Details for gene: BMP4


This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]


Symbol
BMP4
Name
bone morphogenetic protein 4
Entrez ID
652
Ensembl ID
ENSG00000125378    (more details)
KEGG ID
hsa:652    (more details)
OMIM ID
607932
Uniprot ID
Q53XC5  
GO ID
hsa:652    (more details)
Chromosome
14
Strand
-1
Start
53949736
End
53958761
miRNA Interactions
hsa-miR-195-5p (RPM: 125.6474) / hsa-miR-124-3p (RPM: 4110.4386) / hsa-miR-34a-5p (RPM: 81.3502) / hsa-miR-16-5p (RPM: 2473.4704) / hsa-miR-27a-3p (RPM: 980.3062) / hsa-miR-374a-5p (RPM: 52.6724) / hsa-miR-107 (RPM: 234.4574) / hsa-let-7b-5p (RPM: 3396.2052) / hsa-miR-129-2-3p (RPM: 79.8688) / hsa-miR-200b-3p (RPM: 566.8348) / hsa-let-7i-5p (RPM: 2025.2084) / hsa-miR-98-5p (RPM: 1660.0964) / hsa-let-7e-5p (RPM: 3790.2074) / hsa-let-7g-5p (RPM: 3559.4376) / hsa-let-7a-5p (RPM: 32160.4734) / hsa-miR-194-5p (RPM: 48.9448) / hsa-miR-203a-3p (RPM: 1346.5646) / hsa-miR-18a-5p (RPM: 3.6074) / hsa-miR-21-3p (RPM: 238.3548) / hsa-miR-1-3p (RPM: 26.3428) / hsa-miR-24-3p (RPM: 581.6226) / hsa-miR-1343-3p (RPM: 3.6608) / hsa-miR-23b-3p (RPM: 2125.0486) / hsa-miR-23a-3p (RPM: 613.2568) / hsa-miR-17-3p (RPM: 13.6088) / hsa-miR-155-5p (RPM: 106.9134) / hsa-miR-27a-5p (RPM: 7.3838) / hsa-miR-186-3p (RPM: 0.0884) / hsa-miR-126-3p (RPM: 494.5936) / hsa-miR-210-3p (RPM: 361.0562) /
Involved Diseases
primary open-angle glaucoma /
Involved Pathways
Signaling pathways regulating pluripotency of stem cells / TGF-beta signaling pathway / Thyroid hormone signaling pathway / Pathways in cancer / Cytokine-cytokine receptor interaction / Hippo signaling pathway / Basal cell carcinoma / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Metabolism of proteins / Post-translational protein modification / Post-translational protein phosphorylation / Extracellular matrix organization / Elastic fibre formation / Molecules associated with elastic fibres /
