Details for gene: CDK4


The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]


Symbol
CDK4
Name
cyclin dependent kinase 4
Entrez ID
1019
Ensembl ID
ENSG00000135446    (more details)
KEGG ID
hsa:1019    (more details)
OMIM ID
609048
Uniprot ID
P11802  
GO ID
hsa:1019    (more details)
Chromosome
12
Strand
-1
Start
57747727
End
57756013
miRNA Interactions
hsa-miR-216a-5p (RPM: 20.4176) / hsa-miR-195-5p (RPM: 125.6474) / hsa-miR-15b-5p (RPM: 133.5752) / hsa-miR-29a-3p (RPM: 1246.9046) / hsa-miR-124-3p (RPM: 4110.4386) / hsa-miR-34a-5p (RPM: 81.3502) / hsa-miR-340-5p (RPM: 285.763) / hsa-miR-424-5p (RPM: 9.04) / hsa-miR-506-3p (RPM: 0.6452) / hsa-miR-182-5p (RPM: 77446.6216) / hsa-miR-454-3p (RPM: 66.0634) / hsa-miR-147a (RPM: 0.0014) / hsa-miR-183-5p (RPM: 37556.6894) / hsa-miR-377-3p (RPM: 4.0398) / hsa-miR-135a-5p (RPM: 34.8504) / hsa-miR-497-5p (RPM: 49.4968) / hsa-miR-107 (RPM: 234.4574) / hsa-miR-3194-3p (RPM: 0.0228) / hsa-miR-495-3p (RPM: 8.062) / hsa-miR-103a-3p (RPM: 2034.8158) / hsa-miR-148a-3p (RPM: 10339.6222) / hsa-miR-5691 (RPM: 0.0126) / hsa-let-7f-5p (RPM: 17066.6836) / hsa-let-7c-5p (RPM: 4028.6728) / hsa-miR-130a-3p (RPM: 723.372) / hsa-miR-431-5p (RPM: 2.9008) / hsa-miR-378a-5p (RPM: 22.027) / hsa-miR-206 (RPM: 4.6758) / hsa-let-7i-5p (RPM: 2025.2084) / hsa-miR-130b-3p (RPM: 68.2014) / hsa-miR-98-5p (RPM: 1660.0964) / hsa-let-7e-5p (RPM: 3790.2074) / hsa-let-7g-5p (RPM: 3559.4376) / hsa-miR-30e-3p (RPM: 538.304) / hsa-miR-30a-3p (RPM: 889.1386) / hsa-let-7a-5p (RPM: 32160.4734) / hsa-miR-449a (RPM: 1.3118) / hsa-miR-486-5p (RPM: 3314.1068) / hsa-miR-301b-3p (RPM: 9.609) / hsa-miR-539-5p (RPM: 2.3354) / hsa-miR-301a-3p (RPM: 142.8494) / hsa-miR-577 (RPM: 1.8138) / hsa-miR-4430 (RPM: 0.0026) / hsa-miR-3677-5p (RPM: 0.0806) / hsa-miR-1304-3p (RPM: 12.7066) / hsa-miR-143-3p (RPM: 93089.5152) / hsa-miR-3135b (RPM: 0.0038) / hsa-miR-3652 (RPM: 0.0324) / hsa-miR-766-3p (RPM: 5.2956) / hsa-let-7d-5p (RPM: 1078.3154) / hsa-miR-145-5p (RPM: 548.8656) / hsa-miR-18b-5p (RPM: 0.3398) / hsa-miR-616-5p (RPM: 3.0294) / hsa-miR-18a-5p (RPM: 3.6074) / hsa-miR-548d-5p (RPM: 1.1692) / hsa-miR-5690 (RPM: 1.0164) / hsa-miR-185-5p (RPM: 29.191) / hsa-miR-548a-5p (RPM: 0.0098) / hsa-miR-548i (RPM: 1.7968) / hsa-miR-548ar-5p (RPM: 0.0164) / hsa-miR-548ap-5p (RPM: 0.0048) / hsa-miR-548au-5p (RPM: 0.1902) / hsa-miR-449b-5p (RPM: 1.2108) / hsa-miR-548as-5p (RPM: 0.0316) / hsa-miR-1-3p (RPM: 26.3428) / hsa-miR-122-5p (RPM: 0.5028) / hsa-miR-548c-5p (RPM: 0.235) / hsa-miR-548b-5p (RPM: 0.2842) / hsa-miR-548am-5p (RPM: 0.2292) / hsa-miR-548o-5p (RPM: 0.235) / hsa-miR-24-3p (RPM: 581.6226) / hsa-miR-548ab (RPM: 0.3238) / hsa-miR-548y (RPM: 0.046) / hsa-miR-193b-3p (RPM: 184.968) / hsa-miR-548h-5p (RPM: 0.3692) / hsa-miR-34c-5p (RPM: 46.7356) / hsa-miR-764 (RPM: 0.0112) / hsa-miR-4695-3p (RPM: 0.0182) / hsa-miR-548j-5p (RPM: 0.0632) / hsa-miR-3910 (RPM: 0.0044) / hsa-miR-548w (RPM: 0.4064) / hsa-miR-3913-5p (RPM: 2.6744) / hsa-miR-548ak (RPM: 0.0892) / hsa-miR-222-5p (RPM: 13.2904) / hsa-miR-20b-3p (RPM: 0.5872) / hsa-miR-3179 (RPM: 0.0296) / hsa-miR-660-3p (RPM: 0.609) / hsa-miR-25-3p (RPM: 1063.0626) / hsa-miR-548aq-5p (RPM: 0.0114) / hsa-miR-3934-5p (RPM: 0.4022) / hsa-miR-4284 (RPM: 0.1674) / hsa-miR-224-5p (RPM: 33.3102) / hsa-miR-31-5p (RPM: 310.1326) / hsa-miR-708-5p (RPM: 69.2328) / hsa-miR-744-3p (RPM: 3.4814) / hsa-miR-216b-5p (RPM: 11.7092) / hsa-miR-106a-3p (RPM: 0.061) / hsa-miR-17-3p (RPM: 13.6088) / hsa-miR-545-3p (RPM: 0.0276) / hsa-miR-4423-5p (RPM: 0.3674) / hsa-miR-196a-5p (RPM: 0.311) / hsa-miR-155-5p (RPM: 106.9134) / hsa-miR-34b-5p (RPM: 1.8778) / hsa-miR-34b-3p (RPM: 5.6562) / hsa-miR-28-5p (RPM: 190.0872) / hsa-miR-93-5p (RPM: 357.1536) / hsa-miR-1267 (RPM: 0.087) / hsa-miR-483-3p (RPM: 2.3898) / hsa-miR-17-5p (RPM: 83.6404) / hsa-miR-520a-5p (RPM: 0.0512) / hsa-miR-125a-3p (RPM: 24.5112) / hsa-miR-3622b-5p (RPM: 0.0704) / hsa-miR-576-3p (RPM: 1.0164) / hsa-miR-616-3p (RPM: 0.3382) / hsa-miR-3199 (RPM: 0.1412) / hsa-miR-296-5p (RPM: 12.5874) / hsa-miR-4638-5p (RPM: 0.0318) / hsa-miR-1307-3p (RPM: 130.8454) / hsa-miR-210-3p (RPM: 361.0562) / hsa-miR-423-3p (RPM: 1928.5158) / hsa-miR-1306-3p (RPM: 0.8504) / hsa-miR-6805-3p (RPM: 0.0046) / hsa-miR-548ay-5p (RPM: 