Details for gene: COL2A1


This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]


Symbol
COL2A1
Name
collagen type II alpha 1 chain
Entrez ID
1280
Ensembl ID
ENSG00000139219    (more details)
KEGG ID
hsa:1280    (more details)
OMIM ID
619248
Uniprot ID
P02458  
GO ID
hsa:1280    (more details)
Chromosome
12
Strand
-1
Start
47972967
End
48004554
miRNA Interactions
hsa-miR-29b-3p (RPM: 118.8178) / hsa-miR-29a-3p (RPM: 1246.9046) / hsa-miR-106a-5p (RPM: 7.9736) / hsa-miR-484 (RPM: 434.5276) / hsa-miR-301a-3p (RPM: 142.8494) / hsa-miR-214-3p (RPM: 21.2784) / hsa-miR-3929 (RPM: 0.0406) /
Involved Diseases
cataract / myopia /
Involved Pathways
PI3K-Akt signaling pathway / Focal adhesion / ECM-receptor interaction / Protein digestion and absorption / Developmental Biology / Axon guidance / Nervous system development / Immune System / Adaptive Immune System / Collagen degradation / Degradation of the extracellular matrix / Extracellular matrix organization / Collagen formation / Signal Transduction / Collagen biosynthesis and modifying enzymes / Signaling by PDGF / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Assembly of collagen fibrils and other multimeric structures / Integrin cell surface interactions / Non-integrin membrane-ECM interactions / ECM proteoglycans / NCAM signaling for neurite out-growth / NCAM1 interactions / Signaling by MET / MET activates PTK2 signaling / MET promotes cell motility / Collagen chain trimerization / Signaling by Receptor Tyrosine Kinases /
Sequence
CGGCCCGCGGTTTGGGCGAGTTCGCCAGCCTCGAAAGGGGCCGGGCGCATATAACGGGCGCCGCGGCGGGGAGAAGACGCAGAGCGCTGCTGGGCTGCCGGGTCTCCCGCTTCCCCCTCCTGCTCCAAGGGCCTCCTGCATGAGGGCGCGGTAGAGACCCGGACCCGCGCCGTGCTCCTGCCGTTTCGCTGCGCTCCGCCCGGGCCCGGCTCAGCCAGGCCCCGCGGTGAGCCATGATTCGCCTCGGGGCTCCCCAGACGCTGGTGCTGCTGACGCTGCTCGTCGCCGCTGTCCTTCGGTGTCAGGGCCAGGATGTCCGTAAGTCTTCCCCCGCCCCTGCCTGCCTGCCTGCTTTCCATGCGTCCCTCAGCATCCTTCTCCCCGGCCCGCTCCAGCTCTGGAGCCCGCGGCTCCGGGCTAAAACGGCTCCCGGGGTCGTAGCGCGCCGACTTAGGCACAGGACACGCAGAAGTTCACCAAGAAGAGTTCTGCCAATCAAGGACTCTGTCCCAGGGTCCTCGGTGCCCATCGCAGTTGCAAGTATTTGCAGGTCCCTACGTTGCGCTAGAATACTGAACTTGCAAAGTGTTGGCTCGGAGAAGTTTGCGCACAGATATAAATGGGCTCTTTTCCACCAGCTTTGATAATTAGGCGCACATGCACACAGCTCGCCTCTTCGAAGCACTTCGAGTTCAGCAAAAACAGATCTCAACTCATCGAACTTAGGTGAAGTAGGAAAGAGAGAGCGCGAGCGAGGGAGCAAGCAAACGCCAAAGGGTTGACTTCACAGCCTGTCCAAGGCTTGGTGGCTGGTGGGCTCAAAGCAGAGTTAGACAAAGGGGACTAACACTCTGACACTGGTGGGCTGAAATCCCAGGCCACAAAGAACGGCTTCCGATAGGCCCTCTGAGACCTCAGCGCCTCTTTAGGGTACCCTCCCCCTCCCAGCTGGCCCTGGAGCAAGGTGCAGCCCTAGCGCTCATCTCGACTTCCCTCCGTCCGCCTGCGCCTCTCTTCTGATAAAGGGTACAGAAACTTCCAGTAGGAGAGGCCATCTGAAAGACGATAACATTCCAACCAGACCGTGCTTTTCAAATGCCCCCGAAAATAGCGCCCCCTTCCCCGCGGTCTTACCCCATTCCCCGCCGCCCCGAGGTACTACAATGAGTTACTTTTCTAAATTCTGGAACTCACCGAGCCAGGCTGCGTGGTGTGTGTGTGTGTGCGTGTGTGTGTGTGTATGTGTGTGTCAGGGAAGGGGAGCAGGCTGGTCGATTGCTACGGTTGCTACAACTATTTCAACCGGTATAGTTAGAGATGGCTCTTGTAGTCGGGTCCAAATGCTGTTCGGACTGCACCTTTCTACCCCTCCTTTGGTAAGGTCCACTGTCTGGGATTATATTCAGGACAAACGAAGCCTGGAAAGTGTATTAGGTAGAGAGGATTTTTTTTTCCACGTGTTTGGGCACGTTTCCGACGGCTGGGATTCCAGCCCTGTCTTTGTATGTTACAGATTGTAAATCAATCGCAGAGGGAAACTCTTCGGCGGGGGGAATAAAAGTTCTCTGCCTTCGAGGCTCTGTGGGCCCTCTCCTGCCACCAGGCTGTTTCCAGGGATAGCGTGGAAGGCGGCGGGCTCAGGCGGGCTTTCCGGTCATTAGCGCAGCGGGGGCAGGGCTGGAGCCTGCGGCGCAGCTGCGAGGAGCCGGGAGCAGGAGACTCTGGCCGGGTCACCCGGTAGTGCGCTAAGCTGGAGGCGCGCTCCTGGGCATTTGAGGAATACAGCGTGACTATACGTGGCCTGGACTCAGACTGACTATATTTTTGTACTACATTTACAAGCACACGCCCACAAAGCTGTCTTCTTGACTGACCCCTGCCTTAGTGCGCAATGGAATTAGCTGGGTGGCTTTAAAATAATTCTCAAATTCTCCATCCGGTATTAGGGTCGCTTGCTTAATTAGGCGGTAGAGCTCTCTCATCGCCGCATCTTTCCTGGGAGGGAGTGATTCCACAGCTTCTCCGGCCCAAACCTTCCAGTCGCTCCTCCTCCCAGAGGGAGTGTGATTCTGCATCCGAGAGGCTGATTTTGCGCCCTGGAGCATCCCACCTTTTATAACTTCCCCCGCCTGGGGTCAGCGGACCCAAAGGTGTGACGTGGGGAAATGCGCAGTCTGCGTGGACGTCAGGAATGTCAGACACCTAGAGCTCGGCCACACCCCTCCTCTCCATCTTTCCACGAGTTTGAGAAACTTACTGGCGGCGGCGTCTTTGACCCTCATCTGCATTTCAGAGCCCTCGCCTCCGAAAGTGCCCCTGGCTCAGGGGAGAGATCTCAATCCTCCTTTGTGAGGCTTGTTTGCATTGGGAGATTGGCAGCGATGGCTTCCAGATGGGGCTGAAACGCTGCCCGTATTTATTTAAACTGGTTCCTCGCGGAGACCTGTGAATCGGGCTCTGTGTGCGCTCGAGAAAAGCCCCATTCATGAGAGACGAGGTCCAGTGGGTTCTCTCGTACTCCCAGACCCCCTCTCCCACAATGCCCCCCTGTGCCCGCCCGCCGCCACCTCTCGGCTCCAGCCCTGCGCAGAGCGGCGGTGAAGCAAAACAGTTCCCCGAAAGAGGTAGCTTTTTAATTGGCTTGCCACAAAGAATCACTTATACGGCCCTGCGGTAATGAGGGGAACCGGATCAGGCGCGCCGGGATGCTATCGGCAGCCGTTTTGGAGCAGCAATTATGGTGGTGCTGGGCTCCTCCGTCCACACCTAGGGGATCCGGTTACGGCGCTGGCTCCTTTCTGGGGCAGTCATTTAATCCCACTTTTCACTCTCCCGGTGTCTGTGAGCGAGCCGTGTCCAGAGCCGCAGCCACAGAGTCACTCAGCGGCTCTTACACCCAGCGCAGCCTGGCCCCGCCCCTGCGCCGGCGCTTCCCGGGCCGCCCTTCCCCGGGAAATCTGATCCGCACGGGGAGTGGCCCCTCTCCTAGCATTTCCCCCTCTCCTCCCTGGGTCCTCATGGGCGAGGGTGGGCTCTCCTGTAGTCTGGGCTGGAGCGCATTAACCGATGCCCCCTCTCCCACACCTTCCTCACCGCCTGCATTCCACTGCTCCAGCTATTTTAACGGCGGGTGTGTCCCCGCAACTTCTGTATTTTCCCTGGAATCCCTCACCCTCCTGTGATTATCTTGCCCAAAGGCTAGGCGGATTTCTTCTAGTGGGAAAGTAAAAAGGAAAGTTTATCTTTGGATTTTCACTCTCTTTAAAGAGCAGTGGGCAGGCTCGTTTCTTTCTCGCCCTCTGGGTTTGTGGCTCTTTCCTATTATTCATCCCCTGCTGCTGCTATTGCCTTGGGGATTTTGATGAGAAAAACAGCGCTGGGCGCTCCCTAGCACGTGGTGCGGGCTCTACAGCCCTTGGCTGCTAAGGAGCGCTCTTGTCAGCACAGGTTTCATTTGCAGCATGAATTCCAGACGGCAGGGCGCTGGTGGAGGAGACTAGTCCCTGCTATTCTTCCTCTGCAGTCTTGGAGGAGGCCAGGCCTGGACTGGCCAATCTTAGCCCTAGCCAGGTATTCAACGACCCCTGCTCCCCAAACTGGGGTGCTGTTTTCAGATGGAGGCAGGGCCTCTCCAGGCAGGGCTACAGGTGGAGGTCAGCACTGGGGGCGCTTTGGCTCCACTGGCCTCCTAAGCAGTTTATTAGCCTGCCCAAGCCCCAAGTGTATTGTTTGAATGGGTCTATCCCCCTCCCCAAATTGGTCCTAATTCTAATATGGTTCAAAGAATGAGACAAGATCCTAATTCTAATAGCTCGTCTTTTCACCCCCCTTTCTTATATACCTATTTTTGGAGCCTCACTGCTTATAGATTCCAATTTTTGTAGGTAGAATTTTCTACATTCCCTCTGAATGTTAGTTGTCAGTTGTATTTAGCTAATCCCATAATTCCCAGAGGAAGGCAGAAGAAAGAAGACTTCTCTGCTCCTGGGCTGGTGGAAGGGAGGTCTCGCCATTTTTCTGTCTCCTTTCTTTTTATAGTCCCAGAATTCCTATTCAGAATATCTTGTCTCCTCCCTTCCGCTCACCCTCCAACTCCCTCCACCCACTCCATCACCTGGTCTCCCCCGTATTAGGTGGGTAAAGAGAATATAGTATAGTAACCCCCCACCTTCATTGCTGGGTCAAGATTTTCACTGGTGAATAGACAACATGGTGCAAGGTGCATAATAAATATTTGTTGAATACATGGAAAAATCAATGATGTTTTAGGAAAATAATTTTTAAGTTCTATATGTCCAGGTGGCCCCAGCCTACATTCTTCAGCATTTGAATTCTGTCAAGTTGACTGCAACCTCTCTCTTTTTCTCTCTGGCTCCCCACCCCCTCCTTCCCTTGGCTCTCTGCTTCTCCCTCCCCACCCTTGGTGCAGAGGAGGCTGGCAGCTGTGTGCAGGATGGGCAGAGGTATAATGATAAGGATGTGTGGAAGCCGGAGCCCTGCCGGATCTGTGTCTGTGACACTGGGACTGTCCTCTGCGACGACATAATCTGTGAAGACGTGAAAGACTGCCTCAGCCCTGAGATCCCCTTCGGAGAGTGCTGCCCCATCTGCCCAACTGACCTCGCCACTGCCAGTGGTTGTAATTTATTTATTTCCTGTTCAACATAAATAAATTACTTGCAAGCACTGCAAACACGCTCCCATAGATGCTGGTCGTCTCTGCAAAGCAGAGGGGCTAGTTATCCATGGGACCTGGTAGCTGGGGTAGAAAGGAAAGGCCACTTCTCACTTGCAGGTTGAAACTGAGTGAACGAGCCTGAGACACTAGAGGGGTCCTTCTTTGCCCAACATCTCCAAAAACATTTGCTTCCAAGACACATGAAGGACAGATGTGATTCTACAAAAAAAAAAAAAAAAAAATCCTCTCTGAAATCATCTCTGCAAATTACTAGAGCCACTATGGAGATCAAATGCTCTGTCTGGCCAATCCACGAATTAATTCCTCCTCTGCCACCGACACCTTGTCTTCTCCTTAGAAGACTTCTATGTATGTGGTCTTCAGTGTGGAGAAAGCTCTGCCAGCTAGTGGGGAGACTGCAGGGGCAGAGGCTCCCTCTTTGAGTTATGGAACATTGGTGGTAGTTTCCTCTCTGCTATTACCTCTCTTGGAGTTGACCATTAATTCAGAAGCAAAATAATAGGAGAGGGAAGGGCTAGGCTTTGGGAGTTCTCGTGGGGACGGGTGGAGACAGAGCCCCATGTATCTGCACTGTAGTGGGTGGTTATAAACTCCCAGTTAGATCCAGTGCTGGTGGATGATATATGTGCAGGTGACCCCTTCCCAGCATTCATACAGATGTCCTATCTCCCTGCAGAGTGAGTGGGGACGCTTGTGTAGGTTTTTTGGGTAGCTCTTGCTGTCCGCTTCCTGCTGAAGTAGAGAAGGCCGTGGCAAGGGAAGTGAGAAGCTGCCTTTCCTTAACACTTCACCAACACTGGCTCCCTAATGTGCAGATTCCCAGATCCTTTCTGAGGGGCCCGTGTGAGTGAAGTGTTGATTGCCTTTACTATTTTGCTGCTACTGTGAAGGAGAGGTTATTGACTGGGGATGGCACAGGCTATGATGCTCCGATGCTCTTCATAACTCATATGCCTTGCTGTTTTTGTGTTTTTATTTGTGCTTGCTTCAAGGAGACCCAGCTCTAATGTAAGACCTTTCTAAGTACCTAACTCTTCCTCTGGGAGGGCTTGGGGTTCGGGAACGGCTCCCTACCCTGTGGGGGGAAGAGAGACTGAATCTGTGCTTTCCTTCTTGTGGCTGATTAGATCTTGAGCTCTTCATTGCCTTTTTGTGCTGCCCTTGCTCCTTTCTTTTGCATGCTGCCTGCTTTTTGAATAACAAAGTCTGGGTCACCTCCATTCCTCATGGGACCTCAGCAACCCCAGGGCCACAGTGGCCCTAACACCCCAACAGAGGGGTTCAGTGGAGTCACAGGAAGCTGCCGCCTTCCTTGATTGTGTCCTTTTACTTGTTTGATCTAATGAGTGTTTGAGTGACAAGAATAGGTATTTTTCCATCTCAAGATTCTTACCTTCTTCTTCTCTATATTTTTTCCCTTGCAGGGCAACCAGGACCAAAGGTAAGGGCTTTCTTCTTTTTCTTTTTTCATATTTTTTTGGCTTTATATTTTCTGCTTCAAAAGCAATGCTATGTTAATCCAGTCTGTGATTTTTTAGACATCAGAAGATATCTGTTTCAGAGGGTACCTCAACACAGGGGCTGCTGGCAGGGTTTTAGACTAGGGGCTTAGTGGGCTTACTCGGCTTAATCCTGTGAATGTTTCATGTTTCAGGGACAGAAAGGAGAACCTGGAGACATCAAGGATGTAAGTGCAAATTATTCTCACCCGGTATTGCAGCTGCTGCTCTAAATGGGTCATTTCCTTGTGCTCTCCTCTAACTTACCATCCTGTGGGGCTCTCTCTCACAGATTGTAGGACCCAAAGGACCTCCTGGGCCTCAGGTAAGAGAGGGAGAAATCTCTTTCTCCGTCCCTTCCTCGCTGCGCGCAAGTTACTGATCTGCAGGCTCCTGGCCTTGCTGTCATCTTACCATGTTCTTCACCTTCAGGGACCTGCAGGGGAACAAGGACCCAGAGGGGATCGTGGTGACAAAGGTGAAAAAGTGAGTAAAAAGCAATGCTGCTTGACCCTGGTGGACTTCCCAGGTCCCCCAAGGCCCCACCATGTGTTTAAGGGCCTGGTCACCTCTTAAAGAGCAGCCAAGGGACAGATGGCTCTTGGAGAAACACTGCTTCCCATTGATGCCTTTTTCTCTTTATGCCAAGGGTGCCCCTGGACCTCGTGGCAGAGATGGAGAACCTGGGACCCCTGGAAATCCTGGCCCCCCTGGTCCTCCCGGCCCCCCTGGTCCCCCTGGTCTTGGTGGAGTAAGTATCCTTACTTCCCATTCCTTCAGGCTGTCCCTCCAGAAATGTGGCTTTTAAATTGCTGCTTGCACTTACCTGGCTGGCTCCCAGGGCTGCCAGCAGTGTGTACATAGCCTGTCCATGGGCTTTGCCCTCAGGCCTGTAATTTAGAAGAGTCACATATTAGGCATGAGACTGTGGTGCTAAGGGCTGGCTTTTTTCACTAACTGGGATTCTATAAAGAAAGTCCTCAGTTACCTGGCTTCCTGGCATCTGTACCACGTAGTTGATGCTGGGGGGTGGGTGTAAGGGATAGGAGGAAGGATGACTGGGCACTTGTATTTCCCTGGAAGACGAGTGACCACTGTCCTTGGAAGACATTTATCCTTGGTTCTTGCCAAGTACATTCCAAGCAACTATTCACTCTCATGAAAGAGCTCCACTGAGTGAAGGTGTGTGGCTAAAGTCAATTCTGGAATCAAACCAATCAACAAATTATATGATTGCCTAGTTTTTGCAGGTTTGCTATTTTGATGTTTGCTGTATTTTAAATTCTTAAACTCAAATGGGATCACAGATGCCTACTACATCTCTTGCTGAAATATTCCAAGACTGTTGATTTTAGTCTTTTGCTGGGCACTAAAGTCTTAAAGAATAAAGAACACCCTTAGAAGGTTTGGTTATGTTTCTCCATATACGTTAAATAACATCTGTCATATTTTAGAGCATAAAAATAATTTTATAAAATGAAATGCAAGGAACTGATACTTCCTCAAATAACACTTTCCCTTCCAGTGAAATGATTTTGCCACTGTCATCTAATAATCCATTCCCAAAATTACTTTCCAGGCATCAGTGGTAATTCTGATCAATGATAGGTTAGTCTCCAACAATCAGAGTTTATCTCAGTAGAGTTCTTTGTATCCATATAGAGCTTACCTAGCCAAGTAGGGAAGACCTAGTGCCTTTCAACCTCCTAACGTTGTTGGGTTTCTTTGCAGAACTTTGCTGCCCAGATGGCTGGAGGATTTGATGAAAAGGCTGGTGGCGCCCAGTTGGGAGTAATGCAAGGACCAATGGTAAGAAAAGACACTAGTTCTTTGCAGCCAAAATGGCAGGAGGTGGCCCTTAGCAGAGCCAGAGAGTCTGACAACCTCTGCTTTACAGATAATTGCTTAGAGTGGCTCTCCTCCGTAGTTATGTAACCTCCCATTCAGCTAGCCCAAAGCATTTGGTTTTTAATGGCAATGGATGCCACTTTTAATGATGCGCTGGAGTGACTAAGAAGAATGAAGATGGGGAGATGCATATAGGCTGATCTGTTAGAAGACCAGTTGCTATTGCTCTTGGAATGAGAACTGAAGAATGCAGACAGCAGCTACTGTTCTCCAGCATCCACAGACTTCCAGCAGGAAATCTCAGCCCGCAGCTCTGACTTGGCACATGCTAAATGAAACTCAGCCTTTAGTAAACATGGCTGCTGTCCAGGAGAAAGCAAGGCCAGCTTTTCTGTCCAAATGGTGCCTATAAATAAAAATAGAGTGTTGCGTGGGGAGTGGGAAATGAGAGGGAGCAGCCACTCTAGGCCCCTTGCCCACAGAGTAACTTCTTGTCCTTTGCCCGGGCTGTTGGCTGGGAGAAGATGGCACACTGGAGGCCACTGAGGAAGCATGTGTAGTAAACCCCTCATTTTCTGTTCCGATGCAGGGCCCCATGGGACCTCGAGGACCTCCAGGCCCTGCAGGTGCTCCTGTAAGTATCTGCAATTCTTTTTGCCTCCATCGTGTCGCAGATGATTCCCAAGCACTATGATGTTTTAGCAGTTTATAGGGATTGACCTGGTATCCTCATTTTACTTTTTAGGGGCCTCAAGGATTTCAAGGCAATCCTGGTGAACCTGGTGAACCTGGTGTCTCTGTGAGTACCAGCACGGCCCTGTCCCTTCTCTGGGGGAGCCTCTAATGATAGACCACTAGGACCGCAGCTGCTGTCCCTCCCAGGCTCTGCCCAGCTCTTTCCCACAGTCGGTGGCCCCAAGGAAATTCGGATGTCACTTCCTAGCTGTGGAGGAACTCTGACAGACAGCCCAATGTGGCAAGGACCACCAGGGACTCTGTCCTAACAGCCCCCTTTCCGGGTCACCCCAGCCTGTGCTATCTGCTGCGTCCCACTATGATCTCTGCACCTTTGCTCTGACCTTCCCATCTTTCTTCTTCATAGAAGAACTGGCTTCCAAAACTACAATGTCAAAGTTTTGTCCATTGCTTAGGTGTCTTCCCACTATAACCATCTCTTAAACTATCTTCCTTTGTTTGTAGGGTCCCATGGGTCCCCGTGGTCCTCCTGGTCCCCCTGGAAAGCCTGGTGATGATGTGAGTATACACGAGTAGACAAATGAGGAGCTGCCTCCTTTGAAAGGGCCTGGAGAGGGTGTGTGCTTGGGGAGTGACAGGGAGGCACCCAGGGTGGAGGTATCTTGAGGAGCAAGACTGGGCAGTCCCAAACCCTGACGCCATCTCCTATCTATATGGCCACTGTGACTGTGCTGGCAAGTTCCCTGGGGACCGCTTTGGATCCAAGGGGAAGACAAATAATTAAAACATCATTAGCCCCAGGAAGGGAAATTGAGAAATGAGAGAAGGGAGAGAAAAAATACAAGGCAGAAAGATGTAGAGAAGGAAAAACAAAGAAAGAAGCGTTCAACAACCCAGCATTATCTTAATTGTAAATGAGTTAGAAAAAGCACAGCCTGAGTCAGGATGTCTACAAAGGATGCAAACGAAATGAAGAGACAAGAATTGGCACTCTTGTGCTATTTTTATGAATTGCATTAGACAGTAAAAGTCTCTTGAGGTTAGAGAGAGCACATACAGTCAGCAGAACCTAGGAGAGGAGAGAAAAAGCCTCTCAGGGGAAGTTGGAGGCTGGTGAGGACAGAGGAGCTTGCCCATGGGCTATGCATGTGTCCAAAAGAATAAATGGTGACCCATGAAAGGCATCCAGGCACGTGGAGTCTGAAGGAGGTGAGGGAGATGAGTGAGCCGGTAGGCAAAGGCATGGAGGGCTGGAAGGAGGGAAGCCCTCTGGGGTGCCCCCACTATGCTACTGCGTCTCTGAGGAAGCTGGGATATCTCTCTCTCTCCCTTCAGGGTGAAGCTGGAAAACCTGGAAAAGCTGGTGAAAGGGGTCCGCCTGGTCCTCAGGTAAACGCCACCGTTCCCAGCCTCAGGCATCTTTCCTAGCGTCTCCCTCCCTGTGGCCTTAAACACAGTGCATCCAGTTCAATGAGGTCACTTCTGAGATGAAACGCCAGTAGCCCCTATATTTATCACGACCATGTTTGTAATTTCCACTCAGGCTCTCATGAGGGAGGCTGGGCAGTTGTTATTTATACCACTTTGCATAAAATGGGGGGTACGGGGAGGGGTGGTCTGGGTTTTACAGAAAGAGCTGTCCAAGTGTGGGGATTCGAGACAACGCCCTGGTGGCCCAAGGGAACTGGAGGCCCTCCTGCAGCCCAGGGCAGCTTTCCACTGTTATTTTACTCTGTGCTCTGAACACCTCCACTTTGGATTGCAGGGTGCTCGTGGTTTCCCAGGAACCCCAGGCCTTCCTGGTGTCAAAGGTCACAGAGTAAGTATCACGGGTGAGAAGGTTGGAAGGAAGAGATGCCTGGTGGGAGAGAAAAGCACTTTGGGGTGCGTGCATTTCTTCCAACTTGGGTTTCCCAGAAGTCTGATTGAACATTTTCTCTTGTTCCCTAGGGTTATCCAGGCCTGGACGGTGCTAAGGGAGAGGCGGGTGCTCCTGGTGTGAAGGTGAGAGGCCAGAAAGTACAATGGGATGGGGAGGAGGGAGACAATGAGGAGCCCCTCTTCCTAGCCAGGGAGACACTGTGGAGCTCAGTGGAACTAGCTCCTCAGAACAGCCTTGGCTGGGAACACCAGCCCTACATCCTGATGGGCCAACAGCAGGCCTGGAGAGCTCAGGGCATTGTCCCTCACAGGACTGAAGTTTGTGTCAGTGCGAGCTGAGATGACCAGGGCTTTTGGCGTCTTCCCTAGGAGTTTGCTGGCGGCCAAGAATGGGGTCCCAGACACTGACCTTGTGCATCATTTTTCCAGGGTGAGAGTGGTTCCCCGGGTGAGAACGGATCTCCGGGCCCAATGGTAAGTATGGACACCCTCCAGGAAGGTTTATCAAAGACTCTTCAGACTATCAGATGGCTGCAAAGAGCTCCCTTTGTGCAAAGTTCATATTCTGTGTTGTAGATTTCATCTGATTGTGAGCAAAAAGCAAAATGTATTAGACAGATGATTTGTTCAAGATTTCACCAACATTTCCTTAAGATACCCATTTTATCACACTAAAGATGCTCCCATTTAAAAAAATTCTGTTGAGTCTCAACATTTTGTCAAGCTCATCTACTGCAAGGAGCAAGGTGTGCTTGTAACAAAGGTTCCCAATAGGTAGCAACAGGAACATTCGTGTGTTCCGCCTGTGGAGAAAACTGTTGGGTGTGATCTGAGGCATCCTGGCTAGTCAAGGAGCCAGCACCATCAGGAGGTCCTTGTTTTCCTGGGTGTGGGCATCCTCCCTCTCCTCTGGTATCCGCAAAGGGCCTGCAGGTAGAAATGGTCACCCTGAGCACCGTAAAGCCAACTCATGCTTAGGCTGTCCTGGTGTGTGTTCCAGGGTCCTCGTGGCCTGCCTGGTGAAAGAGGACGGACTGGCCCTGCTGGCGCTGCGGTGAGTAATTGACAAAGCCAAACACCACCATTTGCCGAGCACTTTAGAGTTTACAGGTTTGTTTCTCTTGACCCTCGAAACAACCCTGTGAGGCATAGGGAGTATTGTTATCCCTTAAGAATTCACCCCCAGTGTGCCCATCAAAACTTCCCAGGCTGAGTCTGCACAGTTGAAGGAGGAAGGATAGGAATGGGAGGGTCGATGGGTGAAAGCATGATTCTCTTAACCAGTCCAGATTATCAGGTAATCCCTTCAACAACCACCACCCACTCCCTGGGCAATCCAGCTGGAGTTTACAGACAGACTTAGCTGGCTATAGCACCACCGTGCTACTCTCTGTTCTTCCTGGTTGCTCAAATGCCCTAGAAAAGTGGAACAGGTGAGCATCAACTCACAGGGCTCTATGCTGGCTGCTGCTGTGAGGGATGTTATGCTATAGTACCAGGGGCCACCATTCCATAGGCACTTCCTGTGTTTAATACCCTATATGCTTTACTTCATCTCATCTTCCTCCATATCCTGAGAGGTGGTTCTATTCTTCTCCCCATTTTACGGATGAAAAAACCGAGACACAGAAAGGTGAAATAGCTTAAGATAAATAGTGCCTTGCAGCCTTAGACTCTGGTGGCCTCTAGTTAATGTGGGAAATTAAGGGTGAGGGGATTGGCAGCTGATGGAGGGTGCAGGGTGCCAGACAGAGGCGTTTAGCTCTGATTCCTTAGCAATAGAGAGTCCTTGTAGGCACTTGGTCAGGCGAGTGATGCGATGAAAGCTGTGTTTAAGAAAGATTATGCTTTCTGCTGATTTCATACCCCCAACACCCAAGCTCTGAGGCCCCTCCTCACAGGTCCTTGCAGGGCTGGCCAAAATAAAGCAGCTTCACTCCGTTGTGCTGCTTTCCAGCTAATGTGTCTGTTTGGCAGAAGTTTCCCTCAAAGGCAGATCAGTGAAATAAGCAGAAGCCTCGACCCCCCTTTGTCAGCCAGAGCTGCTGAAGTGCCTTGCCCCAGGGTCACTTTGTGTGAGGGGATTAGAGAGCACTGGGGCTGCCAAGAAACACTGCCGTTTCTACAGATTAGCAGGATGCTGGCTTGTGGCCTTTTAGCGAGGCTCAGAGCTGCGGTGGCCCTAGTCTGCATGGGCTAAAGACAAGCTCCATCTCCTGTCCTTGTTCCCTCCTTCCTGGGCACAGCCGCCCTGCTTCTTGGTTCTCTCTGTTGGTTCCTGTCCGCACGGTAGTTAGGCTGGCAGCGTGTGTAGGATTTGGCTTAGAAGATTGACAACATTGCCTTTGAGCCCTTCTTTGCTACTCCTCCCTCTCCCCTCCCATCAGACTCCTCTCTGGAGTCTGCTCTGCGAGGCCTCTGCTCTGTGGTATCCCAGCAGCCTTCTCAGCCTTGACTTCCAGAAGGGGGCTGTGCAGTGTCCGGGGTGTGCAGGCCCCAGACACGGGGTAGGCTCATGGAGATCCAAGTGCTGATCTAGTGTCAAGGCTGGCCTGGAGACTGGGCTGGGTTGGTGTCTGCCTGCTGTGGTCATGTGCCCTCCCTTGGGCCTGTATCCTCTCTCCAGACTTGCTGCAGGGAGAGGTGGCAGATGTCAGCCTAGTTCTGGCCTCTCAGAGCAGCATGGCAGCTCCCTTTCACTCAGGCCCAGGCTGGGCCCTCCTGCTGGCTGACCCCTGGGGAGAGGGTGCTCCAGAGCTCCCCAAGGAACTGCTTCCCGAAGCAGCCAGGCCAGCCCAGAGGGGCTGTGGCCAATCCTGAAGCTTTATGTTCCTGCTGACATTTTTTCTAAGTTTTCTCTTGCTTTCCTCTTAAATGCCAATCTGGAGAGTCTCCGTTAGGAGAAATGGACCCCAGCCAGGAAGAAGAGTTGAGTTGTATTTAAAACACGAGCTCCCCCTAAAGCATCCTTCTTTAGCTTCTAAGGAGAGGCAGAGACTGACAGGCAGGACTCAGCAGGAAAAGGTACCCCCCTGACCTGCTCAGTCAGGCCCTAGGCCCAGCTCCACCCAGCCTGTGGCCCCCAGAGTTTCGGTAAAGAGTTCCCTGGGCCTTAAGGAACCTTGAGAGAGCATTTGAGGGGTGCCACCACAAACTTGGCAGAAAAAACCCTCCCCCTCCAAGTCCAGTCCTAGAGAAGGAGCTGGCAACCTTGCCTTGCTTTGTAAGCAAAAGCCTCTTAGGGCTTGAGCTCAGATGTAGTGTTTGAGCTGTGGCTGGTGCCCTGCCCCATCAGGGAGCCAATGGTAGACATCCTATGGGCATCTTTGTTTTCCGTAAGAGCAGGCTGTCTGGGGATGGGCCAGAGGAAGAGGCAACCTGGAGTCAACCAAGAGGAGGCCTTAACCAAGCCTTAACCACAGAGGTTAACCAAGCCTTGAAAGCGCTTCCCCCTGAGCAGGCAGGAAGCACTGAGTCCACATGGTTGCCTCGCTGTTTCATTTCCTTACACTCAATTCTCTCAGTCTTTAAATGATCACTTGGCCTTGAAGTTACGGATATTTGGGGTCTGAACTGAAGTTGAAGAAAAGAGAAAATGATTTAAGCTTTGTTTAAGATTAGGGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAGCACCTTGGGAGCCTGAGGCGGGTGGATCACCTGAGGTCAGGAGTTCCAGACCAGCCTGGCCAACATAGCAAAACCCAGTCTCTACTAAAAATAACAATAAAAAAAATAGCCAGGTGTGGTGACACATGCCTGTAATCCCAGTTACTCAGGAGGCTGAGGCAGAATTGCTTGAACTTGAGAGGTGGAGGTTGTAGTGAGCCAAGACCGCACCACTGCACTCCAGCCTGGCGACAGAGCCAGACTCCGTCTCAAAAACAACAACAAAAAAAGATTAGAAGAAGCCCATTACTGCCTTCTGGCCACCCACTCGCACAGACACCAAAACTGCAGCCCACACCTCGCCATCCTCGTGCTCTGCCCTGGGACACCCCAGGCACAGTGTGTCCTTCGTTTTCTGTAAGGGTGGGCTGGGAGCAGGGACGGACAGGGCCTGTGGGCACCTCTCATGGTCACTTCCTTCTTGCTCACAGGGTGCCCGAGGCAACGATGGTCAGCCAGGCCCCGCAGGGCCTCCGGTAAGTTCATTTCATCCTCAGCAGGTCATTGTTGCTGTGCTTTAAGTCCCGTTAAGCAGCCCAAGGCAGTCTGCAGGGTGTATTGGGTGCAACCACAGCAGCACTCTGATGTCTACTGGAAAGGGGGAGGAAAGAGAAGAAGTTTGTAAATATCAATTGAGCATATCGATAACAAGCTTTGAAGCATGGGCTCATTTTCCTCAGCCATCCTTTCAGCAGTCTTTTTAGAGGAGGGAGGTCAAAGGAGTTTCTGCTTCTCACCACAGATGTAGTCAGAAACTTGCTTTGCCTTCTGAAGCCAGGCAAAGTTTCCTGGGGACGCTGGCAATGGGGACAATTTTCATCCAAGGCCTTTTAGCCACAATGGATATGGAGTGAAATCAGTACAGAGGAGGGAAGGAGTGTGAGGTGTCGGGGTGGCTCGCTTTGGAGGCCAGAACTGGCATTCACCTCTCTTCTCATCCGCCTACTCTCTCCAGGGTCCTGTCGGTCCTGCTGGTGGTCCTGGCTTCCCTGGTGCTCCTGGAGCCAAGGTACGTGCCCTGTTGTCCAGTCAGGAACTTCTGGGTGCCGAGAAGCTGTCCTTTCCCCGTAACCCTTGCTCATTGCTCCCTCAACAACCACCTGCTCCCTTCTGAGAAGTAGCTCCCCACCACCCCACCCACTGGCCCCTCCATCCAGGCAGGGCAAAAAGCCAGACACTCGCAGTCTCACCTGGAGGGAAAGTAAGACAGAAGATAAAATGTGGGAGATCCAGTTACAACTTTGGAGTGGGGAAAGGTGGACAGAGAAGAAGACGGGGATACACCATAGGCCTGGCAGGGGCAGAAGGCCAGGAGTGGCAGCACAGGGAAGCAAACCTAGGGGAGACCCAACAGCTGAGCAAGCTCGGGGCCCTGACGGGCACTGGAGGGAACTGGGCAGGGAAAAGGGCACAGGCAGGGAGCCCCTGCTCCCCTCTGGGTTTCTGCTTTATTTGGGGTGCCTGGCTCTTCCAAACCATGTTAACGGAGTTCTCTGGAGGATTACTAGAGGCCAGTGGGAGGCCAGCCAGTTCAGGGACAGGCCTCGCAGCCCAGGAAGGATTCCAGTGTGAACGTCCCTGGGAATGAATAAGGAGCCTCCATGTGTCACTGGCATCAGGTTGCTTTTCCCCTCCTGGGGGTTTCCATGGCAACCAGACAGTGTCTGAGGTCCCGGAGCCGGGTGAAGGAGACCCATTGTGAAGAGGGACAGCGGAAGGTGAGGGGGGCTGACCTTTTGAAAATAATAATTACCACAGTGAAGCAGGAATGTTCTGAGAAGAAACCTGAGGAGGCTCTGCCCTCTCTCCAGGTCAGCAGCCCTCCCCAGGGACTCTGCCATCTAGAGTGGGTTGTAATTTTCAGGAAAAAATGAAAGTAAAAGCACAAGCCATTTTGTGGGGAGGGGGCTTGCCAGAGGCGCCCGCTAAGGGGAATTGGGCTGTATTGAGAGCAGGGAGGGGCAGAGTCCCCATGTGCTTTTGCCTTGGCTTTCTGGCTTACTGAGAACAGACTGGGGCCGGAGCCAGGGTGTCACTGTTCACCCGTCAGCCAGATGGGAGTGAGGTGGTGCTCTGAGCTGGGATGTTCAGAGACTTAGAAGGGACCTCAGCTCCTCAATAAAATAGAAAAACAGGAGGTGGGGGAGAGAGCGGTGTCCGTCCATCATCCCACGGTGCCAGGATGGCAGGGTCCCCAGCCCACGCTTTTCTGATGGTGTCGATGGAACAGCAGGTTGCCCATTGCTGTAGTATGTAGCTGTGCCGTGGCATGTGGAGGCTCACTGTGTAGAGATGAGGTAAGCAGTAGAGGAGGCAGGCGTGGGAAGTCATCAAGTCATCAGCTCGGTCAGGCAGGGAGAAAAACGGCAGCGTGAACTGTGTGTGAACGCACATGTTCATGTGCAGGGTTGGGTGCATGTGCATAATTTAGTGCTGTGCTTGCAGCTGGCCCTGAGCTATTGCCCACCCACTAGAGGTCTGTGTCCCCTCTCTTCTTCTTCATTTCATCCTCCCTGTCTCTTCCCAGGGTGAAGCCGGCCCCACTGGTGCCCGTGGTCCTGAAGGTGCTCAAGGTCCTCGCGGTGAACCTGGTACTCCTGGGTCCCCTGGGCCTGCTGGTGCCTCCGTAAGTGCAGCTTCTCTTTGGCCTGGGGGGGTCTGGGGTCTGTGGCTTTGGAACTCTTGACTCTGTACTTTGCTCTGACAGTTGTGGGCTCCAACCACCAAACCTTCATTCTGGCCCAATGCCTGTCCCCACCTCTAGATGTATTCCCTTCTATCCCATCTTCCCCTTGAAACACATAGTGGGAATGTCCCTGAAATGGACAGCACCTATGCCAGGTCCCTGGATCTGGATCCTGGAGGGCTGGAGGTGGTTGGGGTTCATTCTTTGCTGCTTATTTGACAATGTCTCCCTTTTCAGGGTAACCCTGGAACAGATGGAATTCCTGGAGCCAAAGGATCTGCTGTGAGTGTTGCCCGTGGACTTTGCTACCCCAGGAGAGCCCAGTCCTGCCTCTCCCCTCTCCTGACACCCCTCCCTTCTTCTCATGCCCACAGGGTGCTCCTGGCATTGCTGGTGCTCCTGGCTTCCCTGGGCCACGGGGCCCTCCTGGCCCTCAAGGTGCAACTGGTCCTCTGGGCCCGAAAGGTCAGACGGTAAGAGCCCAAAGTGACCCCCAAGTTCCACTGACATCTCTGGAGTCAAACCCCATCACCCCTCTTTCCCATGCTCTCCTGCCCTGGCCTCACAGCGGCCTCCATCCGAGGGCATCTTGAACAGGGGTTCTGGGGAGGGGCAGGCTCCCTGGAGAGAATCTGGTGTGAGGACCTGCCTCTCTTTTCAAGGGTGAACCTGGTATTGCTGGCTTCAAAGGTGAACAAGGCCCCAAGGGAGAACCTGTGAGTATCTGCCCCCAAGCCCTTGTCTTCTCTGCTGCTGTTCTATGAGGCACAGGCCTCAGCCCCACTGACCCACCACCTCCCTCCTCCAGGGCTCTATCCCCCAATCTGGGTCCTTTCAGATTATGCCTGGAGGAGACTTAACAGGGCTGAGAAGGCCCAGATACAGCTTCAGCTCCCATCCTTGGTTTGGCTAGTGTGAACAGTTGGATCTTTAGCCCCTCTCACTTCCCTCTGCCCTGCCATGGCTCGTCCTTTATGGCCTCTCGTCCTCAAGCCCCCCCCCAGCCCTGAAACAGTTGCCAAGGCTACTTCCTTCATACTCTGAGTCGAGGCTTGCTCCAAGGCCAGGTGAAGGCTCACTCTGTTTCTCTTTTTTGCTGGTCCTCAGGGCCCTGCTGGCCCCCAGGGAGCCCCTGGACCCGCTGGTGAAGAAGGCAAGAGAGGTGCCCGTGGAGAGCCTGGTGGCGTTGGGCCCATCGGTCCCCCTGGAGAAAGAGTTAAGTGAATGTGGAGGCTCCATCCCATGGGGCCTGTGACCTCGAGAGGGAAGTGGAGTCCTTGTGGTCCGTGTTCTGGTCAAGTCTCGTGACTTTTCCGCATGTCATCCTCCTCTTTCTCCATCCACACCGCGGGGAGAGGGAGTCTGATCCTGATTTGTGCCGCCAACCACCAGACTGACATGAAATAGTCTGAGCTCCTTCCCAGGAAGCGGGGCAGGCTCCAGAAGTTAACCTCTGAGAATCCTGCAGGCCACAGCTACTGCTCCCCAGAAATTGGGGTTGGTGGGTTAGTGGGATGGACCCACTGGAGCCTGGCTGGGTTGGGGCTGTTCTCACTCACTGCCTCTCCTCCCTGTGGCTCCTTAGGGTGCTCCCGGCAACCGCGGTTTCCCAGGTCAAGATGGTCTGGCAGGTCCCAAGGTGAGTGGGAGAAGAGGGGCTGGGGTCCCTCCCTGCATCGCTGAGGTCACATGGTATCCCACTGACTCCCTGTGTACCCTTGTAGGGAGCCCCTGGAGAGCGAGGGCCCAGTGGTCTTGCTGGCCCCAAGGGAGCCAACGGTGACCCTGGCCGTCCTGGAGAACCTGGCCTTCCTGGAGCCCGGGTAAGTAGCAGAGCTGCTGTTGCCCTTGGCTTCAGACCCTCAGGCCCTTCCTGGCTGGCTCCTTCCAGCCCTGCACTGCCAGGATTGGGAGGTCCTGGGGCCGGCTCCTGACCCCACCCTCTTCTCTCTCCTGAACAAAGGGTCTCACTGGCCGCCCTGGTGATGCTGGTCCTCAAGGCAAAGTTGGCCCTTCTGTAAGTCTATCCTCTGAGGGCTGCTAGGAGGGTGGGGGGATCTCCCTGGGGAAGCAAGGGAAAAGAGAGATGGAGTTTGGGTTAGGGAGGCCTGAAGTACTGTGAATTTTGAGAATTGTGACAGGGGGTAGATGGTAGGCACTGGGGCCAGATGTAACCTGTGCAGTAGCTGTGAGCACTGAAAATGCCACCCCAGTATGCATTCGGGGCTTATCCTTGGGGGAATGATGACATCGTGTGTGCACTTTCTGGGGCAGCTTTCTAAGCTCAGCGGTGTCTTGTTGTAGATGGGCCCATGGGTGTGATGTGGTCAATCCTAGATGCTGAGCATGTGTGGCTGGTGCCTAGTCCTGGGCCTGCCATGTAGGCCCTTAGTGGATGTTGGGTGGATGGATGTGGTCAGAGTGTCTATGTTCTGAGAATGGTGTTCTGTCTTTCAGGGAGCCCCTGGTGAAGATGGTCGTCCTGGACCTCCAGGTCCTCAGGGGGCTCGTGGGCAGCCTGGTGTCATGGGTTTCCCTGGCCCCAAAGGTGCCAACGTAAGTAATAATTTGCTCTTCTATTTCCTTCCATGTGGTGCTACCTACCTCCCTGCCCTCTTGGGGAAAGGGCTGGGTCCTGAGTAGAGTTTAACCAGGGACAGTGATGAGTGGGGCTCCTGTGCCATGGGTGGCAGTGGGGGTCTGTATGTGATTTGGGGAAAATCCATGGCCCCACAGAGCCTCGGGGCATTGCGGCCATAATTGTTCCATGTGGCAGTGCCCAGCAGGCTGGTTGCCATTATGGCCCCTGAACAGAAGAGAAGGGCTGATACTTTGCTTTATCTTGGCTGTCCATCAGGATGTGGCCCCAGGCCTCAGTCCCTGCAGCCCGCTCTGCCCCCAACTCCCTCCCAAACCATCCGCCTCATGGCCCTGCCCTCTCTTTCCTTCAGGGTGAGCCTGGCAAAGCTGGTGAGAAGGGACTGCCTGGTGCTCCTGGTCTGAGGGTAAGTATCCTTCCCCGCTGCCCATGACTTGGTGTTGGCCGGGCATCTGCAGGGAGGACAGGGGAACGGCCTCCCCATGGCATGGTCCCGGGACCCCTCAGTATTGAGTGTTGATCTCTGTGGCTGAGCCCCATGCTGGCTGGGCCCTTTGGGTGTCTACACAGGGAGACTTCTGTTTGCCATTGGTCAGCAGGCCGGGGAGCTGGGGAAGGCTTCCATGCTGAGAACAGCTAAGAAAAGACGGGGCCTGGGAAGGAAGGGAGGGGAAGGTGTGGAAATGGAGCTCAGCTGGGGTACCGTGGAGGTCTGGAAACTCTGGGCCAGAAGTACCTTTGCCCAATCCTAGGGGGACTGCAAGTGGGAAGAAAAGCGTGTCATTGACTTTTCTTTTTCTCTTCTGTCTAGGGTCTTCCTGGCAAAGATGGTGAGACAGGTGCTGCAGGACCCCCTGGCCCTGCTGTAAGTACCTGCCCAGCCTCCCCAGGTGGCCCTGGGGGCAGGGGCTGGGAGGGGTGGGGGTGGGAGAGCCCATCCATTAATGGAGCTGACAGATGTGAATGTGGGCTGAGCTGATACACCAGACTCACTCTGAGCTGAGGCAGGGTGTCCCAGGAGGCTGTGTGGACCCACATTGGTGGAGAGGAGTGTGGGTGGCTGATGGGAGTGCAGGGAGGCATGCATGCACTGTCTGAGTGGTGCAGGAAGACGCCTGTGCTGCCCACCCTGCTGACCTCCCCTGGGCCCTACTAGCTGTGGCTCTCAGGGTCTCTGGAACACTGGCTCAGCTCACCTTTTCTTTTCCACTGCAGGGACCTGCTGGTGAACGAGGCGAGCAGGGTGCTCCTGGGCCATCTGGGTTCCAGGTAGGTGGCTGGACCAGGCTCTCTGTGCAGTCCTTTGCCATACCCAGGGCTCCCTGGGACAGCAGCAGGCACTATCGGTGGAGGGCCCACACCTCTTGCAGGGTGCCAGGCATCGAGCCTTCCCTGCACCCCTGGCTGTCACTGCTGCTGCTTCCTTTCTTTGGGTCTGCCCTATACTGTGCCTCCCTGGGGGCCAGGGCAGCAAACTCACTCCTTTGCTAACGCTTGTCACTTCGGCTTCTAGGGACTTCCTGGCCCTCCTGGTCCCCCAGGTGAAGGTGGAAAACCAGGTGACCAGGTGAGTATGGGGCTCTTTGGACCTGCAACCTGTTTAGATGGGAAGGTCTTTTCTGATGCCTAGGAGGCAAGGGCAAGAGGGCATGAGGAGCCCTGTGAGGCCTGGGAATGTCCTGGACCCATGTCCCAGCCTCCACAGATGACACAATCCCCCATGGGAGGAGTGATATTCAGCCCTGCTGTGGAGAATTGTTCAGGGGTCTGTGATATGAAGCCTTCACTCTCACACATCTTTCTTTGTTCTCCAGGGTGTTCCCGGTGAAGCTGGAGCCCCTGGCCTCGTGGGTCCCAGGGTGAGTATCCTGTTGGCCAATGCGGGCTGCCTCCTTGGGCCTGCCCTGGGTCCTATGCTCCTGCTCCTTTCCCCACCTCCCTGCTTCTCCCTGGACCTTCTCCCCCACTGCTGTTGGTTGATCACTTCTTGGTGTCTCTGCCGCAGGGTGAACGAGGTTTCCCAGGTGAACGTGGCTCTCCCGGTGCCCAGGGCCTCCAGGGTCCCCGTGGCCTCCCCGGCACTCCTGGCACTGATGGTCCCAAAGTAAGTGAGGCTGCATCCTGTAGGGGTCTTCGTGGTAGCCTGGGAGTCCCACTGAGCAGGGAGAAGAGGAGCGGGCTCAGGAGGAATGAAGAACAGAAGTGGGGGGAGCTGGAAAGGAGGTCTACATGGGAGGAAGGGAAGGAAGAGGGGTTTGGGGCCCTGGTTACCCAGGCTCCATGAACATGGGTTCAGGGAGAGGTGCTGTCCACTACAGACTCCCTCTTACCTCCCTCCCCAGGGTGCATCTGGCCCAGCAGGCCCCCCTGGGGCTCAGGGCCCTCCAGGTCTTCAGGGAATGCCTGGCGAGAGGGGAGCAGCTGGTATCGCTGGGCCCAAAGGCGACAGGGTAAGTACTGAGGTTACAGCCTCTCACCAAAGCTGTGGCTTTGCCACATTCCTGCCCCTTGTGATCGCTTCCGTTCCCTTATGGCACCTGGTGATGAAGGTTTCTGTTAGCCCTTTTTGAGGAGCTTAAAGACTCCTTTCCAAAGCTCCCTGCCTTTTAGTGACATCCTTTCCCCTGTTCCTTCATCTCACCCCTGCTGCTCCTCACCCACCCTGAGACCACAGCAAATTCCTCTTGGGCAGGGACTGGGCTTTCCCTAGCACCCCAGCCTGGGTGGGACTGAGCAAACCATGGGGGTCCTGGGGTGCCTGGCTGAGGCGGCTGGTTTTCTCTTCCCTCAGGGTGACGTTGGTGAGAAAGGCCCTGAGGGAGCCCCTGGAAAGGATGGTGGACGAGTAAGTGAATGCGGGCTGCTGGACTGCTGGGCATTAGGATCCTAGCCCTGCACCCAGGAGAGCAGGAGAGAGGGCTGGGCAGTCTGCCACTGGGGTCCCTGGTCCTGTCTCTGTCGGGGCTGGGCAACTGCAGGGACTTCTCTGTTAAAATGGGGCCAGAGGGTAAGTGGGAGCTCTGGAGGCGGTGGGAGCACGCACCAAGGTTGGCTTGGTGCCGGGCCGCACGTGCTCGGCTGGCTCAGCCTGCCTCCCTCACCTCTACCTGCTCTCCCCGCAGGGCCTGACAGGTCCCATTGGCCCCCCTGGCCCAGCTGGTGCTAATGGCGAGAAGGTGAGTCCCGGCTCCTTTCCTCTCCACACCTTGCCTCCCTGTCACACCTCCTTCTTATCTCCTGCCAAAGGCGGTTCTGTCTTGTCCTCCCTCACCACTGTCACCCTCGGCCAAGGCCGTAGGAGTGAAGAGGGGGCCCTCTCAGAAGTGAAGCCGCTGGCAGTGTTCCCTGTTGGGTGGGGCAACTGGGCTGGGGTAAACACACATTCAGCAGAGGCCCTCGAGAGGGTGCGGGTATGGGCTGCACAGTAACACAGGCTGTGCCAGGGGGACCTGGAGCCCCCTTCCCACGAGCAAGGCCCCCCAAATGCACTTTGCCCTCTCCCACTCTGCCTCCCCACCTTCTTACCCCAGCTCTTCCTCCCTTCCCCACCCTCAGGGAGAAGTTGGACCTCCTGGTCCTGCAGGAAGTGCTGGTGCTCGTGGCGCTCCGGTGAGTGTCTGCCCCTCTGAGCCTGGCTCTGCCCGAGGCCCCTGGGAACCAGAGAGCCAGGGAGTCAGTGCAGGCCCTCATGCTGCCTGGTGGCCCTGTGTGCTGCCAGGCACTGGCTCCCTCCCTACCCGCTGGGTCTAGGGTGGGAGGAGAGATGGGAAGGGAAGGGGGAAGGCACGTCACTCCCATCATGTGTTCAGGGTGAGGGCTTTTGGGTTAACAGAGCCTCTGCCTGCGTTCAGGACTAAGGCTGCTTTCAGATCCCCGTCTCTGGGGAACAGGAGGCTGGGCAGGGCCCAAGGGGCTCTTGGAGGGGAGCAGAAGCAGGTCAGGCAGCGGGGCCTGACCTCTCGCCATGCCCCCTTCTCTCACAGGGTGAACGTGGAGAGACTGGGCCCCCCGGACCAGCGGGATTTGCTGGGCCTCCTGTGAGTATCTCTGTCCATCCTCCTGGGTCCCTCCACTCAGGCCAGTTCCACATCCAGCACCCTCGGGCATCGGAGCTTGTCAGGGAGGGAAATGGATGCTCCTCTCCTCTCCTTTCCCGCCTCCATACTAATAGAACCATCATGTCCAGACCAGGACACACACGCAGATACTCACAGAGTCTCCTGCTCTTCTGGAAGAGCTCCAGGGTTTTAGCCTGCCCCTCATTCACCTGCTTCCTCCTTCCCATTATAGGGTGCTGATGGCCAGCCTGGGGCCAAGGGTGAGCAAGGAGAGGCCGGCCAGAAAGGCGATGCTGGTGCCCCTGGTCCTCAGGGCCCCTCTGGAGCACCTGGGCCTCAGGTGGGTAACGCTGCACTCCAAGAATTGTTCCCTCAAGGAAGGGCTCCTGGCGTGCAGATGGGAAGGCCCCAGCAGGCTGCGCAGAGGATGGTTCGCAGGCCTGGGAACACCCCCATGTTGGTAGAAGGAGCTTCCATGTGGCATGTGGGCTGTGTGGGTGGGGTGTAGGGACTGACAGAGTACAGGCTGGCCACAGCCAGCCAGAACCAAGCTGCTGATCTCCTGGGGAGGAGGGGGCGGTGGCAGGAAGAGCTTCCCGGGAGGCCAGACCCCAGACCGGTTCTGTGGTTGCCTGACAGGCTTCTCCTAGAACACAAGTCTCCTGTGGCAGAGGGGACAGAGCTGCCTGTGGCAGCCTCTTCAGGCTGGGTTTTTAGTGCCAAGAAAGCTGCATCTTCGAAAACCTCAGGGGTCCATTGTTGGGGCTCAGACAGAAGCCCACCGTCTTCCTTGGGCCACTGGGCCTCACTGTCTCCCTCTTTCCTTTCCAGGGTCCTACTGGAGTGACTGGTCCTAAAGGAGCCCGAGGTGCCCAAGGCCCCCCGGTGAGTGAGGCCTCTGACACCCCACCCTGCACCTCACAAAGAGGCCTGGCCCCAGAGGCTCCCATGGCGGGGGTGTTCTGGGATGCCCCCGACTGTTTTCCCAGCCCTGCGTTGGTCCCCAGCCTAAGCCCACCCACAGCCAGGTGGGAGAGAGGGCGCCTGTGGGCTGGGTGCACTGTGGTCCCGGATTCCCCAGCCCGAGGCTTGTCCCTCGTTCAGCTCCCTGAAGTGCTGACTGTGGAAACCGGAGGCAGGGAAACAGCCTGTGCCTGCTTCTATGACCAGACCCGGGGGCCCTTTCTCCCTCCCTGGATCCCCCTTGCTGCTTTGCAGTCCCTCGCCCTTTCCATACCAGGCTCTGAGACCACCCCCGCCCCCCGCCCATTTTAATCTCAAACCTCCTGAGGGCTTGAGGTTCTCAGGGGCTCTCCTCTCCCCACACAGGGAGCCACTGGATTCCCTGGAGCTGCTGGCCGCGTTGGACCCCCAGGCTCCAATGTAAGTGATGCTCCTGGCATGAGAGGCACAGGCAGGCATGGAATAGCCTGGCCCAGCACCCAACAGGGTCTGGAGAGCTCCAGGCTGGCCTTCACTCCTCTGAGTCCGTTCCTGCCCCCTGGAGGAGTAGCTAACTGATCATGGGGACCTATCCCCTGAGGGTGGCTGGGGGCAGGGTTGTGGCCCTGCTGTCAGCAATGGGTGGCTGCCCTGCTGGCTTGGTGGGCAGGACAGGGCTGCCATGATTACCTTCATCCTGGACAGATGTTTCTTGAGCATGTTCTGTGCACTTGTCTGTGTGCTTTAAAGCAAGTCCGCATGTCCTGGGTCGCTCTCAGGGAGTTTGCATGGAGGGAGCAGTGGTGATGAACTCACTGGGTTCACCAGCGCCATAGGCAGAGGGAGAGAGTGCTGGGGGCAAGCTCAGGGGTCAGAGGGGCAGGGCTGGAGCGGCTCCTGAGGAAGGGGGATTGAGGACAAAGGGAGGAGGGAGGAGAGATTCCAGGTAGATGGGAGAAAGCAAAGCAAGCAGGAGCTGGAGAAGTTGGGGCTGTCTGCCCAGAGCTGTCTCACATGGTGAGAAGGTTGCAGCGGTAGATTGGGGTTGGGGGGGTTAAGCTGCCTGCCCTTAGTGTGGGGAGGTAGAGAAGCCCCCAGAGAGGAAACTGCTGTCACTGAGGCCACAGTGACTTTGGCAGCCTGGATGAGGAAGGGTGAGATGAGTCCTCACTTCCCGCATTTTCTCCTTCTAGGGCAACCCTGGACCCCCTGGTCCCCCTGGTCCTTCTGGAAAAGATGGTCCCAAAGGTGCTCGAGGAGACAGCGGCCCCCCTGGCCGAGCTGGTGAACCCGGCCTCCAAGGTCCTGCTGGACCCCCTGGCGAGAAGGGAGAGCCTGGAGATGACGGTCCCTCTGTAAGTCCCTCACCAGGCCCATGCCAAGGTCCCTGGGAGCAGGGTCGTGAGTGGCTTCTGAGCTCACAGAGCATGGGGTAGGAGGGAGCAGGGGCCGTGGGGATGCCAGGGAGCGGGGCTGCACAGACAGAGCTGTGCTGAGAGGACAGAAGAGGCTGGGCCACTGTCAGTTCTCATCTCCTGCCTCTCCTCTCTCAGGGTGCCGAAGGTCCACCAGGTCCCCAGGGTCTGGCTGGTCAGAGAGGCATCGTCGGTCTGCCTGGGCAACGTGGTGAGAGAGGATTCCCTGGCTTGCCTGGCCCGTCGGTGAGTGTGGGGTATCCCTCCCTCCATCCAAGCTGGGCCCTGCCTGCCAAGGCTTCTACCTCCCTCAGCACCCTCAGGACTGTCCCTTGTCTGCCCTCTCCCTGAAGGGTCAGTGGGCCCTGGGCAGGGGTGCTTACCACTTGCACTCATCATCCTTGTCTCTGTCCCTCCAGGGTGAGCCCGGCAAGCAGGGTGCTCCTGGAGCATCTGGAGACAGAGGTCCTCCTGGCCCCGTGGGTCCTCCTGGCCTGACGGGTCCTGCAGGTGAACCTGGACGAGAGGTGAGCAGTGAGACCCCCTGGGGTGGCCCTGATTGGGGAGAGGGGCCCTGTGAGTCTCTGTGCTGGGTCAGCAAGGACAAGTCCCAGTCAGGGCCCTGGAGAAGGGGGTGGCAGTGTCGGCCGACAGGCCTGAAAGCCTAGGTACAATGGGAAGGTTGTCGGGGAGAGAGACGGGCATAGAGACCAAGGGCTGCTTCCGGAAGGAGGAGGGAAACTTGGTGAGGAAACTTTGGCTTCAAAGTGTGAGTGAGTTGGGCAGAAGAGGAGAGGCCTGGGCTTCTGAGAGGGGCTGGGGGAGCAGAGGGGGAGATGGGCAGGAAGCAGCTCTAAGTGCATTCTTGTTTCACTTTGTCCAGGGAAGCCCCGGTGCTGATGGCCCCCCTGGCAGAGATGGCGCTGCTGGAGTCAAGGTGAGTGTCTGGTGTCTGTGTGTGCAGTGGGTTGGGGAGGACATTGCCTCGGGCCTGACAGGTCAGCTGGGGGTGGCAGGTTGGAACAAGTCTCATCTCAGCCTAGAAGGACCTTCTGTTCCTGTCTCTTCTGGAACATTCTTCTCTGAGCCTGAGACCTCTCTCCTGACAGGGTGATCGTGGTGAGACTGGTGCTGTGGGAGCTCCTGGAGCCCCTGGGCCCCCTGGCTCCCCTGGCCCCGCTGGTCCAACTGGCAAGCAAGGAGACAGAGGAGAAGCTGTAAGTATCCTGAATTCAGTAAAAGCCGCCTTCCCCTGCGCGGTGGGGCTGAGGCAGTCCCTGGGTTTCCGCAGTCTCTGGACTAAGGAGCAGTGGCCTCAGATGCAGAGGAGGCCCCCACCTGTCCTGGCTTTTCTCTGACGCTGCGCTCACTCTCTCCTCAGGGTGCACAAGGCCCCATGGGACCCTCAGGACCAGCTGGAGCCCGGGGAATCCAGGTGAGTATCCAAGTGTCCTGCACTGAGTCCCCACCAGGGATAGGCTGGGAGGGCAGCCAGCCTCCAGGTGGTTCCTGGGCCTCCAGCCCTGTGTTTCCGGGGATTCCTCAGCTTGGGTGGGACAGGAGGGGGCTCCTGTCCTGGCCCTGACCTGACTCAATCGGTGTCTGTCTTGTTCCCAGGGTCCTCAAGGCCCCAGAGGTGACAAAGGAGAGGCTGGAGAGCCTGGCGAGAGAGGCCTGAAGGGACACCGTGGCTTCACTGGTCTGCAGGGTCTGCCCGGCCCTCCTGTGAGTGTCACTGCCTGCGTGGGACTTCCCGAGGCCTCCTGCCACACAGAGCCCACTTGAGCTCCCTGTGCTGCCAGGACAGCTTGGGATCACCCTAAGCAGTTTCTAGGATTTCCTCAGGGCTGGAGGGAGGAGGAAGTGGAAAGGGAATGGGGCTGGGACATAAAGCTGTTCCCCCAGCTCCCAGAATATAGATAGATATGTCTGTGCTGACCGTGGCCTTTTGCCTCTTCCTTCTACACAGGGTCCTTCTGGAGACCAAGGTGCTTCTGGTCCTGCTGGTCCTTCTGGCCCTAGAGTAAGTGACATGGAGTTGGAAGATGGAGGGGGCCCTTCAGAGAGTGTGGGCCTGTGTTCCCATGGGGAGGGAAATGCTGCTGCTTCTGGGGAAGCTGTGGGCTCAGGGGTCCTCACTCAGTAATGGGGGCAGGACTGGCTCATGTGCCTATGGCCAGAAAAGCGCCTGAGGCCACAATGGCTGTAAGACAAACATGAATCAGCCTCTCGCTGTCAGACAGAACAGCATTTTACAAAGAGGAGCTTAGGAGGGTAGGCAAGCCATGGAGCTATCCTGCTGGTTCTTGGCCAAATAGAGACCAACTTAGGGTTCCATGACTGAGCATGTGAAGAACTGGGGGCGGAGTGGCTGGTGCTATCAGGACAGCCACCTACCCAGCCCCAGCGACTCCCCAGCCTTCCCTGTGGTGACCACTCTTTCCTCACGACCTCTCTCTCTTGCAGGGTCCTCCTGGCCCCGTCGGTCCCTCTGGCAAAGATGGTGCTAATGGAATCCCTGGCCCCATTGGGCCTCCTGGTCCCCGTGGACGATCAGGCGAAACCGGCCCTGCTGTAAGTGTCCTGACTCCTTCCCTGCTGTCGAGGTGTCCCTACCATCCGGGAGGCTTGAGCTCTTTTTTGCTCAGGGCCTCTTTTAGGGCATCAGCCTGCAGCTAACAGTGATGGCATCCTTTATCCTGAGGTCTCCTCAGAGGTCACAGGGCCCATGATCAGTGCTGGGAAACTGAAGAGAAGGGCTAAGGAAGAAATAGACATGGTGCTGTGGTTTCCTTGGTCCTCGCCTGCTACACCTCCGCCCCACCCATGGGGCTGGGAAGAGGGACACTCTAGTACATTCTAGCAAATGGGGATGGACATGGAGGGGCACTTTCACACAATCCTGGCTGATCTCTCTGTTTCCTGCTGCAGGGTCCTCCTGGAAATCCTGGACCCCCTGGTCCTCCAGGTCCCCCTGGCCCTGGCATCGACATGTCCGCCTTTGCTGGCTTAGGCCCGAGAGAGAAGGGCCCCGACCCCCTGCAGTACATGCGGGCCGACCAGGCAGCCGGTGGCCTGAGACAGCATGACGCCGAGGTGGATGCCACACTCAAGTCCCTCAACAACCAGATTGAGAGCATCCGCAGCCCCGAGGGCTCCCGCAAGAACCCTGCTCGCACCTGCAGAGACCTGAAACTCTGCCACCCTGAGTGGAAGAGTGGTAAGCTTGGAGAACAGGATCCCCTGCCCCGGGAAGCAGGGAGTCATCCCTTAGGCCTAGCAGCAAGGGAGGAGATGCCCCCTAGTACAGGGCAGAGCTGGGCCTGGAAGTTTCCGCCAGAGGGTTCCTCTCTTATTTCACAGCAGAGAAGCTGCAGCCCTGGCCCCTGTCCTGCCATGGCTACCTGGCCGAGGTGACCTCAGGGTGGACTCCATCCACCAGCTGGGCACTGCTTCTGCTCTCTTTGCATGTGTTCTTCCTTAGGGCTGGACTTAGCTCATGCAGATCTCCCTGCCCCTGCATCCTCCCAGGTCCCCCTCCTTTCAGGCCACATGTGAACCTCATCCCTTGTCCCTGTAGGCCTCTCTGTCTCTTTCAGTCAGGCCTGGGTCTCTCAAGCTTTTGTGTCTGTGCCTGTCTGAGCCCCCATGGGTGCTGCCTCTTCCCCCTGCAGGAGACTACTGGATTGACCCCAACCAAGGCTGCACCTTGGACGCCATGAAGGTTTTCTGCAACATGGAGACTGGCGAGACTTGCGTCTACCCCAATCCAGCAAACGTTCCCAAGAAGAACTGGTGGAGCAGCAAGAGCAAGGAGAAGAAACACATCTGGTTTGGAGAAACCATCAATGGTGGCTTCCATGTGAGTACCTGGGTGCCCTAGATGATGAGCAGAGATGGCTCCTCAAACTCTTTCTTTTCTTTCTCCCTGGAAGCTTTTAGCACCTTCCCCATATTTTCCTCCAGTTTTCTGTTGGGCTTGAGAGGAGGGAAAGAGGAGGAAAAGTATTTTTTCCCCACGTGGAGGTGGGAAAAGAGGTCCTCTGAGCTTGCTCCACTCCTGGAAGCAAAAATGTCCAACTAGCTCCCTGCTGCCCCAGTACCCTTGAGGTCCTTGAACCATGAACTCTTGGCAGCCCCTACAGCCCCTGGTCCCATTGAATGCCAGCTCCCAGGCCTCACACTGCCGCTCTCTGCCCCAACAGTTCAGCTATGGAGATGACAATCTGGCTCCCAACACTGCCAACGTCCAGATGACCTTCCTACGCCTGCTGTCCACGGAAGGCTCCCAGAACATCACCTACCACTGCAAGAACAGCATTGCCTATCTGGACGAAGCAGCTGGCAACCTCAAGAAGGCCCTGCTCATCCAGGGCTCCAATGACGTGGAGATCCGGGCAGAGGGCAATAGCAGGTTCACGTACACTGCCCTGAAGGATGGCTGCACGGTGAGTGGGGCTGCCAGAGAGAAGAGCTGCCTGTGCCCAAACCGCCTGGAGCAGGGCTGAGGGTTGGCCCGCGGCAGCTGTCAGGTCCTAAAGTGACAGGATCATCAGAGGCATGAGTTTGAGGGTCATGTAGAGAAGATAGGCTGAGTGACAGGTGAGAGAGAGGCACATATCATTCCATCTTCTCCATTCCCCTGGCTCAGGGGAACAAAACCCTACCTGGAACCCAGTGACTACTGTAGAAGTGTTCTCGCAATGTGTACAGGGTGAAGAAGCGGTCACAGGTTGGGAGCTCACTGTGGGGAGTGGGGAAGGAGGGGAAGGGCAGGGTGGAGAAGGGCCCTGCCGCTAAGGATAGGAGTTGAAGTGGAGAGGCCTTTGGCAAGCCAAGAAGAGGTCTCAGGAGCCCCCTCAGTGTGGTTCAACCTTGTGGGCTCTGATGCTCGCCAGTTTGTTCAGTTTTGGGCTTCTGGGCAGCTGGAACTGGGTAGCAAGGCATCTACTGAACAGAGCCTCCTCCTTTTTTCTCCCCTAGAAACATACCGGTAAGTGGGGCAAGACTGTTATCGAGTACCGGTCACAGAAGACCTCACGCCTCCCCATCATTGACATTGCACCCATGGACATAGGAGGGCCCGAGCAGGAATTCGGTGTGGACATAGGGCCGGTCTGCTTCTTGTAAAAACCTGAACCCAGAAACAACACAATCCGTTGCAAACCCAAAGGACCCAAGTACTTTCCAATCTCAGTCACTCTAGGACTCTGCACTGAATGGCTGACCTGACCTGATGTCCATTCATCCCACCCTCTCACAGTTCGGACTTTTCTCCCCTCTCTTTCTAAGAGACCTGAACTGGGCAGACTGCAAAATAAAATCTCGGTGTTCTATTTATTTATTGTCTTCCTGTAAGACCTTCGGGTCAAGGCAGAGGCAGGAAACTAACTGGTGTGAGTCAAATGCCCCCTGAGTGACTGCCCCCAGCCCAGGCCAGAAGACCTCCCTTCAGGTGCCGGGCGCAGGAACTGTGTGTGTCCTACACAATGGTGCTATTCTGTGTCAAACACCTCTGTATTTTTTAAAACATCAATTGATATTAAAAATGAAAAGATTATTGGAAAGTA

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