Details for gene: RASGRF1


The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]


Symbol
RASGRF1
Name
Ras protein specific guanine nucleotide releasing factor 1
Entrez ID
5923
Ensembl ID
ENSG00000058335    (more details)
KEGG ID
hsa:5923    (more details)
OMIM ID
606600
Uniprot ID
Q13972  
GO ID
hsa:5923    (more details)
Chromosome
15
Strand
-1
Start
78959906
End
79090780
miRNA Interactions
hsa-miR-27b-3p (RPM: 22876.2392) / hsa-miR-101-3p (RPM: 3335.0564) / hsa-miR-26b-5p (RPM: 2999.0356) / hsa-miR-27a-3p (RPM: 980.3062) / hsa-miR-671-3p (RPM: 91.9442) / hsa-miR-7-5p (RPM: 19.3682) / hsa-miR-3157-5p (RPM: 0.3264) / hsa-miR-139-5p (RPM: 36.887) / hsa-miR-1-3p (RPM: 26.3428) / hsa-miR-483-3p (RPM: 2.3898) / hsa-miR-550a-3-5p (RPM: 3.3892) / hsa-miR-191-5p (RPM: 12993.8088) /
Involved Diseases
myopia /
Involved Pathways
MAPK signaling pathway / Ras signaling pathway / Focal adhesion / Cytokine Signaling in Immune system / Immune System / Signal Transduction / Transmission across Chemical Synapses / Neuronal System / Neurotransmitter receptors and postsynaptic signal transmission / Activation of NMDA receptors and postsynaptic events / Post NMDA receptor activation events / CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling / Ras activation upon Ca2+ influx through NMDA receptor / RAF/MAP kinase cascade / MAPK family signaling cascades / MAPK1/MAPK3 signaling / FLT3 Signaling /
Sequence
AGTCCCTCAGTTTGCCCGGCACCGGAGGAGGGTCGGGCGGCATCTTCCGGGTACTGGGGCTCTGCGGAGCGGAGAAGAGGTTCCAGCGGGGAATGGTATATCTGGATTCAAGAAGCCGCGGCTCGGCGCCAGATCCTGGAGTGTAGATATTTGGGGGGAGGGGAGAGCTAGAGGGAGCGAGCGAGCGAGCGCCAGAGAGAGGCAGCGCGCAGCGCGCACGGACGGGGGGCTGCTGCGCGGAGAAGATGTAAGCGCGTGGGGTCTCGCTGGCCTCTGAGCACCATGCAGAAGGGGATCCGGCTGAATGATGGCCACGTCGCGTCCCTGGGACTGCTGGCGCGCAAGGACGGCACGCGCAAAGGCTACCTGAGCAAGCGGAGTTCGGACAACACAAAATGGCAAACCAAGTGGTTCGCGCTGCTGCAGAACCTGCTCTTCTACTTCGAGAGCGACTCGAGCTCGCGGCCCTCGGGGCTTTACCTGCTGGAGGGCTGCGTCTGCGACCGCGCGCCCTCCCCCAAGCCGGCGCTGTCGGCCAAGGAGCCGCTGGAGAAACAGGTGAGGCGAGCGTCGCGTCCTGACCTCCCTGCGTCCCGGCCGCGGCCCTGGGGGCTCAGGGCCTTCGGCTGGCTGATGGCGCTTGAACTTTGGCCCCTCTACTCTTGGCGCCCTAGGCGCTCTCTGCACCCTCAGCGAGAGGGGAGGCTTGCTCCCAGCCAGGCGAGTGACTGCGGCGGGCAGAGGGGGCAGGGATTGAGGGCGGGGAGTAGATGTGGGCTGCGGCTGCCCTTCGCCGGACGAGCCCCGTGGGAGGCGGGTACAGAGGGGCCGACACCTGGAGATGCAGAGGAAGATGGGGTCCTAAGGACCAGAGACGATGAGTCTGGACACACGTCCAGCCAAAAATGGTGCTCCCAACCCCCACTCCCACCGCCCAGCCCTAATAGCCCCGATCGTCTGTTCTACACCGGGAACGTGTAATTCCCCGCGCTTAGGCATGGGAAGGGCAAGACGGAGGCGTCCGAGCGCTGCCAGCCCTTGCCTCGCCGCAGCTGAGGGCGGAGAGCGGTCTGCGCTAGCTCCTCGGAGTTGGGCTGGGGTTATGGGGCTACACGGGTCGGTTCGGTACCATCGAGCGGTGGTGGGCTCCCAGCTGGCGGCCGCCGGAGCAACAAGCCCAAAGATTCCCAAGGACCGCTCTGATGCGCCGGGGCTAGGGCCAGGGCTGCTGCGGAGGCAGCGGGACGAAGTGGGCGCTTCTCTCCTCCCCCGCCCCCTGCGCCGCCGCCGCCGCCGCAGTCGCGGCTATAGCGCTGCGCTCTGGTTTCCTGAGCTGCAAGGCTGAAGAGCCAGGCCTGGCTCTAACAGGGAGCCCGGGCGGGGTGGGGGTGAGCCTCTGGCGTGAAGGGAGGAGGGGCACCTGCAGAGAGAGCCACCTTTAAGCTTGGTGCGCTTTCCAAAAGCATCTGGTCCAGTCCCTTGCCACTAGGAAGATAAAGCAGATGATAGTGGATCCTAAAATGCCACTGCAGGCAGGAACCTTCCATCCATAGGGCCTAACGGCTGGTGATTGCCTAGATGGGGACACTGAGGCCCAGAGAGAGAAATTCACTTGCCCAGCGTCATGCAAGTTGTTGAGGCCGTCCCAATGTTCTGAAAAGACAACCGAGATCTCAAAAGCCACTGCTGCATGAAGACACAGACTGGTGGTGATTGAATTGGTTGAAATAAAAGCATCGCTTGAAGTCTTCCTCCCAATTGTCAGGACAGAGATCCGAGCTCAGTCTCTCTAGCACATCTCTTCCTTCCCTACCTTCAGCCAATGGGTGTTAGGAGATAGTTTCTGAGGACTGGGAAGTGTGGACAGGAATTTTTGAGGGTGGGTCCCTGGGGATGACAAGCCATGTGGTGAGCAGGGGCTCCCAGATGGAAAGAAGAGCAAAGAGCAGGCAGCTCCTTAAGCTTCAGCTCAAATGGAGCCTGGGGAACTCATGTGGAAGAGCCAGTCCCAGGCCAGACTAGAGAATTTGCTCTCAGCCCTTCAGAACTTGCCCCTCTCCAGCCAGTGTCTACCCATATACCCATACCTACCCGGGGCCTGCAGCCCAAGCCCCAGCCCCAGCCAGATCCCCCCTCCATCCCTCAACCCACTACACTAGATCACAGAGCTGAGCTCCTGGGTAGGCAGGAAGTGAGGGGTGGGGGAAGCCAAGTTGGCATGGGCTCATATTATCTGTTCTCAGCCCCCTGGACGTGAAGGCAGACAGGCCTGAGACTGAATCTCAGCTGTATGACTTCCTGGCTGTGTGACTTCAGTTAACTTGCTGAACTTCTCTGAGTTTCCATTTTGTAATCTACAAAATGAAGATAATAACACCTACCTTTCTGGGGTTTTGAGAGCCCTACATTAAATAATGTATATGAAAGTAAGCGCCCAATACATTTTAGTTAGATCTAGACGAATCACAGTTGAATCTGAATTATACCCACCTGGACAGAGCTATTTAGGTCACCAGATGTTAAAGTCGAACAGAACCTCAGAGATACAGCCTTCCCATTTTACAGACCAAGAAACTGAGAGGCAAAGAAAGGGAGTTACCCAACAACGGGGTAAATCAGTGGCAGAATCAGACCTAGAATTCATCCAATGCCTAAGAATTCCTGAAAATGAGACCCTACATTGATTTCAAATCATCCAACTCTTGGCCCAGGTATTGAATCATCCTAGCAGTAGATCATGGGAGGAACATCAGTGCAAAACTAATTGATGAGATGCACTCATGTTCAGAGCTGTTTCCCCAGAACACTACTAGTCAGAGATCCTCAGGTTTGTTCACGAGAGCAGCCCTCCTGGCACAAGAGAACAGAACCGGGTTAAAAGTAGCAGATGATGGTCTGGCGCAAATTTCTGTTAAAGACTCATACTTAAATCACATATGTTTATATAGGTTCCATTTGCCTCTAGACCAACTTTGACTCCTGTGGAAAACTAGATCCTGCTCCTTCCGGCTACACATGTGTACAAAAATTCATCGCTGTTTCTTTTCTCAATCTTTGAGTAAAATCGATGGTGCCAGCAGCTGCTCCATGTTTCTCTTTGACTTGGGTGCCCCATGGCATAAGCCACAGAGCCTAGCATGATAGGTCTAACTCCAGGCCATTCTGTGACCAGGCTTGAGCCTACGAGAAGCTTTGGCTCAATCTGCTGGGCATGTACAGAGTGCCTGAGTTGAGAGGCGTCTACGAAGCCATCTGTTTAACTAGACTAGCTGGTGTCTGATGAAGAATTGGTTTCAGCAGGAAGCCATTTTACCAATGTCCAAGCAGACAGCTTCCTCCCTGAAGGGCCAGGGATGGTTTTTGAAGGAATAGAAACCAACTCTTGGCTGGGAACCCCTAAGTGGCTGGGGCAGAATCAGGGACCGTGCACATAGTAGATGCACAGGAAATGCACACTAAGCTGGACTTGTTAGCCTATCATATGTTAATTCCATATTTTATGTCCTCAACCTAGAAGCTGACTGTCACAGGCTGTGAGCCCCTGAGGAAGACAGACATAGATAAGGGTGAGCTCCTCACCCCGTGAAGATGCTCTAATAGCGGGATATGCAAGGCGCTCTGGCACCAAACACCAAGCCCATCCTAACATTGTGCAGTCTCATCTGGCTGTATCCAGACCAGTCTGACTGCCTCTGCTGCAGCCTCAGTGTCCAGGGAGCTCTAGCCTAGGATCCTAAGGCCTCATGAAGTCAGACTGGCACAGCCATGCCCCCTATTCCATCTGGCAGCTGCAAGCCACCTCCCTGGCCTGGGCCCTTTGCTCAGTCCTGACCTCTTCTGCTCCCAGCCCTGTAGCCCACACACTGAAAGCCCAAGTGCTGTTGACTTAGAGCTTGGGTTCATCTTCCCTAGAGGCTGGCCCTTGGTGTTCCATACCCTTCTTTGGCATGGAGTCCCCCAACCCCGACTTTTCCCACTCTCATTCCAAGCTCCCTGAAATAAAATGTCCAGCCCCAGCTTCTCAGTAGGGTACCCAGCCAAACCAACTCCAGCACTCCTTTCACTCTTCCCAACCAGGAAGGGTCAAAATGTGGGCACCAGGCTCTTCCTGATTCTCTTAGGACAGAAGAGACTCAGACAAATCCTGGCAGCCAGAACCTCAGAACCTGATGTTGTTGGAGGTCCCAGAAGCTGGGGGGGGGGGGTCTTAGAACCTGTTGTCTACCCACTTAGTTCCCTTCTCTAGAGACAAGACAAAGCCCCACTCCTGAGTCCTCATGCACAGGACACATTACTGGTTGGCCTGGCAGATTCAGATCAACAACAGCCCCGAGGTTAATGAGTACACTCATTTTACAGATGAGGAAACAATTTCATCTGTGGCTGCCCAGCAAGGCAATGGCAGAAATGAGATGCGTTCTCTGGCTTTCTCACTCTGTAGCTATTCTGTTGTCACCACAAAGCACACCCTCCTTGGAGTTATAACACATTCAACCTCTCAGCCAATCAGAAAAATGAAAAGCTGAATGTAGAAAAATAAGGTTGCTCTAAAAGCAGCAGCCCTTAGACACAGAACCCTGGGACGCTGGTATACATATGGTGCCAACAACGCAGAATGTAAGATGCTTGCACCTATAGGAAACCAGCAAGACTACCCAACCCGTTCCAGACCATGCCCAATCCTAGCAGGTGTGGGGCCCCAGGATCAACTGTGTGGGCTACTCATCACCCACCCCATCCCCCAAATGTTCCTAGAGTTGGAATGAAGTTGAAGAGGCACAGTAATTATGCCTGGAGTGGGACAAGGGAATATCGGCTCCTTGCGCCTATGCTTGGTGACAGTGTGGTGAGGATCAGAAACAAATCGTACATCCACAAGCCTGAACTAAAATTCCACATTGTTTATTCACGCAGCAAACATTTTGGCCCTTGGTGTCAGGCCTGTGGTAGGTCCTTCAGACACAGAGAAGAAGAAAACTTAATCTTTGTCTTCAAAACACTCACAGTTGAGTAGGGAGCTCGCCTCTCTCCTCAAAACTCACTCCCACAGTAATCACCAAGTGATGGCAATTCTTCCCTCCTGAAGAGCCTGGGACTCTTTCTCCCTGCCTTGCCTTGTTCAGGAGCTCATGGAACCCTGCCTGAGACTTATTGTAGCTATTCTGTTGTCACCATAAAGCACATACTCCTTGGAGTTATAGCACATTCAACCTCTCAGCCAATCAGAAAAATGAAAAGCTGAATGTAGAAAAATAAGGTTGCTCTAAAAGCAGCAGCCCTTAGACACAGAACCCTGGGATGTTGTGAAAGCATCAGTGGCTCCCATTGCCTTTAGAAAGATATTCAAACTCCCAACCATGACCTGGAGTACCCAGTAAGATCCACCCTTTGCTGGCCCCTCTAACCCAGAGCCACCCATCCCACTCTCCTCCTTCCTCATCCTGCTTAGGCCACCACTTTTCAGAGCTGCATGTGCCTCCCCTTTCCTATCTCAAGGCTGTGGCAGAAGCCATTCCCTCCACCTGAAATGATCTCCCACCAACCATGCCCTTAGAATGAACAGCTCCTTCTTCTCCTGCAGGTCTTAGCCTAAACGTCACCTCTGTCATCACGTGCATTTACAGCACTGGACTCTTCATTCATACAGCTGATCACAGTCTGTGATTACCTCATGTATTTGGCCAGTTGCAAACCATCCTTCTCCCCACTGGAATGTAAGCACCAGGAGAGCAGGAGGCAGGCAGAGGCAGGAGACTAATCAGGGGCTGCTGGAACCCAGAGTCCAGGTGAGAGAGGTGGAAGCCCTGAGAGGATGAAGGAACGGGGTCTTTACGATTAAAAAAAACTTCACCAAGAGACACTCACGTGGAAAATTGGCAAGACCTGCCATCCCATTGGTTGTAACAGAAAAGAAGACAGGATCAAACCTGAAGTCCATGGTTCTGCCTGAGGCCACCAGGCAGATGCATGTCACCAGTAGAGAGGGGAGAGCTGAAGACAAGCAGGTTTATGGGCAGTGGAAGAGGATGAGTGGCAGTGATCTCATCACATTTAATCTCAGGGAGGTCACATTTGAGAAGCCCAAGGGCAGAAAAGGGCTTTAATGCCCCCACCCTCTAGTATGGTAAGGACACTTATTACAGAAACCAGCGGAGCCCCACGAGGAGGACAGTGGGTGGTGTGTGCTGAGAGGGGTGGACCGAACAAAACGGCATGTGCAGAAGCTCAGCAGGTGGCGGCCCTGTTGTCCAGAGCCCAGGGAATGAAGTGATGTGGCTGCCAGGTGCACCGCAGGGGACGTGCAGGCTGGCTGAGAATAGTGCCAGCTGGGCAGAGCCTCATGAGGTCACTTTGGGGTCTGCCTGCACTCAACGCTTTCACAGCCTGGCCTGGCTGGTCAGCCTTTGCTTGCACTTCTTCAAGAGCAACGAGCCAGCACTGGGAAGTTGAATTTGGCGGCTCGTCTACACTAGGATTTCAGTTTTCAAGACTGCCAGGCAGGTGCCATCACTCCTCCTTCATAGTATTTGCCAAACCTGCACAGGAGAAGTAGGATTTGAACCTTCTCTCCCACTGGGTCACTATAGACAAATCCTTAACTTCCCTTCATCGATGATTTTCTGCCTCATTCTGAGGAGCCCTGGGGGCCACACTCCCACATCAATCAGAGCAGTCCCATTTTTAACTGTTTTATATGTTAGGTTTCCACATGAGATTTTATCTTTCCTAGTGCTTTAAAAAGCTTGACCTTCACCATGAGTTATTACTAAATGCCCTTCAACTCTGCCATGCTATGAATGCAGATTTAAATGTATATAATTTTGTAGCAGGATGTTTCAAAACGCCAGATCAAAAATGTTGAATGACAATAAATACCATTTATTGAGCACCTGCTGTGTGCCAGGCACCAGAGTACATGTTTTACCTACAGCTCTTCCCTTAATTATTCCAACAGCCCTGTGAGGTTATCACTAATTGCCCATTTTCTAGATGACAAAACTGAGGCTCAGAGATGTTAAGTTGTTCAAAGTTACAGAGCAAGTACATGCAGAAGCTGGGCCATGAACCCAGGAGGTCTTCCTGATTCTAAAACCTGAGCTCTTCATCCACAAACACATCATAAAGACTGGCTGGGGACTGTTATTCCTTGCTGTCTATTGCCAAAATACATGGAGAAAGAAAGAGAATTAATAGCAGGTGAAAATATGTCACAGTCGCGCCAGTGATTTTTGTGAAGGCGGCTTTTGTTTCTGCTTGGGTGGGAACCTCGCAACTCTGAATCCCCTGAGCATTGATGGGAAGCGCACCAAGGCAGGCATCCACACCCCACAATCCGGTTTCCCTGGAATCTGTGGGAGCATGGAGCCGGTGCCCGTGTGCGTGCAGCCAAGAACAGAACTCAGCCCCCTGATGTTTATGCAGGAGCACTAGTGACGCGTGGACTTGAGAGAGGTCCAGAACACTGCCAACGCCCAAACACTTCCGTGAGGGCGACTGTCGTGCAGGGAGCAGCTGGGAGGTGTGGACACCCCCACTCTCTGTCCCCGACTCAGAGAGGAGAGTACAGCCCCTCACATGCAGCCTTCATTTCCAGCCTCCAGCCTCCTTCACTGAGGAGTTATTTTGTCCCTGATAGTGAGGCAGCATTGAGAATTCGCAGCCATGGCGACCCGGCATTAGATCCTGGCTCTAAGTCTCGGCTCTGCCACCTCCTAGCTTGGGAAGGCTTTTAAGTTCTCTGAGTCTCAGTTTCCCCATCTCTGTGTTAAACTACACGCTGTTTGGAAAGCCCTAGCACAGCGCAATAGGTGTTATCAGTAAATTGCAGCAGCTGGGGCTTTGGCTTCCACCTTTATGACAAGACTGTTCCTCACTATAGCAGTGACCCAGGTCCCTGGGGTCTCTCGCAGGCTGGAAGCAAGCCAACACTGAGCCCTGACCCTGCATATGAAAATAGGATGGAAATCTTAGCTCAAAGAACCTGTGAGTTCCTGAAAAGGTCCAAGCAAGCAAGCCCTTACCAAAGGACAGATGATTGCTGCAGGAGCTTTCTTCATCCCTGTGGACAAATCATCACGAAGCCCTGTTAGTTTTTCCTCCTGGGTATATCTCTCAGAGCTGTGCCCTCTGTCCCTCTCTTCCTCCACCACTGTGGTCCAGGTTGGCATCACCTCTCACCTGGACTCATCTTACGCAGTGGCCTCCTAACTGGTGTGTCGGTCAGGGTAGGTTGGGTTGTGCTGCAATAACAACCAACCCCCAGATCTCCATCAGCACAACTAAGACTCATCTCTTGCTTGTGCTTTATGTCCCATGCAGCTGGCAGGAGGCCACTGCTCATGATGATCACTCAGGGACCTGGGCTGGTAGAGGCTTGGTCCTGACACCAGCCTCCATGGTCCCCTCCACTGAGGGGAAGGAGTGTGACAGATGTCTCATTGGCTTTTCCCAGAAGGGACCCACTCTGAGCACAGTTCACTAGACAGGGTGAGCCACCTGGCTTTATTTCAGAAGAGGTGCAGAAGTACAGACTTACTGTGTGCCTGGACACAGAGCGCCAGAAAGGCTGAGAGGAGAATATGGTGCTAATGGTAGCCACTGTCCCCACACATGCACTGTGCCCCCACCCCCAGTCCACTGGCCTCTCTGCAGCCAGAAAAATCTTTCTAAAATGCAAATCTGATCATCGGGCACACACACAGTAGCTGAAGAGAGGTTTTATGGTGGTTTCATGAGGACACGGATAGTATGTGGTGTGAGTGTAAGCTCAGAGCTTACAGGGGCAGGATCCTTGCCTGGCCTCCCCTCCTTTCATTAAGCTCGGTGACTCTGTCATTCTTGACCAAATGTCACAGAAGCATTTTGGCCACTAGGCTTCCCTGGAATTAACAAGGGAGAGGATTTTAAAGGCTAAAGTGTCCTCCTGAGATGTTAACACTCCATTGACAGCCTTCACTCAACAGAGATTTACCAGTACCTCTGAGGGGCCAGGCCTATGCCTCCCTGGCACTGGGAGGATGGGACAAACAGCAGGGGCCCTCCCTGGAGGGGCTTGCCATACAGCGAGGGGACAGCCTGTGAACAGACAGTGACAATGCAGTGTGATCCCTGCTGGCACACAGGAGAGCCAAAGAGGGGTGAGAACTATGGGAGTCCAGTAAGGGCACTTCCCCCAGCCCTGGGGTGTGGGGGGTGATTAGGGGCATATAGGTTGCAGGGGACACCAAAGCTGCCCTAAAAGCCTGTGTGCTATGTCACAAAGCTCAGGCCTTCCCAGGCCCAGTGCAGAGCCAGTGCAGGGCTCTGAGTGGGAAAGGGGCTGCTCCGATCTGTGTGTTAGGAAGATCACCAGAGTGTGAATGAACAGGAGAAAACCCATCTGGAGGCAGGAAGCCAATTAAGAGGAGGCTGCAGAACTGAGCAGTAGCAAAGGCCTGAATTTGGGGAGTACCATGAGCACTAAAGGTCTCCCCTCCACTCCCATCCCAGCCGTGACTCAGCCACTGAAGCCTGTGCTTTAGTGGTGGGCCATTAATAACACCCAGAGCTCAAGATTCTGAGACTCTGCAGCCCCATGCCCTCTGCCCCATGCCCTCTGGGGCTTCCCACATCCTGGGTTTGGGGCGGCAGTGGGAATGTCAAATTCTCATCCCGTGAAAGCTTCAAGTGTTGTCTCCACACCTTCCAAGTCAGCCACCCACTCAGATAAAGCACCTTTTCAGATTACAAAGTCTTTTTCACGATTAGCATTTCATTTAACCACCACAGTGACCCTGCAGTTACTGTGGTTCTACATAAGAGAGGCACGATCCTCATTTGACAGACGAGGCTTGCATAGACAGAGTTCATTCTCTCCACAAATACCAATTGAGTGTCTATTTTGTGCCAGGCCCTGAGCTCTCGCTGCTAAATGTCAGAATCAGAATCTGCACCAGGCCTCCAGGTTCTAGGTCTAGTGGACATTGAGGCTGGTTGTTAAATGAGGTCATTTATACTCTAAAGACTAGATTTTACTAATCCATCAGGGCTAATGCAATTTCTTTCCCCTGAAACATGAGATAATTATTTTCCAAAAGATACTTCCTAGTTGAGCTTTCTTTTTTTTTTCAAACTGGAAAATCCAACTCAGATCTTAAAATAAAGTCCTTTCAAAATCAGTTTTAGAAGAATGAATGAATTTTTGGTAACCTTAGCTGGTATTCCAAAACTCCATGTAGAAATTTAGAGAAACGTGATCAAGATGAACTTTTCCTGTGAGACTATATGAGTGAAATATAATCAACTTTGTTTAGATACCTCTTGGGCTCTTAGCCAAACTCAAGAAATTAGTGAAATCATTTGGAAGAACCTGTTCACATGTAGTGTTCTCAGCCTGCCCAGTTTCCCTGTGCCCTAAGCCTGCTGCTGCCCTCCCACCCCCTTTCCTCCCTCAATGGGCCTTCCTGCCCCCTCACTGCACTAGTGGCCACCCCAGCTCCCTTCATCTCTGGTCACATCTGCAGGCAGCAAGGAATTGGAGTTGGAGGGAAGGGCTGGTGTTTCAGGAGGAAAGCCAATATCAGGTGGGCACCAGTGAGGAGAAGCAAGTAATTACATCTTAGAGTTTCCTGGTAGCCTGAGCAAGGAGGGAAACAGGCTAGTTATGAGATAGTCATTGCCTCATGGAAAGACAAAGTCCAGTTGCTCAGGCAAGAGTACCTGTGTCCCAGAAGCTTACATACAGGGGACCAGCAGGGAAATGATGATGACCTCGAGGGCAGAGGCACCGCCAGTATAGGGCATGCCCCCATGAGTCGCATCTGCTGGCTCTTAGGGGAGGCTGAGCATGCTCAGTGAAGACCACATTCCAGGAGGCTTAAATGGTGGGGTCCCAGGGAGGTGTGTCCTGGTGTCCAGATAACACAGGGTGCAGCTTGGAGAAGCCTGGGGAATGGAAGGTCAATTGGACCCTCTTAAATAGCCATTGCTTTCTTTTATTTTAAATTTTAGGATTGGTAATGCATGTCCATAGCTCAACATTCAAGAGACAAAAAAAGTATACAGTGACAATGCTCCTTCAATGACTCTGTTCACTTCCCTAGTGGCCATTATACCAGTTTCTTATCCATTCTCCCAGAGGGATTATATATATATACATGTACATGCAAACATCTGTCTGTCTATATGCATGCATGTATAATTATATAAATGGTAACACAGTCTGCACCATGTTTTTCTCACTATTTTGTGGAGAGGATTCTCTGCAAGTACATTGATCACCATTCTTTTTTGTGGCTCTATAGTATTCCATGGTGTGGACATGCTATCATTTTTTTTTTTTTTTGGCCAGTCTCTTCTTGAGGGATATTTAGGTAATTTAAAGTATTTTGCTATTACAAATGGAGCCGCAGTTAATAAGTAAATATCCCTGCACATGGGCCATTTCCAACCAAGTTTTTGACAGAAGCTGAAGGGCAGATATATCCATACTGAAGTTTGTACCTTCATTCAGCAAGTATGAGAAAAGGGGCTGTTGAAAAGGGGAGGGCAGGCTGGCTGAGGCGTCATCACAGATCGAAAGATGTTTGTGCAGGACCAGCCAAGTGTAACAGCCACCAGGACCCGTTTCATCTGTAGCCATGGCGCCCAGGCCCTGGAGTAGTTTACATTAAAACAGAGACCCTTCCGCAGACAGAAGCTTGGAGGCCTACACTGACATGGGCCCCCAGGCCTTGGGTCAAGCACAGCCTCGTTCGAGGCTGATTCTGAAAGAGGGGGGCTTTCAAGGGCTTCTAAGCCCTGAGGTTGCAGTCACTTCCTGAATCTCCTCCCACCTACTTCCTCTCAACTCCCAGCGAGGCCAGGCAGGGAGGATGAGTGAGCACATAGCATGGCACCCAGGAGGTCAGTCTCTGGCCGCAGGCCTCTTCCTGGGCTGGTTTGGGGCCCAGAGTGACGTATGTCTTAGGCCTTAAAGACTGGGAATCTGGACAGAGACCTGAGACAGGCACTGAGAACAGGGACAAAGCAGAGGTTCTGGTGCGGCCACCACGGCCCAGGAAGACTCAGACTTGAGAACTCAGAGGCAGAGTTGGGCAGAAAGAAGCCAATTGGAGCTAGGAAGGAGGTCACAAAGTGGGGTCCTGACCCTGCATGAAGCCACATCAGGAGAGGTAGGGGGTATGAGTAGTCAGGGTGGATGAGTTCTTTCTGGATTGGTGTGGGGGATCTAGTGGGGCATGGGAGAAGCTGATACTTCCTGCTCCGTGGACTGCCTTCCTGCTCAATGGAAGTATTAGCCTCTGCTGGCCCCACAAGTGCAGGAAGTATTCCCTGACTTGGGAATAATGTGCTTAGTGAATCCCCCACTGTACACCACGGCATGAGCACGTGCAGCCAGGGCTGGAAGGAACCAGCGTTGGTGAGCATGCACTGCATTGCAGCAGCTGTGAGAGAGGTTGGAAGATGCTCTTGGGGTGGCCTGCAAGGGTCATGGGACAGTGACTTCCCCTGGGAAGGAGATGGAAAAGGGAGCTGGAGGATCTGGGTGGGGCCGGGGGGGCCTATATGGGTGTCCCCATATAGATGGAAGGAAGGAGAGAAGATGGACCCTGGGCCAGGGCAAGTGCACACATACGCACATGCATGCACACACACACACACACACACCAGGTTCTCTGTAGCACAGCCACTCCCTGCACTGGGATATCACGCAGCATGTGGCAGAAGCACAGCACCTGTGGGCCCTCAGCCCCAAAGGTCAATGATGGCGGGGAGGAGGAGCCAGGACCCAGCTGGGGAGAGCTGGCCCTAACCAGAGCAGCAGAGTGGGACCTGGTAAGGGGTGGGATCAGCCAAGAGTGGTAGCATCTATCCCCGAGCCCACCCCACCCACCCCTTCTCTCAGAGGAGGCAATGAGCAGAGGCCCAGGCAGCAGGTCTGAACTCCCAAAAGGCGGGATGAATTGGAGGGGGCAAGGAGATCAGAGGGGACTGTTTGATGGTCCAGGTGGGTAATGAAGAATCCCTGAAGCAGGCATGGCAGTGAGGATGGGGGAAGGCACAGATTCCAGAAATACTAGAGAGGAAAAACGGATACAACTGGCAGCCAGTTACACAGCGGGAAGAGGAGAGAAGCAGGAACTGAAGATAATGTGCAAGATGCCACAAACGCCATCTCCCTGTAACCCACTGATCTTGCATGGCTGTGACCGTTCTGGTTATGAGCCCCTCCCCACCACGCCCTCAGGACAGTGGCTGGATCCTACGTTGTGTGTATGTGTGCAGGCATATGAATGCTCATGCATGTGTGTTTTCCAGTAATGTGCCACTGCTAGGTTGATTAGACCCATCATTTGACCTTGTAAATGAATCCAGTGGTTTACAAAACACTATTTGAGCCTTTTCATGAACGAGGAGCTCCCACAATGCTGTCCTAAACAACCCCATGAGGTGAGTAATATTGTCCCCATTTTGTGAAAGAGGAAACTGTCCACAGAAGTGAAGAGGTGTGTTGAAGACCCCAAGGCCAAATAATAAATAATAAATTTGAACCCAGGTCTGATGACTCCAAACCCTGGTAGACCCCACAACCCCAGGGCCCCAAAATGGACTCCCTGGAACACTGGTTTTATGGAATATTAATAGATCTTCCCAAAAAATGAAAACAAGATTCCATGGGTGTTCCAGAAAAGGCTCCTTATGGAAGGACTGCCCTGTGCCCTGTCAGCTATCCCTGAAGAGGCACGGATGGCTTTCATGAAAAACCAGTCCCCCCAACCCCTTCCAGCCAGCTCCATTGCCCATGCCTGAGGGGTATATTCAATACCACCCTCTTTGTGGCTTTTGCTATTAGCCAATTAATAAGCTGGGCTCCTGGGCAGTGGTGACAAACGCATTCAGTCACCCATTCAGTCAACCAGGGCTACCCTGTGCTCTGGCCAAGGCACGGTGCCAGGCTCCAGGGAGAGTTCTTGGTCAGGAATCATTTCTTTGAAAGGAGCAGGAGCCTTTTGCTCAAAGCAGCTTGAGCAAGAGAGGACTATCCTGGAAGAAACACAGCGGTAGTTAATGGAACCCAGGGAGAAAATACACGTCTGGGTCTCCATGGCCTGAACACCTCCGCCTAGCCTTGCCCCCACCACTTGATTCCATCACCACCTCTTGCCACTTTCTCTGAGACCCTTCTGCTTCCTTCTTGGCTTCTTACTTGCACTTAGAGCTCAGCACATGCAGCTCATCAGCCTGGTCTCTCTGTGCCACTATGCCACATTCCCAGGAGCCTCAGATGGGTGAACCCTGGTGCATGTCCACTGCTGCTCCAGTCAGCTGCATCCAGGACCATGGGCCTCTGAGAGGGCATGAGGAGCAGGGGAGAAGTCCTGGGTTTCTAGTATGACAACAACCACGTTGCTCCTCCCTCAGGGGTTCCAAACTCTGGGTGATTATAACCAGCTGGGGGGCTTTCAAAAAGACCAGTGCCTGCAACCTCCCCTCCCCTCCCCTCCCCACCCACCACTCTGTTTTAATGGATCTGAGAAGGGACTTGAGCGACAGGGCTTCTTTAAGTTCCCAGACATCGCTAATGTGTAGCCTGGATTGAGACTATGGGCTGTAGCTGGAAAGATAATCAGAACATCATTATGATATGAGTTGAGAATGGCCTTGATGGCACAGGATGGGGCGCTATCTGGGAGCCCCCAGCAGCTTGCCCATTTGGAAGAACCACCATACCTTTCCAAAAGCACATATACAGCTGACATGCATGTTGTCATTGATGGCTGCAAAGTGAACTATGTCTGGCTTCTAGTGGGGGCTAAATACTGGTTGAATTAATGAACGAGAAATGACTTGGAGAGTAAAAGGTGTGGGAAATCTTCACTCTAATACCACGTGTATAGAATAGACCAAGGCAAGTGTTGTTGGGCCTGTTTGTCAGAAAGGAACCAGGGCTCAGAGAGATGACAAGGCTGCCCAGAGTGCCCAGCTCTGAGCTTCACTGCCAGACCCAGACTCAGCTATGGAGGGTTCCACCTGCTCCTCTGTCTGTAGGGGAACCAAACATCCCAGTTTGCTCAGGACTGTCTTGGCTTTAGTACTGAAAGTGCCACACCCCCAGGAAACTCATTAGTCTCAGGCAAACCCAGGACAGTTGGTCACCCCACTGTCAGTGGTTGTCCAATGTTCTGTGTTCAGTGGAGAGGCTGTAGGGGCTGCTGGTCAGTTGGGAGAGGCAGGAGGCAAAAGAGAGTCTAAGTAGGTGGGGCTTCAAGCCCCCAGCCCCAGCTTCCAGAGGGGAAGTAGATCCAGCTCCAGACTGACCTGGGGTAGCAGGGGCCATTTTGCAGCCCAGTTGGACAGGAGAGGCATACTGGGGCCAGGAAGGACATACTGGACAGGAAGGGCATACTGGGGCCAGGTATGCGCTGGAGCTCAGGCACCGCCAGGTCAACTGAGGCCACAGGTGTGGTTCCAGAACATTTCCTCCAGCAAAGACAAGGGCCCACATGTGAGTCTAGTCCTGGCACAACCCCAGATGTGATTTCTGAATCCCTGCCTGTGAGCCTGGTAGGTCGCAGGTATAGTTTGTGGATCAATCCCTCTTTTCCTACTGAAGCCCCAGGCAAAAGTCTAGACTAGTGAGTTGTTCTCAACCTTGGCTGCCCATTGGAATCACCCGGGGATGCTACGTCAAACTCCAGTGTCCAGCCATGGTTGAGACTCGCAGGTCTAGGGATACTCAGCAACCCAGGTCAAGCCTCAGGAGGTCCAGGCTCCATCCATGCACTTGGGAAGGCCTTGGAATCATTGTGGATCTGTTACAGTGATTTTGATTCTGCGAGTATTTCTCGCTCGATCTTAGGACTCCTGGTGGAATCTCAAATCAGGTTATCCATCTCTTACTTCAGGTCTAGGAAAGCTCTAGGTCCATCCTTGATCTCTGTGGAGGCCCCAGGTGGAGCTCTGGGCCCATCTCTGCAGCCCTGCAGGGGCTTTAGAAGTGGTTCACCAAGTCTTGCCTCTTCTGTAGCAAAATCGGGTGCGGCCCATTGGTGGTTTCTTCCTCTGTTGCATTTCTGGGGAGTCCCTGAATGAGGCTGTGGTCTGTTCATACAACTGCAGTTGGACCCCAGCGATGGTTCTGTGAATCCCTGGATGCATTATGGGGCCTGGGTGTGGCTCTGAGTTGGCCCATGCAGGCTAGTGAGGCTCACGATAAGGGTCTTTCTACACAGCCCATGGCACCTTCCAGGTGTGGTAGTGGACCTGGGCCTCCCGCCCAGGTGAAGCTCCACATAGGGTACTGGCCCTGCCCTCACAACCTGGTGAGTGCTCTGGTAGTGCTGAGGCTGTCCTTGCAATACTGGGCTAAGCCAGGTTCGGATGTATCTCTGGACTATAAGACTTCCCATCATTGACCCTCACATCAACTGCCTATCCTCACCCTAAACTGGCTCCAGTCCAGTTCAGGGAAGAGCCTCAGCCCAATTTCCCCACAGGGGCCACTTGCCCTTAGAAGGAGCCATGGGCTTATCAGTTCCCCTTGAAGCATGAGCATGTACGGAATCACCTAGGGTGCTCTTTAAAATAAATTCCAGCCATACCCCTAGGGATCCTGATTCAGAAGGCAGCTAGTGCCTGGAGATCTACATTTTTAGCAAGCGCCCCAAGGGATTTGGAGTGGAAAACTGGGATACTGAAGTAGGAGAAATGTATTTTTACATCTACTTACCTCTGGGGCAGCTCCTGCCCAGCAGAGCTGTAGATCTGAGCCTGGACCTAGAAAACTGGTGGCACCCAGCAAGACTGAAGACAGTCCTGGCCCCACATGTAGTTTTATCTCAAGTAATGGTGGCTTGCCTTAAGCAATGCTTCTCATACCACAGGGTGCAGCAGGATCACCTGGGGGGCTTGTTTCAAAACAGAGGTCTGGGGTGGAGCCCAAGAACTTACAGTCCTAACAAATTCCAAGGTGATTTGGGTGCTGCTGCAGCTCCAGTGACTTTAAGGACTCTCATGGCAGTAAGGGTGGTGGGACATTCTTGGAAGAACAAGAACCACAGTACAGGCAGCATTCCCAGCACACGTAACTGAGAAGAGGTGGAATCCAGGTGTTCCAGGGCAGCCAGTCTTGTCCCCATGCCATCCTCAACCACCTGTAGCCAGAGCCTGACACGCCACCTCTAGCTTCCCACCCTCAGTGCAACTCAGCGGCACCCCGTGTCTGCCAGTGCCACCCTCGGTGCTCTGCTATCTCTGCTTGGCCTCACACCTCCTCCTCACCTGCCCTTCTCGTCTCTCACAACCCCGACTCCAGGTGGTCTCCTTATAGCTTCGGATGATACTGCCAACCAACTGCCTCTCCTCCTATTTCCTAAGGCAAACTCCCCGCCTCACTTCCCTGTTGGGGCAGTTTGGGGAGCCCTTGCTCTACCTGGCTCCAGTCCAGTTAAGGGAAGAGCCCCAGCCCAGCTTCCCCACAGGAACCAGCTGCCCTTAGAAAGAGCCATGGGCTTATCAGGCATCATGACTCCCCTTCTGGGATCTGGGCAGTCTGGTGGAGGACTGCGGGGGATACTAGATCTATTCCAGCAACTCTAGTAGGCCTGTGAAGATTTGTTATTGAAACTTGGACTCGGGTCCTGTATCTGAATGTATCCTATATCCTTGATCACATATAGTGAGTCCTGATCTCATCCAGGGCCCAGGGAAGGTGGGCATGAGGCTCTCTGTTGCATTGGAGAGTTCTAGGATGTCCCTGGGACTGACTCCAGAACAATGCTGCTGTTCCGCAGAGGAATCCAACCGGGATCCAGGCAAGCCTATGTGGTCCCATTGTTGTGGCAGGTGTGATTTGGGTCCTATCCTGTGGTCACACTGAGGCTCGTGTGTTGTGAGTCTGAGAAGCTCTGGGTAGCTCTGGTTGGTCTCAGCATCATTCTGGGGATGTCCAAGTTGTGATCCTGGCCTCATCACAGCAGCTCCAGTGTTGCCCCCAGTGTGAGTCTGGTTTTTACTCTGCAGCTTTGGAGGGATCTGTCTCTGGCCTCTGCCCAACCTTGTAACTCTGAGGAAGCTCAGGTGGGAGTTCAGCTTTCAAAGGTGACTCAGGTCAGCCAGAGCTCTGAACCGATACCAGCTGAGGTTATGAGACTGTCTCAAGAGCTCTGGTGCTATGCAGGGTCATTGTTTTTCCATGGAAGAAATTGATATTAAGATTATTTATTGGCCGGGCGCGGTGGCTCACGCCTGTAGTCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCAAGACCATCCTGGCTAACACGGTGAAACCCCGTTTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCAGACGCCTGTAGTCCCAGCTCCTCGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCAGAGCTTGCAGTGAGCTAAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTGCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGATTGTTTATCAAGAACTCCCAGAAACCCCCTAACTGCTCCAGACCACCACCCTCGTGAGGTCCTCAGGCAGTCGCTGGCAATATAATGCTCCTCAGTTCTCTCCAGCTATCTCAGAGCTCCAGGGAGCTGAGCTGGCCTGACTGAGGCTTTGGAGCTTGGGCCTTGAACCAAAGCAGGCCTGTGACTCCTCCTTCCTCCCTAAGCTCATTTCCCAATAGCAGATGGTACTACTCCAGAATCCAGAAAGCCTCTCCCAAAACACACCCAAACCAGCCAGAAAAGATCATAGGGACAGGAGAGCAAGTCTTAGGGCCAGAAGATATGTGTTCAGATTTCTAGGACAGTGGGAAGGAGATGGGAGCCCCTGGCCCTGGTACACTCAGTCACAGCCTGGAGAAGAGGAGGGAGCCAAGAAAGGGAAAACTAGGGGGCCCTAATATGGGGTGCCACTTTGCAGCTGGTACCACCCTGACCAGCTGACTTCACCTGCCATGTGGAAAGAAGCTGGGAAGAGTGGGGAGGGAAGACCTGGGAAGGGGACACAGAGGAGAAAGGCAGGAACAGAGACACAAAGAAAGAAGGAGACAGCTGCAGAGGGCCAGGCACAGTGGCTCACAACTATGATCCCAGTACTTTGGGAGGCCAAGGAGGATGGATCACTTGAGGACAGGTGTTCGAGACCAGCCTGGCCAACATGGCAAAACCCCGTCTCTACTAAAAATACAAAAAAAAAAAAAAATTAGCCGGGCATGGCGGCGCACACCTGTAGTCCCAGCAATTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGAAGGTGGAGGTTGCAATGAGCAGAGACTGTGCCACTGTACTCCAGCCTGGGCAACAGAGTGAGACTCTGACTCAAAAAAAAAAAAAGAAAAAAGAAAAAGAAAGCTTCAGAGAATGCAAAGGAGAGAGAGAGAAATGGAAAGAACAGAGAGGAAAGGAAATGATCCCTTTCCAGGCTCAAAGAGCCAAGAGGTGGAGTTTTTCTAGAACTTTGGCCTATCCATGCCAGAGGCAGCTCTGCTCCTTGTTGAAGGTGCAGTAAGGGGAGATGGCCTTGCAGTGGGTCCTGAGACCCGCCATGAAAACAAGGCTTCAGGCTCAAGCATGTCCAAGCCAACATTCATCTCCCTTGCATATTTGCTCCTTGGGGACACAGCATGAGCATCGGCAGCCCAGCCTGAGGGTGCAGCTGCTCTCCCGGGGCTGGAGACCAGCAGAGGATAAGAGGTCTGAGTGTCCCTTGGGGAGGGTTGCCCTGAGCCTTGACATGCTCCTATGCAGCCACCAGTCACCCACGAGATGGGCAATTCAGATCCTCAACAACTTTGTGTCTATTTCCCTGAAGTTGTCCTGAACTTCTAAAATGGAGTAGGGCCTAGAAGATCATCATATTTTTACCCCAAGCCCATACTAGCCAAGAAATCACCTGTGCTTCAAAGTAGGCACCCAAGCTTGCCAAGGAGAAAGTTATTAAAAATATTAATAAAAAAAGAAGTATAGTGAACATGCATTGGATGCTTGCTTGCAGGCACCAGCATTATCTCACTTGACTCTCACAACAATCATGCAAGGAAGGGACTCTTCTTATGCCCATTTTGTAGATGAAGAAACTGAGGTGAGAACCTCAGTGACTGGCCCCAGGTTACACAGCTAGCAAGTATTACCAACAATAGCATTTCCCAGATAACACAATGCCACCTACACCTGTCATTTGTTGTCATCTGAAACATGTAGGAATATGAACCTCCACCTGCTTAGTCCTCCTCCAATTATTAAGGCCACTTCTTTATCTCAAAAGGAAATCAAGTTTCCCAAATAGAGTCTCCCTTTATTTAAAAAACCCCAGACAGAAACTAAGGCTGAACTGAAGCATCTGTCTCCCTTTTTTCCCAGTTATATGCTCTGTCCCCGTCAGGGGAGCTGCCCAGGTAGGGGCTAGGTGGAGAGTGGGCTCTTTGACCCAAACTGGACCACAAAGCTGGGCTATTGCAACCCTGAGACTTCCATGTGCTCTCCATCTCCAAAGTCCCAGAAGATCAACGGGACACACAAGCATATCCCAGACCCAACCTCACACCTGTGGAACCAAATGCGACCTGAGCAGAATGTTAGCACCTGTGCATTTCCCAGGCAGAAGCAAGGCACCCCGAACATTACTCCCCAGCCCCTGCTGCCACCATCCATGGACCTCATGGGGACATCCTGGGTTGGGGGCTTCCACTGTCTTCAGGTGTCTGTGTCAGCTCATGGCAGGGAAACTTCCATTTGGGTGAATGGTGCATAAGAGCCTCATAAGGGCCAAGGTTTTCTGCAAGTGCCATAAAGTGTAATGGTGAAAGCTAGGTTGTGGGATATGGGTTTTTACTGTAAAATAATTATAATGTCTGTGAATGTTTAAAATTTTCATAATGAAACGTTGGCAGTGGGTGAGGAAGGCAGACAAAGATCAAGGCCTTTTCAGCCCAGGCACCTCAAGGACCCAAGAAGAAGCAATAGGAAGTCCCTTCTTCTGCCCCCGTTTCCCCCAAATCTTTGACTTCCCTTACTTAAGAAACACCAGCATTTATAGTCTTTACTATTCTGATACCATCACCAAAATATCTCTTTCTGTCCGACTGCTGCAGCAAGACCTGCTTCCCCTGGAGAAATCTGCCCAGTCCCTCCATCCTGGCTGGAAAGCAGGATAAAGATGGGAAATTGGTTGGCACAGAGAAAATTCTATCACTTATATTCCTCACTCCCAGGGCTCCACTTATTTGGGGTGAGTCTACATTGGGACAAAAACAGTGGTTACAGATCCTCACTAACCAAAGACAGCAAACGGGGTCTTGCCATCCCCACATGGGCCTGTGTCCCTGAGAGATACAGCAGTGTGGCTGGGATGTCACAAGTGCCCACAAAGGTTGCTTGCAAAATCATTATTAGCAAGTGCAAGAGGAGTGAGGACCATCATGAGGTCCTGGGTGCCTCATCAGGATGTCATCAGAACCCCAAGGTGAAGCATTCATGTGTCTGTTCATTCACTCATTCTTCAGCTATTCATCAGCATCCACTCAGTACTAGGCTCTGTGCAGGGTTCTAGAGTTTCCAAATTAAGCAGGTACAAGCCCTGGCCCTGAGCAGTCCAAGACCAAAGGGTCAGCCAGGTTGTGAGGCTCCAAGGAAGGAGGGGCCTCAGGGAGAAGTCCTGTAGGTGAGGGGAAGGATGGAGTGCAGACACCCCCCACCCCCAAGCCTAAGCCCGGCCAGGCCTGTGGTCCAGGCAAACTCTTTTCCCTGAGACCTGAATCTCTGGCCTGTGTGTTCCCTGGGGCCCAGGGAGAGGTCATCGCCTGGCCTCTGCTGGGGTTCAGCCTGCCAGGCTGACCCCAGGACACAGTGCCATGCCTAGACCCTCAGACCACACTTAGGCCACACACCTGACCCTCACAGAGAAGAGGGGTGGGCCAGAAACATACACAGCCTCTGAGAGCTATGGGAGAGATTGGGAACAACCCAAGGCCTATCCAGAAGTGCAGGGAAAGACCCAAAACACATCCACACACATCCACACTCTCATTCACATTCTCCAGATATATCGATAGATGGATAGATATAAAAGCGTGTGTGTGTGTGTATATATACACATATATATAAATATATATGTATGTATATATATATGATACATCGATATAAAAGCATGTGTATATATATGTATGTATATATATACTTATACATATAAATATACGTGTGTGTGTGTATATATATATATATATATATAGGCTCAAAAAGACCTTGAGCCCAGCTCATTTAACTCCCCATTTCATAGATGAGGAAGCTAAGGATGACAAGGAGGAAGAGACTTAGTTGCCCCCAAGCCACACTGTCTCAACTGCAGAACTGACACCAGATAAGACCCCCTTTCCAGTGCTCTTTCCCTACCCAGAAAGCCACTTGCCCCCTATTAACTCTTCTCCATTACAGTGAAGAGAACAAACAGCGTGAACAGAAGGACCCTGGGCTAAGAGCCAAGCCACTGTCACCCTAGACAGCCATCCCAGAGACACCTCACACCCACCTCCAAGCCTCAGCCCCCTCTGTGAAGTGGGGTCGTGCCACCTACCTCCACCGTGGCTGGGCTCCCTCAGGAACACAGGGACAGTGCCTGCAGGGTGACAGGCACACAGCAGGGCCTCACAAAATCAGTCACTTTCCCTTTTTTTTCCCCACACCACTGGTTGTGTTTTAGGTTTTCCTGCACATAGGTTTGGAAATCTGACATTCTCACTGAGTCCCTTTCACCTCTCTAAGCTCCCTTTTTTGTAGCATCTTCCAGGAGCCTGGAGCTCATCCTCTCTCTCTAGACGTGGGCTTTGGTCTTTCCCAGTGGATTATACTCTGTCTCTGTGTCTCTGTAGGCTTCTCCCTCTCCCACCTGCCCCCCACCCATCTATCTCTATCTTATCTCTGTCTCTGTCTCTATCTCTGTCCCTACCAATTCCTACATAGAGCAAAGTCTCATTTACTTGCTACCCAAAGTCCAGATTTGTGCTGATTCAGAAACTCTGGGTGGAAGCTGACTTTCCCTTAGCAAACAATTTCTACAAGTCAGTCGGGCAATGTGGTTGCATAAAACAGATGTCAGGGGGCAGGTTTACGAGCACAAAGGGAACAAACTGCTCTCAAGTCATTCGAGGCACTTATATTCCAGCTCAGGCCTCCTGCAGCAGCAAAAGCACCACTGGGCAAAGGCAGCCCAGGGTTCTGGCTTCAGTGATGCTGCTTCTAGCCCAGTGACCTTGGACAAATGAATGTGTCTTGCCTCCACATGCCCTCTAAATGGGGATAACAGACTTAATTTCTAGGGCAGTTGTGTCTCTAGTCAGGTGGTGTGTGCAAAGAACCTAGTACCATGCCTGAGGCGTGGTAGATCCTCCAGTTTCCCCTTCTTCTTAAGGTGGAGGCCCTCACAGCTGCCTGGACTGCAGTTCTTCTGGCTGGGAGCCTGAAGTGGCTCTGGATACTCCCAGAGCTCGCCCTGGCCCCTGGAGCCTGGCTGTTATGCCTCACAGGGAAGCTTCTGGGTCACGCTTGTCCCGAAGGCCACCCCTCCATAAACTGGCCACTTCACTTGAACGCTAAGCCTGTCAGTCACTCAGGGTCTAGGCAGTGTCTCCTATCCCAGGAGGACAGCAGATGCAGGATGCTTGTTAGGAGACTGTGACAGTAGCCCAGGAGAAAGGTCGTGGGGCCTAACCTAGGGCAGCAGTGATGGGGTCAGAGCGAGGCCACACAGATGGAGTAGACGGGCAGATGAACTGGCAACTATTGGAGTGACAGGAAGGGAGTGGGGAAAGCCTCTGGGTAGCCTGCGGCCGGCTTCCTGAAGCCTCCAGGAACCCCGTGCCTGGTCTGCAGGATGGAGAGTTGGGCATCATAACCTGTCAGAAGCTCAAGGTCTCTGATGACTGGGTTCAGGCCTGGAGGGTCTTCCTGGCATCCTTCCTCACAGTTAGGTTTCCAGCAGGGGTGAGGCTGTAGGGGATTCCAGTACACATGGGTAGCAGGGAGCCATCTGCTTCCCTACCCAGTAGGGCTGATTGGGAAGAAGTCTCTGTGAAGAGTGAAAGGCCTCAGCCAAGCCCATCACCCCATGCAGCTCTGAGTCCCCTGGTGACCCAGTAGGGAAGGAGAACACTCCTGCTGTGGTCCCAGCAATGGGCTCCTATAGCTCTGGGACATTCCCCTTGGGGCTCTAAGGAGACCCAGCAACTCCACTGTGCCTGTATGTAGCTGAGTGCCTTGTTTCTGATTTGGGACTCTGAGTCTCACCTACCTACAGGCTCCCTGAGGTGGGGACTTTGCCTTTTTGTCTTTGCATCCCAGGGCCAAGCCCAGGGCCTGAGCAGGCGGCAGTTGCCCAGTGCAGGTGTGTCATCCCAGCTTCTCTGCTTTCCCGCTGTTTGGCCTTAGGCAAGCAGCTCAACCTCTCTGAGCTTCAGGTTCATCAGCTGTAACACAGAGAATACCTGTTCTGCTTGGTGAATGTGGAAATAATGAGATCATGGGAGACAAGCATTTGTGTGTTCATCATCTCTCGAGAGATGGGGAAAGTGCTAGGTAGCTGCCTGCCACTATGTGTCACCTGCTTCCTCCTCTAGGGGGGCAGGGTGCCCACTGGAGCCTTTCAGATTCAGTTATTTGAGGCTGTAGCTGACATTTCATTCTATAGCCCCAGTTATCTGTTTCCTAGGAAACAAGAGACAGACATTGACTCTGTAACAACTCACTCTCTCTCTCCTCTCTCTCTCTCTCTCCTGCCATACTCATTCCCCCCGCCCCCCACTTCACATACACCCGGCTGCCACCTAGACTGACAATTAACAAAAATACATAAATGTCAGCAGAAGCTAAAATTAGTTTACACACTGCACCTTGTGCTGCTGCTCCCTGCCACCTGGACACCGAGGGATGGAGGGACGGGCACCCTCTCTGGCTCAGTGTCACACCATGGCTGGCCCGTGGTGCATCCTCTGAACAGCAGACCTAAGGGCCCCTCTTTGTACCTCACCCCCTGCCTCTCTCCTCCCAGTTTCACCAGGCCCAGGCCCAGGCTGGGCCCCCAGCACTTCGTTTGTCTGCCCTCTCTCTCCGACGAATCCCTCTGCATGCGGAGCTGGCCCCTCAGAGCCCCCTGCCCCTTCCTCCTGCCAATGCCCCAGCCCAGTCTATGACTCTCCCAACATGCCCAGTTGCTCAAACCTGAAACCTGGGCTTTGTCCCTGCTGCTCTCTCCTCCCACGGCTCCTCCTCTCAGCTGCACCCCAGGTCCCTGCCCACCTGCCCACTGGCATCCCTGTACAGCCCCCTCCCCCTCCCAAATATGCTATGAGCTCTGGACACCAAGCTGCCCCCATGCTCTTCCATTCAGCTGAAATAAAACTGAACCAATGTCCCATCCTCTGGGAAGCCCTCCTGATCTCCCTGGGATAAGTCAGTGGGTGACTTTCTCTGTGCCCCCACAGCCCTTTGTTCTTACCTCCATGACAGTAGTGATCACACCACATTAATTACAGCAATTACAGTGCTTACTAGGTGCCAAGCATTCTTCTAGGAGCTTTACATGCATTTAACTCATATAACAGTATTGCAGATGGGTGTCTATTGTCTGGCTCTTCTGCTTCCCTGAGTCCTTAAGGGGCAGGGCCCATGGTTGGCATGGTTCTAAGTTAGTCACCTGCACCCAACACAGAGGTGGCTTTCAGTGGGCTCTTACAGGGACCGTGTCTGTTTACTCATCGCTCTAACCCCAGGACCTAGAAGGGCACTTATTCCATTTTTGTGGAGTGAGTTAAATACATGCTGCATTGAATTGGTACCCAGTTCCCAAAAGGATGTTCTAATGATGTGCTTTCCCTGCCTTCCCTCCAGCGCGCCTGATGATTTCAAACTGGCTTTTTTGCAATTTGTTGTTGAACAGGGCTTTGTGTGTTTTGTTTCCTTCTTACAATATCCTAAGCATAGGCTCTGTTACACGATACAAAAGCCCTTTTAATCGAGAACTGGAAACTGCTAAATAGAATGGCATTCTGATTATCACAAACAAGGAATCTGTGCCTAGCTGATGTGGCAGCAGGCACTTTGCAAAACAGCTAGATTGATTGCAAGAGTCGTTGTTGGTCCCATGGACACTCTGGTAATTGGAGATGTCTTCTTCTTGATACAGCATTACTTCACGGTGAACTTCAGCCATGAGAACCAGAAAGCCTTGGAGCTGAGGACAGAGGACGCAAAAGATTGTGACGAATGGGTGGCAGCCATTGCACATGCCAGGTATGTCTCCTTGCCCAGGGCAGGAAGCCCCTACTCCACAGTCCAGGCAGAAAAGACCAGACCCAAGGGCCTTTGAACAAAGCCAAGCCCCATGAAGTGGAGGGCATGGGAAAGGAGGAGGAGAAGCATCTCTTGGCAGGGTCCACCCTTACATCCTGCACCTCTGGGATGAGCCTCTCAGTGCCACAGGGAATGAGAGGCCATGAGTATTGCAGCTCCTACCCTGCTCCCACACTAGTTACCTTTTTTATATTAGCAGAACCAAGTATGATTTGGTTTGGTTAAAGGATTTTGTGGCTCCTGAAGCCTAAGGCCTCCAACATTCTGACCCAAATGCAGCCACTCATTTGCTGCATTACCATGGACCAGTCCTCTCTGCTCTCTGGACCTTGGTTTTCTCATCCAGAGGCTGACATTCTAAGCCTCTCTGAACTTTGACACTCAGGGATTCTAGGCCTGCTCCTCCCCTCTGCTCCAGCAGTAAGTGCCCCCTGTAGGGAGACTCCCTGGGCCAGGAGAGGGGAAAGCCAAAGGACAATAGGTGCCACAGAGACAACAGGGGCTCCAAGCTGAACTGAGTCCCTTTTGGGTCCTAAGGAAATGATGGGTTTGTGAGCCAGGATGTGGTCCCAGAGCTGACAATCGCCTGGCAGAGCTGAACATGGTTAGGGGCAGCAGCACCCAGACTTACGTTTCTGGGCAGTGGATTTTTCTACCTTAGTGGATAATAGTGTTTCTGTGTCTCCTGCCTAAAAAAATGGAAGCTCCTGAGGGCAGCGACCAGATGTGATTCTTTGCATTACCAAGGCCTGATAAAGGCATAGACAGAGTGCCCAGTAAATATGGGTTAGAGGAATGCAAGGATGGATGGGTGGTTGGAGGATGGATGCAAAGCTGGTTGTTGAGTTTATATATGGAAGATAAATGGTGAATTAATGCAGGATACATGGATGATACATGGACAAGTTAAAAGTATGTGTGGATGATGGACATATGGTTTGATAGATGGATCCTAGGGCCCGTCCTTGAGCCTTGGGTCAGACTAGTTAACCAGAAGCCCTTATTATGACTATAGCAATGACATTGGCCCTGAGATAAGGCCATCTCTAGTTCTTTCCTCAAGGGGTATCCATTCTAGCTACAGAGACCAGGTTGTCACATATGAACCAATAGTCAGGCCCAGTGCACAGTGCTGGGAGACAGATGGATGCAACATAAGTATTCCCCCAGGGATATCGCAGTCTAATCAGGTAGACATTAGACATATGCACAGGTAGCTCTGGTGTATAGAGGCTGAGTTAAATACAAAACAACATGAGAGAGAGACATTACTTCCATCTGCAGGGAAATGGGAGAATCTGGGGAAGCTGGAAATAGGGTAAGATTTGGCCTGAGTAAGGGGATTGGGAGTCAGACTTAATGGGTTAGATTGGTAGCATTGAAATGCTCATTTCTCCCCACCCACCCCCCTACGACAACAACAAAAAAAAGCCTTAAATAAAGGTGCTGATACAGGAAAGAGAATTCCAAGAATAATGAAGAGGCAAAGTTTGGGTGTCATAAAGTAGATGAGGTTGGCCAGGTGCAGTGGTTCACGCCTGTAATCCCAACCCTTTAGGAGGCCAAAGTGGGCAAATCGCTTGAGGTCAGCAGTTGGAGACCAGCCTGGCCAACATGGTGAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCATAGCGGGGGGTGGTAGGGAAGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGACAGGAGAATTGCTTGAACCAGGGAGGCGGAAGTTGCAGTGAGCCAAGATCGCGCCATTGCACTCCAGCCTGGGCAACAGAGCAAGGCTCAGTCTCAAAAAATAAAAAAAATAAAAATAAAAGACAGAAAGTAGATGAGGTTGGACTATGGGCTGCAACCAGACCATAACTGGATCTTGAATACCGCTAAGGTGTTTGACCTTTCCCCTGTGAACGGTGGGAAGCCATTGAGGGTTTTATACAAGGGGAGTAGCATGATCAGAACTATGATCTGAATTGAAAATTGCTCATGATGTAGAGGATAAAACTGAGTGAGGAAGAACCCAGATGCAGGGGGAGCGATTGGACCTCAGTCTCCTAAGCACTAAAGTAGAACCAAGAGCCAGTTATTTTGAGTAGCAAATGAAATTATTTATGTGAAGGGGCTTTGTAAATGTAGAAGTATTATAGAATTCTAACTTTTACGTGCTGATAACCAGGACTACATTGATTTAGAATCTCAATCAATACAAAAAGTTTATAAAGGTAATGAAATACCAATACTTATAGAGTAGAGTGGCTAAAATGCTTAAGACAGACAATAGTGAATGTTGAAGATGAGTGGAACAAACGTAACTCATCTAGTGCTGGCAGGAAGATAAAATGGCACAACCACTTTGGAAAATTGCAAGGCAGTTGCTTAAAAAGTTAAACATACATCTGCTCTGTGACCCAGCAGTTCCACTTCTTAGTGCTTATCCAAGAGAAATGAAAAGATGTCCATAAGAAGTCTCATATGCAGATATCCCTTAGCAGCTTTATGCATGATAGTCCAAAACTAAGAATAGCCAGCGTGTCCATCAACAGGCAAATGTCTAAAGTCACCTTGGTATGCTGCTCAGCAGTAAAAGGAACCAGCTACAAATGCATGCAACCTGGTGGAAGAATCTCAAAATCAATTTGCTGAGTGAAGAGCCAGACACAAAATAGTACATGATATTTGGTTCCAGTTACATGAAATTCTAAAATAGGCAAAATAAGCCTGTGGTGATAGAAATCAGAATAGTAGTTGCTTCTGGTGTAGGGATTGACAGGGAAGAGGCATAAGGGAACTTCCTGGGGTGATGGAAATATCATCTGGATTTGAGTGCATGCGTTTATCAAAACTGATCAAACTGCACTTAAGACCTACGCTTTCTACAATATGTACATTAAACCTCAAATTTTAAAAATGAATGATATATATATATATATATTTTAAAGATAGTGTTCTAATTTTCTATTGCTGCATGAGAAGTTACCACCAACTCAGCAGCATGAAACAACACCCATTATTTTACCTCCCTGTTCTTTGGGTCAGAAGTCCAGGCTTAGCTGAGGTCTCTCTCTGCCAGGGTCTCACAGGCTAAAATTAAAGAGTCAGTGGGCTGAGCTCCTCTCTGAAGACTCTGAGAAATCATCACTTCCAGGCTCGTTCTTGTTGTTGGCAGGATTTAGTTCCTTGTAGCCATGGGACTGAAGTCCCTGTTTCCTTGCTGACAGCTAAGAAGGGGAGGAGGGGGCAGTTCCTAGAGGCTGCATACTCCTTGCCACATGGCCTCCTCCATCCTCAAGCTAGTAACTCTCCAGCCTCAGATTTCTCACTGCCCCTTCTACAACCAGCAGAGAAAACTCCCCGCTTTTAAAGTCTCATTCAATTGGATCACAACCACCAAGACAATCTCCCTGCCTTAAGGTCAACTGAGCCACATTGACACAAGCCGGTGACAGGAGAAGAAGCCCTGCAGGGCAACTGTGCAACGGTGCATGCCAGGCAGGCCATGCACACCTCTCCTGCCTACCATGGACAGGATAATTTTTCAAGCAATTCACTAAATTAAAGACTGGCTCTAAGAAGCCAATAAAATAATAATAATCCAATTGACATCAATGTTGCCAAGCCTGTCTGGGCCTCCAGAGCCTGACAGAATGTTCTGCATCTGAGGGTGTCTGTCTGCTCTACAGTCTGTCCAGCTCTCACAGTTCATCATGTGCTTATGATAACCCAGGGAGGGGTCCCTTCAGCCCATTTGACAGACGTGTGACCCAATGTCACACAGGACATGGGTGCCTGAGCGGGGGTGGTGGAGTCCCAGATCCTGGCTCCCAGCTTAGGGCTCTGCAACTGCCAGGTAATGCAGATTCAACACAAACTAGAAGCCTTCCTCCTCAATAAAGGAGCAGCTGGTGATCAATACCACCTACCTGTGAACAAAAACCTCTCCATATGCATCATCCTTTTGGAAGCCAGCAGCACGTGTCAATGGGACAATGGTGGAATGATGGGACATGCTGATTGTTTGCCTTCTTCCTTTGTCAAGCCCTGGGGTCTGGGTCAGCCCACTGGCCTCCCAGGAATGTCTCCCATTCAACCTGGGGGGTGGGGAGTGATACAGTGATGGTCGCAGAAAGGGAAATCGAGGCACCTTCCTTAGAATAGTCAACATCATCATCAGCCATCCTGGCTGAGCTGAGGCTTGTTGAGCAGTGCTTGGGACAATAGGAGCTATCATTGTACCACTTATCTACTATCTAGGGAGTTGGCCATAAGACCAGAGGCGGACACTATAACTGTAAGCATCACTGAACCTCAGACACCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTGTGTCTGTGTGTGTGTGTGTGTGAGTGTATCAGTGGAGACACTGGCTGTCTTCCACAGCCATATTGAGTATTAAGTATTTTTACATATTCCCAATTTAGTTTTTATTTACATATACATAATAGATACTTCCTATGTACGAAAAAAGGCACTGGAGTGTATTAATATCATGTAGAGACACAATGTTCTCTCGCGCTGTATGTATAATATTCTGGTATTATGGGATGCCTCTGTGGGGGGTGTGTGTTTATATACAGCAAGGTATAAAATGCAACATCAAGTGCATTTTACAGTGTACGTTTCAGGGGAGAGAACTGTATACCAAACCAGAAGACAAAACCACTAAAGGGGGCACAAATGCATGGTCAGGGGCTGGAGCCCGACTCTAGCTCCAGCTTTGACGCTCATGGACTGTGATTTGGACCTCAGTTTCTTCATTTGTGAAATGAGATAATTGGTCTTTTGTGATCCCCAAGTTCCCTTCTCACTCTGAGAGTCTGTGAGTCTGTAAAGATTGCACCTGCACGAGGGGGGATAGAAGGATAGGGAAGGATAAGGGAGGATAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGATTGGGAAGGGAAGGATAGGGAAAGGAAGGGAAGGATAGGGAAGGGAAGGGAAGGATAGGGAAGGGAAGGGAAGGATAGGGAAGGGAAGGGAAGGATAGGGAAGGGAAGGGAAGGGAAGGATAGGGAAGGGAAGGGAAGGGAAGGGAAGGATAGGGAAGGGAAGGGAAAGATAGGGAAGGAAAGGGAAGGGAAGGATAGGGAAGGGAAGGGAAGGATAGGGAAGGGAAAAGAAAGGAGGAAGGAGAGGAAAGGAAAGGAGAGGAGGATGGAGGGAGGGTTGGAAGAGGGACAGAAGGAGGGAGGGAGGTTAGCAGAGCAGCCTGCAGATGAGGCGGACGCCTATTTTACAGCACTCTGACGGGGTCCATTAGTAAGAAGAGACTAACGAAGCAGCTGAATTTTCACACCCATGGGGTGAGGGGAGTTGTGGTGGTACAAAAACAGACTCCTTCATGCTCTCAACTGAATTTCCTTTACAAGGAAAAACAAGTCTCTTGAGAAGTTGGAAAAACTTAAAAACCTGATATTCATTTTCATCACAGAAGCACAAAATCTTATTATACTTTAATAGGATAGCATTATAAACTAAAGGATTCTCTCTTCTAGCCCTGTTATTTATCTTTAAAAGTGGGTGGGAACAAGAACACAGATGTGCTTTCTGGATCAGGCTCGCACTCGGGCCCACCGCCCCGCCTTGCTCCAGCTCTCTCCCTGCCTGGACTGCCCCCACCTCTACCCTGCCAAGCCCTCTCACTCTGCAGGGTGCTGGGAGTCAGGGCCTTCTGCTAAGTGCAGGTGGGTGGGTGAGCCCCTCTCCCGGTCAGTGCCCTGCTTGGTTCGCCAGAGGACAAGGAGTCAGCATCTTACCTGCCATGTCCATCTGTCCACAGCTACAGGACCCTCGCCACAGAGCATGAGGCATTAATGCAGAAATACCTGCACCTGCTGCAGATCGTGGAGACAGAGAAGACCGTGGCCAAGCAGCTTCGGCAGCAGATCGAGGATGGGGAGATCGAGATCGAGCGGCTGAAGGCAGAGGTGACTGCGGGCTGGGGGGTGGGCCCAGGCCCTAGGCACAACATCTCAAACCCTGGGCTCCTGCAGGATTGGGGAGCCACATGACAGGCAGGGAAAGCAGCTCCCAGATGCAGTTCTTCCAGACTCCAAACTTAGGACGTGGTGGTACTGGCAGAATGAGAAGGTCCTGTGGTCAGACTGGGTTTAAATCTCACCTCTGTCACTTATTGACTGCAACCTGGAACAAGTCCCTCAATGTGCCTGTGCCTCAGTTTCTGCAGCTGTAAAACAGGGCTTTCTATAAACACCTGACCAGGTCGTGAGGATTGAGTGAGATTATC

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