0.357) / hsa-miR-548bb-5p (RPM: 0.0048) / hsa-miR-548ad-5p (RPM: 0.3028) / hsa-miR-548ae-5p (RPM: 1.1262) / hsa-miR-513b-3p (RPM: 0.1202) / hsa-miR-504-3p (RPM: 0.16) / hsa-miR-1-5p (RPM: 0.0594) / hsa-miR-6501-5p (RPM: 0.0094) / hsa-miR-6821-3p (RPM: 0.0074) / hsa-miR-6741-3p (RPM: 0.6252) / hsa-miR-6790-3p (RPM: 0.0104) /
Involved Diseases
uveal melanoma /
Involved Pathways
PI3K-Akt signaling pathway / Epstein-Barr virus infection / Cell cycle / p53 signaling pathway / HTLV-I infection / Tight junction / Pathways in cancer / Pancreatic cancer / Bladder cancer / Hepatitis C / Measles / Influenza A / Viral carcinogenesis / Small cell lung cancer / Chronic myeloid leukemia / T cell receptor signaling pathway / Glioma / Melanoma / Non-small cell lung cancer / Developmental Biology / Cellular responses to stress / Cellular responses to external stimuli / Generic Transcription Pathway / RNA Polymerase II Transcription / Gene expression (Transcription) / Transcriptional regulation by RUNX2 / Cell Cycle / Disease / Cell Cycle, Mitotic / Reproduction / Meiosis / Cellular Senescence / Meiotic recombination / Signal Transduction / Transcriptional regulation of white adipocyte differentiation / Signaling by PTK6 / Signaling by Non-Receptor Tyrosine Kinases / SCF(Skp2)-mediated degradation of p27/p21 / Oxidative Stress Induced Senescence / Senescence-Associated Secretory Phenotype (SASP) / Oncogene Induced Senescence / RMTs methylate histone arginines / Chromatin modifying enzymes / Mitotic G1 phase and G1/S transition / Chromatin organization / Cyclin E associated events during G1/S transition / G1/S Transition / Cyclin D associated events in G1 / G1 Phase / S Phase / Cyclin A:Cdk2-associated events at S phase entry / Ubiquitin-dependent degradation of Cyclin D / PTK6 Regulates Cell Cycle / Transcriptional regulation of granulopoiesis / Diseases of Cellular Senescence / Evasion of Oncogene Induced Senescence Due to p16INK4A Defects / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects / Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) / Diseases of mitotic cell cycle / Diseases of cellular response to stress / Aberrant regulation of mitotic cell cycle due to RB1 defects /
