTGCCGAGGGCCACGTCACCATGTTCCTGCTGAAGAGTGACTCCTACGGTGGCCGCCACCACCGCCTGGCGCTGCACAAGCCCCCGCTGCACCATGTAGGCCCCCTCATTCCCGGCGCCCTCCTGTCCCTGCCCCTTGCCCGCCGCTGAGCCCACCCCTCTCCCCGCAGCAGTCCAAGGTGATTACGCTGTGCCTGTACCGAGACCTCAGCGGCATGTTCACCACTGAGAGCCGCCTGGGTGGGGCCCGTGACGAGCTCGGGGGCCGCAGTGGCCCGGAGGCCGAGGGCCTGGGCTCAGAGACTAGGTGCGTGGGGGCTGGGGGCGCAGGTAGGGGCTTGGGTCCCTGGGGCTGGCAGGCCGCCCATGACCTTCTGCTGGCCCCCAGCCCCACAGTGGATGACGAGGAGGAGATGCTGTATGGGGATTCGGGCTCCCTCTTCAGCCCCAGCAAGGAGGAGGCCCGAAGAAGCAGCCAGCCCCCTGCTGACCGGGACCCTGCACCCTTCCGGGCAGAGCCTACCCACTGGTGCCTGCTGGTGCGGGAGAATGGCACCATGGAGGTAGGTGGTGCCCTGCACTGTGGCCCAGCGGGTTCCACCCACCTGCCTCCACTGACTGCTGCCCACCCTGCAGATCTACCAGCTTCCCGACTGGCGGCTGGTGTTCCTGGTGAAGAACTTCCCTGTGGGGCAGCGGGTCCTTGTGGACAGCTCCTTTGGACAGCCCACTACACAGGGCGAGGCCCGCAGGGAGGAGGCCACGCGCCAGGGGGAGCTGCCCCTCGTCAAGGAGGTGCTGCTGGTGGCGCTGGGCAGCCGCCAGAGCAGGCCCTACCTGCTGGTGAGTGCGCCTGGCCTGGCCTCCCCTTCCCATCTTCCCCCTGGCCCTGCCCGTTCCCCCACAGCCCCGCCCCTTCCCGTGGCTCCACCCCATCTCCCCCACGGCCCCGCCCCTTCCCGTGGCTCCACCCCATCTCCCTCACAGCCCCGCCCCTTCCCATACATGGCTCCACCCCATCTCAGCCCCGCCCCTTACCCACAGCCCACCTCTTCCCATGGCCCATCCCATGTTCTCCATGGCCCTGCCCGTTCCCCCATGGCTCCCCTCATCCTGCCAGGTGCATGTGGACCAAGAGCTGCTTATCTACGAGGCCTTCCCCCACGACTCTCAGCTCGGCCAGGGCAATCTCAAAGTCCGCTTTAAGAAGGTGCCAGTGGCTGGACTGCTGGGGCGTGGGGTGGGTGTGGTACAAGGTGTGGGTTTCAGACCGGCAGCCCCTGGAGGACCTGCATGGTTCCCCCCCAGGTCCCTCACAACATCAACTTCCGTGAGAAGAAGCCAAAGCCATCCAAGAAGAAAGCAGAAGGTGGCGGCGCAGAGGAGGGGGCTGGGGCCCGGGGCCGCGTGGCGCGTTTCCGCTACTTCGAGGATATTTATGGCTACTCAGGGGTAGGCCAGCGCCTTTGCAGGGGTCTGTGGTAGAAGGGAGACGCGGCCTCATCCGCAGCATCCTCATCCACAGCATCCTCACGGTGCCTGCCCCCAGGTCTTCATCTGCGGCCCCTCCCCTCACTGGCTCTTGGTGACCGGCCGAGGGGCTCTGCGGCTACACCCCATGGCCATCGACGGCCCGGTCGACTCTTTCGCTCCATTCCACAATGTCAACTGTCCCCGCGGCTTCCTGTACTTCAACAGACAGGTGGGGCCCGGCCGGTTCCCAGCAGCACTGGCTGATGCTGCCCCAGCTGGGGGCTGAGGGGGAGGGGACAGGAGAAGGGACCATTGGCTCCACCCTGAGGACCAGGAAGGAGTGTCCAGAGGGCGATGGGGTTGAGGTCGAGGAGGTGGAACCTGTGACTTGGTTGCTCCAAAGGTCTGGAAAGGGGTGGTTGGGAGCTGGGGCTGCAGCCCCTGGGGTCCCCACCACTGCTCTGCCGGCTCGCCGGGCAAGCCCTCGCAGGGCCTGGCCTCCACACTTCTCAGGAGAGCTGACGTGAGTGCTAGCTCTGCCCCTTGGCTGCTCTGTGACTTTGGGAGGGCACACAGGCTTTCTCATCCTGGTTCCCTATTTAAGCCACCACACCACCAGGTCACTTGAGACCCTGCCTGGGATGCGGTGAGTGCTTCCTGGGTGCCTGAGGACTCAGGACTGTCCATGAAAGAGGGCAGCCCTGGCTCCCTCTGCCTGGTTTTCAGTCCCCAGCATGGCAGTCTGTGGGCTGCCCTTTGCAGCCTCCAGTGCCCTCCTGGCCTAGCTTTCCCATCCCCTGTGGCCAGCACCCCTAGCCCCAGCTGAGCGTGGGAAAATGGACAGGAGGAGCCCCAGAGGCTGAGTGGCAGCCCCTTCCAGGACCTCGCCAGGACACAGCTGCCCCTCACCCACCCCTGCTCCCACAGAGCTGAGGGCAACATCCCAGGGCTCTTGGCGGCCTGGGCCTGCCTGCCCCTGCCCTTGGCTAGCCCTGGATCCCCTGACCCCTGTGCCCCCACCCCAGGGCGAGCTGAGGATCAGTGTCCTGCCTGCCTACCTGTCCTATGATGCCCCATGGCCTGTCAGGAAGATCCCGCTGCGCTGCACGGCCCACTATGTGGCTTACCACGTGGAGTCTAAGGTCTGCCCCCACCCCCACCCCACCAGGGACCTTCTGGGCCTGGCCGGGCCACTGGTGTGTGACCCTCACTAACCCACAGGTGTATGCTGTGGCCACCAGCACCAACACGCCGTGTGCCCGCATCCCACGCATGACTGGCGAGGAGAAGGAGTTTGAGACCATCGAGAGAGGTGGTGACGCCCACACCATACTCCCATCCTCAGCCGCATCTTGGGGAAGCCCTACTCTGACTGTCACCCTTGGTCCCCACAGATGAGCGGTACATCCACCCCCAGCAGGAGGCCTTCTCCATCCAGCTCATCTCCCCGGTCAGCTGGGAGGCTATTCCCAATGCCAGGTGAGGCTGGGCCGGCGGGGGTGGGGTCTGCCCAAGGCCTCCAGGCAGCATCCTGAGGCCCCTGGCCCCCACAGGATCGAGCTGCAGGAGTGGGAGCATGTGACCTGCATGAAGACAGTGTCTCTGCGCAGTGAGGAGACCGTGTCGGGCCTCAAAGGCTACGTGGCCGCCGGGACCTGCCTCATGCAGGGGGAGGAGGTCACGTGCCGAGGGCGGGTAAGGGGCCAGTGAGCGGGGGCGGGAACTGGCAGCCCCTCTGCCATCCCCACAGCCATCCCACAGCCATACCCATGCCCTCCAGATCTTGATCATGGATGTGATTGAGGTGGTGCCCGAGCCTGGCCAGCCCTTGACCAAGAACAAGTTCAAAGTCCTTTACGAGAAGGAGCAGAAGGGGCCCGTGACCGCCCTGTGCCACTGCAATGGCCACCTGGTGTCGGCCATCGGCCAGAAGGTGTGCCAGTCCCACCCGGCGTGTGTCCCCCGGCTCACCCTCACCCGGCTCCCCGTCCGCGCCCGCTCACCCTCGCCCTCGCCCCCAGATTTTCCTGTGGAGCCTGCGGGCCAGCGAGCTGACGGGCATGGCCTTCATCGACACGCAGCTCTACATACACCAGATGATCAGCGTCAAGAACTTCATCCTGGCAGCCGACGTCATGAAGAGCATTTCGCTGCTGCGCTACCAGGAGGAAAGCAAGACGCTGAGCCTGGTGTCGCGGGTACACCTGTGGCGGCGGTGCTCGTGTCTGGGTGGGTACCCGCCCAAGGCACCTCTGACGCCCCCTTCCCGCCCCCAGGATGCCAAGCCCCTGGAGGTGTACAGCGTGGACTTCATGGTGGACAATGCCCAGCTGGGTTTTCTGGGTATGTGGGCAGGGCCCTGGGGAGCTGAGGCTCTGGGGGTGGCCGGGGCTGACCCTGGGCCTCTGCTCCCCAGTGTCTGACCGCGACCGCAACCTCATGGTGTACATGTACCTGCCCGAAGGTGAGTGCTTCCTCCACCCCCTCTGCCTGGGCCGGGGCTGGGCTAGCAGTGACCCCTAGGCCTTTCTGGTCTAGCCAAGGAGAGTTTCGGGGGCATGCGCCTGCTGCGTCGGGCAGACTTCCACGTGGGTGCCCACGTGAACACGTTCTGGAGGACCCCGTGCCGGGGGGCCACTGAAGGGCTCAGCAAAAAGTCGGTCGTGTGGGAGAATAAGCACATCACGTGGTTTGGTGAGTGTGGGGGAGCAGGTGTGTCTGGGTGGGGGGCCCTAGGGTTGGCCTGGCTCACACCAAAACCCTCACCCTACCCCTGCCAGCCACCCTGGACGGCGGCATCGGGCTGCTGCTGCCCATGCAGGAGAAGACCTACCGGCGGCTGCTGATGCTGCAGAACGCGCTGACCACCATGCTGCCACACCACGCCGGCCTCAACCCCCGCGCCTTCCGGTGAGCCCCGGCCCCGCCCCCGTGCAGCACCCCCTCCACCCCAGCCTGCCCTGACACCTGTGCCTGTACGCCCCAGGATGCTGCACGTGGACCGCCGCACCCTCCAGAATGCCGTGCGCAACGTGCTGGATGGGGAGCTGCTCAACCGCTACCTGTACCTGAGCACCATGGAGCGCAGCGAGCTAGCCAAGAAGATCGGCACCACACCAGACATAGTGAGTGCGCGCCCCGCCCCCCGCGCGCCCCGCCCCTCCGTGTGCATCCCCACCCACCCACCCACCCACCCTTCCATCCCCTGCAGATCCTGGACGACTTGCTGGAGACGGACCGCGTCACCGCCCACTTCTAGCCCCGTGGATGCCGTCACCACCAGCACACGGAACTACCTCCCACCCCCTTTTTGTACAAAACACAAGGAAAAACATTTTTTGCTTGAGA

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