Details for gene: IRX5


This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]


Symbol
IRX5
Name
iroquois homeobox 5
Entrez ID
10265
Ensembl ID
ENSG00000176842    (more details)
KEGG ID
hsa:10265    (more details)
OMIM ID
611174
Uniprot ID
P78411  
GO ID
hsa:10265    (more details)
Chromosome
16
Strand
1
Start
54930865
End
54934485
miRNA Interactions
hsa-miR-29c-3p (RPM: 661.3514) / hsa-miR-147a (RPM: 0.0014) / hsa-miR-27a-3p (RPM: 980.3062) / hsa-miR-374a-5p (RPM: 52.6724) / hsa-miR-129-2-3p (RPM: 79.8688) / hsa-miR-378a-3p (RPM: 1540.7796) / hsa-miR-522-5p (RPM: 0.0018) /
Involved Diseases
myopia / Retinitis pigmentosa (RP) /
Involved Pathways
Sequence
AGCATCTTGGCAGGACCTTTGCAAAGGCAAAAGCAGAGCCCCCCGGTGCAAAGAGCGAGGGGAAAAAAGAGAAAGCAGCAAGGGAGGGGAGGGGAGGGGAAAAAAAGCCCAGCTGGGGCGAGCGAGGCGCGCAGAGGAGCGGGCGCGGCGGTCGCAGCCGGAGGCGCGCGGGAAGCCAGCGAGGAGGCGCCGCGGGCCGGAGCCCCGGAGCCGGGGCCAGAGGAGCGGCGGCCCAGGGCAGCCAGAGGCCAGGTGCCCGCCCGCTCGCCCTCGCAGGGCGCCGCCCGGCTCGTTGGCGGCCGCGGCGCGGCGCGCCCCATGCCCGTGTGTGGCCATGTCCTATCCGCAGGGCTACTTGTACCAGCCGTCCGCCTCGCTGGCGCTCTACTCGTGCCCGGCGTACAGCACCAGCGTCATTTCGGGGCCCCGCACGGATGAGCTCGGCCGCTCTTCTTCGGGCTCCGCGTTCTCGCCCTACGCTGGCTCGACTGCCTTCACGGCGCCCTCGCCGGGCTACAACTCGCACCTCCAGTACGGCGCCGACCCCGCGGCCGCCGCCGCCGCCGCCTTCTCCTCGTACGTGGTAAGTGAGCGGGATCCGCGGCGGGCGAGGGGCAGCAGGGGCCGGGCGGGAGGACGGGGGCGGAGGGGGACACGGGCCTAGGCGCCAACACCGACCTCCCCCGCCAAGCTTCGCGGCCCCTTCAAACTTGGGCGATTGTCTCCGCCAGCTTCGCCCAGGCCTTGGACTCAAGAGTTGCTCGCAAAAGAGAGCCGCGTCTTGCTCGGATCGCTGAGCTGGCGGGAAGGGGTTCTGTGGGGAGAGGTAGCTGCAATTAAAGAGCAGCATTTGGTGTAAACGTAAGCTCCGGGCTGCCCTGCAAATTTTATATTTTTGGTTTTGCCATTTTGGAAAAGTAGTTCAAAAGAAATAGACTCGAAATTTGAGCAGAAGCGTGCTAAGTCTATGTAAATGTGTTTGGCCTAGCCTTTAATTAGTCCTCCAAAATGTTGCAAATCCGTAATCCTATCTTCGCAATCCGATTTGGGAGTATTAAATTTCTGAAAAGTCGGTCGAGCTGCGGTGCATCCGGGATTTTTCGGCCGGGTTGTAACTTCGGTCTGGGGTAGTATTTTTGGAGGGTGGGAGTGCGTGGGCATGGCTCAGCTTTTTGTTTGCATTTCTTAGCTGTTGAAAAAAGAAAAAAAGAGCCTTGACTTCCCTTGTTTTCCCCCCTTGCGCCCAACGTGCGTCCGCTCCCCCGCCGAGCGCGGAGTCGCCTCAGTTGCCCAGGCCTCTATCTGCATGGAGGGCCGGGCCGCCGTGGCCAGATCTGCGCACGGGGTACGGACGTGCCCGGGCAGATGGGGGCCTACGGGGTGACACCGAGGCCGGGACAGCTTCAGGGGCCCCAGAAGGACCTGACCCAGAAATTGAGGTCCCCGCTGCCTTCTGAGGAGGGGGAGGAGTTGCTCCTAGGTCTGAACCCCGCCAGCCTTGCCCCGTAGGAAGCTGGAGTGCGGGCCTCGTCCACCCACAGACCCCGGGGAGCGCAGGGAAAAGGGTGCTTCGGTCGTTCCGATGGCAGTGGAGACCACGGTCCACACTCACCTCTCTGCGTCTCCACCGCAGGGCTCTCCCTACGACCACACACCCGGCATGGCGGGCTCCTTGGGGTACCATCCTTACGCGGCGCCCCTGGGATCGTACCCTTACGGGGACCCAGCGTACCGGAAGAACGCCACAAGGGACGCCACGGCTACCCTCAAGGCCTGGCTCAACGAGCACCGCAAGAACCCCTACCCCACCAAGGGCGAGAAGATCATGCTGGCCATCATCACCAAGATGACCCTCACCCAGGTGTCCACCTGGTTCGCCAACGCGCGCCGGCGCCTCAAGAAAGAGAATAAAATGACGTGGACGCCGCGGAACCGCAGCGAGGACGAGGAAGAGGAGGAGAACATTGACCTGGAGAAGAACGACGAGGACGAGCCCCAGAAGCCCGAGGACAAGGGCGACCCCGAGGGCCCCGAAGCAGGTTGGTGGACATGGGAAAGGGCGTGTTGGGCGGGAGTAAAAAGGAAAAGAGAGGCCTGGAGGGGGCGCGCACGGGGCCTGGAGGTTGGGGGCAGGGGTCCCTGCCTTTGCGGGCGGGAACCGGGTCCCGCCGCGCGGCCTCTGCGCCCCTGACAGCCTGGGTTTCGCCCGCAGGAGGAGCTGAGCAGAAGGCGGCTTCGGGCTGCGAACGGCTTCAGGGACCACCCACCCCTGCAGGCAAGGAGACGGAGGGCAGCCTCAGCGACTCGGATTTTAAGGAGCCGCCCTCGGAGGGCCGCCTCGACGCGCTGCAGGGCCCCCCCCGCACCGGCGGGCCCTCCCCGGCTGGGCCAGCGGCGGCGCGGCTGGCGGAGGACCCGGCCCCTCACTACCCCGCCGGAGCGCCGGCGCCCGGCCCGCATCCAGCCGCGGGCGAGGTGCCTCCGGGTCCCGGCGGGCCCTCGGTTATCCATTCGCCGCCTCCGCCGCCGCCTCCTGCGGTGCTCGCCAAGCCCAAACTGTGGTCTTTGGCAGAGATCGCCACATCGTCGGACAAGGTCAAGGACGGGGGCGGCGGGAACGAGGGCTCTCCATGCCCACCGTGTCCCGGGCCCATAGCCGGGCAAGCCCTAGGAGGCAGCCGGGCGTCGCCGGCCCCGGCGCCGTCACGCTCGCCCTCGGCGCAGTGTCCTTTTCCAGGCGGGACGGTGCTGTCCCGGCCTCTCTACTACACCGCGCCCTTCTATCCCGGCTACACGAACTATGGCTCCTTCGGACACCTTCATGGCCACCCGGGGCCCGGGCCAGGCCCCACAACCGGTCCGGGGTCTCATTTCAATGGATTAAACCAGACCGTGTTGAACCGAGCGGACGCTTTGGCTAAAGACCCGAAAATGTTGCGGAGCCAGTCTCAGCTAGACCTGTGCAAAGACTCTCCCTATGAATTGAAGAAAGGTATGTCCGACATTTAACGCGGGCTGCGTCGGTCCCGGACTTTTCTAATTTATTAAAAACATGGCCTTGGCAGTTATTTTTCCATCACCGAGAGAGAGAGACAGAGAGAGAAAATAAACTACCCCTCCTATTCAGAAGTTTATAGTTTATGGAGATGGATGACATAAAAATGTAAACATCTCCACACAAAAAAAAAAATGTCTTAACCAACCGAAAAGAAAAATTAAAAAAGGATTTGTATTAAATCTTATTCTGTATATTTAATGTAGCATTTTTGTATTTAAATTGATAATTCAATATCTTTGAAGTAAATTATGAAATCAAGACACCTGTACAGGCATTTAATGTTTTTTTGTAATATAAATATATACATTTGTGTTTCCCCCAAAACTGTTTCATAGTTAAAAAATACAAGTTTAATTTAATTTTTTACACCTATTGATTCTGCTGGGTATGAGCTAAAGTATTACAGAAAGGAAACAGGTTATACTCTTAGATTTAAAAAGTGAAAGAAACTGCAGGCGCCTTTGTAAAATGCAAAATATTTAATTAAAAGAGATTTTAACATAATGAGAGCCACTCATTACTTTTTAGAAGCCTCAATAAACTGTCCATTGCCTTGGTCAAAA

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