Details for gene: BMP2


This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]


Symbol
BMP2
Name
bone morphogenetic protein 2
Entrez ID
650
Ensembl ID
ENSG00000125845    (more details)
KEGG ID
hsa:650    (more details)
OMIM ID
617877
Uniprot ID
P12643  
GO ID
hsa:650    (more details)
Chromosome
20
Strand
1
Start
6767686
End
6780246
miRNA Interactions
hsa-miR-30c-5p (RPM: 3890.0396) / hsa-miR-1277-5p (RPM: 3.0234) / hsa-miR-20a-5p (RPM: 55.9816) / hsa-miR-30d-5p (RPM: 9562.1366) / hsa-miR-30a-5p (RPM: 15590.711) / hsa-miR-29a-3p (RPM: 1246.9046) / hsa-miR-30e-5p (RPM: 2305.0396) / hsa-miR-106b-5p (RPM: 35.4204) / hsa-miR-182-5p (RPM: 77446.6216) / hsa-miR-101-3p (RPM: 3335.0564) / hsa-miR-26b-5p (RPM: 2999.0356) / hsa-miR-106a-5p (RPM: 7.9736) / hsa-miR-19b-3p (RPM: 197.0578) / hsa-miR-19a-3p (RPM: 25.4064) / hsa-miR-125b-5p (RPM: 10044.3546) / hsa-miR-374a-5p (RPM: 52.6724) / hsa-let-7b-5p (RPM: 3396.2052) / hsa-let-7f-5p (RPM: 17066.6836) / hsa-miR-129-2-3p (RPM: 79.8688) / hsa-miR-125a-5p (RPM: 11539.4616) / hsa-miR-200c-3p (RPM: 348.3196) / hsa-miR-200b-3p (RPM: 566.8348) / hsa-let-7i-5p (RPM: 2025.2084) / hsa-miR-98-5p (RPM: 1660.0964) / hsa-miR-150-5p (RPM: 64.1654) / hsa-let-7e-5p (RPM: 3790.2074) / hsa-let-7g-5p (RPM: 3559.4376) / hsa-miR-519d-3p (RPM: 0.0042) / hsa-miR-128-3p (RPM: 329.321) / hsa-let-7a-5p (RPM: 32160.4734) / hsa-miR-7-5p (RPM: 19.3682) / hsa-miR-4664-5p (RPM: 0.02) / hsa-miR-194-5p (RPM: 48.9448) / hsa-miR-548ah-5p (RPM: 1.0636) / hsa-miR-576-5p (RPM: 10.7352) / hsa-miR-203a-3p (RPM: 1346.5646) / hsa-miR-145-5p (RPM: 548.8656) / hsa-miR-21-3p (RPM: 238.3548) / hsa-miR-342-5p (RPM: 28.1628) / hsa-miR-3924 (RPM: 0.0066) / hsa-miR-450a-1-3p (RPM: 0.0026) / hsa-miR-382-3p (RPM: 5.0104) / hsa-miR-505-3p (RPM: 14.5424) / hsa-miR-216b-5p (RPM: 11.7092) / hsa-miR-215-5p (RPM: 12.4448) / hsa-miR-34b-5p (RPM: 1.8778) / hsa-miR-4463 (RPM: 0.0074) / hsa-miR-93-5p (RPM: 357.1536) / hsa-miR-192-5p (RPM: 3146.8498) / hsa-miR-4799-5p (RPM: 0.0586) / hsa-miR-17-5p (RPM: 83.6404) / hsa-miR-20b-5p (RPM: 24.4036) / hsa-miR-151a-5p (RPM: 2651.1674) / hsa-miR-744-5p (RPM: 290.9362) / hsa-miR-335-5p (RPM: 265.7294) / hsa-miR-27a-5p (RPM: 7.3838) / hsa-miR-3609 (RPM: 6.639) / hsa-miR-106b-3p (RPM: 83.1096) / hsa-miR-4651 (RPM: 0.0744) / hsa-miR-941 (RPM: 399.631) / hsa-miR-10b-5p (RPM: 14052.6542) / hsa-miR-210-3p (RPM: 361.0562) / hsa-miR-190a-3p (RPM: 0.756) / hsa-miR-6733-5p (RPM: 0.449) / hsa-miR-6739-5p (RPM: 0.0102) / hsa-miR-6747-5p (RPM: 0.0046) / hsa-miR-6737-5p (RPM: 0.0038) / hsa-miR-6812-5p (RPM: 0.013) / hsa-miR-6766-5p (RPM: 0.0116) / hsa-miR-7155-5p (RPM: 0.0116) /
Involved Diseases
myopia /
Involved Pathways
TGF-beta signaling pathway / Pathways in cancer / Cytokine-cytokine receptor interaction / Hippo signaling pathway / Basal cell carcinoma / Generic Transcription Pathway / RNA Polymerase II Transcription / Gene expression (Transcription) / Transcriptional regulation by RUNX2 / Extracellular matrix organization / Signal Transduction / Elastic fibre formation / Signaling by BMP / Molecules associated with elastic fibres / Regulation of RUNX2 expression and activity / Signaling by TGFB family members /
Sequence
GCCGCCGCCGCCGTCGCCGCCGCCGGAGTCCTCGCCCCGCCGCGCTGCGCCCGGCTCGCGCTGCGCTAGTCGCTCCGCTTCCCACACCCCGCCGGGGACTGGCAGCCGCCGCCGCACATCTGCCGCCACAGCCTCCGCCGGCTACCCGAACGTTCTCGGGGCCAGCGCCGAGTGGATCACCGGGGACCGCGAGGCACCCGCGCGCCGCAGACCCCGCGCGGGCTGGAGCACCCGGCAGAGCGCGCCACAGCGCCGTGGCCTCTGCTGCCCGGGCTGCGCCAGAGCCGCGGACGGGCGCGCAGAGCGCCGGGGACTCCGGAGCCGATCCCTAGCGCCGCGATGCGGAGCACCTACTGCAGGAGATCGGGGGCCTGGGACGCGCTGGCCGAGGTGTGATCGGACCCCAGGCTAGCCACAAAGGGCACTTGGCCCCAGGGCTAGGAGAGCGAGGGGAGAGCACAGCCACCCGCCTCGGCGGCCCGGGACTCGGCTCGACTCGCCGGAGAATGCGCCCGAGGACGACGGGGCGCCAGAGCCGCGGTGCTTTCAACTGGCGAGCGCGAATGGGGGTGCACTGGAGTAAGGCAGAGTGATGCGGGGGGGCAACTCGCCTGGCACCGAGATCGCCGCCGTGCCCTTCCCTGGACCCGGCGTCGCCCAGGATGGCTGCCCCGAGCCATGGGCCGCGGCGGAGCTAGCGCGGAGCGCCCGACCCTCGACCCCCGAGTCCCGGAGCCGGCCCCGCGCGGGGCCACGCGTCCCTCGGGCGCTGGTTCCTAAGGAGGACGACAGCACCAGCTTCTCCTTTCTCCCTTCCCTTCCCTGCCCCGCACTCCTCCCCCTGCTCGCTGTTGTTGTGTGTCAGCACTTGGCTGGGGACTTCTTGAACTTGCAGGGAGAATAACTTGCGCACCCCACTTTGCGCCGGTGCCTTTGCCCCAGCGGAGCCTGCTTCGCCATCTCCGAGCCCCACCGCCCCTCCACTCCTCGGCCTTGCCCGACACTGAGACGCTGTTCCCAGCGTGAAAAGAGAGACTGCGCGGCCGGCACCCGGGAGAAGGAGGAGGCAAAGAAAAGGAACGGACATTCGGTCCTTGCGCCAGGTCCTTTGACCAGAGTTTTTCCATGTGGACGCTCTTTCAATGGACGTGTCCCCGCGTGCTTCTTAGACGGACTGCGGTCTCCTAAAGGTAGAGGACGCGGGCCAGGGCCCGGGGTGGGTGGTGGGTGGGAGGGGGATTTGGGCAGCCACTGCGGTAGAGCCCTTCCTTACGTCCAGGCCAGAAGTAAACAGACCCCTCTCCAGTCCACGTGCAACGGAGCCCTGCAGGGGCTCCCACTTCCAGCTGCCCCGGGCGACCGTAAGCCTCACCCTCCCGGCCCGCACTCTTCCACCCCTCTTTCTTCCCCTCTCCCTGGAATACTTTTGGAGCTGTTAACACTTAGATGAGGTGTTTTATTTATTTATTTATTTATTTTTAATTTTTTTAAAAACTTTTTTGGGTCAAAGAAATCCCTTTGAGAGGGTAGCCCCTGGGTTTCACCCGTTAGCTGAGAACCTGTCCGCTCTGCCATGGTGATCTCCATTCTTCAAGTGTTTCCGGGAGACTTGGTTTCTTTGCTCAGAGCCGTGTCCCATTTAGGAAAGTACTAGGAGTTTGGGGTTCTCCCTACTTGTTTCCAGAAATGCGAGGGGTCAGTACTGAAGGATCACTTGGTACTGTGTTTTTAACAGCTGACACGTGCATTAATAGATATTCACCATTTACGTAATCCCGGGAAGATACATGTGTATCTTGACTGCACTGTGGGGATGCGGGATGGAGCTGCCTTTCGAGACACCCCTGAGGGTAGGGGCCTGGGACACAAGTCATAAGTGGCTTCAGAAGTTGTGGCCTTGAGCTTACAGGGTCTGGAAGCTATAAGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCAGGAAGTTCTATACAGTGCCTCTAAGGAAGTCACATGCACCATTTATGTGTGTTTATATGCCAGACAGCGCTCAGCACTCCGCATTTGGGTTTGTATAGGGGACGCAGGGTGTCAGATCAAGCGGTGGTTTTCCCAGGTTCCCGGCATTGGCTGTCAGCGCTGTGTCACACACAAAAAAGTGACAGTCATTGGCGCTGGTTTGGTTGGGGGGGAGGGCAAATCCCAAATCTGATGTCAGACGAGCTAAGCGTTGGATGGGAGCGATAAATCATCTGGTTCAGGAACTTGGGACCCTTCATTATCCCAAACGTTTGAGCTTCGGTCGGTCTTACCTAGACTCGTGAGTGTGCCAAGCCAGGAGGGCATCCTGGAGGAGGCACGCCAGCCAAATGGGAGACCGGGCCGCGGGGGCGCGAGGGGGGAGGACTGGGCGGGGAACTCGGGTGACTCACGTCGGTCCTGTCCGCAGGTCGACCATGGTGGCCGGGACCCGCTGTCTTCTAGCGTTGCTGCTTCCCCAGGTCCTCCTGGGCGGCGCGGCTGGCCTCGTTCCGGAGCTGGGCCGCAGGAAGTTCGCGGCGGCGTCGTCGGGCCGCCCCTCATCCCAGCCCTCTGACGAGGTCCTGAGCGAGTTCGAGTTGCGGCTGCTCAGCATGTTCGGCCTGAAACAGAGACCCACCCCCAGCAGGGACGCCGTGGTGCCCCCCTACATGCTAGACCTGTATCGCAGGCACTCAGGTCAGCCGGGCTCACCCGCCCCAGACCACCGGTTGGAGAGGGCAGCCAGCCGAGCCAACACTGTGCGCAGCTTCCACCATGAAGGTGAGGCATGGAGCAGGGCGTGGGGGCGGGGAGTCACCCTGCAAAGCCCTCCACCGTGGGCAGACTGCAGCCGTCCCTGTAGAGGCAGCTTGGCCGGGGCACCAGCGGACGTTTCCACTCTTGCTTCTGTACTATCGTTTCTGAATCTGATTTTAACTCACTGCTTGTGTGGTGGGGGAGCCAGGGATTCCCCTTTAGTAACTCCGCACCCTCTTCCTGGCTTGCAGCCAGAAGAGCTACTCCTCCTGGAAGAATTGGAGAGAAATCAAGTGATGGGGAAGATGAGGGCAAAAGGCATGCCTCTAGTCAGCTAAACGTGCAAGAATTCCACAGAGGGAAAAGGAGAAAAAGGGAGGCAGATTGAGATTTCTTTAAGTCTGTTTGGAAGCTTTTGCTCTATAAATCTGCCGCTTAAGCCAGGGTTTTAGGGTAGACAGAGCCAAGGGCAGAGTTTTCAGAGATAGTATTGAAAAATCAAAGCCCAGGGCCCCAAAGTCTTTCTAATTTATAGTTGATCTGGGCCTGGTTTGGAAGATTTTGAATCCCAATCTAATCCCCGTGGGAGATCAATACTACAATCAATCTTATTGTTTCCACAATGACTTTCTTGTCCTGTGCTTAAATCTGAGATAGGCTCTGAGTAGAGACAAGGCAAGCCTTCAGATAAAAGCGTTTGTAGCAGCTGCCTGTTTTTTTTTCATGTGCACCGAAATGTGGATTTTTTTTTCTTTTATGATACTACATGTGGTTTTTCTAAGGTGGGATATTTCTGCTTGTTTCATCAGAAGGGCATTTAGTGGACTGGAAATGTCTTACAGCAGCTATTGAGGTCTGCTGTACCTAAGTTCTTAGAGCAATTAGTCAAAAATATGTTCCACTTCAATTCTTTTTCTACACTTTTAAATGCTTCTTTGGCTTAATACATTTAAAATAGAGCATGGGTTTCTTCAATTCCTAGAAAAGAGTACAAAAGTGTATATCACAGAGCAACCACTTGGCAGATATTTGGGGAGTTGGGAGTGAAGTTCTCTTTCTTGCCTTTCCCTGCTTAGGTGGTAAATTTCAAGTGGGAAATTTACACTGATAATAGACTAATGGGAAATGGCACTTCCAGATGTTTTCTCCCAGTGTGAAGGGTGACTTATACTTGTGAGAGTATTTGTTGGTAATGGGAATAAGTCCCAAAGGCAAGCCACATAGCAGAAGATACGTTCTCATTGAGGCAGCTACACATTACGACGGGGACACTGAATTGATCATCAGTTCATTTACAAGCACATTTCTAAGTGAGGTGCTCTCTGCTAGCAGAAATCAGATTTGAAAGGCAGTAAGATCTCACTCCACTCTTTCAGAATTCATCCAATGAAAGCAGAAATCACCTGTTGTCATATGTAAAATTTGTGTGTATGTGTACATTCTGCCATCTTAACCCTGAAATGATTATAGATCCAGCTAATCATTCCCAGGTAATGCTGATTAGAATACTTTTTTTTTTGTATAGGAATGTAATAAGAACAACTGTTTTAGACACCTCTTCTGGAAATTTAGCATGGAAGCTCTCAACTTTATTTTTAAGGCCTGGAAGATGCTGTGTCTCTGTTACAACTTAAAAGGAAGATCATTTAAGTTAGTTAACACCTAAAACATTCCATTGTGTGAGGATTTTATCAGTGATGTCTGCATATTCTCATCATTCATCTAGAAGTGGTTTGATCAGAACTAAACAGGCTACACGTTATTCAACTGTGTTATTTTAACTTAAAAAGCATGCTTGAGTTTATAAAATCAGAATTTATATCTTTGTGAGTGTAAATGTTACCTGAGAAACAGTACAGAAGTGACCAACTTGATTAAAATCAACTTGTAATAACTTCAGGTCTTAATGCAGTTAGATAATGGAGAAAAGCTATGTAATTTTGCCCCAAATTTCAACTAATCCATTTCTTGTCTCATTATGACTAATATATCATCCTTAATCTGGATGGATATAGCACTTTTTTCAAGACTAATCATTGTTGTATACACCCAGGATTTGCTTTTGATAAACATCCTTGTGCCATGCATGCCACGAAAAAAGTTTTTGGTAAACCATGTGATGAAGGTTGCTGGCTCAAGAACAGAATTTAGTTTCTACAGCATTAATGAGCATTTATTTGAAAAAAGACCATAAAGACCCAATCATAAGAATTACCTGTTGGGTTTTCTTTGTAGGTGTGATCGAATGGTTTGGTGGAATTACTCGACGAGATATCATGATAGCATTCTTTCAACCAATATGAGTATAATGCGACCATATCATAGGGGATCTGAGACAGAATTATCAGTTGTATTTTTCCTATTGAATTTTGTCTAGTCCTTTCTCCAGTGGCTTTTATTTGGGAGAATATCAGCTTTGCTAAAATGTTATTGTTTTCAAGATCATTAAAAAGTGCTTCAGCTACATAGACCTTTGGAAACTGCCATTGAACATAGAAAAGTCAGTTCTGCAAGTGGAAAGAGTGTTTTGTGTATTGCTGTAGTTGGAAACACATTGAAACTGGTTGACTTCACTGGCCCTCCAAAAAGTCTTTATGCTTTTTTGTCAGATGGGAGAGAGAAAGACCAGGTGCTTCTTGTTCTCCTCACTCTGAAGGACACAGTCTTCTTTCTACATGAAATAACTGGATTATTTGCCTCTGTGACTGAAGCTTTCAAATAGAGATTAACCCTCTTTCCACAAATATAATTATTATGAAAATATCCATATAATAGAAAAGTTCAAGAAATAACTATTGCCCTGCATTAGAGACTTTGTGGCACAAATTCCCCCGTGCAAACAACAGATTTGGACACATAGATCCACCAAAACCAATACTTACCTGGTATGGTTCCCTAGTGGCCCCAGGTATTTCATTGTCATTACAGAGGCCACATTAAGTAGGAAAATTACTCTATTTGGAAATGGTTGTTGAGATTGAGGCTTTGGTGTCCAGTGATACTTCCTTGGCACTGACATTTTCCGTTCCACCTGTTTTTTAGTGGTTCCCCTAAATTTCTCTTAATCCCTTTGCAGTGAACTATTTTGCGTTCTTAGACTTGCTCTTTGTGTATTTTCACTGAGACAATAAGAGAATATTTCATCATTCCGAAGGTGTTGGTGTTAAGGGTGGGCAGAGGCCAAATCAGGGTTGTTGATGACAACCATGCTCTCTATTCCTTTATTTGCCATTCCCTTGTTGTATTTTTTTTAAAATGGAATGTTTTTAACCTTTTGTATTTGATATTTTTTTTCTCCTTGATCAGTTGTCTGTTATTTTATTATCTGGAAAATCTTATATTATACTCAGCCTCTTTCATTTTGTGTTAGGGCAGTGACTTCCAGCCTTACTGATTGCCAGCATATCCCCAGGTTTTGTTGTTGTTGTTGTTGTTTTACTGGAGATTTTTTAGCCCAAAGTGTGTTTTAAAATCCTCGAAGCATAACGGTAACTTACTTTTTTGATAAAACTTACCATACTTTATTTAGAACAAAAGGGCAGCCACAAAATAGCAGTGGCTCCTTATAAAATAGACACATTCCAGTGGGCCCCGTCACTTTTCTGCTCATTTCTGTCTGTTCTGTCCATCATACCTAAGTCATATATTTCTGTTCATTTAGTTGGGACAGAACTCACCCAATGTTATCATTGTACTAAATATAAATGTGCCCCTAATGGTTTTGACTTTTGCTTAAGTTTTTGAGTCCTCATGTATGTTAGGTAGTGCCATCTAGTAGCCAGAAATTTGGGAACTGGCTGGGCATGATGGCTAATACCTGTAATCCCAGCACTTTGGGAGGCTTAGGTGGGTGGATCACTTGAGGTCAGGAGTTCCAGACCAGCCTGGCCAACATGGTGAAACCACATCTCTACTAAAATATAAAAAAATAGCCAGGTATGATGGCCCATGCCTGTAATCCGAGCTAATTGGGAGGCTGAGATGGGAGGACTGCTTGAACCTGGGAGGTGGAGGCTGCTGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACCCTGTGTCACAAAAACAAGAAACAAAACAAAACAAAAGACAAGAAACCTGAGAAGCGCAGTAGATTCAATTATATATATCTACTTTTAATTTGCTAGCTCTGTGACCTTAGGAAAGTTACATAACCTCTCTGAACTGCAACTGTTTCATTTACAAAATGGAGATAATGATAGTTTTTCTCTAATTGGTTTGTTGTGAGATAATTCATATAAAGCTGATGGTGCCAGATTACACTCAAAAAAAGCATTCAGCTGTCATTATCATTATGACTTCTTTTGTTAATGTTATAGCCTTTCCTTCTCTAGGGAAAAGGAGGCCAGAGTGGACCTAGGCTGACTGAGAGAATTCAGCTCAGTCTTTTGAATTATTTTGAGGTAGAGGAATGATTGATATAGTATAGATTATTAAATTAGGACTTCACTTTTGGAGAAAAGTTCAGATATCATTGTTGTCTTATTTTTCTTCACTTTCCCACATTTTTGCAGCCATAGCTCCATCCATTTGGTTAAGAACTTAGAAGCTCACAAACTCGGGTCAAAGACAGGTCGAAATCCTCAAATCCCTTAAGAACTTCAGCTTATTCAGGAAGGGATATTTACAGAAAACTAGCAATTGTATAAGTCTCCAAAAAAGCATACATTACTTGAGGATCCATATATTTTTGGCATCCTCAGGGTTGCTGTGATGATTTATAGAAGGTTTGTTTATTTAATTTACTTTATTTCAAATAGGTTTTAATTTTTGTACCCTTAAGAAAAGATTCGTACTCTTCCCTGGCAGATTAAAGAAAATGAGCGTATATTCCCTAACCTTGGCCAGTTACTTTCCTGGGTTTGAGGGTTTCTGTGAACGTCTAACTTACCTCTGTGACCTGTTTCTGCAACCAGGGGTGTTGCAATGGATGCTTTTGTCTTGAGGATGGGACCTTTCAAGAAACAGATTCACTGAGGTGCAGTGGGAAGGTCAGAGAAAGATCTTCGTATCGCCTATTATTATTTGCTCGTCTATTTTTTCTCCTTTCTTAAGGCCACTAACTGATTCTCCTTTGCTAAGGCTGCCTACTTCCACTGAGACCTTGAACCACATGAAATTGTTGTTGTCTGTGTTTCTGGTCAAATAGTGGCAATTTTGTATGATTCAATCTTGTCATTTAATTTTTTGGGAGGTTATTATTCTATTTCATACCTTTTTTATACCCATCTTCTTTACTTCATTTACCTGTCCCTCATACTTGACTTGTAGCTTGTCCCTTCACTGTCATCGTCTGGCCATGTGGGTGTGTACGTGTGTGCGAGAGAGAGAATGTGTGAGAATGTATGTTTCTTTATGCATTGGGATTTAGGGTTTTTCTTGCAATTGTGATTTCTCTGGGCACTTTTGTTAATATAGCTAGTCAGCGAGTGCTCTAGATAATTTTCCTTGCCTCCCCCTCTTTGAAAGAAAAGAGGGTGTTCTTAGATGTATTCTTATCAGATAAGCCAGTAGCTCAGGTGCTGGTCTGGCTTTGGTGTCATTGGGGTCTGAGGTTGCTGACTTTTACCTTCTCTGCTGAAAAATTACCTTCAGCAGAAACGTCTGAATTGCAAGGAGAAGGAGAAAAAAACAGGCCAAACACAGTCCTTGGTACTCCTTGGGAGCCACTGAGAAGAGTCCAGGTTCAAATGGTCAGAAGGTTATTTTAATGATTGTGTCTGGCCTAAAGTACCATTAGCTTCCAGTGGAGTTTAGAATGTGGATGGATCCTGAAAGGTATTCCCCAGAGGTTTGGATTAATAGGCACAAGGGAACCCTAAAGGACTCTATTGGCCTGATACTCCCCATATCCACGTAGAAGAGCTTTAGAAGAACCTTCTGTTCTGAGACCCTGGCTGGGCCCACCCAGAGCTGGCCCATTCAACTCTTACTCCTTTGCCACCACTAATGGTTCTTCTACTAGTTTTTATATTATTTAACAAAAAGGCACTTTAAAAATGCACTCCTGGCAATCTATACTGGAATATGAAAAACATGCTGCAAAACCTTGACACTCCAAGTGTGGTCTTACAGTTCCCAGAATCCCCTCCTTGAGGAGCTGCTAGAAATGCTGAATCTCAAGCATCTCCCCAGACCTACTGAATCAGAGCCTGCATCTGAAGCTTTACGGTGTACAAGCTGTTTTATGTGAAGGCTGAAGTTTGAAAAGCACTGCATTAAAGCGTTAGTTTGGTATAAACTGCCCTGACTGAACTTGGTGTGTCCACTTAGCTTGCATGATGACTGTTGCTTTGATGATGAAGGCTTACACGGGTAGATCCTTTGAGTGAGTGATCTGACATGATTCTCCTTTGCTAAGGCATCTAGATTCAGTGCACAACTTACAGCTGTTTGTCTTTAGGGGAAATACAACTGTAAAATTAATAAAAACATAGTCTCTTCTTATGATAACATGGAACGATGGCAAAATAGATTTTGTTAGCACTTGGGTAGGAATTCTGAATGAAGCAGGCAAATTCTGTTGGCAGTGAAATGATAGGATGTGGTAAAGTTAGAATAAAATAAACTTAAATGTCTCAAACTCTCATGGTATATACTACCAGTTTAATAATAATGTTGTACCTTTGATGATTTGCAGACTACAAGCATTCAAGGTGCTGTGTTATATATTACTTGCTTGGAGAATAATACTTCTTAAAAATTGAAATTCAGAAATTTTAAATCAGACAAAGCTTTTGTGCATGGCCCACTTAAATGGCTATTTTGAAATAATGATAGTGGATATAGAAGGATTATTCTGTAATAGGATGAGACTGTTCCTTTTGTCATGGAGATCATAATCATATTTTTGTAAATTTTTATTATTTTTTTGGTTTTGTGTCCATCCTGCACACTATTACTGGGTAGGTACATGGTTTTTTAACATGGTTTATCTTTCAAAACTATAAAGGCATTGCAAACAGAAGACAGGTCATTTATTTTTCTTCCAAAAGCATCTAAAATGAGATTTTGATATTTGAGGTCATAAAGAGGTGAGAGAACAGACAACAGTTGGGAAAGCTATTTCTCTTGAAATTGTTTGGCCTTAATTACTACAGTGTCCTAGTACCACCCATACGTTTCCAAAGAAGTAGATCCCTGTAAATGCCTTTGTCTCTGGACTTTTGAGTAAAATAGTAGGGTGTGCTTTGCAAAATGTCATCGTTGATGTTGAGTTTCAGAGTCTTTAATTAGGAAGCTGAAATCTGTATATCGAGATTTGTAAATCATCTAAATTGCAGAGTAATGTTTTAGAATACTGCTTAAGGGATTGGCATTAAAGCCTTTTTTAAAAAAGAAATGCAATAATTTCCTCAAATCCTCACTCATTAGACCTCTACTAACTATAGTGCTGACTTTTTTTTTTTTTTACCCTAAAGTCTGGAATTCCAAAGAAATGCTTCACCATTTCCCCCATTATTATAGCCACCTGGAAGCAGTATTCATGTATTAGATCAAAAACACAACAAAGAATTATGAAAGGTTGTTTCCTGGTATGCAATGCATGATGACATGAACTTACAGAACAGAGAGAAGGGAGGCTCCATGTTTATTTAAAGAGGAAATTTTTATTTTCTGGTTACCTACTTTTACATGGGTTACATCAAATCCCACGATGAGGTTTAAAAATTCTCATAGATAATCAAACGTCATTACTTGGCTTACTGAAATTCAGACTTTTCTTTTTTCTTCCCTGTTTTTCTCTATCAAATTAGAATCTTTGGAAGAACTACCAGAAACGAGTGGGAAAACAACCCGGAGATTCTTCTTTAATTTAAGTTCTATCCCCACGGAGGAGTTTATCACCTCAGCAGAGCTTCAGGTTTTCCGAGAACAGATGCAAGATGCTTTAGGAAACAATAGCAGTTTCCATCACCGAATTAATATTTATGAAATCATAAAACCTGCAACAGCCAACTCGAAATTCCCCGTGACCAGACTTTTGGACACCAGGTTGGTGAATCAGAATGCAAGCAGGTGGGAAAGTTTTGATGTCACCCCCGCTGTGATGCGGTGGACTGCACAGGGACACGCCAACCATGGATTCGTGGTGGAAGTGGCCCACTTGGAGGAGAAACAAGGTGTCTCCAAGAGACATGTTAGGATAAGCAGGTCTTTGCACCAAGATGAACACAGCTGGTCACAGATAAGGCCATTGCTAGTAACTTTTGGCCATGATGGAAAAGGGCATCCTCTCCACAAAAGAGAAAAACGTCAAGCCAAACACAAACAGCGGAAACGCCTTAAGTCCAGCTGTAAGAGACACCCTTTGTACGTGGACTTCAGTGACGTGGGGTGGAATGACTGGATTGTGGCTCCCCCGGGGTATCACGCCTTTTACTGCCACGGAGAATGCCCTTTTCCTCTGGCTGATCATCTGAACTCCACTAATCATGCCATTGTTCAGACGTTGGTCAACTCTGTTAACTCTAAGATTCCTAAGGCATGCTGTGTCCCGACAGAACTCAGTGCTATCTCGATGCTGTACCTTGACGAGAATGAAAAGGTTGTATTAAAGAACTATCAGGACATGGTTGTGGAGGGTTGTGGGTGTCGCTAGTACAGCAAAATTAAATACATAAATATATATATATATATATATTTTAGAAAAAAGAAAAAAACAAACAAACAAAAAAACCCCACCCCAGTTGACACTTTAATATTTCCCAATGAAGACTTTATTTATGGAATGGAATGGAAAAAAAAACAGCTATTTTGAAAATATATTTATATCTACGAAAAGAAGTTGGGAAAACAAATATTTTAATCAGAGAATTATTCCTTAAAGATTTAAAATGTATTTAGTTGTACATTTTATATGGGTTCAACCCCAGCACATGAAGTATAATGGTCAGATTTATTTTGTATTTATTTACTATTATAACCACTTTTTAGGAAAAAAATAGCTAATTTGTATTTATATGTAATCAAAAGAAGTATCGGGTTTGTACATAATTTTCCAAAAATTGTAGTTGTTTTCAGTTGTGTGTATTTAAGATGAAAAGTCTACATGGAAGGTTACTCTGGCAAAGTGCTTAGCACGTTTGCTTTTTTGCAGTGCTACTGTTGAGTTCACAAGTTCAAGTCCAGAAAAAAAAAGTGGATAATCCACTCTGCTGACTTTCAAGATTATTATATTATTCAATTCTCAGGAATGTTGCAGAGTGATTGTCCAATCCATGAGAATTTACATCCTTATTAGGTGGAATATTTGGATAAGAACCAGACATTGCTGATCTATTATAGAAACTCTCCTCCTGCCCCTTAATTTACAGAAAGAATAAAGCAGGATCCATAGAAATAATTAGGAAAACGATGAACCTGCAGGAAAGTGAATGATGGTTTGTTGTTCTTCTTTCCTAAATTAGTGATCCCTTCAAAGGGGCTGATCTGGCCAAAGTATTCAATAAAACGTAAGATTTCTTCATTATTGATATTGTGGTCATATATATTTAAAATTGATATCTCGTGGCCCTCATCAAGGGTTGGAAATTTATTTGTGTTTTACCTTTACCTCATCTGAGAGCTCTTTATTCTCCAAAGAACCCAGTTTTCTAACTTTTTGCCCAACACGCAGCAAAATTATGCACATCGTGTTTTCTGCCCACCCTCTGTTCTCTGACCTATCAGCTTGCTTTTCTTTCCAAGGTTGTGTGTTTGAACACATTTCTCCAAATGTTAAACCTATTTCAGATAATAAATATCAAATCTCTGGCA

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