Details for gene: XRCC3


This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]


Symbol
XRCC3
Name
X-ray repair cross complementing 3
Entrez ID
7517
Ensembl ID
ENSG00000126215    (more details)
KEGG ID
hsa:7517    (more details)
OMIM ID
613972
Uniprot ID
Q53XC8  
GO ID
hsa:7517    (more details)
Chromosome
14
Strand
-1
Start
103697609
End
103715504
miRNA Interactions
hsa-miR-1277-5p (RPM: 3.0234) / hsa-miR-195-5p (RPM: 125.6474) / hsa-miR-765 (RPM: 0.4272) / hsa-miR-124-3p (RPM: 4110.4386) / hsa-miR-34a-5p (RPM: 81.3502) / hsa-miR-147a (RPM: 0.0014) / hsa-miR-548aa (RPM: 0.2412) / hsa-miR-107 (RPM: 234.4574) / hsa-miR-548t-3p (RPM: 0.1036) / hsa-miR-548h-3p (RPM: 0.6602) / hsa-miR-548ap-3p (RPM: 0.0018) / hsa-miR-103a-3p (RPM: 2034.8158) / hsa-miR-1288-3p (RPM: 0.0092) / hsa-miR-548z (RPM: 0.6624) / hsa-miR-548d-3p (RPM: 0.0012) / hsa-miR-4673 (RPM: 0.0558) / hsa-miR-4784 (RPM: 0.0222) / hsa-miR-5580-3p (RPM: 0.0162) / hsa-miR-410-3p (RPM: 194.4724) / hsa-miR-3150b-3p (RPM: 0.0582) / hsa-miR-127-3p (RPM: 3339.395) / hsa-miR-548an (RPM: 0.0018) / hsa-miR-1-3p (RPM: 26.3428) / hsa-miR-4690-5p (RPM: 0.0154) / hsa-miR-671-5p (RPM: 10.1036) / hsa-miR-4689 (RPM: 0.1026) / hsa-miR-3179 (RPM: 0.0296) / hsa-miR-660-3p (RPM: 0.609) / hsa-miR-2355-5p (RPM: 2.178) / hsa-miR-1306-5p (RPM: 5.6804) / hsa-miR-574-5p (RPM: 176.4618) / hsa-miR-361-3p (RPM: 73.5598) / hsa-miR-155-5p (RPM: 106.9134) / hsa-miR-223-5p (RPM: 0.4706) / hsa-miR-4484 (RPM: 0.092) / hsa-miR-140-5p (RPM: 21.3322) / hsa-miR-4710 (RPM: 0.0186) / hsa-miR-760 (RPM: 7.6702) / hsa-miR-3180-3p (RPM: 0.436) / hsa-miR-4651 (RPM: 0.0744) / hsa-miR-1262 (RPM: 1.6152) / hsa-miR-151a-3p (RPM: 2381.562) / hsa-miR-190a-3p (RPM: 0.756) / hsa-miR-6867-5p (RPM: 0.0198) / hsa-miR-6748-5p (RPM: 0.0138) / hsa-miR-6768-3p (RPM: 0.0008) / hsa-miR-548bb-3p (RPM: 0.0006) / hsa-miR-6736-5p (RPM: 0.0498) / hsa-miR-6769b-5p (RPM: 0.003) / hsa-miR-511-3p (RPM: 0.1802) / hsa-miR-6858-5p (RPM: 0.2032) / hsa-miR-1910-3p (RPM: 0.3614) / hsa-miR-6511a-5p (RPM: 0.4256) / hsa-miR-6769a-5p (RPM: 0.0464) / hsa-miR-6746-3p (RPM: 0.2608) /
Involved Diseases
uveal melanoma /
Involved Pathways
Homologous recombination / HDR through Homologous Recombination (HRR) / DNA Double-Strand Break Repair / Resolution of D-Loop Structures / Homology Directed Repair / Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) / HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) / Resolution of D-loop Structures through Holliday Junction Intermediates / Homologous DNA Pairing and Strand Exchange / DNA Repair /