Sequence
ACCCCATTCCCACTCCGTGTCCTGGGGCCCGCCCAGCCTCCTTAGGCGCCGCGCCTGCTCGCGGTCTCCGCTGACACCCCAGGTGCGCGCCTCCACCCTCCGCGCCCGGCCAGGTGCCCAGGCCTGACCTGCTCCGGGCCCTGGAAGCAGATCCGGCACTGAGGGGTTCGGAGTCCGCTGTCCAGGCTACTGCTGAGCGACAGGGCGTCCAGCGCGCCCGGGGGCGGCAGCGGCGGCGCGGGCGGCGGCAGGGGTCCGGCCCGCGGCTCCTTGTCGCCGGCCAGGCCCCGGGCCCGCGGCTCCGACCCGTAGTACTCCTCCTCGTCGCCGTCGCCGTCCCGGGTGGAGCAGCCAGCGAAGGGCGCCCAGCCGCAGCCGCCTCCCCGGCCCCCCCGGGGTTGCGGCTCGGCCCGGGGCCGCCCCCCGCCTGTCAGCACCAGCAGCTTCAGCTCGTTCAGAAACATGCGGAGCCGAGACTTGAGCATCGTCCGGACACCGGGGGCGGGGGGCAGCGTGCAAGGGGGGCTCGCTAGCGGCGGGGGGAGGGGAGAGGACAAGGCCGGGAAGGGGGCGCGCGCTAGAGAGCCGAGCCGGGCCGGGGTCTTCGGGGCCTGCGACAGCCGTTCACTGCTGCCACCGCCGGGGCTCCGGTGCTTGCGGGGCCGAGCGGGCTGGCGGCCCGGGGGCGGCGGGGTGGGCGGCCATGGCCAGGGCAGGGGGCGGGGAGGGGGGCTCAGGGTGCCGCACCCCGCGGGTCTGGGTCTGGAGCGGGCCGGGCCCCCGGGGTTACGCGCCCGGGTCCTCCTGCGGCGGGGCCGCCCCCCATCGCCGTTCTCTCGGTCCCAGTCCCCCTCCGGCTCCGGGATCAGGCTTGGCTCGGCCCGTGCGCTCGGCGGTGGCAAATGGCGGCTCCTTCCGGCGGCGGCGGCGGCGGAGACCCCCCCGGAGTGGCGGGCGGGCGGGGCGGGCGCCGGGGAGCGGGTGAAGGATGGAGGGAGGGGCGGGGCGGGGAGGGGGAGAGGAGAAGGGGCCGCGGCTGCGCATCCCCGCCCTGCCCCGCACGAGCAGGTGTCCCAGGGGCGGGGGCAAGTGTGGGATCCCGAGGAGGGTGGAGGAAGGGGAGTGGCCAAGGAAGGGGAGTGTGCACACAAGTTGACTAGGTGTGTGTCTGGGAGTGGGGGATGAGCGGGTGAGCATGGAAGGTGAGTGGTTAAATGACGCAGGTGTACCAGGGAGGGTGAGGCTTGTGCAAAATGGGAATGTGCAAAGAAAGAGCTGTGCAAGTGTCGGAGGTGTGAGGGAGGTACATGGGCAGGGGTGGGACTCAAGCAATATACACTTTACCCAAAGGGCTGAAAAGTGTGATCGATGGGGACTGGGAAAGAGAGGTGTGTAAGGAATGGAATCGGATTGTCTGAGAAACAGAAGCCTGTGATTGTAATGTGTGAAGGAGGTGAGGGAGGGAGCAGGGGAGGTAGGCGTGCTAAAGGGATGGGAGTGTCTTTCCTGGTACTCTCCTGCCCTCACCTCCACTACACTGAAGTGAACAATACACACACTTACCCCTTTCCTTTTATGGAGACTTCCCTCTGAGGCCAAGTTCTACCCCCATCACATTTTTTTCTTTCTTACACTTACATTCTCCCTCTCCTCCCCTTTGCAAAGCTGAGGGAAAAGGGATTCCAGGGGAGCTCATTGGGTCAAACATACTGGGAAAAAATTTAATTAGTGAAAGAGTAATTAACAGAAGAAGGGAGGGGACAGAGCCTGGGACAGACTGCCAAATTAAGGTTCCTCAATAGAAAGTGATGGAGAGACAGTAATGTTCCCATGAAGTATTCAAATGTTTTGGATGGACTAATGAATGAATCAGAAAAAGGGGCTGGGACCCAAGCAGACAGAGAGGACGTCTTCTGTTGCAAAGACAGTAAGCTGTGAAGGTCTTATGTGGAAGGTGAGGCTGAAGTGGGGAATGCTGGTGTGGGAAGGGAGTTTGAAAAACTCACAGACAATTATCTTAGCCTTCCAGAAGGCTTACAAAGCACCCACCCCTAGCAAGGTAGCCAATAAAACATTCACCTCTTGAGCCCCTTAGTCAGTTCAGTCCTTGAGGTTTTTCTTACTAGTGTTCCAGCTGCCCTTGCCAGGAGGGGCCCAGGGCTACAAGTATCAGGATGGAAAGAGGAGGCATCTGTATTAATATGTATTCTATTTTGCTCTAAGTCATGGTTTATATTCATCTTCTAGTTTGAACTCTTATATTCTCAGCCAGATGGTTAAGGAAAACAGAAGTTAGAGTGGAAGGAGTGGCAAATAGGGTAATAAAATGGCTTTAGATTTTAGACAAATTCTCACAAATGAGACACTAACCGCTTTCCTCCTTTACTCCCATACCCCCAAAGGGCTGGGAGATAAAGACCTTGGAGCCAATAAAACAAAGTAGGAGAAATCTACTTGTGTCTACCTAGGTGTCTGGGCAGAGGCCATTTGGGAACAAGTGTGTTCTGGACAGTGCTAAGTGCTAAGAAAGCGGCACTAGGGAAAAAGAGGGAAGCACAATAACTCCAAATGAGTAGTCACAAGGTTTGCAGAAGGGGGCATGTCATTTTCATTCATTGTGGTGGTCTGGAGGGTGCAGGGGGTGTGGTGGTAACTTTCTTGCACATGTGCAATCCTGTATCCGTCTTATATATGATGTGATAAATAATATCATATACATACATATATACATAGAAGCATATATGCACACATACAAATATCACATAATCATAGAACCTTCCTACTGGAAAAAAAAAAAAAACTTAAAAGGTCAAGTATTCCTGTCTCCTGCTCATCAATAACTTCTCTGCCAGATGGCCTCAGGTCTTTGCATTAACACTCCCAGGGAGGTTTGGAAGTTGGAAAAGTGAGAGGATTACCTTGTCACTGAGCCTGTTGGATTACTGTATTAATCTGCCTTCCGTCATCCTTTAATCGTAGTTTTGCCCTCAAATGGGCATTGTTTACTCCCTATTGTAGAAGACCCCATTGTTGGCTACATCTTTATAGATAGTCGTACCACTACTTTAAAGGGCCAGTGACAGACACCAAAAACAAAATAAAAACCCACATACACACTGGAAGCAAGCACTCAGTAAAATGTTGTAGAATTAATGAATGAAACAATGACACAAATGAGAGTATGTTTTCTCATGGTGGAGCGAAAAGGTGACAGCATCACCTCTGGTACCCCAACTCCCACCCCCTCCCCAATGCAGACAGGCTGAAAGACCGGTAGTGAGACTGGAGTTCAGCCTTCAGACCGGTAGTGAGACAATCCTTCAGCCGGGAGTTGGGCTCTGGGTGGCCTAGGTTGCCATGGCACCGCCTCGGGCTCCACCCTCTCTTGTCCCCCTCACCGCTCCCCCCCTGCAGCGGGGGTTGTGGCAGCCAGTCACGTGCCCGCCGCGTAGCCACACCTCTGCTCCTCAGAGCAATGTCAAGCGGTCACGTGTGATAGCAACAGATCACGTGGCTGCCATCGCCCCTCCGCCCCCTTACACTCTTCGCCCTCCTCCCAGTCGAAGCACCTCCTGTCCGCCCCTCAGCGCATGGGTGGCGGTCACGTGCCCAGAACGTCCGGCGTTCGCCCCGCCCTCCCAGTTTCCGCGCGCCTCTTTGGCAGCTGGTCACATGGTGAGGGTGGGGGTGAGGGGGCCTCTCTAGCTTGCGGCCTGTGTCTATGGTCGGGCCCTCTGCGTCCAGCTGCTCCGGACCGAGCTCGGGTGTATGGGGCCGTAGGAACCGGCTCCGGGGCCCCGATAACGGGCCGCCCCCACAGCACCCCGGGCTGGCGTGAGGTAAGTGCAGTCCCTTCCCAGGAATGAGAACCAGTGCCCGCCCCCCTCACAGCTTTCCACGCGTTCGTTTCGCGAGCTGGTTATGGAAGGGTCGCTCAAGGGCGGGAAGTGGGGCCTTTGTGGTCATGGGAAAGTATAATTTTAGGGACTGAGGTGTAGGATCTTCGATGCAAGGCATGTGTCATGTGTGATCTTTGTGCGGGGCGCGATTGTCCCAAAGGAAAAAGCGTTTTCTATTGCAGGGCCTCACGTGGCTGGAGGGGTTGGTATTGAGTCATTGTGTTATCTCTGGGGCCGGCCCCAAGGAAGACTGGGAGCGGGGGATGGGATGCTGGTGGTGTTCTTTGCGCTTTTTTTTTGGGAGTCCCTTTGTTGCTGCAGGCTCATACCATCCTAACTCTGTAAGCGACTTTTGGTGATAGGAGTCTGTGATTGTAGGGTCTCCCTTGATCTGAGAATGGCTACCTCTCGATATGAGCCAGTGGCTGAAATTGGTGTCGGTGCCTATGGGACAGTGTACAAGGCCCGTGATCCCCACAGTGGCCACTTTGTGGCCCTCAAGAGTGTGAGAGTCCCCAATGGAGGAGGAGGTGGAGGAGGCCTTCCCATCAGCACAGTTCGTGAGGTGGCTTTACTGAGGCGACTGGAGGCTTTTGAGCATCCCAATGTTGTCCGGTGAGAAGGTGGTGGAGGGTTGGGCGTGGGGAGTAAAGGGAAAAGACAGCCTATAGGTGGGGTGTGATGATCTGTAGAGAAGTGGGGACCCTGAGGAAATAATGAGAGGCCATGTTGGGTTAAAGGGGATTGAAAAGTGAGCATTTACTCTGGTCAGGCTGATGGACGTCTGTGCCACATCCCGAACTGACCGGGAGATCAAGGTAACCCTGGTGTTTGAGCATGTAGACCAGGACCTAAGGACATATCTGGACAAGGCACCCCCACCAGGCTTGCCAGCCGAAACGATCAAGGTGAGTGGGGTTGGTAGGCATTGAGAGGTGGATTGGGACCTTTGTAGTAGAACCTTCTGGGATTTCAGGTATGGTGCCTAGTTTCCAGTGCATCTGTACCTCCCCTTTGAAACTAGGATCTGATGCGCCAGTTTCTAAGAGGCCTAGATTTCCTTCATGCCAATTGCATCGTTCACCGAGATCTGAAGCCAGAGAACATTCTGGTGACAAGTGGTGGAACAGTCAAGCTGGCTGACTTTGGCCTGGCCAGAATCTACAGCTACCAGATGGCACTTACACCCGTGGTCAGTAGAAAGATGGTACCAAAATGGGTTCTGGTTGGGAGTAGGAGAGTGATTGCCCGTAGCAATTGAGAAGTCATGTGCTTCATGTGTTCAGTCAAGCAAGTTGTGTTTCATGGTAACCCATGGGGTCCCCATCCATTCTTCCTATTCCCTTTAGGTTGTTACACTCTGGTACCGAGCTCCCGAAGTTCTTCTGCAGTCCACATATGCAACACCTGTGGACATGTGGAGTGTTGGCTGTATCTTTGCAGAGATGTTTCGTCGAAAGTATGGGACCCACATACCCTGGACTACCTTGAATTCCCCAAATCGCTTGTTCATAAACCACATCCATACCTTGCCCATTCTTTTTTTTTGAGACCAGGGCTTGCTGTGTTGCCCAGGCTGGATTGCAATGGCATGATCACAGCTCACTGCAGCTTCAACCTCCTGGGCTCAAGTGATCCTCCCATCTCAGCTTCCCAACTAGCTGACACTACAGGCACGCACCTCCATGCTTGGCTAGTTTGTTAATATTTTTATAGAGATGGGGTCTCAGTATATTGCCCAGGCTGGTCTTGAACTCTTGCACTCAAGCAATCCTCCCACCCCTACCTCCCAAAGTAGCATAAGCTACTGCATCTGGCCCCATTCTTTTACTTGCGTACTACTAACTTGCCCATAGCAGAAAGCTCTGAAATGTTCTGGAATTAGGAACTTCATATCCCTTTATTCTCTTTATTTTTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTGAGATAAGGTTTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCCCAATTACAGCTCACTGTAGCCTCTACCTCCTGGGCTAAAGCAATCCTCCCATCTCAGCCTCTTGAGTAGCTGAGACTACAGGTGCACGCCACCATGACTGGCTTTTTTTTTTTTTAGATGGAGTCTTGCTCTGTCGCCAGGCTGGAGTGCAGTAGTGCGATCTCTGCTCACTGCAACCTCCACCTCCCAGATTCAAGCAATTCTCTTGACTCAGCCTCCCAAGTAGCTGGGACCACAGGTGCACGCCACCATGCTCAGCTAATTTTTGTACTTTTAGTAATGACAGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACCTCATGATCCACCCACATCAGACTCCCAAAGTGCTAGGATTACAGGCGTGAGCCGCTGCACCTGGCATTTCTTTTTTTTTAAAAAAAGAGACAAGGTCTTGCTTGCCCAGGCTGATCTAGAACTCCTGGGCTCAAGCAGTCCTCTCACCTCAGCATCCCAAAGTGCTGGAATTGTTGGCCTTTATTCCCTATACTTCCTATTTTGAGCCACTAAGCAGTAACCATTCAACTAAGATATCTTTGAAAATGACTGCTACCTTATATCCCTTCTCACCTTAGGCCTCTCTTCTGTGGAAACTCTGAAGCCGACCAGTTGGGCAAAATCTTTGAGTAAGTGACCAACATGGGAGAAAAAGATTTTCTATTCTGAGTCCTCTTTCTGCTGAACCCAGGATGGCAACTGGCTCTGCCCATGGGGATGGGAACTGGAGGACCCTCCTGACCAGAGTTCTCCTGTCCCCCACAGCCTGATTGGGCTGCCTCCAGAGGATGACTGGCCTCGAGATGTATCCCTGCCCCGTGGAGCCTTTCCCCCCAGAGGGCCCCGCCCAGTGCAGTCGGTGGTACCTGAGATGGAGGAGTCGGGAGCACAGCTGCTGCTGGTACTGGAGATGGCTGTGGGCACAGGGAAAGAAATAGAGACTGGGGAAAGAAATAGAGCAGTATGCAGGGCCCTGGCCACTGTGGTTAATGAAACTTGGTTGGTAGATGGGCTGTAGTTTTTATTACAGCTGCAAATAGCCACCCACAGAGAAGGATATAGAAGAGAACCCATCCTGGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGTATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAGTACAAAAATAAGCCGGGGGTGGTGGCACACGCCTGTAATCTCAGCTACTTGGGAGGCTGAGATAGGAGAATCACTTCAACTCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCATACCATTGCACTCCAGCCTGGGTGATAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAGAAAAAAGAAGAAAGCTCATCCCAGGTATTGTTGTGGGTGGGCAGAAGTCTGTTTTCTTCATGGTTTTCTGACCTTTGCCTCTCCCCTCAGGAAATGCTGACTTTTAACCCACACAAGCGAATCTCTGCCTTTCGAGCTCTGCAGCACTCTTATCTACATAAGGATGAAGGTAATCCGGAGTGAGCAATGGAGTGGCTGCCATGGAAGGAAGAAAAGCTGCCATTTCCCTTCTGGACACTGAGAGGGCAATCTTTGCCTTTATCTCTGAGGCTATGGAGGGTCCTCCTCCATCTTTCTACAGAGATTACTTTGCTGCCTTAATGACATTCCCCTCCCACCTCTCCTTTTGAGGCTTCTCCTTCTCCTTCCCATTTCTCTACACTAAGGGGTATGTTCCCTCTTGTCCCTTTCCCTACCTTTATATTTGGGGTCCTTTTTTATACAGGAAAAACAAAACAAAGAAATAATGGTCTTTTTTTTTTTTTTAATGTTTCTTCCTCTGTTTGGCTTTGCCATTGTGCGATTTGGAAAAACCACTTGGAAGAAGGGACTTTCCTGCAAAACCTTAAAGACTGGTTAAATTACAGGGCCTAGGAAGTCAGTGGAGCCCCTTGACTGACAAAGCTTAGAAAGGAACTGAAATTGCTTCTTTGAATATGGATTTTAGGCGGGGCGTGGTGGCTCACGCCTATAATCCCAGCACGTTGGGAGGCCAACGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAATTAGTCAGGCGTGGTGGTGCACACCTGTAATCCCAGCTACTTGGGAGACTGAGGCAGGAGGATCGCTTGAACCCGGGAGGCAGAGGTTGCGGTGAGCCGAGATCATGCCATTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTGTCAAAAAAAAAAAAAGAATATAGATTTTTAAATGGC

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