Sequence
GCTAAAGGAGCACAATGCCTGATGCTGCAGGAGAAACATTAGGTAACTATTTAATGGAGTTTTAATTTTCTGTTATTATTTTTAATAATTAATTGTGATTTTGACTATTTGGAAGCTACAGGTATATTTTGTCCTCCTTTTGGGGTGGTGTTATTGCCCTGCCCTGTTTTAATCAGTGGTTCTTAGAGAAAGTGAACTCAGGAGTGACTTAAAATGAAGGAAGACGGACTTTGGCTAAAATTACAATTAAATAATCAAATCATTTTCAAATATAAAGGGAGCATGCAGATGATCTGGCCCAATCCTTTCATTCTGCAGATGAGAAAACTGAGACTCATAGGAATGAAAAGACTTGCCCAAAGCCATACAGCTTGTTTCTGTTGTTTGGTGCATTAGGCCAAAAGACCTAGGCCTAATAGATGGAAAAGATGGCAGGATGTCTTGGCCTTGCTCTGACAGTTGCTTCTCTGATCTCAGATATTTCCCACCCTTTGTAATCTGTGTTCCACACAGGAAGTAGTTCTTGTTTTTTAAATATCGAAGGTGTATAAACGTAAAGTTTTTATAGATGAGCCACCCAGGGCCAATATCTGTTTAAGTAAAGACCTAAATGCTTTGCAGAGACAGTAAAGTGTCATGTCTGTCCCAGGGAAAGAAATCCAGGACAGGAAATGCTCAGTCTTCCAGCACTCCTCTGGCTACCTGGAGCTCAGGCTATGAGCCTCAACCCCTCCCTGAAGCATTAGCTCTGGAGCAGAGGCTGTGATTTACTTCAGAGATCTGGGCAAGTCCCTTTAACCTGGTAGTCCTGCCTTTCCTTGTTTGTAAAACAGAGAGATGAGGCTGATAGCTCCCTCACAGCTCCATCAGAGGCAGTGTGTGAAATTAGTTCCTGTTTGGGAAGGTTTAAAAGCCACCACATTCCACCTCCCTGCTAATATGATTACTAAAATGTTTTTATATGAAAGGGCCAATTCCTCATCTCCCCTCTTCCTTTAAAAACAGACCAAGGGGCATCTTTTCTTGTCTCCCTGTGGCCTAAAAGGTTACTGCTTCTGTGGTTATCTCCTTGGAAAGACAGAGTGTCAGGACTCTTAGGTACACCAAAAATGAACAAAAAAATCAACAACAACCATAACACCAACAAAAATAACTGCTGTGTCGGTTCTTAAGACGGCTTCTGAGCTAGAAACAGATTTTTCTAACTGTAAAAAACGTGGCCCCAGCCTGTCTGCAGGCCACCTCTGTCTTTAGGCCTTGGGGGGAGGAGGGAAGTGAGCTCATTTACTGGGGTCTACCTCAGGGTCATCACCAAGGTGTTCTACAAAACGCACTTTAAGAATGTTTTGGAAGGAAATTCACCTTTTAACAGCCCAAGAGGTATCTCTCTCTGGCACACAGTTCTGCACACAGCCTGTTTCTCAACGTTTGGAAATCTTTTAACAGTTTATGGAAGGCCACCTTTTAAACCGATCCAACAGCTCCTTTCTCCATAACCTGATTTTAGAGGTGTTTCATTATCTCTAATTACTCAGGGTAAATGGTGATTACTCAGTGTTTTAATCATCAGTTTGGGCAGCAGTTACACTAAACTCAGGGAAGCCCAGACTCCCATGGGTATTTTTGGAAGGTACGGCGACTAGTCGGTGCATGCTTTCTAGTACCTCCGCACGTGGTCCCCAGGTGAGCCCCAGCCGCTTCCCAGAGCTGGAGGCAGCGGCGTCCCAGCTCCGACGGCAGCTGCGGACTCGGGCGCTGCCTGGGCTTCCGGGACCCGGGCCTGCTAGGCGAGGTCGGGCGGCTGGAGGGGAGGATGTGGGCGGGGCTCCCATCCCCAGAAAGGGAGGCGAGCGAGGGAGGAGGGAAGGAGGGAGGGGCCGCCGGGGAAGAGGAGGAGGAAGGAAAGAAAGAAAGCGAGGGAGGGAAAGAGGAGGAAGGAAGATGCGAGAAGGCAGAGGAGGAGGGAGGGAGGGAAGGAGCGCGGAGCCCGGCCCGGAAGCTAGGTGAGTGTGGCATCCGAGCTGAGGGACGCGAGCCTGAGACGCCGCTGCTGCTCCGGCTGAGTATCTAGCTTGTCTCCCCGATGGGATTCCCGTCCAAGCTATCTCGAGCCTGCAGCGCCACAGTCCCCGGCCCTCGCCCAGGTTCACTGCAACCGTTCAGAGGTCCCCAGGAGCTGCTGCTGGCGAGCCCGCTACTGCAGGGACCTATGGTGAGCAAGGCTACCTGGTGAGGGGAGACAGGCAGAGGGGGTCTAGGAGCCTCCTTGGGGGGAAGAAGCTGGTCACAGGCTGTGACCGAGGCAAAAGGTGGCCTAATTATTTTCCAATAGTGGTGCTGGAGGTGGGGATGCTGGCGCTGAAAGACCTTTAAATATCGGCTACTGCCCCTGCCCAGGCCTTCTCTGTCCAGCAGTCCCTGGGAGATTCTCACCTTTGGGAAGTGCGGGGCAGGAGAGCAGAAACAAGAGAAGCCCTTGGTAGGGGGGTCGTTGGGAAAAACTGTGGGGTCTTGGGCTGAACGCGTTGCCCACGGGCTGGAGGTTGCGATCCCCGGACGGAAAGCGCGGGAGGAGGAAGGAGAGAACCGGCTCTGAGGTCCAGAGAGAGTGAGGGGGCAGAGCGACGGCGAGATGGGGAGAGAACACCTAGCTGGAGCAGGTTCTGCGGTAGAGAGCGCAGTCCTGCTGGCCTCTGGAGAGTGCGCGCCGCTCCGGAGGCTGCGTCGAGGGGAGTGTCACCCAATCTGGCCCCCAGCTGGCGGGGCGCCCTGAGAGCTTGCGAACTGCAGTTGCAGGACGCGCCTTCTCCACGAGCTATTTTCGTCGACTTGCGGAACCCAAGGAACCTCGCCTCTATCATTTCACGGTGTAGGGTCCCTAGAGACGACAGCCAAGATCCCAGGGGCTCCCAGGACGCTTGTTCCTGCGGTGTCGTGTCCTATGGGGAGTTCCTGGCGGGACGAAAGGCGGACGCGCGGCTCTTCCTGGCCCTCCAGGCCCGGAACCGACGGGAAAGGTTCCCGTGATTCCCGAGTCCCTGCAGGCTTCTTCCAGCGGGAGTTGGTCCGGGGGCCTTAGAGGCCTCCAAGCACTGCTTTGGAGGATGGTTTCCAAGGATCGCGGTTTGTGAGTTGAAGGCTTTGTGAGAGGTTAAACCCCCAAAAGATACATACTTGGTAAACTGAGGCTACCTGTAAACACATTTCGGCATTAGGAGAAGATTCGAGTAGGGAAGTGAAGGACAACCACCCCGAGTTACATTCCTTTCCCCCAATAAAAAGCTCTGGGGATGAAAGTTCTTTTGGCTTTTATCTTTTCGATTTAAAAATTTGAGAAGAAAAATGTGACTAGAGATGAATCCTGGTGAATCCGAAATTGAAACACAACTCCCCCTTCCCCTTCCTATCCTCTCGGTTTTAGAACCGCGCTCTCCCGCCCCAGGAGATTCCTTGGGGCCGAGGGTTTTCCGGGGAACCCGGGCGCCCGCCCCTTCTACTGTCCCTTTGCCCCGCGGGCACAGCTTGCCTCCGTCTGCTTTCTCTACTTCTGGACCTCTCCTCGCCGGGCTTTTTAAAGGGCTTCTGCGTCTCAAAACAAAACAAAAAAACCCTTTGCTCTTCCCAACCCTTTCGCAGCCCGCCCCAGCGGTGGCGCGGGACCAGCAAAGGCGAAAGCCGCGCGGCTCTTGCCGGGCGCGGACGGTCGCGCAGGGGCGCCCGCGGCCTCCGCACCCGGACCTGAGGTGTTGGTCGACTCCGGGCATCCACGGTCGGGAGGGAGGGCTGAGCTGTTCGATCCTTTACTTTTCTTCCTCAAAGTCTACCTGCCAATGCCCCTAAGAAGAAAACCAAGTATGTGCGTGGAGAGTGGGGCGGCAGGCAACCCGAGTTCTTGAGCTCCGGAGCGACCCAAAGCAGCAACTGGGAACAGCCTCAGGAAAGGGAGGTCGGGTGGAGTGGGCTTTGGGGCAGGAGTCATGGGGCCCGGGCCCCGGGGACGACCTGGCGCTCCCGGCCCTGCTGAACGCTGAGTTGCGCCTAGTCGGGTTTTCGAAGAGGCCCTTGCGCAGAGCGACCCACGCGCGCGGCAGCATCTTCGATTAGTCAGGACATCCCAGTAACTGCTTGAACTGTAGGTAGGTAAAATTCTTGAAGGAGTATTTGCTGCGTGCGACTCTGCTGCTGGTGCAACGGAGGAAGGGGGTGGGGGAAGGAAGTGGCGGGGGAAGGAGTGTGGTGGTGGTTTAAAAAATAAGGGAAGCCGAGGCGAGAGAGACGCAGACGCAGAGGTCGAGCGCAGGCCGAAAGCTGTTCACCGTTTTCTCGACTCCGGGGAACATGGTGGGATTTCCTTTCTGCGCCGGGTCGGGAGTTGTAAAACCTCGGCCACATTAAGATCTGAAAACTGTGATGCGTCCTTTCTGCAGCGACGCCTCTTTCTGAATCTGCCCGGAGCTTCGAGCCCCGGCGTCTGTCCCTCAGCCTGGCATGGCTTCTTCGGGGGTCTGCTTTGCATGGGGAGAGGGGCCACGCAGCGGCGGACTAGGTTTGGGGATTCTCGGTAATGGACCCGGAGCAATGACTAACAGCCGCTCCCTCTCACTTTCCCACAGCGATCACCCTCTAACACCCTCCCTCCCATTCCCGGCCCCGCGCGTGACAAGGTCGGCTGCTTTCAGCCGGGAGCTAGATCGGTGGCCCGGCTCTTCGGAGCCTTAGCAGGCGTTCGCCAAGGGGTGACTGGCTGTCATTGGGAGCAATATTTGGCCTTGAGGAGACCCTGGGGAGGAAGTGGCGGGGAGCTCGTGTTTGCTTGTGTGTGTGTGGGGGGGTGTGTGTGTACACGCGCGTGGGCAGGGTCCCTCTGCGCTTTCCTTTTTAAGTGCCTCTCGGTGGTGAGGCTTTGGGCGGGTGAGACTTTCCCGACCTCGCTCCCGGCCCCACTTAAGCCGGGTTCGAGCTGGGAGACGCAGTCCCTTCAGTGCGCCCCAAATCCTCTGGCTTCAGGTGGCCCGGCGCGGGGGCCCAGCACGACGCACCGCGCCGAGAACCGGGTTCTCCGTGCGCTGCGCCAGTAGCCCTGGGAGCGCGGCGGCCGCGGGGCACCGGCCGAGGGCTCTGCCGAGCGCCGCCGGGAGCTCCTCCCGGACCGCTGAGGCTCGGGCGGCGGGCGCGGAGGTTGGCCTCGCCTGGAGGGGCGGGCCCGCGAGGGGCGGGGGGCTGTGGAGGAGGGGAGGGCGCGCAAGCCCTTTCGCCGCCTGCCGCGGGAGGGGCCTCGGCGCTCACGTGACTCCGAGGGGCTGGAAGAAAAACAGAGCCTGTCTGCGGTGGAGTCTCATTATATTCAAATATTCCTTTTAGGAGCCATTCCGTAGTGCCATCCCGAGCAACGCACTGCTGCAGCTTCCCTGAGCCTTTCCAGCAAGTTTGTTCAAGATTGGCTGTCAAGAATCATGGACTGTTATTATATGCCTTGTTTTCTGTCAGTGAGTAGACACCTCTTCCTTCCCCCTCCCCGGAATTCACTCTGCCCTCACCACCCCTGCTCGCCGGCTGTCCCTTCCGTCGGACCTCCTTTACAATATCCACACTCTGCTCCCTGGCAGCACTGTCGCTCCCTTCTTGGCCCGGCAGCCGGGGCGCTGGAAGCGTACGGGTTCCTTTTAAAGTGCTGCTAGCGCGCACTCGCCCTCTCAGCGTTGCAAGAAAGGGGAGCGCGAGGGAGCTAAAGAGATGAAAGCCCGGGGTTGTACCTTGAGGGCTAACCACTCCCTTCCCCTATCCAACTTGTCTGGGAGAGCCCCCAGTGTCTCCGTGGCGCGTTCCCACTCTCTTGTCAAAACTCACAGAGGTCTCTCCGGAATCGTCTCTCACCCCTTCCCTGGGGATGAGCGGGCACGATCAGGCACTTTTGGCTGAATATTTCAAACTCATCGGCCACAATAAAATAAGCCCTCAAGCCACCCGGTTAGCTCCCAGACCACCTTCTCGGCTTCTGGACCCTGTCGCCCTCTGTCTTCGCCCAGCCCCTGCCTCTCACTTTCCCTCCCTCTGGCTCTGAACCAACTGGAAGTTGTGAAAGTTGGGCTCTGAGGGTGGAGGAAAAGGGAGAGAAGCTGAAGGTCTAAAGTGGAGAGCAATGCCATTTTAATTCTCCCTCCCCCACCCCTTTTCACCCCCTCAATGTTAACTGTTTATCCTTCAAGAAGCCACGCTGAGATCATGGCCCAGATAGCAGTTAGGACAAAAAAAGATTAACAGGATGGAGGCTATCTGATTTGGGGTTATTTGACTGTAAACAAGTTAGACCAAGTAATTACAGGGCAATTCTTACTTTCAGGCCGTGCATGGCTGCAGCTGGTGGGTGGGCGGGTGGTGTGAGGGAGAAGACACAAACTTGATCTTTCTGACCTGCTTTCCATCTTGCCCCTCCATTTCTAGCCCTAAATGCATATGCAGACACATCTCTATTTCTCCCTATTTATTGGTGTTTATTTATTCTTTAACCTTCCACTCCCCTCCCCCTCCCCAGAGACACCATGATTCCTGGTAACCGAATGCTGATGGTCGTTTTATTATGCCAAGTCCTGCTAGGAGGCGCGAGCCATGCTAGTTTGATACCTGAGACGGGGAAGAAAAAAGTCGCCGAGATTCAGGGCCACGCGGGAGGACGCCGCTCAGGGCAGAGCCATGAGCTCCTGCGGGACTTCGAGGCGACACTTCTGCAGATGTTTGGGCTGCGCCGCCGCCCGCAGCCTAGCAAGAGTGCCGTCATTCCGGACTACATGCGGGATCTTTACCGGCTTCAGTCTGGGGAGGAGGAGGAAGAGCAGATCCACAGCACTGGTCTTGAGTATCCTGAGCGCCCGGCCAGCCGGGCCAACACCGTGAGGAGCTTCCACCACGAAGGTCAGTCTCTTCCCCCAGTCTGCGTGGGGGAGGGCTGGTGGGACTGGCTAGAGGGGCAGTGAAAGCCCTGGGGAAGAAGAGTTCGGGTTACATCAAAGCCCCAGTCCAGGAGGCTGAGGAACAGAGCTGCTTACCTCCAAGAATTTGCAGAGCTGCCGCCGAACTTATTTTTTGGAGACAGAGGGGGAGGTGTTCAGGGGAAGGGGAATGACAGCACTCAGACGTGGGCTAGCCCCAGCGGTGTGTTTTTGCTATATCAAAGCCTTTTCTGCTAGGTTTTCTGCCCGTTTTTTTCAAAGCACCTACTGAATTTAATATTACAGCTGTGTGTTTGTCGGGTTTATTCAATAGGGGCCTTGTAATCCGATCTGAATGTTTCCTAGCGGATGTTTCTTTTCCAAAGTAAATCTGAGTTATTAATCCACCAGCATCATTACTGTGTTGGAATTTATTTTCCCCTCTGTAACATGATCAACAAGGCATGCTCTGTGTTTCCAAGATCGCTGGGGAAATGTTTAGTAACATACTCAATAGTGGAAGAGGGAGAGGGTGGTTGTCTGCATGTTTCCTCCTGCCTGTGCTCTGTTGGCCCCTCTTTTTCTTTACAACCACTTGTAAAGAAAACTGTGGACACAAAGCCAAGGTGGGGGGTTTAAAAGAGGAGTCTGATTGTGGTGCCATAGAGGAGTTGACACATAGAAATTATTAGACATATCAAGGAGGCTGGATATAGTTTCTGTCTTTGGTGCTTGAGAAATGCTAGCTACATTTTGCTGGTTTGTTAGCTGCCCCACTTATCTGCTCCTTCAAATTAAGGGGTATGCTTATTTTCCCCCAGTAGGTTTCCCCTGCATAAGCAGAATTCACCATTCATTGCCCAACCCTGAGCTATCTCTTGACTCTTCCATCTTTGAAAAAAGTTCATATGCTTTTTCTTTTCCCCTTCCTTCCTAACTGTGCCTAGAACATCTGGAGAACATCCCAGGGACCAGTGAAAACTCTGCTTTTCGTTTCCTCTTTAACCTCAGCAGCATCCCTGAGAACGAGGTGATCTCCTCTGCAGAGCTTCGGCTCTTCCGGGAGCAGGTGGACCAGGGCCCTGATTGGGAAAGGGGCTTCCACCGTATAAACATTTATGAGGTTATGAAGCCCCCAGCAGAAGTGGTGCCTGGGCACCTCATCACACGACTACTGGACACGAGACTGGTCCACCACAATGTGACACGGTGGGAAACTTTTGATGTGAGCCCTGCGGTCCTTCGCTGGACCCGGGAGAAGCAGCCAAACTATGGGCTAGCCATTGAGGTGACTCACCTCCATCAGACTCGGACCCACCAGGGCCAGCATGTCAGGATTAGCCGATCGTTACCTCAAGGGAGTGGGAATTGGGCCCAGCTCCGGCCCCTCCTGGTCACCTTTGGCCATGATGGCCGGGGCCATGCCTTGACCCGACGCCGGAGGGCCAAGCGTAGCCCTAAGCATCACTCACAGCGGGCCAGGAAGAAGAATAAGAACTGCCGGCGCCACTCGCTCTATGTGGACTTCAGCGATGTGGGCTGGAATGACTGGATTGTGGCCCCACCAGGCTACCAGGCCTTCTACTGCCATGGGGACTGCCCCTTTCCACTGGCTGACCACCTCAACTCAACCAACCATGCCATTGTGCAGACCCTGGTCAATTCTGTCAATTCCAGTATCCCCAAAGCCTGTTGTGTGCCCACTGAACTGAGTGCCATCTCCATGCTGTACCTGGATGAGTATGATAAGGTGGTACTGAAAAATTATCAGGAGATGGTAGTAGAGGGATGTGGGTGCCGCTGAGATCAGGCAGTCCTTGAGGATAGACAGATATACACACCACACACACACACCACATACACCACACACACACGTTCCCATCCACTCACCCACACACTACACAGACTGCTTCCTTATAGCTGGACTTTTATTTAAAAAAAAAAAAAAAAAAGGAAAAAATCCCTAAACATTCACCTTGACCTTATTTATGACTTTACGTGCAAATGTTTTGACCATATTGATCATATATTTTGACAAAATATATTTATAACTACGTATTAAAAGAAAAAAATAAAATGAGTCATTATTTTAAAGGTAAA

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