Sequence
ACTCAGGGTGCTAGGCGCCTATTGGAGGAGAAGGCCGAGAGGAGCAGGACGGCGGGAAGAGGAGTGCGGAACCCGCGGGAGGTGAGGCCCGCCGAGCCGGGCTGCGAGCCGGGCTGCGAGCCGGGCGGCAGCGGGGTCGGAGGTCGTGGGCGGCAGCGGGCGTGAGGGGTGAGGCAGGGTCAAGGGGCGGGGGCGGCCGCGGGTCTCCATTGCCCGAGCCTGTGGGAGCAGGCGGGCCTGGGGCTGCAGCACTCACCCCGGGAGCCCCGCCGCAGCTCGGGTAGCGTTCAGGCACCTCGCCGGGGCCGGGCCGCGTGCGTTCGGAGCGGGGAAGGCGGTCTCCGGGGCCCCCGGTGCGCGCGGGGAGGCGTCCGCTCAGGGGAGGCCGAGGTGGGCCCGCGGCTGCGCCCCCGGCCTTCGATGCCTTCGCTCGTCCGCCTGGGACCGCGCTGGCTTCGCATCGAAGTGGGAGAGGTCTGAACAGTTATTTTAATACTTTGATTTGGAAAGAAAATCCTTTAGGCCGGGCGCGGTGGCTCACGCCTGTAATCCGAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCACGTGCCTGTAATCCCAGCTGCTTGGGAGGCTGAGGCAGGAGAATTGTTTGAACCAGGACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCACATTACTGCACTCCAGCCTGGGCTACAGAAAAAGACTCCATCTCAGAAAGCACACAAAAAAAAGAAGAAAATGTTTGTTCATCCTGCCTTTAATTCCTTATTACAAGGCGTGAATTTTTATTGTTTTTTTTGAGACAGTCTGGCTCTGTCATCCGGGGTGGAGTGCAGTGGCGTCTTCACAGCTAGGCACAACCTCGACCTCCCAGGCTCTCAAGTAGCTGGGACCGCAAGCGCCACTACACTGGCCAGCTATTTTTCTTTTTTTTTTTTTTTTTCGGTAGAGAGTAGGTCTTGCTGTGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTCAGGCGACCTTGGCCGCCTTGGCCTCCCACGGTGCTGGGATGACAGGCATCAGCAGTGTTGAAGCCTGTGAGGTGGGGTCCCTGTGGCTGACTCTGCCCTCTCCTGGGGCCATTGGCAGTGCAGGGGTCCTTGTGTGTGGAGGAAATAAGGAGATGATCAAAGTATGATTCCACGAATCACACGGTTTATTGTCAAAGAAGATTTGTTCTCGGGTTCACAGTGCTCAGAGGGGAGGAGAGGGGAGGAGGTGAAGACACCTGGCAGGGAAGCAGGGCCTCCATGGATGGGGTGCATTCACGGCAGGGAGGTGAGTGGCAGAACGGCCAGGGTCCGGTTGCTCTGCTGGGATGGAGCGGGCCCCTGGAGAGTGAGATCTGGTGAGAGTTCGAGGTTTGCCTTGGTAGCAGTGGAGAGCGTGAGAGCGGGAGCTCTCTGAGAAGCTGGGACCGAGGTCCAGCTCCCAGGCCAGCAGCGTATAGCTTGCCTCAAAGCATCTGCACAACCTTCAAGCTGATGTCTGTTTTTGCAGTCCAGCAGTCAGGGTCAGTAACTCACATAAGGGAGTGTCTGACAAGGTTTAAGTGGCATTCCCAAGGTTGCGGAGTTCACTCAAGTCCTCACATATGTGGTCTGATAAGACATCACACTCTTGCAGGGGGGTCAGGTCACCCCAAAACATCAGACTATGTAAGTGCTGTGAATCACTTCAAAGCTACACAGCAGGTCCCAGGGCCCAAGGCAGAGGAGTGAGTCCACCTCGGAAGGCTCAGAGCAGCTCCAGGCAGTAACCACGGCATTTCCAGAGTCTGGTGTGTGAGCCTAACAGCTCTGGTGTGACCGTCCGTACTCACCTAGCAGCACGTGACATCAGCTCTCCCCCTGAAGTCATTGCTCAGCTCGGGTGCTGCAGGAAGACATACAGGTCTGTCTTGGGCCAGCCCCTTGCCTGCTGTGGGCTGCTCCCTGTGTGTGGCCTTCACCCCGGTGTAGAGAGATGGGCTGGTCACACCCCTGCCCCTCACAGCGGCGAGAGGACAGAGGCATGTGCCGGGCTGTCTGTGGAGCTCCCAGGCCAGTGTCTGGGATGCGGCAGGTGCTTGGTGTTAAAGGGAAAATATTCCAGGATATCTGTGAAAGCACGTTAGGCAGAGACCAGGCTTTCATTCAGAACCTTTGAGAGATGTGGGAACCACCACACTGCGGTCTTGCAGTGGGAGAGAGGCTGGGCTCAGCTCTGAACAGGCCATGGGCTGGTGGCGGCTTACAGCTCCAGAGCTGGGCAGGGGCAGAGGATGGAAGGTTGCTAAGAGGAACCCCCAGGGGCGAAGGGGATGCAGGTTCAACTGACCTGCCAGATCAGGCCGCCCGGGGGACAGTGGAAGATGAGGCGCCTAATCAGCTGTCAAGGGTGATGGGACACGGGAGGAGGTCGTCACTAAACAGACTTTGAGCCAGGCCTGTTAAACCAAGTTCTCAGCAGGATGTGCACAGAGGGCCCAGGAGGAGCCTCAGGAGCCGGACTGCCGTTGGCCAACCGGTGAGTCTGTTATCCGTCAGTGGACACTCTGCTTCCAGGTGCCTTGGCCTCGGCCCGCGTCCTGAAGGCGGGAGACGTTGCAGCCACGTGCTGGCCTTCCCGGTGCTCCTGCCAGCGTCCCGCTGCTTGACACAGTCCAAGTTTTGTATCCAGACCCAGCCTGGGACAGCAGCCTCCCGACAGCCCCCAGGCCCAGCCTGTCTGTGACAGTCACGCCTGCTCAGGGAACCATCCCTCCGTGCAGATCTGGGCTGTGTTTTGGGTGGTACCTCGGGTGTGGGGTCCCCTACCAGGTGCGAGGTTCATACTCCCCAGGCTGCCTCCTGTCCTCAGGGCTTGGAGAGTCCCATGTTCTGAAAATGACCTCTTTTCGAGCCGGGCAAGGCCGCATCTCCTTTGGCAGTGTAGTGTCTTCCCTGGAGGTGGCATTCCTTTTTGATTTGCCTTCTGTGCTTGGGAACCTCACTTCCTCACTCTGGCCAGCTCTGCCAGCAGTTTGGAGCTGGTTCAGCGCCCCACCGCCCTGCCTTGGCCTGCGCCCGGCCCTCCAGGGTGGCTTCTCGCCAGTTCCTGTCAGGCCTGCCTGGGCAACCAGGCCTGGGCACCTCCCTGTCCCTTGCTCAGAAAACCCACAGGCTGTGGGGGCCCGGGAGCCAAGCCTGGTGCGCGGGCAGGAAACGCATCCTGGAGCACCAGCTTCCCTGCCCTGCCCGCCTCACGGGGTGCCTGGGGGCGTGCCTCAGCCTGCTGCTCCTGTAGTCTGTTCCTGTCTCCCTGAGCAGGCTGAACATGGGCATACGAGTGACCAGCGTGATCGTGTCCAGGCCAGTGCCGCATTCTGTGTGGTCCAAGGGAAAACCTTCTCCAAGTCCACGGCCCGCCCTTTCCTCTGCTGGGTTACGGCCAAGGGCGCCAGGCCTCACTGGAGGACATGGATCCTGGACCCGGCCCTCGAGGCTGCTGCCTTCCAGTTTCCCCATGTCCTGGACACTCTTGGTCTCACCATTTGGGAGGCCGACAGGGGATGCAGAGTGGCCTGTTGGAAAGGCCTTATGTGACCCCAGGCTGAGTCCCTGAGCAGCCTGCTGAGGCCGGAGGGGAGAAGAGCTGAGCTTCTCCCTTGCTGGGCCAGGCTCGGGCTGTGGAATGGCTGCCAGCTCCCTTCCTGGGAGAGGCTGGGTGGGGTCCACAGCACCTTCCTCCCGTCCCACAGGAAGCTGTCTTCTGCTGTTGGCTGCTGGGGGCGACTGATGTTTGGATCCCTGAGCACCCTGCCAATCCCAGACTCACCTTCCCACTCTTTCCAGAGTCCCCAGGGAGACACTTAAGGGAAATTAAACTGCAGAGTGCAAGAGATGCCTCAGTCAAGTCAGCCAAAAACACGCGGGTCATCCCCAAGCCCCAGAGAGGTGAGTCGGGCAGGGCACTCAACTGCTGCAGGAGGATGGTCTTATTTCTAGCACTTTCCACAGGAGGTAAATGTGGTGGGTTTGGGGGGTTTTTCAAATGCATCAGTGTCTGGAATGGGTTCTAAGCTGCTAAATAATTCTTAGAGGTAAATGACAGACATGTTGCCCTAGATGTAGCTAGACAGCCTTCCCTCTACAGTGAAGTCTCCTCCACCCTCAGTGACAGAGCCCCGATGACACGGACACCTCGGCTGCTGTCACTTCCCTGGTTCGGGCCTCCCACAGGCTTTGAATTGAAGGCGAGTGCCTCAGAATTTGCATCCATTGTTCTGTCTTTCCTGGGAAGTTATTCATCCTGGTGGCCAGCCCACCGACAAAATGGATTTGGATCTACTGGACCTGAATCCCAGAATTATTGCTGCAATTAAGAAAGGTACATTTATTTCTATTTACATAAAGGGTGTGGGTGGGTGTGTGCAGTTTATATAAGGCAGGTTAACAAAACGCTGGCTGGCTAAGCCTTCCTTCCTTTGCCTACCCTGATTATTAAACCGAGGGCGGGATGTACTATGGGATTTTCAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTCTTAACTACATGGATTTCTTTCAGTTACTTTTATTTTTATCAAAGTAATACATGCATATTGTCTAAAAGGTAAAATGGAGCCACATAAAGTCTTTTAGTTTTTTTTTTTTGGAGACGGGGTCTCGCTCTGTCACCCAGGCTTGAGTGCAGTGGTGCGATCTCAGCTCAGTGCAAGCTCCGCCTCCCGGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCAGTCACCACGCCCGGCTAATTTTTTTGTAAATTTAGTAGAGACAGGGTTTCACTGTTTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCACCCGGCCGTCTTTTAGTTATTTTTTTAAAAAATATTTACATCTGGGCTCCTAAACGTGTTTATGTTGTAATGTTTGATTTGTCAGTGTTACTGATTATCCATGGACTTCTCTTGGGGGCTGTGAGGACTGAGCGTGCCTACACCTGTGTACCCCAACTTCCTCTCCCCCCAGCTCCCTGCCCATACTTAGAACCTAGTTTGGGTGACATCAGCTGTCAGGGTTGTGACTGGGTGCATACTGGCCATTGTTGAACCTGGTGTGGTGGTGCAGGGGATGGTTTTCTTTCTTACAGCATCTTTTTTCGCCCGAGTTAGTAAATGCTCAAAACTCAGGCCCCACGTGCAGCCCCTGCCCCCTGCTCCCCATGCCAGCCGCCTGGCTGTCATCCGGGGACCCTCCTGCCAGCTTCCATCCTCCCCCGTCTCCCCGGGCCTCAGCTACGTGAACCTCAGCACGCTGTCTGTGGCGAGAAGCCGGAGTGCTCATGGAGCTGCCGCAGCAGCCTGGTGACAGGGCAGGGCCTCGCTGTCCTGACCCTCCATCCTTGGCTGTTGGTTTTTATCCTCCTGTTGGTGGCCTTGTGATCACAGCTGCTGCCACAGCTGCAGACACGACGCTTGCAGACCAGGGACAGAGAAGGGCTCAGCCAGGGAGTTCCTTTCTCACCTGTGTCTCTTATCCAAAAACCAATGTTTCCAGAAGTCCCTGCAGACTTCACGGCTGTGAAGGGGGCTGGGGCTGTGAGGCTTACCAGGGGGAGCGCCCTGCCACAGCCCCGATCCCGGTGAGTCCTCAGGGCCCACAGAGCCTTCTGGAGCAGCCTGTCTGCGGGAAGCCCCCTCCGCTGGATCTGGTGAAACCCAGGGGCGCTTTCTTCATTCCCACCCTTCCATCTCCTTGTGTTTTCTGTGTGGCTTTTCTGAAGATCACACCAGTGCTTACTGTTTTCCAGCCGCACAATGGTTGTCTTTTCACTGCAGCGTTCAGCGCACCCGTGTTGAGGGGGTTTCTGATGTGGTGGGTGTAAGTCCCCGTGGCCGGGTGGGGCGCTTCGTCCACCACTGCTCCCTCTCGTGTGCGCTTCCTCGCACTTCCCTGATCGGCTGATCAGTCTGCAGCATTTGTCGTCTTTCTACAAGTTTGAAATTAGAAAGTGATGCACTTATCTGAGTCCAAAATTAACTTCCTTGCCCTCCTCCCCAGATGGCAGGTCCTGGGGATCTGCACCCCTGTAACTGCTGCCACCGCCGTTCTGATTCGCACATGCTCTGCCCCCTGCCCTGACTGCCCTGCGCAGCTGGCGTTTGGACCTGGGCTCTGCTACCCTCCCAGCGCTCCCCTCCCCAGGGCACATGTCCTCTCCCGCGGCTCAGCCCAGATCCATGCCTGGTGGGCGGGTGGTGGAAAGCTCGGTGCTGGTTTTTTCCTGCCCCCTTCTGGAGCACTGTCTCCAGCTGGCATGGAACTGGGTGCCTGTCGTTTCTTCTCAGTACCGGAACCTGCTCTCAGCACCGGGACCTGCCCAGCCCTGTCTTCTGGCTTCTGCCCCAGCTCACGAGGCTGGTATCTGTCCGAGTGCCAGGACTCAGGGCGCAGTGTCCAGCAGCCCTTTCCTCGTGCCTGTGCATCGGCCACACTGTGTCCAGGGTTTCCAGGGAGCAGGGGATCCGGTCCCTACCCACCTTGTCCCCAGAATCGGAAGCACGGTGCTCTCACAGTGCTCTTAACAAAGCACCTTTTGTCACTGTGTTGCCCTGCGTTGTGACAGTCTGACATTTTCCTGTAATTTATCTGTGTTATTTCAGCCAAACTGAAATCGGTAAAGGAGGTTTTACACTTTTCTGGACCAGACTTGAAGAGACTGACCAACCTCTCCAGCCCCGAGGTCTGGCACTTGCTGAGAACGGCCTCCTTACACTTGCGGGGAAGCAGCATCCTTACAGGTAGGTGGGCCCTGGCATCTCTGCCAGGGGTGACATGTGGCTCCAGCATCATGGTCCCAGTGGTGCAGGGCAGGGGCTGTGCAGACTTCACCCAGGGACCAGCCTCAGGGCGTGTGGCAGCTGCTCCAGCCCCAGAGTTCCCATCTTGCTTGTCCTACACCCATGGGGCTGTGGTCACAGCATCGGGTCAGAAGATGCGTGAGGTGGACACGGGCTGTGGGACCTCCTGGGGACCTTGCTCCATGGACCAGAGGAGGGGGTGCAGGAAGCAGGGGTGGATTTGGCAGTCAGCACCCAGAGCCCTTCAGGCTCTGGCAGGGTGGGAACGGTGTGAGATGGGGCCCTGGCCACGGTCCCACCACCACGTGTGGGAAACCAGGTCTCAGCAGGGGAAGGAGGTACCCAGGGAACCCCATGCGCCTGGACGGACAAGGTTTCCATCCCTGCATCTCAGCAGGCCCTAGTAGGCAGCGGGGTCCTGGCATGAGCAGGGCCCTCTCTCCCCTGCAGGTGGCTCAGTGGCCCAGGCCCCGAGGAACGTGCTGAACTTGGGGCTGCCGTGGTGGGCAGGTGCCACGGCCACACACACGGTGCTGTGGGCAGGGCTCTGGGCAGGCCTCACAGTCAGGGTGGCCTGCTCCACCTGGACGGGGTGCCCAAGGCAGTGTGCAGACTCCAAGGGAGGGGCTGCTCCTCCCGGCCCAGGCCCCAGGCCAAGAGCGCAGCCTGCACCGCATGTCCCACCTTGAGCCTTGCCCTGAGGGGCTTCGGTGTCGTGGAGGAGGCTGTGTCAAATGGCTCATCCAAGGCCCTTTAGCCAAGAGGCTGAGACCAGCATTGCTCCAGAATGGTATCTGTCACAGAGAACTGACGGCATGTGGTGTGCATGTGTGCGCGCCTGCGGGAGCCCATTAAAGCCGCTTGAGAACTGTTCAGCACCCCAGGGCATCCCAGCTGGACAGAGCTGTGCCTTTTTCTTCACATGGAGGCTGTTAGGGAGCGCCTCGGGGCTCTCTGGAAGCTTTGGCTGAAGGCGTCTGGTGCTGCAATTGCCCCATAGGGGGATCCCTGCGGGCATGTGATGGTGGCCCTGGGGCTCCCCCTGACTCTGCATCTCAGGTGCACCCGCCCTTCCCGGCTGGGCCCCCCTCCCTGCCCTCAGCACCTTGCTCACCCCCATGACCGCAGGCACCTGTGCTCCAGCCACACTGCACCTGGCACAGGCAGGCTGACCATGCCTCCCGCAGTCCCCAGCCCTGCCCGCAGGCCCAGGAGAGTCAGGCCTGACACTATCCCTGCCCTTTAGCACTGCAGCTGCACCAGCAGAAGGAGCGGTTCCCCACGCAGCACCAGCGCCTGAGCCTGGGCTGCCCGGTGCTGGACGCGCTGCTCCGCGGTGGCCTGCCCCTGGACGGCATCACTGAGCTGGCCGGACGCAGCTCGGCAGGGAAGACCCAGCTGGCGCTGCAGCTCTGCCTGGCTGTGCAGTTCCCGCGGCAGCACGGAGGCCTGGAGGCTGGTGAGTGGCCACCCCTTCCGTGGGGTCTGGGCAGGTGGGCGGCCCCTGCTTTGTGTGGGACAGCTTTCCGTTGAGGTGGGGCAGTGGCCGCCTCTTGCGCTGTTCCTACCATTGCGTCTCCCTCCTTCTCACCCTGATTGCCCTCGCTCCTTCCAGAACAGGGAGGGGGAAGTGAGGCTGGGCTCAGCTGACAGCAGGAGGGGTGGGAGGGTACGAACCCCACCACCAGGCAGCCGGCCCTCAGCAGAGCTAGGCCCCCAGGGGTCGCTGGCTGAGCACAGCGATGCCGGCCCACGTTCCGCACAGCTGCCAAGCCCAGAGTCCACAGAGCCAGCAACGCAGGGAGGGCAGCACAGCCTTTCCCCGGGTGCCCCGCCGCCAGGCCAGGTATGCTCCTGGCGCGGCCCCGTGAGCCTGTACGCTCTGTCTGTGAAACGAGGGTTCCCTGCATTGGACTAAAGCGTTCAGAGCATGCCTGCCTGGGTCTCTCAGGTGTTAAAAGTTCACGTAGTTTTAAACTGTGAGCTGTGAGGAGGAGAGATGTTTCTCAGTAGCTCCTTAACTTTTAAACTAATTCCCTGGTGTCAACATGCGATTCCCACGTTGTCTTAAACTCCACGTGAACAGAGTGGCAGTATTTTTTCATCGGTGGCACCTCCGAGCACATCTGCTAGGCTCACTTCCCACACAGGGCCGGACCCCAGGCCCTGGACCCACAGGCCCAGCCAGCCACCTCCTCACGGGCCTGACCTGCCAGCAGCGGTGTGGCTGGGAACCTCACCTCTGCCACCCTCAGGTCAGCGTCATCCCCAGGACCCAGGGTGTGCTGTGCCTGCCTGAGCTTCAGTGCTGGGTGGAGGGTGAGGGGTCTCCTGAGCCTCCGTGTCGGGTGGAGGGTGAGGGGTCTCCTGAGAGCCCAGCTGGGGTCTGCTCACGCCACAGGCATTTTTGTCCCTGCAGCCCAGGGGAGGGCACCCTCTTGTCAGGTGCCTGAGTCCCTGCGGCTGGTCTTGGGGATGAGCCTGGAGACAGCCAGAAGCCGGGAGGACAGGAGTTGGCCTTGAAAATGGGAGTCTCCCGCTTACCGCACGGAAGAGCTGCTGTGAGGTGGAGGCGGGACTCGAGCGTGCTCAGGAACGGGACGGGAGCCGCCCTCATTCTCCAGCGTCCTCCGTGCCAGGCTTCGTGCAAATCTGATTTGTGCAATGACTCCCCCTCAGCTTCCACCCCGTTGGCCTTTTCAGTGAAGCCCACACTCCCCGATACCCAGGGACACAGAAGCCTTAGGACACCCTCCCTGAATCCCCCAGCTGTGCCCAGCCCAGTGACTGCTGCGGGATGACAGCACAGTCCAGCCTTGCGGGCCAGGGGAAGGGAGGGGGCCCCACGGCCACCGTGACCACATGCAAGGTTAGGGGTCAGATGTGCTTTCCTGGGGAAATGACTTCCTTTCCTGGATCCAATCTAAAGGCCCGAATTTTGAAAAGAAAGCGGCAGGCGGGCTCTGAAGTGATTCCGACTCCCGTGCTTAAGCCGCGTGAGGCTCTCCCAGGCCTGCTGGGGCCCCGCCCACCGCTGGGCTGTCCACAGCCACCCTCCTGCCAGCTTCACGATGTCCCCATGACTGTGCAGCCCCTACATAACGTCACCCCAACAAAAACACGCTGCTTGACCGGTTCCACCTGCTTCCGAGCCTTCCAGCCCAGCCTCTCTCCAGCCAACAGGACGGAGGAAGCCCAGGGCCCCGACCTTCCTGTGGCTCCTGACTAGGGGCACAGTCACTGCTGGGGACACTGGTGGGGAAGGGAACCAGCCACAAAAGGGATGTGGCCTCCCAAGGCAGTATTTATACGTTCCTGGCCTCAAGCGGGCCAGATGCTTCTCAGAAGCTTAGTTCTGACACAGAATGGGGCGGGGGGTTCCTGACCCATTTTTGCAACTCTTCTTTACGTTTGAAATTCTGTCAAAGCAAAATCAGCTCAGAATTAAAGGTTACGCGGACACTCACAAACAGGCTGCATGACACGGCGTGGGGGCACTGGCTCTCCCACAACTGCATGTGCCACTGCAGGAACAGGACGACGCCCCGTGGGCCACGGGGTCCTGGCTGGGCAGCCTTCCTGGCATAGTCAGTGCTTAGAGAGCTCGCCGGCCTTGTCTTTTTGTTTTTGTTTTGCAGGAAACTGGAGTTTTATTATTACTCAAATCAGTCCCCCTAAGCCTTCCTGTTTTTTAAATTGAGATGTAATTTACATGCCATAAAATTCCCTCTAAAAGTGTACAGTTCGGCCTGATAGGCGCAGTACCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCTGAGGCAGGCGGATCATGAAGTCAGGAGTTCGAGAGCAGCCTGACCAACATGGTGAAACCCAGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTAGCGCACGCCTTGTAATCCCAGCTACTCAGAAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGCGACAGAGTGAGTCTCTTGTCTCTCAAAAATTAAAATAAAATAAATAAATTCAGTGGCTTTTAATAGAAGCACAAAGTTCTGTGCCCGTCACCACTATCCAATTCCAGAACAGTTCCCTCACCCCAAAAGGAAACCCTACCCATGAGCAGTCAGCCCCCACCCCCAGCAGCCTGCCTCCCCTTTCCCTACCTGTGACTCTTCCTGTCCTGGGAGCTCCATGCAAGTGCAGCCGGACAGCACGTGGTCTCGTGACAGGCTTCCTGCATTGGCATTGTGTTTTCGAGGTTCATCCGTGCTGGAGCAGGTGTCAGAACTGCCTTCCCTTTTAAGATTCGATCATCCCACTGTAAGGATGGGCCGCACTTCATTCGTCCACTCCTCAGTTGATGGCCTTTGGGCCGTCTCCCCCCGGGCTGTCATGAAACGTGCTACGGTGGACGTTCTTTCTCTTGGGTATCTACCTAGGAGTGGGGCTGCTGAGTCATGTGATTTGTTTAACTTTTTAAGGAAGTACCGATTGTTTTCCGAGCTGCACCATTTTACATTCCTAGCGGCAGTGCACAGGGGTCAGGGGTCTGCCTCCTACACATCCTCACCAACACGTGTCTTTTCAAGCTGGCTTTTTGAATTTCACCATGGAGCCCAGATTGCAGGAGCTTTGAAGAGAGGAAACGCTTGCTCAGTGGGGGCCTTGAGGGTGGCCATGTGTCGGGGCTCAGGGGCCATTTCCAGAAGGCGTTGCCCTGATGCTGCCACTTGCTCCCTGCCCTGCAGTGGGGAACGGAGGTTCACAGGGGGAAGGAGGGGCAGGGTGGAGCAGGAGAGGCCTCCCATCTGTGGCCATTCCAGCCCAGGGCCCAGGACAGGGGAAGTCCTTGCCTGGGTGTCAGAAGTGGAGACCCAGCCCATATTCCTCCTGAGGGGTCACCTGGCCCCGGAGGTGGCTGCCAGTGGGAGGGTGAGAAAAAGCACCAGCCTCCTCCCTCCCCAGGCGAGGGGCAAAGAACCTGTGAGGGGCAGAGAGTTAGAAATGGCGGGAGACATCTGCACTTGATTTGTGTGGCAGTCACAGGCCCGTCTGGAGTCCCCTGGGCACATCAGGCACTCTTGCTTCCCAGGAGCCGTCTACATCTGCACGGAAGACGCCTTCCCGCACAAGCGCCTGCAGCAGCTCATGGCCCAGCAGCCGCGGCTGCGCACTGACGTTCCAGGAGAGCTGCTTCAGAAGCTCCGATTTGGCAGCCAGATCTTCATCGAGCACGTGGCCGATGTGGTGAGTGTGGGAGAAGCCCCATGACACCCCCAAGGCAAGCTATTCAGGACCATTGGGGCAGGTGTAGCCACCACGGCAATGGGGTCTCACAGCAGGGCAGGGAGAGTTGGGGCTCAGCTCTGAACACAGCATGGGTCATGGGGGTTTACGCCCGAGGAGCAGGTGGGGTCAGAGGATGGAGAGTGACTGAGAGGAACTGGCAGGGGAGGGAATTCTGGCTAAAGCATCCTGCCAGGACCCTTGCTGAAGGTGTGCCTTGGGGATCAGACGGCCTCTGGGGACTGTGGAGGATGGACCAGTCAGCTACTGAGGGCGACTGGATACGGAGAGCAGGGGTCCTGCTACAATCTCAGCAGGGATTGCCAAAACTGGATTTCATGAGGACGTGCACAGATGGGCCTAGGAGGAGGCTCAGGAGCCTGACGGCAGTTTGGCCAAACAGAATCCTGGCCAGGAGTGGCTGTGGGCCAGGCAGGCAGGGCGGCAGGCTGCGACACCCAGTTACATCTGAATCTCAGGCAGCTTTGAAGCGTGTTCTAGAATGAGGATGCCCATATTCAGATCAACTTTCTTCATGATCTGAAACTCAGATGTAACTGGGCGCCTGTACACCATCTGTCAACCTTGCCCATGAAGACGGAGTGGGGAAGAGAAGCCCCAGGCGGGTGGCAAGGACCTCCTCTGGGCTGTGGGCCCCTGACCAGCTGCCCCAGGAGACCACCGCCCTGAGAAGGATGCGACCTGCTCTCCAGGCTGCTGCCCTGGTGAGATAGCTGTGTTGGTTTCCCCTTGCCCCTGAGGGGAAGACGGCCCTCACTAGGGGCACAGGGGCTCCACCTGGCCAAGGCCTGCTGGGCACCCAGCTCAGACAGGTGACCTCAGATCCTTGACCACTGCCTGGCTGCTGGCTTCCCTGCAGACACTGGCTGGGCTTGGAGGAGGGACCTATGGCAGGGCCTTGCAGAGAGCAGGGGCCACTCACCGGGGGCCAGTGGAGTCCGTCCTGTAGCCAAGAAGCAGGCAAGAGAGGCTGGGACCCATCCCTGCAGCTGGGGCAGCAGTGCTGTGAGCTGTCAGTGCTTAGTTTATAGACATCATCCTGGGAGGGAGAAGTGATGAAGTAGAAAAGACGCAGAAGAAAAGATGGGACGTTTGGGAGTAAACCCCTGACCAAAGGCAAGTAAGGAAATTCCACCCTGTGCAGGGGGAGCGGCTGCCATGTCCAGCCCACCCTAGACATGGCTGTGGCCTGGCAGAGCAGCTCCTGGGTGGGCCTTCCCCCACTTCTCTTTTTTTTTTTTAAGACAGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGTGCAATCTCAGCTCACTGCAAGCTCCACCTCCCGGGTTCACGCCATTCTCTTGCCTTAGCCTCCAGAGTAGGTGGGACTACAGGCGCCCACCAACACGCCCAGCTAATTCTTTGTATCTTTAATAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTGGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGCCAGCCTTCCCCCACTTCTAAGAGGTCTTATAAAAACTTTCAAGTAAAGCATAAGGCATATAAACTTTTAATTTAAAAAAATGTACAATAAAATACGTTATCGCACACAACGTGAGGAAGTTACACATGGGAAGGGAGCCGTGGGCCCAGCTCATGCCCCAGGTCTCCTGGGAGAGACCACGCCGCACCAGGGCACCAGCTTAGGCCCAGCCCCAGCCCCAAGGTCACGCCAGCCGTGTGGTTATTAGTATCATGTCCTATGCACACAGACGCAGGAGAAATGAGTGAGCGCTGCGGCTCCCGGCCAGGGGCCCTCCCTGCCGCCCTGGCTGTCCCGGGCCAGCTCCGGGCCACACTCGGCAGTCCCATCCTGGAGCGGGGCCAGGTCGGGGTCACTGCAAGAGAAGATAGAAGGTCAGGGCTGGGCCGCCAAAACCTGACAGTGTTACTAAGTTCTGTTCTGGAAACAGCTCTCTGGGGAACCCCCACCCCAAGTCTGCCTAGAGAAGAGGGTGTTGCTGGTTGTGAGCCTCCCTGGGGCCGAGGGGTCATGGGGGACTGGTGCGTCTTTGGTCTCTGCTCCCTGGAGCACCAAAGGCCTGCGTCTGGCACGGGGGAAGCCAGGGGTGTGGACACAGAGCCTTCTCTTGCATAAGCAGAGCCTGGTGCCATTCCCACCCCCCCACTCTGTGGCCCTTGGGCTTGCATGAGGATGGGGACCCTGAGCCAAGCCCCTCTTGGAGGCCCAGCCTGGCAGCTAGCAGCAGTCACCACTTGCCCATCCCCAGCTCCCCCCAGTCCCTGCATGTGCAAAGTCCCTCCCTGGCCCAGCTGCCTGCTTCCTGGGGCTGCAGGCCGTGGGACTCACGTTAGCGGTGGCGTCTTCCAGGCCACTGCTGCTGCTGTCGTTTTCCACAAAAAGAGGCTCGGCCAGAGACGCCCTGGAGATGAAGCACAGACGAGTTTCACTCAGGGCGTGCAGGCGGCCCTCAGGCGTCTTCAGAGCTCCGGGCGTGACACCAGCGTGTGGCTGCAGACCTTGGACTTGAGGGACAGCCTAGGGGCCCCTTAGCAGCCTCCATCTGGCCAGAGCTGCTGGCAAGGCCCGTGGGGCCTGAACTACACTGCTTGGTGCCAGGAGCAGCTGTGTCACCCTCCCCCATCACCATGGCTCACCAAGCTGTGCGGTCAGAGGCCAGGCCAGCCATGCCAATGGCTCTGGCACCCACAGGCCACGGCAGCACCCAGAGGGAGGCCGAGGACACCTGCCTTCACTGGGGGGGTCCTCCCCTGGAAGCTCTCCTGGGAGCTGGTGGGCACAGGGCTGTTTCCACCCCTTGGCCAGGCCAGGCCAGCTCAGAGCACAGGGCTAAGGCCTGGATGCACGGGAGGCACTGGCCTTGAGGGTGTCTCAACCTACAGCCCCATCCTGACCCCCAGGTGGTCTCCCAGAGTGCCCCACGCCTTGGCAGAGGCAGGCCAGGCCTGACTCGCCTGAGTAACGCCTGAAGGGCATCAGGCCCCTGCCTTGCTGAGCGTCTGAAGAGGTCATGGCCACCACGGGCTGGCTTTGGTGGCACTGTGGCCAGGTTTGGGTGGTCTGAGTACCTGGTGCGGGGCCACTGAAGGAGGGGGCTGGTTGCTGCTGACCTGTGAGGGGGAGAGGGTGAAACCATGGCAGAAGGAGAGCAGACCCCCGCAAGGACTCAGGAGCCTGCGCAAAGGACACCTCTACAGAGGACGGTGTTGGCACAGCCAAGGGGTGACTGCCTGGGGGGGCCAGAGGAAGGACATGGGGCCAAGGGAACCAGTTGTGTGAGCCTGAAGCTTCTATAGTTGGGGCCTCTTTGAGAAAAATACAGAATTGGGCTCAGAGTATGGGGACTACAGAGTATGGGCACTGTGAGCCCCAGGTGGGTAGGAAGGTTTTCAGACGGTCGAGTGACAGTCCAAACGGGGTCTGGTCACCTGGGGCGGGGACTTGCTGACCAGCATAGACAATGACAGCTGTCCCCACAGGACACCTTGTTGGAGTGTGTGAATAAGAAGGTCCCCGTACTGCTGTCTCGGGGCATGGCTCGCCTGGTGGTCATCGACTCGGTGGCAGCCCCATTCCGCTGTGAATTTGACAGCCAGGCCTCCGCCCCCAGGGCCAGGCATCTGCAGTCCCTGGGGGCCACGCTGCGTGAGCTGAGCAGTGCCTTCCAGAGCCCTGTGCTGTGCATCAACCAGGTGAGCACCAAGGCAGGGTTGCACCCCTGAGCTCGTATTTTTAGCCAGGATGCGGAAGCAGAGCCGGTCTGGAGGTGGGGCGGGTGGCAGTGAGGTGGCCTCCGGCTCCTGCGGGTAGCAGCCTGTGCCTAACCATCGAGAAGACCCTCAGCCGTTGCAGCTGACCTGGACTGTGCTCTTCCAGGTGACAGAGGCCATGGAGGAGCAGGGCGCAGCACACGGGCCGCTGGGGTGAGTGCAGCCATGTGGTGTGTGCACCTCTGTGCAGGTGCCAGGGGCACAGCTGGGCCGAAGTGGGCGGGGCCACCAAGCCTGAGCGCCAGCTTGCCTGCTTCCTGTTTCTCAGGTTCTGGGACGAACGTGTTTCCCCAGCCCTTGGCATAACCTGGGCTAACCAGCTCCTGGTGAGACTGCTGGCTGACCGGCTCCGCGAGGAAGAGGCTGCCCTCGGCTGCCCAGCCCGGACCCTGCGGGTGCTCTCTGCCCCCCACCTGCCCCCCTCCTCCTGTTCCTACACGATCAGTGCCGAAGGGGTGCGAGGGACACCTGGGACCCAGTCCCACTGACACGGTGGCGGCTGCACAACAGCCCTGCCTGAGAAGCCCCGACACACGGGGCTCGGGCCTTTAAAACGCGTCTGCCTGGGCCGTGGCACAGCTGGGAGCCTGGTTCAGACACAGCTCTTCCAGGGCAGCGGCTCCACTTTCTCATCCGAAGATGGTGGCCACAGACTGACCCCCATCTGAGCTGGGGGGATGTTCTGCCTCTCCCTGGGTCTGGGGACAGGCCCGCTTGCTGGGTACCTGGTCCCCACTGCTGAGCTGGCCCTTGGGGAGAGGTGATTCTCAGGGCTGGAGCCTGGGGTGTCCTACAGTGACTCCCTGGGAGCCGCCTGCTTCTTCTCTCCACATGGAAGCCCAACTGGGGTTGCGTCTGAGGCCTGCCCCCTGGGCTGGGGCCTCAGACCCCCTCAGCCTTGGGACCGTGCCCACGAGGGTCTCCCCTCCTGCACACAGGGCAGTCCTTACTCCCCCACCACTCAGGCCACAGTGGGGCTGCAGGCAGGCGGCTCCTCCTCACCCACCTCTGGGTCCTTGGCTCCCGGGGGCCCCACCTCGGCACACACTGTGCCCCACAAAACTTCAGTGTGGTACAAGGTGGAGAAAGCATATCCCACCAACCTCCAGTGTCAGGGTCCAGGAGAGCCTGGGGGTGGGGGGACTGCCTTGTCTCTAGTAGTGTGGCCTGTGCCAGCACCACAGCCGGTCAGAGGAGCGCAGGCAGCGCAGGGCTGGCACGTGACAGGCTCGTCAGCCACCTGGGAACACAGTTCTGGGCAAAGAGGATCCGAGGTTGAGAGGAAGGAGGGTCCCGGTGTATCCTGGCCCTGGGGGTCTGGGCGTCCAGCTCAGCCCTGGCCTGGCTGGGTGGTATTCTGGTAGGGATATGGCAGGACTCCTGGCAGGGCCACCTGCAGGACCCTGTCCTGCAGTCCCACACTGTGCAGACCCAGTCCCACACTGTGGCCAGGCCTTACATCTGGCTGGAAAGCAGAGCCTCCTGGGAACACATCTGGCTGCACAGGCTGAAATATCCACCCAGCAGGCAGAGTGGCGTGGCCTCCCCATGGGCACAGTGGTGACCCCCTTGATTCCCACCGTACAACCCCCTCCACCCCCCACTCAGTGCCTCCACATGCTGCCTGGCACAGACCAGGCCTTTGACAAATAAATGTTCAATGGATGCAGTTCCAGG

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